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Protein

Probable M18 family aminopeptidase 1

Gene

apeA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93ZincSequence analysis1
Metal bindingi168ZincSequence analysis1
Metal bindingi426ZincSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM18.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable M18 family aminopeptidase 1 (EC:3.4.11.-)
Gene namesi
Name:apeA
Ordered Locus Names:TM_0365
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734581 – 451Probable M18 family aminopeptidase 1Add BLAST451

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0365.

Structurei

Secondary structure

1451
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Helixi14 – 30Combined sources17
Helixi34 – 46Combined sources13
Turni47 – 49Combined sources3
Beta strandi65 – 72Combined sources8
Beta strandi74 – 79Combined sources6
Helixi83 – 85Combined sources3
Beta strandi88 – 93Combined sources6
Beta strandi98 – 109Combined sources12
Beta strandi112 – 122Combined sources11
Helixi126 – 128Combined sources3
Beta strandi129 – 131Combined sources3
Beta strandi133 – 140Combined sources8
Beta strandi146 – 157Combined sources12
Helixi167 – 169Combined sources3
Turni176 – 179Combined sources4
Helixi182 – 184Combined sources3
Beta strandi186 – 190Combined sources5
Helixi201 – 214Combined sources14
Helixi218 – 221Combined sources4
Beta strandi224 – 230Combined sources7
Beta strandi235 – 238Combined sources4
Beta strandi243 – 246Combined sources4
Helixi249 – 264Combined sources16
Beta strandi271 – 277Combined sources7
Helixi279 – 281Combined sources3
Beta strandi285 – 292Combined sources8
Helixi293 – 304Combined sources12
Beta strandi308 – 310Combined sources3
Helixi311 – 319Combined sources9
Beta strandi322 – 326Combined sources5
Helixi334 – 339Combined sources6
Helixi342 – 344Combined sources3
Beta strandi352 – 357Combined sources6
Helixi371 – 383Combined sources13
Beta strandi388 – 390Combined sources3
Beta strandi393 – 395Combined sources3
Helixi405 – 409Combined sources5
Turni410 – 412Combined sources3
Beta strandi415 – 419Combined sources5
Beta strandi421 – 424Combined sources4
Beta strandi427 – 433Combined sources7
Helixi434 – 450Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLFX-ray2.80A/B/C/D2-451[»]
ProteinModelPortaliQ9WYJ9.
SMRiQ9WYJ9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M18 family.Curated

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
InParanoidiQ9WYJ9.
OMAiKETQAVP.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1. 1 hit.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.

Sequencei

Sequence statusi: Complete.

Q9WYJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMERKNVWH HRKKEEIEAF SKEYMEFMSK AKTERMTVKE IKRILDESGF
60 70 80 90 100
VPLEDFAGDP MNMTVYAVNR GKAIAAFRVV DDLKRGLNLV VAHIDSPRLD
110 120 130 140 150
FKPNPLIEDE QIALFKTHYY GGIKKYHWLS IPLEIHGVLF KNDGTEIEIH
160 170 180 190 200
IGDKPEDPVF TIPDLLPHLD KEDAKISEKF KGENLMLIAG TIPLSGEEKE
210 220 230 240 250
AVKTNVLKIL NEMYGITEED FVSGEIEVVP AFSPREVGMD RSLIGAYGQD
260 270 280 290 300
DRICAYTALR ALLSANPEKS IGVIFFDKEE IGSDGNTGAK ARFYLKALRQ
310 320 330 340 350
ILKMQGAKDS EFVLDEVLEN TSVISGDVCA AVNPPYKDVH DLHNAPKLGY
360 370 380 390 400
GVALVKYTGA RGKYSTNDAH AEFVARVRKV LNEQGVIWQV ATLGKVDQGG
410 420 430 440 450
GGTIAKFFAE RGSDVIDMGP ALLGMHSPFE ISSKADLFET YVAYRSLMEK

L
Length:451
Mass (Da):50,381
Last modified:October 24, 2001 - v2
Checksum:iC2310E30DA36BCD8
GO

Sequence cautioni

The sequence AAD35452 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35452.1. Different initiation.
PIRiE72387.
RefSeqiNP_228176.1. NC_000853.1.
WP_004083171.1. NZ_CP011107.1.
WP_010865103.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35452; AAD35452; TM_0365.
GeneIDi897324.
KEGGitma:TM0365.
PATRICi23935611. VBITheMar51294_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35452.1. Different initiation.
PIRiE72387.
RefSeqiNP_228176.1. NC_000853.1.
WP_004083171.1. NZ_CP011107.1.
WP_010865103.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLFX-ray2.80A/B/C/D2-451[»]
ProteinModelPortaliQ9WYJ9.
SMRiQ9WYJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0365.

Protein family/group databases

MEROPSiM18.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35452; AAD35452; TM_0365.
GeneIDi897324.
KEGGitma:TM0365.
PATRICi23935611. VBITheMar51294_0370.

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
InParanoidiQ9WYJ9.
OMAiKETQAVP.

Miscellaneous databases

EvolutionaryTraceiQ9WYJ9.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1. 1 hit.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.
ProtoNetiSearch...

Entry informationi

Entry nameiAPEA_THEMA
AccessioniPrimary (citable) accession number: Q9WYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: October 24, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.