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Protein

Probable M18 family aminopeptidase 1

Gene

apeA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931ZincSequence analysis
Metal bindingi168 – 1681ZincSequence analysis
Metal bindingi426 – 4261ZincSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-379-MONOMER.

Protein family/group databases

MEROPSiM18.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable M18 family aminopeptidase 1 (EC:3.4.11.-)
Gene namesi
Name:apeA
Ordered Locus Names:TM_0365
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Probable M18 family aminopeptidase 1PRO_0000173458Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0365.

Structurei

Secondary structure

1
451
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 103Combined sources
Helixi14 – 3017Combined sources
Helixi34 – 4613Combined sources
Turni47 – 493Combined sources
Beta strandi65 – 728Combined sources
Beta strandi74 – 796Combined sources
Helixi83 – 853Combined sources
Beta strandi88 – 936Combined sources
Beta strandi98 – 10912Combined sources
Beta strandi112 – 12211Combined sources
Helixi126 – 1283Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi133 – 1408Combined sources
Beta strandi146 – 15712Combined sources
Helixi167 – 1693Combined sources
Turni176 – 1794Combined sources
Helixi182 – 1843Combined sources
Beta strandi186 – 1905Combined sources
Helixi201 – 21414Combined sources
Helixi218 – 2214Combined sources
Beta strandi224 – 2307Combined sources
Beta strandi235 – 2384Combined sources
Beta strandi243 – 2464Combined sources
Helixi249 – 26416Combined sources
Beta strandi271 – 2777Combined sources
Helixi279 – 2813Combined sources
Beta strandi285 – 2928Combined sources
Helixi293 – 30412Combined sources
Beta strandi308 – 3103Combined sources
Helixi311 – 3199Combined sources
Beta strandi322 – 3265Combined sources
Helixi334 – 3396Combined sources
Helixi342 – 3443Combined sources
Beta strandi352 – 3576Combined sources
Helixi371 – 38313Combined sources
Beta strandi388 – 3903Combined sources
Beta strandi393 – 3953Combined sources
Helixi405 – 4095Combined sources
Turni410 – 4123Combined sources
Beta strandi415 – 4195Combined sources
Beta strandi421 – 4244Combined sources
Beta strandi427 – 4337Combined sources
Helixi434 – 45017Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLFX-ray2.80A/B/C/D2-451[»]
ProteinModelPortaliQ9WYJ9.
SMRiQ9WYJ9. Positions 2-451.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M18 family.Curated

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
InParanoidiQ9WYJ9.
OMAiENPTIFH.
OrthoDBiEOG6BW4VB.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.

Sequencei

Sequence statusi: Complete.

Q9WYJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMERKNVWH HRKKEEIEAF SKEYMEFMSK AKTERMTVKE IKRILDESGF
60 70 80 90 100
VPLEDFAGDP MNMTVYAVNR GKAIAAFRVV DDLKRGLNLV VAHIDSPRLD
110 120 130 140 150
FKPNPLIEDE QIALFKTHYY GGIKKYHWLS IPLEIHGVLF KNDGTEIEIH
160 170 180 190 200
IGDKPEDPVF TIPDLLPHLD KEDAKISEKF KGENLMLIAG TIPLSGEEKE
210 220 230 240 250
AVKTNVLKIL NEMYGITEED FVSGEIEVVP AFSPREVGMD RSLIGAYGQD
260 270 280 290 300
DRICAYTALR ALLSANPEKS IGVIFFDKEE IGSDGNTGAK ARFYLKALRQ
310 320 330 340 350
ILKMQGAKDS EFVLDEVLEN TSVISGDVCA AVNPPYKDVH DLHNAPKLGY
360 370 380 390 400
GVALVKYTGA RGKYSTNDAH AEFVARVRKV LNEQGVIWQV ATLGKVDQGG
410 420 430 440 450
GGTIAKFFAE RGSDVIDMGP ALLGMHSPFE ISSKADLFET YVAYRSLMEK

L
Length:451
Mass (Da):50,381
Last modified:October 24, 2001 - v2
Checksum:iC2310E30DA36BCD8
GO

Sequence cautioni

The sequence AAD35452.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35452.1. Different initiation.
PIRiE72387.
RefSeqiNP_228176.1. NC_000853.1.
WP_004083171.1. NZ_CP011107.1.
WP_010865103.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35452; AAD35452; TM_0365.
GeneIDi897324.
KEGGitma:TM0365.
PATRICi23935611. VBITheMar51294_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35452.1. Different initiation.
PIRiE72387.
RefSeqiNP_228176.1. NC_000853.1.
WP_004083171.1. NZ_CP011107.1.
WP_010865103.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLFX-ray2.80A/B/C/D2-451[»]
ProteinModelPortaliQ9WYJ9.
SMRiQ9WYJ9. Positions 2-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0365.

Protein family/group databases

MEROPSiM18.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35452; AAD35452; TM_0365.
GeneIDi897324.
KEGGitma:TM0365.
PATRICi23935611. VBITheMar51294_0370.

Phylogenomic databases

eggNOGiENOG4105DFM. Bacteria.
COG1362. LUCA.
InParanoidiQ9WYJ9.
OMAiENPTIFH.
OrthoDBiEOG6BW4VB.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-379-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9WYJ9.

Family and domain databases

Gene3Di2.30.250.10. 1 hit.
HAMAPiMF_00466. Aminopeptidase_M18_1.
InterProiIPR022983. M18_aminopeptidase_1.
IPR001948. Peptidase_M18.
IPR023358. Peptidase_M18_dom2.
[Graphical view]
PfamiPF02127. Peptidase_M18. 1 hit.
[Graphical view]
PRINTSiPR00932. AMINO1PTASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiAPEA_THEMA
AccessioniPrimary (citable) accession number: Q9WYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: October 24, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.