Q9WYI4 (AROQ_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	TM_0349

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00169
Subunit structure	Homododecamer By similarity. HAMAP MF_00169
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	3-dehydroquinate dehydratase HAMAP MF_00169		PRO_0000159934
Regions
	Region	98 – 99	2	Substrate binding By similarity
Sites
	Active site	22	1	Proton acceptor By similarity
	Active site	97	1	Proton donor By similarity
	Binding site	71	1	Substrate By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	84	1	Substrate By similarity
	Binding site	108	1	Substrate By similarity
	Site	17	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WYI4 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0CD0053918257FB7	FASTA	144	16,566
	10 20 30 40 50 60 MKVLVVNGPN LNMLGKRDKN IYGNFSHEDL VKMIEDWGRK NGVEVEVFQS NHEGKILDRL 70 80 90 100 110 120 HRLDFDGLVI NPGAFTHYSY AIRDALEIVK VPKVEVHISN IHRREEFRRR SVTAEVCDGQ 130 140 ISGLGVYGYL LALEYIKKKL EELT

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD35435.1.
PIR	C72389.
RefSeq	NP_228160.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WYI4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	897305.
GenomeReviews	Gene locus TM_0349 in contig AE000512_GR.
KEGG	tma:TM0349.
NMPDR	fig|243274.1.peg.344.
PATRIC	23935579. VBITheMar51294_0354.
TIGR	TM_0349.
Phylogenomic databases
HOGENOM	HBG284657.
OMA	VHMSNIH.
PhylomeDB	Q9WYI4.
ProtClustDB	PRK05395.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_0349-MONOMER.
Family and domain databases
HAMAP	MF_00169. AroQ. [Tree]
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.9100. DHquinase_II. 1 hit.
KO	K03786.
PANTHER	PTHR21272. DHquinase_II. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. AroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_THEMA

Accession

Primary (citable) accession number: Q9WYI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program