Q9WYI2 (AROC_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	TM_0347

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Chorismate synthase HAMAP MF_00300		PRO_0000140668

Sequences

	Sequence		Length	Mass (Da)
	Q9WYI2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 2353443592578C02	FASTA	376	41,750
	10 20 30 40 50 60 MKLTIAGDSH GKYMVAILEG LPSGIRVDEE LIRRDLFRRR NCYGRGKRMK MEEDAFEIVS 70 80 90 100 110 120 GLWKGITTGA PVTILIPNRA GNPVKDVRSV PRPGHIDYAA WVKYKLPDLN IYVERSSARW 130 140 150 160 170 180 TVALTAAGSL LKSLLKEFGI EVLGFVTRLG NVEARDIPGD FEELKRRRDE SVVFCPDPEA 190 200 210 220 230 240 TKEMVAEIDR AKEEGNTLGG KVKVIARGVP AGIGSYSDLF KKLDSKIGSL FFAIPAVKGV 250 260 270 280 290 300 VIGSEEMWYG FDYLDEFELE DGKIKRKTNN LGGIEGGITN GEDVWVNVSV KPIPTTGKPL 310 320 330 340 350 360 KSVDLRTMEP AKTPYVRSDV TAVPPASVVC EAALAVVISD ALLEHLGDGN IDDLKRRFEN 370 ENLPRWNDGF WKEHYR

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD35433.1.
PIR	A72389.
RefSeq	NP_228158.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WYI2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	897303.
GenomeReviews	Gene locus TM_0347 in contig AE000512_GR.
KEGG	tma:TM0347.
NMPDR	fig|243274.1.peg.342.
PATRIC	23935575. VBITheMar51294_0352.
TIGR	TM_0347.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	IQTITEN.
PhylomeDB	Q9WYI2.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_0347-MONOMER.
BRENDA	4.2.3.5. 6331.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_THEMA

Accession

Primary (citable) accession number: Q9WYI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program