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Q9WYG7

- PYRF_THEMA

UniProt

Q9WYG7 - PYRF_THEMA

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, TM_0332
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Substrate By similarity
Binding sitei26 – 261Substrate By similarity
Active sitei54 – 541Proton donor By similarity
Binding sitei106 – 1061Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei180 – 1801Substrate; via amide nitrogen By similarity
Binding sitei181 – 1811Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:TM_0332
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Orotidine 5'-phosphate decarboxylase
PRO_0000134595Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM0332.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Beta strandi9 – 113
Helixi12 – 198
Beta strandi23 – 275
Helixi29 – 324
Helixi37 – 437
Turni44 – 463
Beta strandi48 – 558
Helixi59 – 6911
Beta strandi74 – 807
Helixi81 – 833
Helixi85 – 9410
Beta strandi96 – 1027
Helixi112 – 12413
Beta strandi128 – 1303
Helixi133 – 1397
Turni140 – 1423
Beta strandi147 – 1493
Helixi167 – 1704
Turni171 – 1733
Beta strandi175 – 1806
Helixi181 – 1844
Helixi189 – 1968

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VQTX-ray2.00A1-201[»]
ProteinModelPortaliQ9WYG7.
SMRiQ9WYG7. Positions 1-198.

Miscellaneous databases

EvolutionaryTraceiQ9WYG7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 6110Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiARSIKSW.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYG7-1 [UniParc]FASTAAdd to Basket

« Hide

MTPVLSLDME DPIRFIDENG SFEVVKVGHN LAIHGKKIFD ELAKRNLKII    50
LDLKFCDIPS TVERSIKSWD HPAIIGFTVH SCAGYESVER ALSATDKHVF 100
VVVKLTSMEG SLEDYMDRIE KLNKLGCDFV LPGPWAKALR EKIKGKILVP 150
GIRMEVKADD QKDVVTLEEM KGIANFAVLG REIYLSENPR EKIKRIKEMR 200
L 201
Length:201
Mass (Da):22,809
Last modified:November 1, 1999 - v1
Checksum:i4C2FAD77302F206D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35419.1.
PIRiF72390.
RefSeqiNP_228143.1. NC_000853.1.
YP_007976680.1. NC_021214.1.
YP_008990695.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35419; AAD35419; TM_0332.
GeneIDi897284.
KEGGitma:TM0332.
tmi:THEMA_03060.
tmm:Tmari_0330.
PATRICi23935545. VBITheMar51294_0337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35419.1 .
PIRi F72390.
RefSeqi NP_228143.1. NC_000853.1.
YP_007976680.1. NC_021214.1.
YP_008990695.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VQT X-ray 2.00 A 1-201 [» ]
ProteinModelPortali Q9WYG7.
SMRi Q9WYG7. Positions 1-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0332.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35419 ; AAD35419 ; TM_0332 .
GeneIDi 897284.
KEGGi tma:TM0332.
tmi:THEMA_03060.
tmm:Tmari_0330.
PATRICi 23935545. VBITheMar51294_0337.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi ARSIKSW.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Miscellaneous databases

EvolutionaryTracei Q9WYG7.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Crystal Structure of orotidine 5'-phosphate decarboxylase (TM0332) from Thermotoga maritima at 2.00 A resolution."
    Joint center for structural genomics (JCSG)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiPYRF_THEMA
AccessioniPrimary (citable) accession number: Q9WYG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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