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Protein

Transaldolase

Gene

tal

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal), Probable transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BRENDAi2.2.1.2. 6331.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Ordered Locus Names:TM_0295
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736871 – 218TransaldolaseAdd BLAST218

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0295.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi10 – 18Combined sources9
Beta strandi24 – 26Combined sources3
Helixi30 – 34Combined sources5
Helixi42 – 50Combined sources9
Beta strandi54 – 57Combined sources4
Helixi63 – 74Combined sources12
Beta strandi80 – 87Combined sources8
Helixi88 – 99Combined sources12
Beta strandi104 – 109Combined sources6
Helixi112 – 121Combined sources10
Beta strandi124 – 129Combined sources6
Helixi130 – 135Combined sources6
Helixi140 – 154Combined sources15
Beta strandi159 – 164Combined sources6
Helixi168 – 177Combined sources10
Beta strandi180 – 184Combined sources5
Helixi186 – 192Combined sources7
Helixi196 – 214Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VPXX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-218[»]
ProteinModelPortaliQ9WYD1.
SMRiQ9WYD1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
InParanoidiQ9WYD1.
KOiK00616.
OMAiVRHPMHV.

Family and domain databases

CDDicd00956. Transaldolase_FSA. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
IPR033919. TSA/FSA_arc/bac.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFLDTANL EEIKKGVEWG IVDGVTTNPT LISKEGAEFK QRVKEICDLV
60 70 80 90 100
KGPVSAEVVS LDYEGMVREA RELAQISEYV VIKIPMTPDG IKAVKTLSAE
110 120 130 140 150
GIKTNVTLVF SPAQAILAAK AGATYVSPFV GRMDDLSNDG MRMLGEIVEI
160 170 180 190 200
YNNYGFETEI IAASIRHPMH VVEAALMGVD IVTMPFAVLE KLFKHPMTDL
210
GIERFMEDWK KYLENLKK
Length:218
Mass (Da):24,213
Last modified:November 1, 1999 - v1
Checksum:i3FF8B0A85CFA6EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35383.1.
PIRiG72394.
RefSeqiNP_228107.1. NC_000853.1.
WP_004083013.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295.
GeneIDi897220.
KEGGitma:TM0295.
PATRICi23935469. VBITheMar51294_0300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35383.1.
PIRiG72394.
RefSeqiNP_228107.1. NC_000853.1.
WP_004083013.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VPXX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-218[»]
ProteinModelPortaliQ9WYD1.
SMRiQ9WYD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295.
GeneIDi897220.
KEGGitma:TM0295.
PATRICi23935469. VBITheMar51294_0300.

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
InParanoidiQ9WYD1.
KOiK00616.
OMAiVRHPMHV.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BRENDAi2.2.1.2. 6331.

Miscellaneous databases

EvolutionaryTraceiQ9WYD1.

Family and domain databases

CDDicd00956. Transaldolase_FSA. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
IPR033919. TSA/FSA_arc/bac.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_THEMA
AccessioniPrimary (citable) accession number: Q9WYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.