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Protein

Transaldolase

Gene

tal

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal), Probable transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BRENDAi2.2.1.2. 6331.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Ordered Locus Names:TM_0295
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218TransaldolasePRO_0000173687Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0295.

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi10 – 189Combined sources
Beta strandi24 – 263Combined sources
Helixi30 – 345Combined sources
Helixi42 – 509Combined sources
Beta strandi54 – 574Combined sources
Helixi63 – 7412Combined sources
Beta strandi80 – 878Combined sources
Helixi88 – 9912Combined sources
Beta strandi104 – 1096Combined sources
Helixi112 – 12110Combined sources
Beta strandi124 – 1296Combined sources
Helixi130 – 1356Combined sources
Helixi140 – 15415Combined sources
Beta strandi159 – 1646Combined sources
Helixi168 – 17710Combined sources
Beta strandi180 – 1845Combined sources
Helixi186 – 1927Combined sources
Helixi196 – 21419Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VPXX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-218[»]
ProteinModelPortaliQ9WYD1.
SMRiQ9WYD1. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
InParanoidiQ9WYD1.
KOiK00616.
OMAiGRDFYEV.
OrthoDBiEOG6PS600.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFLDTANL EEIKKGVEWG IVDGVTTNPT LISKEGAEFK QRVKEICDLV
60 70 80 90 100
KGPVSAEVVS LDYEGMVREA RELAQISEYV VIKIPMTPDG IKAVKTLSAE
110 120 130 140 150
GIKTNVTLVF SPAQAILAAK AGATYVSPFV GRMDDLSNDG MRMLGEIVEI
160 170 180 190 200
YNNYGFETEI IAASIRHPMH VVEAALMGVD IVTMPFAVLE KLFKHPMTDL
210
GIERFMEDWK KYLENLKK
Length:218
Mass (Da):24,213
Last modified:November 1, 1999 - v1
Checksum:i3FF8B0A85CFA6EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35383.1.
PIRiG72394.
RefSeqiNP_228107.1. NC_000853.1.
WP_004083013.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295.
GeneIDi897220.
KEGGitma:TM0295.
PATRICi23935469. VBITheMar51294_0300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35383.1.
PIRiG72394.
RefSeqiNP_228107.1. NC_000853.1.
WP_004083013.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VPXX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-218[»]
ProteinModelPortaliQ9WYD1.
SMRiQ9WYD1. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295.
GeneIDi897220.
KEGGitma:TM0295.
PATRICi23935469. VBITheMar51294_0300.

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
InParanoidiQ9WYD1.
KOiK00616.
OMAiGRDFYEV.
OrthoDBiEOG6PS600.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BRENDAi2.2.1.2. 6331.

Miscellaneous databases

EvolutionaryTraceiQ9WYD1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. "Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases."
    Schuermann M., Sprenger G.A.
    J. Biol. Chem. 276:11055-11061(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiTAL_THEMA
AccessioniPrimary (citable) accession number: Q9WYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1999
Last modified: April 13, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.