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Q9WYC7 (LEUC1_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase large subunit 1
EC=4.2.1.33
Alternative name(s):
Alpha-IPM isomerase 1
Short name=IPMI 1
Isopropylmalate isomerase 1
Gene names
Name:leuC1
Ordered Locus Names:TM_0291
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. HAMAP MF_01027

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmaleate + H2O. HAMAP MF_01027

(2S)-2-isopropylmaleate + H2O = (2S)-2-isopropylmalate. HAMAP MF_01027

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01027

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP MF_01027

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP MF_01027

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4184183-isopropylmalate dehydratase large subunit 1 HAMAP MF_01027
PRO_0000076860

Sites

Metal binding2981Iron-sulfur (4Fe-4S) By similarity
Metal binding3581Iron-sulfur (4Fe-4S) By similarity
Metal binding3611Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WYC7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 18D41B4BFAA825BF

FASTA41845,447
        10         20         30         40         50         60 
MGKTLAEKIF SEHVGRDVKA GEIVLARVDI AMAQDGTGPL MINEFRELGF KEVKVPKAFL 

        70         80         90        100        110        120 
FIDHASPSPR KELSNSQKMM REFGKEMGVK VFDAGDGISH QILAEKYVKP GDLVAGADSH 

       130        140        150        160        170        180 
TCTAGGLGAF GTGMGSTDVA IIFGLGQNWF KVPETIKVVV NGKLQDGVYA KDIILEIARI 

       190        200        210        220        230        240 
LGSDGATYKA LEFHGSCIEN MNVEDRLTIS NMAVEVGAKA GLMPSDEKTR EFLKKMGREE 

       250        260        270        280        290        300 
DFRELKADPD AVYETEIEID ATTLEPLVSL PHYVDNVRKV SEVEKEKIKI DQVFIGTCTN 

       310        320        330        340        350        360 
GRLQDLEIAL KILEKHGKHP DVRLIVGPAS RKVYMDALEK GIIKKFVELG AAVIPPGCGP 

       370        380        390        400        410 
CVGIHMGVLG DGERVLSTQN RNFKGRMGNP NAEIYLASPA TAAATAVTGY ITDPRRFI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD35379.1.
PIRC72394.
RefSeqNP_228103.1. NC_000853.1.

3D structure databases

ProteinModelPortalQ9WYC7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID897215.
GenomeReviewsGene locus TM_0291 in contig AE000512_GR.
KEGGtma:TM0291.
NMPDRfig|243274.1.peg.287.
PATRIC23935461. VBITheMar51294_0296.
TIGRTM_0291.

Phylogenomic databases

HOGENOMHBG330745.
OMAKGEISDP.
PhylomeDBQ9WYC7.
ProtClustDBPRK00402.

Enzyme and pathway databases

BioCycTMAR243274:TM_0291-MONOMER.

Family and domain databases

HAMAPMF_01027. LeuC_type2.
[Tree]
InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR011826. HAcnase/IPMdehydase_lsu_prok.
IPR006251. Homoacnase/IPMdehydase_lsu.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
KOK01703.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF16. PTHR11670:SF16. 1 hit.
PfamPF00330. Aconitase. 2 hits.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01343. HacA_fam. 1 hit.
TIGR02086. IPMI_arch. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEUC1_THEMA
AccessionPrimary (citable) accession number: Q9WYC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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