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Protein
Submitted name:

5-methyltetrahydrofolate S-homocysteine methyltransferase

Gene

TM_0268

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi207ZincPROSITE-ProRule annotationCombined sources1
Metal bindingi234ZincCombined sources1
Metal bindingi272ZincPROSITE-ProRule annotationCombined sources1
Metal bindingi273ZincPROSITE-ProRule annotationCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandMetal-bindingPROSITE-ProRule annotationCombined sources, ZincPROSITE-ProRule annotationCombined sources

Enzyme and pathway databases

BioCyciTMAR243274:G1H0Q-681-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
5-methyltetrahydrofolate S-homocysteine methyltransferaseImported
Gene namesi
Ordered Locus Names:TM_0268Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB04422 2-Amino-4-Mercapto-Butyric Acid

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi207 ↔ 272Combined sources

Proteomic databases

PRIDEiQ9WYA5

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0268

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q7MX-ray2.10A/B1-566[»]
1Q7QX-ray3.10A/B1-566[»]
1Q7ZX-ray1.70A/B1-566[»]
1Q85X-ray2.00A/B1-566[»]
1Q8AX-ray1.70A/B1-566[»]
1Q8JX-ray1.90A/B1-566[»]
3BOFX-ray1.70A/B1-566[»]
3BOLX-ray1.85A/B1-566[»]
SMRiQ9WYA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105C3R Bacteria
COG0646 LUCA
COG1410 LUCA
KOiK00548
OMAiKYPRPLN

Family and domain databases

Gene3Di1.10.1240.10, 1 hit
3.20.20.20, 1 hit
3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR003759 Cbl-bd_cap
IPR006158 Cobalamin-bd
IPR036724 Cobalamin-bd_sf
IPR011005 Dihydropteroate_synth-like
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
IPR017215 MetH_bac
IPR036594 Meth_synthase_dom
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF02310 B12-binding, 1 hit
PF02607 B12-binding_2, 1 hit
PF00809 Pterin_bind, 1 hit
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF037472 DHPS_mtfrase, 1 hit
SMARTiView protein in SMART
SM01018 B12-binding_2, 1 hit
SUPFAMiSSF47644 SSF47644, 1 hit
SSF51717 SSF51717, 1 hit
SSF52242 SSF52242, 1 hit
SSF82282 SSF82282, 1 hit
PROSITEiView protein in PROSITE
PS51332 B12_BINDING, 1 hit
PS51337 B12_BINDING_NTER, 1 hit
PS50970 HCY, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WYA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNRREVSKL LSERVLLLDG AYGTEFMKYG YDDLPEELNI KAPDVVLKVH
60 70 80 90 100
RSYIESGSDV ILTNTFGATR MKLRKHGLED KLDPIVRNAV RIARRAAGEK
110 120 130 140 150
LVFGDIGPTG ELPYPLGSTL FEEFYENFRE TVEIMVEEGV DGIIFETFSD
160 170 180 190 200
ILELKAAVLA AREVSRDVFL IAHMTFDEKG RSLTGTDPAN FAITFDELDI
210 220 230 240 250
DALGINCSLG PEEILPIFQE LSQYTDKFLV VEPNAGKPIV ENGKTVYPLK
260 270 280 290 300
PHDFAVHIDS YYELGVNIFG GCCGTTPEHV KLFRKVLGNR KPLQRKKKRI
310 320 330 340 350
FAVSSPSKLV TFDHFVVIGE RINPAGRKKL WAEMQKGNEE IVIKEAKTQV
360 370 380 390 400
EKGAEVLDVN FGIESQIDVR YVEKIVQTLP YVSNVPLSLD IQNVDLTERA
410 420 430 440 450
LRAYPGRSLF NSAKVDEEEL EMKINLLKKY GGTLIVLLMG KDVPKSFEER
460 470 480 490 500
KEYFEKALKI LERHDFSDRV IFDPGVLPLG AEGKPVEVLK TIEFISSKGF
510 520 530 540 550
NTTVGLSNLS FGLPDRSYYN TAFLVLGISK GLSSAIMNPL DETLMKTLNA
560 570 580 590 600
TLVILEKKEL PRAEVKEEKL VEIILSGNRS ELEKLVEDFL KEKDPLSVIE
610 620 630 640 650
EHLRPAMERI GELYDKGKIF LPQLILAAQT VKPVFDKLTS MLPSDSQGET
660 670 680 690 700
FVIATVKGDV HDIGKNIVAS VIRSSGYRVV DLGKDVDTSE IVEAVEKERP
710 720 730 740 750
VALGLSAMMT TTVGRIKEVV EKLKEKNLKI PVIVGGASLN EKLAKELGAD
760
YYAKNASEAV KILKSLGR
Length:768
Mass (Da):85,704
Last modified:November 1, 1999 - v1
Checksum:i39E1A42EDE37A26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35357.1
PIRiB72397
RefSeqiNP_228081.1, NC_000853.1
WP_004082972.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35357; AAD35357; TM_0268
AGL49192; AGL49192; Tmari_0266
GeneIDi897179
KEGGitma:TM0268
tmi:THEMA_03385
tmw:THMA_0275
PATRICifig|243274.17.peg.265

Similar proteinsi

Entry informationi

Entry nameiQ9WYA5_THEMA
AccessioniPrimary (citable) accession number: Q9WYA5
Secondary accession number(s): G4FHI2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health