Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

5-methyltetrahydrofolate S-homocysteine methyltransferase

Gene

TM_0268

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi207 – 2071ZincCombined sources
Metal bindingi234 – 2341ZincCombined sources
Metal bindingi272 – 2721ZincCombined sources
Metal bindingi273 – 2731ZincCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-281-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
5-methyltetrahydrofolate S-homocysteine methyltransferaseImported
Submitted name:
5-methyltetrahydrofolate--homocysteine methyltransferaseImported (EC:2.1.1.13Imported)
Gene namesi
Ordered Locus Names:TM_0268Imported
ORF Names:Tmari_0266Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000013901 Componenti: Chromosome
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi207 ↔ 272Combined sources

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0268.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q7MX-ray2.10A/B1-566[»]
1Q7QX-ray3.10A/B1-566[»]
1Q7ZX-ray1.70A/B1-566[»]
1Q85X-ray2.00A/B1-566[»]
1Q8AX-ray1.70A/B1-566[»]
1Q8JX-ray1.90A/B1-566[»]
3BOFX-ray1.70A/B1-566[»]
3BOLX-ray1.85A/B1-566[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Hcy-bindingInterPro annotationAdd
BLAST
Domaini315 – 556242Pterin-bindingInterPro annotationAdd
BLAST
Domaini557 – 65094B12-binding N-terminalInterPro annotationAdd
BLAST
Domaini648 – 768121B12-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105C3R. Bacteria.
COG0646. LUCA.
COG1410. LUCA.
KOiK00548.
OMAiIGKNIVC.
OrthoDBiEOG6091CH.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR003726. HCY_dom.
IPR017215. MetH_bac.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037472. DHPS_mtfrase. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF82282. SSF82282. 1 hit.
PROSITEiPS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WYA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNRREVSKL LSERVLLLDG AYGTEFMKYG YDDLPEELNI KAPDVVLKVH
60 70 80 90 100
RSYIESGSDV ILTNTFGATR MKLRKHGLED KLDPIVRNAV RIARRAAGEK
110 120 130 140 150
LVFGDIGPTG ELPYPLGSTL FEEFYENFRE TVEIMVEEGV DGIIFETFSD
160 170 180 190 200
ILELKAAVLA AREVSRDVFL IAHMTFDEKG RSLTGTDPAN FAITFDELDI
210 220 230 240 250
DALGINCSLG PEEILPIFQE LSQYTDKFLV VEPNAGKPIV ENGKTVYPLK
260 270 280 290 300
PHDFAVHIDS YYELGVNIFG GCCGTTPEHV KLFRKVLGNR KPLQRKKKRI
310 320 330 340 350
FAVSSPSKLV TFDHFVVIGE RINPAGRKKL WAEMQKGNEE IVIKEAKTQV
360 370 380 390 400
EKGAEVLDVN FGIESQIDVR YVEKIVQTLP YVSNVPLSLD IQNVDLTERA
410 420 430 440 450
LRAYPGRSLF NSAKVDEEEL EMKINLLKKY GGTLIVLLMG KDVPKSFEER
460 470 480 490 500
KEYFEKALKI LERHDFSDRV IFDPGVLPLG AEGKPVEVLK TIEFISSKGF
510 520 530 540 550
NTTVGLSNLS FGLPDRSYYN TAFLVLGISK GLSSAIMNPL DETLMKTLNA
560 570 580 590 600
TLVILEKKEL PRAEVKEEKL VEIILSGNRS ELEKLVEDFL KEKDPLSVIE
610 620 630 640 650
EHLRPAMERI GELYDKGKIF LPQLILAAQT VKPVFDKLTS MLPSDSQGET
660 670 680 690 700
FVIATVKGDV HDIGKNIVAS VIRSSGYRVV DLGKDVDTSE IVEAVEKERP
710 720 730 740 750
VALGLSAMMT TTVGRIKEVV EKLKEKNLKI PVIVGGASLN EKLAKELGAD
760
YYAKNASEAV KILKSLGR
Length:768
Mass (Da):85,704
Last modified:November 1, 1999 - v1
Checksum:i39E1A42EDE37A26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35357.1.
CP004077 Genomic DNA. Translation: AGL49192.1.
PIRiB72397.
RefSeqiNP_228081.1. NC_000853.1.
WP_004082972.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35357; AAD35357; TM_0268.
AGL49192; AGL49192; Tmari_0266.
GeneIDi897179.
KEGGitma:TM0268.
tmi:THEMA_03385.
tmm:Tmari_0266.
tmw:THMA_0275.
PATRICi23935413. VBITheMar51294_0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35357.1.
CP004077 Genomic DNA. Translation: AGL49192.1.
PIRiB72397.
RefSeqiNP_228081.1. NC_000853.1.
WP_004082972.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q7MX-ray2.10A/B1-566[»]
1Q7QX-ray3.10A/B1-566[»]
1Q7ZX-ray1.70A/B1-566[»]
1Q85X-ray2.00A/B1-566[»]
1Q8AX-ray1.70A/B1-566[»]
1Q8JX-ray1.90A/B1-566[»]
3BOFX-ray1.70A/B1-566[»]
3BOLX-ray1.85A/B1-566[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35357; AAD35357; TM_0268.
AGL49192; AGL49192; Tmari_0266.
GeneIDi897179.
KEGGitma:TM0268.
tmi:THEMA_03385.
tmm:Tmari_0266.
tmw:THMA_0275.
PATRICi23935413. VBITheMar51294_0272.

Phylogenomic databases

eggNOGiENOG4105C3R. Bacteria.
COG0646. LUCA.
COG1410. LUCA.
KOiK00548.
OMAiIGKNIVC.
OrthoDBiEOG6091CH.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-281-MONOMER.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR003726. HCY_dom.
IPR017215. MetH_bac.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037472. DHPS_mtfrase. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF82282. SSF82282. 1 hit.
PROSITEiPS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
  2. "The genome organization of Thermotoga maritima reflects its lifestyle."
    Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
    PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.

Entry informationi

Entry nameiQ9WYA5_THEMA
AccessioniPrimary (citable) accession number: Q9WYA5
Secondary accession number(s): G4FHI2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 13, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.