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Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 115ATPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.8. 6331.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene namesi
Name:murC
Ordered Locus Names:TM_0231
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001821771 – 457UDP-N-acetylmuramate--L-alanine ligaseAdd BLAST457

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0231.

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni7 – 9Combined sources3
Helixi11 – 22Combined sources12
Beta strandi26 – 30Combined sources5
Helixi36 – 43Combined sources8
Beta strandi48 – 51Combined sources4
Beta strandi61 – 65Combined sources5
Helixi74 – 81Combined sources8
Beta strandi86 – 88Combined sources3
Helixi89 – 100Combined sources12
Beta strandi104 – 108Combined sources5
Beta strandi110 – 112Combined sources3
Helixi113 – 126Combined sources14
Beta strandi132 – 134Combined sources3
Beta strandi145 – 148Combined sources4
Beta strandi154 – 158Combined sources5
Helixi163 – 167Combined sources5
Beta strandi171 – 175Combined sources5
Helixi183 – 186Combined sources4
Helixi190 – 202Combined sources13
Beta strandi205 – 210Combined sources6
Turni214 – 216Combined sources3
Helixi217 – 219Combined sources3
Beta strandi221 – 224Combined sources4
Beta strandi226 – 238Combined sources13
Beta strandi243 – 249Combined sources7
Beta strandi252 – 261Combined sources10
Helixi264 – 279Combined sources16
Helixi284 – 293Combined sources10
Beta strandi300 – 307Combined sources8
Turni308 – 311Combined sources4
Beta strandi312 – 317Combined sources6
Helixi322 – 335Combined sources14
Beta strandi337 – 345Combined sources9
Helixi359 – 364Combined sources6
Beta strandi367 – 372Combined sources6
Helixi388 – 397Combined sources10
Beta strandi402 – 404Combined sources3
Helixi408 – 410Combined sources3
Helixi411 – 414Combined sources4
Beta strandi419 – 426Combined sources8
Helixi431 – 445Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6UX-ray2.30A1-457[»]
ProteinModelPortaliQ9WY73.
SMRiQ9WY73.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WY73.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU. Bacteria.
COG0773. LUCA.
InParanoidiQ9WY73.
KOiK01924.
OMAiLTMGAGD.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
HAMAPiMF_00046. MurC. 1 hit.
InterProiView protein in InterPro
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005758. UDP-N-AcMur_Ala_ligase_murC.
PfamiView protein in Pfam
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIHFVGIGG IGMSAVALHE FSNGNDVYGS NIEETERTAY LRKLGIPIFV
60 70 80 90 100
PHSADNWYDP DLVIKTPAVR DDNPEIVRAR MERVPIENRL HYFRDTLKRE
110 120 130 140 150
KKEEFAVTGT DGKTTTTAMV AHVLKHLRKS PTVFLGGIMD SLEHGNYEKG
160 170 180 190 200
NGPVVYELDE SEEFFSEFSP NYLIITNARG DHLENYGNSL TRYRSAFEKI
210 220 230 240 250
SRNTDLVVTF AEDELTSHLG DVTFGVKKGT YTLEMRSASR AEQKAMVEKN
260 270 280 290 300
GKRYLELKLK VPGFHNVLNA LAVIALFDSL GYDLAPVLEA LEEFRGVHRR
310 320 330 340 350
FSIAFHDPET NIYVIDDYAH TPDEIRNLLQ TAKEVFENEK IVVIFQPHRY
360 370 380 390 400
SRLEREDGNF AKALQLADEV VVTEVYDAFE EKKNGISGKM IWDSLKSLGK
410 420 430 440 450
EAYFVEKLPE LEKVISVSEN TVFLFVGAGD IIYSSRRFVE RYQSSKSSPS

RVLGSNK
Length:457
Mass (Da):51,872
Last modified:November 1, 1999 - v1
Checksum:i7D9AEDC50482351D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35322.1.
PIRiA72402.
RefSeqiNP_228045.1. NC_000853.1.
WP_004082924.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35322; AAD35322; TM_0231.
GeneIDi897130.
KEGGitma:TM0231.

Similar proteinsi

Entry informationi

Entry nameiMURC_THEMA
AccessioniPrimary (citable) accession number: Q9WY73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families