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Q9WY57 (GCSPB_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 2
EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:TM_0214
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00713

Catalytic activity

Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Probable glycine dehydrogenase [decarboxylating] subunit 2 HAMAP MF_00713
PRO_0000167021

Amino acid modifications

Modified residue2621N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WY57 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 992607C3A1B61EF8

FASTA47453,468
        10         20         30         40         50         60 
MTIFERSKKG RKAFRLPESD IPEYSLPDRF LRRTPPELPE VSEPDLVRHY TNLARKNYSV 

        70         80         90        100        110        120 
DLGIYPLGSC TMKYNPKLNE KAANLEGFRE IHPYQPVETV QGSLRLMYEL KKMLCEITGM 

       130        140        150        160        170        180 
DDMTLQPAAG AHGELTGMLI VREYFKNRGD TGRKKVLVPD SAHGTNPASA SMVGFEVVEI 

       190        200        210        220        230        240 
KSKNGMVDVE DLKKLLDEEV AAVMLTNPNT LGLFEKDILK IAEMTHECGA LLYYDGANLN 

       250        260        270        280        290        300 
AIMGKVRPGD MGFDIVHLNL HKTFSTPHGM GGPGSGPVGV KKHLVDFLPF PQVKKNGELY 

       310        320        330        340        350        360 
ELFVPEKTIG RVRSFFGNFP VLVKAYTYIL TMGRDGLERV SEMAVLNANY LKKKIEKFLE 

       370        380        390        400        410        420 
IPYNGFCMHE FVASAEKVFR ETGVRTLDIA KRILDFGVHP PTVYFPLIVP EALMIEPTET 

       430        440        450        460        470 
ENKETLDKYA EILERVVKEA YENPDALKNA PHNTPVRRVN EVLASKKPVF RWRG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD35306.1.
PIRH72403.
RefSeqNP_228029.1. NC_000853.1.

3D structure databases

ProteinModelPortalQ9WY57.
SMRQ9WY57. Positions 2-473.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID897096.
GenomeReviewsGene locus TM_0214 in contig AE000512_GR.
KEGGtma:TM0214.
NMPDRfig|243274.1.peg.213.
PATRIC23935300. VBITheMar51294_0216.
TIGRTM_0214.

Phylogenomic databases

HOGENOMHBG288344.
OMARHYTRLS.
PhylomeDBQ9WY57.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycTMAR243274:TM_0214-MONOMER.

Family and domain databases

HAMAPMF_00713. GcvPB.
[Tree]
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK00283.
PANTHERPTHR11773. GDC-P. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_THEMA
AccessionPrimary (citable) accession number: Q9WY57
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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