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Q9WY57

- GCSPB_THEMA

UniProt

Q9WY57 - GCSPB_THEMA

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, TM_0214
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:TM_0214
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi243274.TM0214.

Structurei

3D structure databases

ProteinModelPortaliQ9WY57.
SMRiQ9WY57. Positions 2-473.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY57-1 [UniParc]FASTAAdd to Basket

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MTIFERSKKG RKAFRLPESD IPEYSLPDRF LRRTPPELPE VSEPDLVRHY    50
TNLARKNYSV DLGIYPLGSC TMKYNPKLNE KAANLEGFRE IHPYQPVETV 100
QGSLRLMYEL KKMLCEITGM DDMTLQPAAG AHGELTGMLI VREYFKNRGD 150
TGRKKVLVPD SAHGTNPASA SMVGFEVVEI KSKNGMVDVE DLKKLLDEEV 200
AAVMLTNPNT LGLFEKDILK IAEMTHECGA LLYYDGANLN AIMGKVRPGD 250
MGFDIVHLNL HKTFSTPHGM GGPGSGPVGV KKHLVDFLPF PQVKKNGELY 300
ELFVPEKTIG RVRSFFGNFP VLVKAYTYIL TMGRDGLERV SEMAVLNANY 350
LKKKIEKFLE IPYNGFCMHE FVASAEKVFR ETGVRTLDIA KRILDFGVHP 400
PTVYFPLIVP EALMIEPTET ENKETLDKYA EILERVVKEA YENPDALKNA 450
PHNTPVRRVN EVLASKKPVF RWRG 474
Length:474
Mass (Da):53,468
Last modified:November 1, 1999 - v1
Checksum:i992607C3A1B61EF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35306.1.
PIRiH72403.
RefSeqiNP_228029.1. NC_000853.1.
YP_007976563.1. NC_021214.1.
YP_008990812.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35306; AAD35306; TM_0214.
GeneIDi897096.
KEGGitma:TM0214.
tmi:THEMA_03655.
tmm:Tmari_0212.
PATRICi23935300. VBITheMar51294_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35306.1 .
PIRi H72403.
RefSeqi NP_228029.1. NC_000853.1.
YP_007976563.1. NC_021214.1.
YP_008990812.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WY57.
SMRi Q9WY57. Positions 2-473.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243274.TM0214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35306 ; AAD35306 ; TM_0214 .
GeneIDi 897096.
KEGGi tma:TM0214.
tmi:THEMA_03655.
tmm:Tmari_0212.
PATRICi 23935300. VBITheMar51294_0216.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGCSPB_THEMA
AccessioniPrimary (citable) accession number: Q9WY57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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