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Q9WY56 (GCSPA_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:TM_0213
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712

Catalytic activity

Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712
PRO_0000166980

Sequences

Sequence LengthMass (Da)Tools
Q9WY56 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DDF0EDE9BB29BB1A

FASTA43748,942
        10         20         30         40         50         60 
MNYPYIPHTD EDVRAMLDFI GVSSIEELFS SIPVSARSSL NIPESRDEFS VFKQLKEISE 

        70         80         90        100        110        120 
MNNSLEDYAV FLGAGVYKRY VPTVVYDLAM KPDFLTAYTP YQAEVSQGTL QALFEYQTMV 

       130        140        150        160        170        180 
CELTGMEVAN ASMYDGATAL AEAALMSFRL TGKEKVVVAR SVHPEYRAVL RTYLEKRGFT 

       190        200        210        220        230        240 
VVEAGYDETG RVLLEEVDEE TAAIAVQYPN FFGIIEDLDY VRSRSGNALL IVVVEPVSLA 

       250        260        270        280        290        300 
LLEPPGSYGA DIVVGEGQSL GLPMWFGGYS LGIFATREEY VRQMPGRLIG QTVDQAGNTA 

       310        320        330        340        350        360 
YTMILQTREQ HIRRARATSN ICSNHAHAAL IAAVYMSVMG PDGLKEVARR SYNAAHYLQE 

       370        380        390        400        410        420 
RLEEIGFKLC FSGEFFNEFV FNVPEDYPDR WRKMMEKKIL GPLPLEEFYP ELGDTALACA 

       430 
TEVISKEDIE KLLEAMK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD35305.1.
PIRG72403.
RefSeqNP_228028.1. NC_000853.1.

3D structure databases

ProteinModelPortalQ9WY56.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID897091.
GenomeReviewsGene locus TM_0213 in contig AE000512_GR.
KEGGtma:TM0213.
NMPDRfig|243274.1.peg.212.
PATRIC23935298. VBITheMar51294_0215.
TIGRTM_0213.

Phylogenomic databases

HOGENOMHBG288345.
OMAVANASMY.
PhylomeDBQ9WY56.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycTMAR243274:TM_0213-MONOMER.

Family and domain databases

HAMAPMF_00712. GcvPA.
[Tree]
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK00282.
PANTHERPTHR11773. GDC-P. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_THEMA
AccessionPrimary (citable) accession number: Q9WY56
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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