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Q9WY56

- GCSPA_THEMA

UniProt

Q9WY56 - GCSPA_THEMA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TM_0213
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166980Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0213.

Structurei

3D structure databases

ProteinModelPortaliQ9WY56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
InParanoidiQ9WY56.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYPYIPHTD EDVRAMLDFI GVSSIEELFS SIPVSARSSL NIPESRDEFS
60 70 80 90 100
VFKQLKEISE MNNSLEDYAV FLGAGVYKRY VPTVVYDLAM KPDFLTAYTP
110 120 130 140 150
YQAEVSQGTL QALFEYQTMV CELTGMEVAN ASMYDGATAL AEAALMSFRL
160 170 180 190 200
TGKEKVVVAR SVHPEYRAVL RTYLEKRGFT VVEAGYDETG RVLLEEVDEE
210 220 230 240 250
TAAIAVQYPN FFGIIEDLDY VRSRSGNALL IVVVEPVSLA LLEPPGSYGA
260 270 280 290 300
DIVVGEGQSL GLPMWFGGYS LGIFATREEY VRQMPGRLIG QTVDQAGNTA
310 320 330 340 350
YTMILQTREQ HIRRARATSN ICSNHAHAAL IAAVYMSVMG PDGLKEVARR
360 370 380 390 400
SYNAAHYLQE RLEEIGFKLC FSGEFFNEFV FNVPEDYPDR WRKMMEKKIL
410 420 430
GPLPLEEFYP ELGDTALACA TEVISKEDIE KLLEAMK
Length:437
Mass (Da):48,942
Last modified:November 1, 1999 - v1
Checksum:iDDF0EDE9BB29BB1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35305.1.
PIRiG72403.
RefSeqiNP_228028.1. NC_000853.1.
WP_004082888.1. NC_023151.1.
YP_007976562.1. NC_021214.1.
YP_008990813.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35305; AAD35305; TM_0213.
GeneIDi18092586.
897091.
KEGGitma:TM0213.
tmi:THEMA_03660.
tmm:Tmari_0211.
PATRICi23935298. VBITheMar51294_0215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35305.1 .
PIRi G72403.
RefSeqi NP_228028.1. NC_000853.1.
WP_004082888.1. NC_023151.1.
YP_007976562.1. NC_021214.1.
YP_008990813.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WY56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0213.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35305 ; AAD35305 ; TM_0213 .
GeneIDi 18092586.
897091.
KEGGi tma:TM0213.
tmi:THEMA_03660.
tmm:Tmari_0211.
PATRICi 23935298. VBITheMar51294_0215.

Phylogenomic databases

eggNOGi COG0403.
InParanoidi Q9WY56.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGCSPA_THEMA
AccessioniPrimary (citable) accession number: Q9WY56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3