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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:TM_0211
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001226101 – 364AminomethyltransferaseAdd BLAST364

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0211.

Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 12Combined sources6
Beta strandi16 – 20Combined sources5
Beta strandi23 – 30Combined sources8
Helixi32 – 41Combined sources10
Beta strandi44 – 47Combined sources4
Beta strandi51 – 58Combined sources8
Helixi61 – 68Combined sources8
Beta strandi69 – 71Combined sources3
Beta strandi80 – 87Combined sources8
Beta strandi93 – 103Combined sources11
Beta strandi106 – 111Combined sources6
Helixi113 – 115Combined sources3
Helixi116 – 124Combined sources9
Beta strandi133 – 136Combined sources4
Helixi138 – 140Combined sources3
Beta strandi141 – 148Combined sources8
Helixi151 – 155Combined sources5
Helixi156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Helixi163 – 165Combined sources3
Beta strandi170 – 176Combined sources7
Beta strandi179 – 185Combined sources7
Beta strandi188 – 199Combined sources12
Helixi200 – 202Combined sources3
Helixi203 – 217Combined sources15
Beta strandi220 – 222Combined sources3
Helixi224 – 233Combined sources10
Turni239 – 241Combined sources3
Helixi249 – 252Combined sources4
Helixi255 – 257Combined sources3
Helixi267 – 275Combined sources9
Beta strandi279 – 289Combined sources11
Beta strandi297 – 300Combined sources4
Beta strandi303 – 314Combined sources12
Turni315 – 318Combined sources4
Beta strandi319 – 327Combined sources9
Beta strandi335 – 340Combined sources6
Turni341 – 343Combined sources3
Beta strandi344 – 351Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOOX-ray2.40A1-364[»]
1WOPX-ray2.00A1-364[»]
1WORX-ray1.95A1-364[»]
1WOSX-ray1.84A1-364[»]
ProteinModelPortaliQ9WY54.
SMRiQ9WY54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WY54.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
InParanoidiQ9WY54.
KOiK00605.
OMAiLGWLVHL.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRTPLFEKH VELGAKMVDF AGWEMPLYYT SIFEEVMAVR KSVGMFDVSH
60 70 80 90 100
MGEFLVKGPE AVSFIDFLIT NDFSSLPDGK AIYSVMCNEN GGIIDDLVVY
110 120 130 140 150
KVSPDEALMV VNAANIEKDF NWIKSHSKNF DVEVSNISDT TALIAFQGPK
160 170 180 190 200
AQETLQELVE DGLEEIAYYS FRKSIVAGVE TLVSRTGYTG EDGFELMLEA
210 220 230 240 250
KNAPKVWDAL MNLLRKIDGR PAGLGARDVC RLEATYLLYG QDMDENTNPF
260 270 280 290 300
EVGLSWVVKL NKDFVGKEAL LKAKEKVERK LVALELSGKR IARKGYEVLK
310 320 330 340 350
NGERVGEITS GNFSPTLGKS IALALVSKSV KIGDQLGVVF PGGKLVEALV
360
VKKPFYRGSV RREV
Length:364
Mass (Da):40,333
Last modified:November 1, 1999 - v1
Checksum:i66F33CCC151CC6F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35303.1.
PIRiE72403.
RefSeqiNP_228026.1. NC_000853.1.
WP_004082884.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35303; AAD35303; TM_0211.
GeneIDi897085.
KEGGitma:TM0211.
PATRICi23935294. VBITheMar51294_0213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35303.1.
PIRiE72403.
RefSeqiNP_228026.1. NC_000853.1.
WP_004082884.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOOX-ray2.40A1-364[»]
1WOPX-ray2.00A1-364[»]
1WORX-ray1.95A1-364[»]
1WOSX-ray1.84A1-364[»]
ProteinModelPortaliQ9WY54.
SMRiQ9WY54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35303; AAD35303; TM_0211.
GeneIDi897085.
KEGGitma:TM0211.
PATRICi23935294. VBITheMar51294_0213.

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
InParanoidiQ9WY54.
KOiK00605.
OMAiLGWLVHL.

Miscellaneous databases

EvolutionaryTraceiQ9WY54.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCST_THEMA
AccessioniPrimary (citable) accession number: Q9WY54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.