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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:TM_0211
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364AminomethyltransferasePRO_0000122610Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0211.

Structurei

Secondary structure

1
364
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 126Combined sources
Beta strandi16 – 205Combined sources
Beta strandi23 – 308Combined sources
Helixi32 – 4110Combined sources
Beta strandi44 – 474Combined sources
Beta strandi51 – 588Combined sources
Helixi61 – 688Combined sources
Beta strandi69 – 713Combined sources
Beta strandi80 – 878Combined sources
Beta strandi93 – 10311Combined sources
Beta strandi106 – 1116Combined sources
Helixi113 – 1153Combined sources
Helixi116 – 1249Combined sources
Beta strandi133 – 1364Combined sources
Helixi138 – 1403Combined sources
Beta strandi141 – 1488Combined sources
Helixi151 – 1555Combined sources
Helixi156 – 1583Combined sources
Beta strandi159 – 1613Combined sources
Helixi163 – 1653Combined sources
Beta strandi170 – 1767Combined sources
Beta strandi179 – 1857Combined sources
Beta strandi188 – 19912Combined sources
Helixi200 – 2023Combined sources
Helixi203 – 21715Combined sources
Beta strandi220 – 2223Combined sources
Helixi224 – 23310Combined sources
Turni239 – 2413Combined sources
Helixi249 – 2524Combined sources
Helixi255 – 2573Combined sources
Helixi267 – 2759Combined sources
Beta strandi279 – 28911Combined sources
Beta strandi297 – 3004Combined sources
Beta strandi303 – 31412Combined sources
Turni315 – 3184Combined sources
Beta strandi319 – 3279Combined sources
Beta strandi335 – 3406Combined sources
Turni341 – 3433Combined sources
Beta strandi344 – 3518Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WOOX-ray2.40A1-364[»]
1WOPX-ray2.00A1-364[»]
1WORX-ray1.95A1-364[»]
1WOSX-ray1.84A1-364[»]
ProteinModelPortaliQ9WY54.
SMRiQ9WY54. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WY54.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
InParanoidiQ9WY54.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG6T1WS5.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRTPLFEKH VELGAKMVDF AGWEMPLYYT SIFEEVMAVR KSVGMFDVSH
60 70 80 90 100
MGEFLVKGPE AVSFIDFLIT NDFSSLPDGK AIYSVMCNEN GGIIDDLVVY
110 120 130 140 150
KVSPDEALMV VNAANIEKDF NWIKSHSKNF DVEVSNISDT TALIAFQGPK
160 170 180 190 200
AQETLQELVE DGLEEIAYYS FRKSIVAGVE TLVSRTGYTG EDGFELMLEA
210 220 230 240 250
KNAPKVWDAL MNLLRKIDGR PAGLGARDVC RLEATYLLYG QDMDENTNPF
260 270 280 290 300
EVGLSWVVKL NKDFVGKEAL LKAKEKVERK LVALELSGKR IARKGYEVLK
310 320 330 340 350
NGERVGEITS GNFSPTLGKS IALALVSKSV KIGDQLGVVF PGGKLVEALV
360
VKKPFYRGSV RREV
Length:364
Mass (Da):40,333
Last modified:November 1, 1999 - v1
Checksum:i66F33CCC151CC6F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35303.1.
PIRiE72403.
RefSeqiNP_228026.1. NC_000853.1.
WP_004082884.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35303; AAD35303; TM_0211.
GeneIDi897085.
KEGGitma:TM0211.
PATRICi23935294. VBITheMar51294_0213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35303.1.
PIRiE72403.
RefSeqiNP_228026.1. NC_000853.1.
WP_004082884.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WOOX-ray2.40A1-364[»]
1WOPX-ray2.00A1-364[»]
1WORX-ray1.95A1-364[»]
1WOSX-ray1.84A1-364[»]
ProteinModelPortaliQ9WY54.
SMRiQ9WY54. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35303; AAD35303; TM_0211.
GeneIDi897085.
KEGGitma:TM0211.
PATRICi23935294. VBITheMar51294_0213.

Phylogenomic databases

eggNOGiENOG4105D43. Bacteria.
COG0404. LUCA.
InParanoidiQ9WY54.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG6T1WS5.

Miscellaneous databases

EvolutionaryTraceiQ9WY54.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGCST_THEMA
AccessioniPrimary (citable) accession number: Q9WY54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 13, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.