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Q9WY54 (GCST_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:TM_0211
OrganismThermotoga maritima
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Aminomethyltransferase HAMAP MF_00259
PRO_0000122610

Secondary structure

1 .................................................................... 364
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9WY54 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 66F33CCC151CC6F1

FASTA36440,333
        10         20         30         40         50         60 
MKRTPLFEKH VELGAKMVDF AGWEMPLYYT SIFEEVMAVR KSVGMFDVSH MGEFLVKGPE 

        70         80         90        100        110        120 
AVSFIDFLIT NDFSSLPDGK AIYSVMCNEN GGIIDDLVVY KVSPDEALMV VNAANIEKDF 

       130        140        150        160        170        180 
NWIKSHSKNF DVEVSNISDT TALIAFQGPK AQETLQELVE DGLEEIAYYS FRKSIVAGVE 

       190        200        210        220        230        240 
TLVSRTGYTG EDGFELMLEA KNAPKVWDAL MNLLRKIDGR PAGLGARDVC RLEATYLLYG 

       250        260        270        280        290        300 
QDMDENTNPF EVGLSWVVKL NKDFVGKEAL LKAKEKVERK LVALELSGKR IARKGYEVLK 

       310        320        330        340        350        360 
NGERVGEITS GNFSPTLGKS IALALVSKSV KIGDQLGVVF PGGKLVEALV VKKPFYRGSV 


RREV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000512 Genomic DNA. Translation: AAD35303.1.
PIRE72403.
RefSeqNP_228026.1. NC_000853.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WOOX-ray2.40A1-364[»]
1WOPX-ray2.00A1-364[»]
1WORX-ray1.95A1-364[»]
1WOSX-ray1.84A1-364[»]
ProteinModelPortalQ9WY54.
SMRQ9WY54. Positions 1-362.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID897085.
GenomeReviewsGene locus TM_0211 in contig AE000512_GR.
KEGGtma:TM0211.
NMPDRfig|243274.1.peg.210.
PATRIC23935294. VBITheMar51294_0213.
TIGRTM_0211.

Phylogenomic databases

HOGENOMHBG299834.
OMAGESARAF.
PhylomeDBQ9WY54.
ProtClustDBPRK00389.

Enzyme and pathway databases

BioCycTMAR243274:TM_0211-MONOMER.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_THEMA
AccessionPrimary (citable) accession number: Q9WY54
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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