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Protein

ATP-dependent DNA helicase RecG

Gene

recG

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei436 – 4361ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi367 – 3693ADPCombined sources
Nucleotide bindingi399 – 4035ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotationImported, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-218-MONOMER.
BRENDAi3.6.4.12. 6331.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase RecGUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:recGUniRule annotation
Ordered Locus Names:TM_0205Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 282Combined sources

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0205.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GM5X-ray3.24A1-780[»]
ProteinModelPortaliQ9WY48.
SMRiQ9WY48. Positions 7-755.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WY48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini383 – 544162Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini563 – 728166Helicase C-terminalInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the helicase family. RecG subfamily.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CB5. Bacteria.
COG1200. LUCA.
InParanoidiQ9WY48.
KOiK03655.
OMAiGRGEHQS.

Family and domain databases

Gene3Di1.20.120.630. 1 hit.
2.40.50.140. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR004609. ATP-dep_DNA_helicase_RecG.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR028993. RecG_N.
IPR033454. RecG_wedge.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF17190. RecG_N. 1 hit.
PF17191. RecG_wedge. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69008. SSF69008. 1 hit.
TIGRFAMsiTIGR00643. recG. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WY48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCSRYFTSS LFLWGEALPT LLEEFLNEVE KMLKNQVNTR RIHQLLKELD
60 70 80 90 100
DPLLENKDLE EKLQAFLDYV KEIPNLPEAR KRYRIQKSLE MIEKLRSWFL
110 120 130 140 150
IDYLECSGEE VDLSTDIQYA KGVGPNRKKK LKKLGIETLR DLLEFFPRDY
160 170 180 190 200
EDRRKIFKLN DLLPGEKVTT QGKIVSVETK KFQNMNILTA VLSDGLVHVP
210 220 230 240 250
LKWFNQDYLQ TYLKQLTGKE VFVTGTVKSN AYTGQYEIHN AEVTPKEGEY
260 270 280 290 300
VRRILPIYRL TSGISQKQMR KIFEENIPSL CCSLKETLPE RILEKRKLLG
310 320 330 340 350
VKDAYYGMHF PKTFYHLEKA RERLAYEELF VLQLAFQKIR KEREKHGGIP
360 370 380 390 400
KKIEGKLAEE FIKSLPFKLT NAQKRAHQEI RNDMISEKPM NRLLQGDVGS
410 420 430 440 450
GKTVVAQLAI LDNYEAGFQT AFMVPTSILA IQHYRRTVES FSKFNIHVAL
460 470 480 490 500
LIGATTPSEK EKIKSGLRNG QIDVVIGTHA LIQEDVHFKN LGLVIIDEQH
510 520 530 540 550
RFGVKQREAL MNKGKMVDTL VMSATPIPRS MALAFYGDLD VTVIDEMPPG
560 570 580 590 600
RKEVQTMLVP MDRVNEVYEF VRQEVMRGGQ AFIVYPLIEE SDKLNVKSAV
610 620 630 640 650
EMYEYLSKEV FPEFKLGLMH GRLSQEEKDR VMLEFAEGRY DILVSTTVIE
660 670 680 690 700
VGIDVPRANV MVIENPERFG LAQLHQLRGR VGRGGQEAYC FLVVGDVGEE
710 720 730 740 750
AMERLRFFTL NTDGFKIAEY DLKTRGPGEF FGVKQHGLSG FKVADLYRDL
760 770 780
KLLEWAREDV QEIDVEGIEL PEEIKLIEVG
Length:780
Mass (Da):89,931
Last modified:November 1, 1999 - v1
Checksum:iE7C7FDE6B6B85D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35297.1.
PIRiG72405.
RefSeqiNP_228020.1. NC_000853.1.
WP_010865074.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35297; AAD35297; TM_0205.
GeneIDi897075.
KEGGitma:TM0205.
PATRICi23935282. VBITheMar51294_0207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35297.1.
PIRiG72405.
RefSeqiNP_228020.1. NC_000853.1.
WP_010865074.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GM5X-ray3.24A1-780[»]
ProteinModelPortaliQ9WY48.
SMRiQ9WY48. Positions 7-755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35297; AAD35297; TM_0205.
GeneIDi897075.
KEGGitma:TM0205.
PATRICi23935282. VBITheMar51294_0207.

Phylogenomic databases

eggNOGiENOG4105CB5. Bacteria.
COG1200. LUCA.
InParanoidiQ9WY48.
KOiK03655.
OMAiGRGEHQS.

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-218-MONOMER.
BRENDAi3.6.4.12. 6331.

Miscellaneous databases

EvolutionaryTraceiQ9WY48.

Family and domain databases

Gene3Di1.20.120.630. 1 hit.
2.40.50.140. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR004609. ATP-dep_DNA_helicase_RecG.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR028993. RecG_N.
IPR033454. RecG_wedge.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF17190. RecG_N. 1 hit.
PF17191. RecG_wedge. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69008. SSF69008. 1 hit.
TIGRFAMsiTIGR00643. recG. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9WY48_THEMA
AccessioniPrimary (citable) accession number: Q9WY48
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.