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Q9WY15

- SYL_THEMA

UniProt

Q9WY15 - SYL_THEMA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:TM_0168
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_0000152106Add
    BLAST

    Proteomic databases

    PRIDEiQ9WY15.

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM0168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WY15.
    SMRiQ9WY15. Positions 1-761.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WY15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEYRPQEIE KKWQEVWEEK KVFYTPQRSE KPKYYALVMF PYPSGTLHVG    50
    HVKNYVIGDI VARYKRMRGY NVLHPFGYDA FGLPAENAAI EKGIHPEEWT 100
    RKNIATIRQQ VKKLGISYDW SREIATCDEE YYKWTQWIFL QLYKNGLAYK 150
    KKAAVNWCPK CKTVLANEQV KDGKCERCGT SVTIRHLEQW FFKITDYAER 200
    LLNDLDKLTG WPEHVKTMQR NWIGKSTGAE IDFPVEGSDT KIRVFTTRPD 250
    TLWGVTFMAL APESPLVEEL VPEEKKEELQ EFLERVKQQD RFRRTSVEAE 300
    KEGFFLGRYA INPVTGERIP IYVANYILME YGTGAIMGVP AHDQRDFSFA 350
    KKYGIPIKVV IKPADKDLDP EKMEEAYEGE GIMVNSGPFD GTPSSEGIEK 400
    VINWLEEKGI GKRSVQYKLR DWLISRQRYW GAPIPIIYCE KCGVVPVPEE 450
    DLPVRLPKDV EFLPTGQSPL SFHEGFKKTK CPVCGGEAQR ETDTMDTFVD 500
    SSWYFLRYVN PHLEDKPFEP DDVNYWLPVD QYIGGVEHAV LHLLYSRFVT 550
    KVLHDLGYLN FDEPFTNLFT QGMIYKDGAK MSKSKGNVVS PDEMIEKYGA 600
    DTLRMYILFM APPEKDAEWS DAGIEGVHRF VKRLWNTFYT VLPFVKEENT 650
    ENLVLKNSTE KELRRKLHSI IKKITEDIEG GFKFNTAISG LMELVNHLSQ 700
    YLNSVPQEEW NRKLLREIVE KLTLALSPFA PHLAEEFWHD LGNDSLVVQQ 750
    SWPSYDPKAL EVEEVEIAIQ INGKVRDKVV VPVDISEEDL KRIVLERERV 800
    KEYVDGKPIR KFIYVKGRIV NIVV 824
    Length:824
    Mass (Da):95,625
    Last modified:November 1, 1999 - v1
    Checksum:i7CB0252A76A844EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35261.1.
    PIRiF72408.
    RefSeqiNP_227983.1. NC_000853.1.
    YP_007976517.1. NC_021214.1.
    YP_008990856.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35261; AAD35261; TM_0168.
    GeneIDi897007.
    KEGGitma:TM0168.
    tmi:THEMA_03960.
    tmm:Tmari_0166.
    PATRICi23935184. VBITheMar51294_0169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35261.1 .
    PIRi F72408.
    RefSeqi NP_227983.1. NC_000853.1.
    YP_007976517.1. NC_021214.1.
    YP_008990856.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali Q9WY15.
    SMRi Q9WY15. Positions 1-761.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0168.

    Proteomic databases

    PRIDEi Q9WY15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35261 ; AAD35261 ; TM_0168 .
    GeneIDi 897007.
    KEGGi tma:TM0168.
    tmi:THEMA_03960.
    tmm:Tmari_0166.
    PATRICi 23935184. VBITheMar51294_0169.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

    Entry informationi

    Entry nameiSYL_THEMA
    AccessioniPrimary (citable) accession number: Q9WY15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3