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Q9WY15

- SYL_THEMA

UniProt

Q9WY15 - SYL_THEMA

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Protein

Leucine--tRNA ligase

Gene
leuS, TM_0168
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:TM_0168
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligaseUniRule annotationPRO_0000152106Add
BLAST

Proteomic databases

PRIDEiQ9WY15.

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0168.

Structurei

3D structure databases

ProteinModelPortaliQ9WY15.
SMRiQ9WY15. Positions 1-761.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionUniRule annotationAdd
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WY15-1 [UniParc]FASTAAdd to Basket

« Hide

MKEYRPQEIE KKWQEVWEEK KVFYTPQRSE KPKYYALVMF PYPSGTLHVG    50
HVKNYVIGDI VARYKRMRGY NVLHPFGYDA FGLPAENAAI EKGIHPEEWT 100
RKNIATIRQQ VKKLGISYDW SREIATCDEE YYKWTQWIFL QLYKNGLAYK 150
KKAAVNWCPK CKTVLANEQV KDGKCERCGT SVTIRHLEQW FFKITDYAER 200
LLNDLDKLTG WPEHVKTMQR NWIGKSTGAE IDFPVEGSDT KIRVFTTRPD 250
TLWGVTFMAL APESPLVEEL VPEEKKEELQ EFLERVKQQD RFRRTSVEAE 300
KEGFFLGRYA INPVTGERIP IYVANYILME YGTGAIMGVP AHDQRDFSFA 350
KKYGIPIKVV IKPADKDLDP EKMEEAYEGE GIMVNSGPFD GTPSSEGIEK 400
VINWLEEKGI GKRSVQYKLR DWLISRQRYW GAPIPIIYCE KCGVVPVPEE 450
DLPVRLPKDV EFLPTGQSPL SFHEGFKKTK CPVCGGEAQR ETDTMDTFVD 500
SSWYFLRYVN PHLEDKPFEP DDVNYWLPVD QYIGGVEHAV LHLLYSRFVT 550
KVLHDLGYLN FDEPFTNLFT QGMIYKDGAK MSKSKGNVVS PDEMIEKYGA 600
DTLRMYILFM APPEKDAEWS DAGIEGVHRF VKRLWNTFYT VLPFVKEENT 650
ENLVLKNSTE KELRRKLHSI IKKITEDIEG GFKFNTAISG LMELVNHLSQ 700
YLNSVPQEEW NRKLLREIVE KLTLALSPFA PHLAEEFWHD LGNDSLVVQQ 750
SWPSYDPKAL EVEEVEIAIQ INGKVRDKVV VPVDISEEDL KRIVLERERV 800
KEYVDGKPIR KFIYVKGRIV NIVV 824
Length:824
Mass (Da):95,625
Last modified:November 1, 1999 - v1
Checksum:i7CB0252A76A844EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35261.1.
PIRiF72408.
RefSeqiNP_227983.1. NC_000853.1.
YP_007976517.1. NC_021214.1.
YP_008990856.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35261; AAD35261; TM_0168.
GeneIDi897007.
KEGGitma:TM0168.
tmi:THEMA_03960.
tmm:Tmari_0166.
PATRICi23935184. VBITheMar51294_0169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35261.1 .
PIRi F72408.
RefSeqi NP_227983.1. NC_000853.1.
YP_007976517.1. NC_021214.1.
YP_008990856.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WY15.
SMRi Q9WY15. Positions 1-761.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0168.

Proteomic databases

PRIDEi Q9WY15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35261 ; AAD35261 ; TM_0168 .
GeneIDi 897007.
KEGGi tma:TM0168.
tmi:THEMA_03960.
tmm:Tmari_0166.
PATRICi 23935184. VBITheMar51294_0169.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiSYL_THEMA
AccessioniPrimary (citable) accession number: Q9WY15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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