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Q9WY15 (SYL_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:TM_0168
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length824 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 824824Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152106

Regions

Motif41 – 5111"HIGH" region HAMAP-Rule MF_00049
Motif580 – 5845"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WY15 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7CB0252A76A844EC

FASTA82495,625
        10         20         30         40         50         60 
MKEYRPQEIE KKWQEVWEEK KVFYTPQRSE KPKYYALVMF PYPSGTLHVG HVKNYVIGDI 

        70         80         90        100        110        120 
VARYKRMRGY NVLHPFGYDA FGLPAENAAI EKGIHPEEWT RKNIATIRQQ VKKLGISYDW 

       130        140        150        160        170        180 
SREIATCDEE YYKWTQWIFL QLYKNGLAYK KKAAVNWCPK CKTVLANEQV KDGKCERCGT 

       190        200        210        220        230        240 
SVTIRHLEQW FFKITDYAER LLNDLDKLTG WPEHVKTMQR NWIGKSTGAE IDFPVEGSDT 

       250        260        270        280        290        300 
KIRVFTTRPD TLWGVTFMAL APESPLVEEL VPEEKKEELQ EFLERVKQQD RFRRTSVEAE 

       310        320        330        340        350        360 
KEGFFLGRYA INPVTGERIP IYVANYILME YGTGAIMGVP AHDQRDFSFA KKYGIPIKVV 

       370        380        390        400        410        420 
IKPADKDLDP EKMEEAYEGE GIMVNSGPFD GTPSSEGIEK VINWLEEKGI GKRSVQYKLR 

       430        440        450        460        470        480 
DWLISRQRYW GAPIPIIYCE KCGVVPVPEE DLPVRLPKDV EFLPTGQSPL SFHEGFKKTK 

       490        500        510        520        530        540 
CPVCGGEAQR ETDTMDTFVD SSWYFLRYVN PHLEDKPFEP DDVNYWLPVD QYIGGVEHAV 

       550        560        570        580        590        600 
LHLLYSRFVT KVLHDLGYLN FDEPFTNLFT QGMIYKDGAK MSKSKGNVVS PDEMIEKYGA 

       610        620        630        640        650        660 
DTLRMYILFM APPEKDAEWS DAGIEGVHRF VKRLWNTFYT VLPFVKEENT ENLVLKNSTE 

       670        680        690        700        710        720 
KELRRKLHSI IKKITEDIEG GFKFNTAISG LMELVNHLSQ YLNSVPQEEW NRKLLREIVE 

       730        740        750        760        770        780 
KLTLALSPFA PHLAEEFWHD LGNDSLVVQQ SWPSYDPKAL EVEEVEIAIQ INGKVRDKVV 

       790        800        810        820 
VPVDISEEDL KRIVLERERV KEYVDGKPIR KFIYVKGRIV NIVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD35261.1.
PIRF72408.
RefSeqNP_227983.1. NC_000853.1.
YP_007976517.1. NC_021214.1.
YP_008990856.1. NC_023151.1.

3D structure databases

ProteinModelPortalQ9WY15.
SMRQ9WY15. Positions 1-761.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM0168.

Proteomic databases

PRIDEQ9WY15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35261; AAD35261; TM_0168.
GeneID897007.
KEGGtma:TM0168.
tmi:THEMA_03960.
tmm:Tmari_0166.
PATRIC23935184. VBITheMar51294_0169.

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_THEMA
AccessionPrimary (citable) accession number: Q9WY15
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries