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Protein

Non-canonical purine NTP pyrophosphatase

Gene

TM_0159

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Magnesium or manganeseUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:TM_0159
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Non-canonical purine NTP pyrophosphatasePRO_0000178252Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0159.

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Helixi13 – 208Combined sources
Beta strandi27 – 315Combined sources
Helixi45 – 6016Combined sources
Beta strandi64 – 7310Combined sources
Helixi74 – 763Combined sources
Helixi81 – 833Combined sources
Turni84 – 907Combined sources
Helixi93 – 10311Combined sources
Turni104 – 1063Combined sources
Beta strandi110 – 12112Combined sources
Turni122 – 1254Combined sources
Beta strandi126 – 13813Combined sources
Helixi151 – 1533Combined sources
Beta strandi154 – 1563Combined sources
Turni163 – 1653Combined sources
Helixi167 – 1693Combined sources
Helixi170 – 1734Combined sources
Helixi175 – 19016Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VP2X-ray1.78A/B1-196[»]
3S86X-ray2.15A/B/C/D1-196[»]
ProteinModelPortaliQ9WY06.
SMRiQ9WY06. Positions 3-191.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WY06.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 156Substrate bindingUniRule annotation
Regioni68 – 692Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
InParanoidiQ9WY06.
KOiK02428.
OMAiCEGLWHG.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WY06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTVYLAT TNPHKVEEIK MIAPEWMEIL PSPEKIEVVE DGETFLENSV
60 70 80 90 100
KKAVVYGKKL KHPVMADDSG LVIYSLGGFP GVMSARFMEE HSYKEKMRTI
110 120 130 140 150
LKMLEGKDRR AAFVCSATFF DPVENTLISV EDRVEGRIAN EIRGTGGFGY
160 170 180 190
DPFFIPDGYD KTFGEIPHLK EKISHRSKAF RKLFSVLEKI LESENR
Length:196
Mass (Da):22,338
Last modified:November 1, 1999 - v1
Checksum:i6C6E4D11901F38A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35252.1.
PIRiE72410.
RefSeqiNP_227974.1. NC_000853.1.
WP_004082779.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35252; AAD35252; TM_0159.
GeneIDi896997.
KEGGitma:TM0159.
tmi:THEMA_04005.
tmw:THMA_0155.
PATRICi23935164. VBITheMar51294_0159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35252.1.
PIRiE72410.
RefSeqiNP_227974.1. NC_000853.1.
WP_004082779.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VP2X-ray1.78A/B1-196[»]
3S86X-ray2.15A/B/C/D1-196[»]
ProteinModelPortaliQ9WY06.
SMRiQ9WY06. Positions 3-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35252; AAD35252; TM_0159.
GeneIDi896997.
KEGGitma:TM0159.
tmi:THEMA_04005.
tmw:THMA_0155.
PATRICi23935164. VBITheMar51294_0159.

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
InParanoidiQ9WY06.
KOiK02428.
OMAiCEGLWHG.

Miscellaneous databases

EvolutionaryTraceiQ9WY06.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTPA_THEMA
AccessioniPrimary (citable) accession number: Q9WY06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.