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Q9WXZ5

- GLMS_THEMA

UniProt

Q9WXZ5 - GLMS_THEMA

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei601 – 6011For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TM_0148
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135400Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0148.

Structurei

3D structure databases

ProteinModelPortaliQ9WXZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini284 – 423140SIS 1UniRule annotationAdd
BLAST
Domaini455 – 596142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
InParanoidiQ9WXZ5.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WXZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGMVGE NLKLEDLVTS LQKLEYRGYD SAGIAYLGDS FGVYKKKGRI
60 70 80 90 100
DVLKNGLKQK LNDRFFVGIA HTRWATHGEP NDMNAHPHMD CKEEIAVVHN
110 120 130 140 150
GIIENYREIR EFLEQRGHVF SSETDTEVIA HLVEEEFEGD LLDAVLKAVK
160 170 180 190 200
KLKGAYAIAV VHKNVPDTIV AARKGSPLVA GIGSGVGILA SDVTPLLRFT
210 220 230 240 250
KDVVFLEDGD VMVLRKDGFE IYNTDGVKQQ RRVYHVNWDE KAAEKGGYKH
260 270 280 290 300
FMYKEIMEDP QALVNALVGR VKNDRPFFEE LEYYEELLKN ADRIRVVSCG
310 320 330 340 350
TSYYAGLVFK YFLENHTDID VEIEVSSEFR YKRPHIKEGD VLIAISQSGE
360 370 380 390 400
TADTLESVRL AKKHGAKIVS IVNVVGSTLD RESDVTLFMN AGPEIGVAAT
410 420 430 440 450
KTYVAELAVL YLLGLKIMEI NGYWDREAEE ILDKLVRMPE LLENVLRKDP
460 470 480 490 500
QIRELSEKYK DYRNFMYIGR GYGYPTALEG ALKLKEITYI HATAYQAGEL
510 520 530 540 550
KHGPIALLDV DFPVFAVMPD DSLFFKTKSN VIESKSRNAP VIVLGTEGNR
560 570 580 590 600
SLEEITGDII HVPPTHESLY PLMMAPVIQL FAYHIADLKG LDPDKPRNLA

KSVTVE
Length:606
Mass (Da):68,082
Last modified:January 23, 2007 - v3
Checksum:iFDB0BE7AE1B14174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35241.1.
PIRiB72412.
RefSeqiNP_227963.1. NC_000853.1.
YP_007976497.1. NC_021214.1.
YP_008990876.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35241; AAD35241; TM_0148.
GeneIDi18092662.
896981.
KEGGitma:TM0148.
PATRICi23935140. VBITheMar51294_0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35241.1 .
PIRi B72412.
RefSeqi NP_227963.1. NC_000853.1.
YP_007976497.1. NC_021214.1.
YP_008990876.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WXZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0148.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35241 ; AAD35241 ; TM_0148 .
GeneIDi 18092662.
896981.
KEGGi tma:TM0148.
PATRICi 23935140. VBITheMar51294_0147.

Phylogenomic databases

eggNOGi COG0449.
InParanoidi Q9WXZ5.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGLMS_THEMA
AccessioniPrimary (citable) accession number: Q9WXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3