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Q9WXZ5

- GLMS_THEMA

UniProt

Q9WXZ5 - GLMS_THEMA

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, TM_0148
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei601 – 6011For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TM_0148
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135400Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243274.TM0148.

Structurei

3D structure databases

ProteinModelPortaliQ9WXZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 423140SIS 1
Add
BLAST
Domaini455 – 596142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WXZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGMVGE NLKLEDLVTS LQKLEYRGYD SAGIAYLGDS FGVYKKKGRI    50
DVLKNGLKQK LNDRFFVGIA HTRWATHGEP NDMNAHPHMD CKEEIAVVHN 100
GIIENYREIR EFLEQRGHVF SSETDTEVIA HLVEEEFEGD LLDAVLKAVK 150
KLKGAYAIAV VHKNVPDTIV AARKGSPLVA GIGSGVGILA SDVTPLLRFT 200
KDVVFLEDGD VMVLRKDGFE IYNTDGVKQQ RRVYHVNWDE KAAEKGGYKH 250
FMYKEIMEDP QALVNALVGR VKNDRPFFEE LEYYEELLKN ADRIRVVSCG 300
TSYYAGLVFK YFLENHTDID VEIEVSSEFR YKRPHIKEGD VLIAISQSGE 350
TADTLESVRL AKKHGAKIVS IVNVVGSTLD RESDVTLFMN AGPEIGVAAT 400
KTYVAELAVL YLLGLKIMEI NGYWDREAEE ILDKLVRMPE LLENVLRKDP 450
QIRELSEKYK DYRNFMYIGR GYGYPTALEG ALKLKEITYI HATAYQAGEL 500
KHGPIALLDV DFPVFAVMPD DSLFFKTKSN VIESKSRNAP VIVLGTEGNR 550
SLEEITGDII HVPPTHESLY PLMMAPVIQL FAYHIADLKG LDPDKPRNLA 600
KSVTVE 606
Length:606
Mass (Da):68,082
Last modified:January 23, 2007 - v3
Checksum:iFDB0BE7AE1B14174
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35241.1.
PIRiB72412.
RefSeqiNP_227963.1. NC_000853.1.
YP_007976497.1. NC_021214.1.
YP_008990876.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35241; AAD35241; TM_0148.
GeneIDi896981.
KEGGitma:TM0148.
tmi:THEMA_04060.
tmm:Tmari_0146.
PATRICi23935140. VBITheMar51294_0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35241.1 .
PIRi B72412.
RefSeqi NP_227963.1. NC_000853.1.
YP_007976497.1. NC_021214.1.
YP_008990876.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WXZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0148.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35241 ; AAD35241 ; TM_0148 .
GeneIDi 896981.
KEGGi tma:TM0148.
tmi:THEMA_04060.
tmm:Tmari_0146.
PATRICi 23935140. VBITheMar51294_0147.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Entry informationi

Entry nameiGLMS_THEMA
AccessioniPrimary (citable) accession number: Q9WXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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