Q9WXX0 (RBSA1_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose import ATP-binding protein RbsA 1
EC=3.6.3.17

Gene names

Name:	rbsA1
Ordered Locus Names:	TM_0115

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]

Taxonomic identifier

243274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga maritima

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
Subunit structure	The complex is composed of two ATP-binding proteins (RbsA), two transmembrane proteins (RbsC and RbsD) and a solute-binding protein (RbsB) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. [View classification] Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW monosaccharide-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Ribose import ATP-binding protein RbsA 1		PRO_0000261113
Regions
	Domain	15 – 256	242	ABC transporter 1
	Domain	266 – 511	246	ABC transporter 2
	Nucleotide binding	47 – 54	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9WXX0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3959BE91CA9DA2EB	FASTA	520	58,633
	10 20 30 40 50 60 MFPLLAFRGD RMEILKAKGI VKRFPGVVAV DNVDFEVYEN EIVSLIGENG AGKSTLIKIL 70 80 90 100 110 120 TGVLKPDAGE ILVNGERVEF HSPVDAFKKG ISVIHQELNL CDNMTVAENI FLAYEAVRGQ 130 140 150 160 170 180 KRTLSSRVDE NYMYTRSKEL LDLIGAKFSP DALVRNLTTA QRQMVEICKA LVKEPRIIFM 190 200 210 220 230 240 DEPTSSLTVE ETERLFEIIE MLKSRGISVV FVSHRLDEVM RISDRIVVMR DGKRIGELKK 250 260 270 280 290 300 GEFDVDTIIK MMVGREVEFF PHGIETRPGE IALEVRNLKW KDKVKNVSFE VRKGEVLGFA 310 320 330 340 350 360 GLVGAGRTET MLLVFGVNQK ESGDIYVNGR KVEIKNPEDA IKMGIGLIPE DRKLQGLVLR 370 380 390 400 410 420 MTVKDNIVLP SLKKISRWGL VLDERKEEEI SEDYVKRLSI KTPSIYQITE NLSGGNQQKV 430 440 450 460 470 480 VLAKWLATNA DILIFDEPTR GIDVGAKAEI HRMIRELAAQ GKAVIMISSE LPEILNLSDR 490 500 510 520 IVVMWEGEIT AVLDNREKRV TQEEIMYYAS GQKKQNGRVA

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD35209.1.
PIR	B72417.
RefSeq	NP_227931.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WXX0.
ModBase	Search...
Protein-protein interaction databases
STRING	243274.TM0115.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD35209; AAD35209; TM_0115.
GeneID	896942.
KEGG	tma:TM0115.
PATRIC	23935070. VBITheMar51294_0113.
Phylogenomic databases
eggNOG	COG1129.
KO	K02056.
OMA	KWLATNA.
ProtClustDB	CLSK874981.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015861. ABC_transpr_RbsA. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 2 hits.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. PS51254. RBSA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RBSA1_THEMA

Accession

Primary (citable) accession number: Q9WXX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program