Q9WXS4 (UXUA_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	TM_0069

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Mannonate dehydratase HAMAP MF_00106		PRO_0000170689

Sequences

	Sequence		Length	Mass (Da)
	Q9WXS4 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 08C9771F1DCBFA3E	FASTA	360	41,890
	10 20 30 40 50 60 MKLVFRWYGE KHDTVTLEQI RQIPGVEGVV GALFDIPVGE VWPFEEIMKL KETVEKAGLK 70 80 90 100 110 120 LEVIESVNVH EDIKLGLPTR DRYIENYKKT IRNLAKAGVK VVCYNFMPVF DWMRTDLHKK 130 140 150 160 170 180 LPDGSETMEY DHRLIEGVTP DELIKRVKEG SQGFVLPGWE WDRLEKLRET FELYKNVDEE 190 200 210 220 230 240 KLFENLVYFL ERVIPVCEEC DVKLAIHPDD PPWSIFGLPR IITNKENIER MLKAVDSPYN 250 260 270 280 290 300 GITFCMGSLG ANPENNIPEM IRYFGKMGRI HFAHVRNLKF TGEKSFYETA HPSFCGSHDL 310 320 330 340 350 360 FEVMKAFHDI GYEGYIRPDH GRLIWGEKAR PGYGLYDRAL GATYILGLWE AIDKMKKRYC

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD35163.1.
PIR	A72423.
RefSeq	NP_227885.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WXS4.
SMR	Q9WXS4. Positions 1-354.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	896894.
GenomeReviews	Gene locus TM_0069 in contig AE000512_GR.
KEGG	tma:TM0069.
NMPDR	fig|243274.1.peg.69.
PATRIC	23934978. VBITheMar51294_0067.
TIGR	TM_0069.
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
PhylomeDB	Q9WXS4.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_0069-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_THEMA

Accession

Primary (citable) accession number: Q9WXS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program