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Q9WXP6

- GCH4_THEMA

UniProt

Q9WXP6 - GCH4_THEMA

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, TM_0039
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.1 Publication

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1431May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase 1B
Gene namesi
Name:folE2
Ordered Locus Names:TM_0039
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0039.

Structurei

3D structure databases

ProteinModelPortaliQ9WXP6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WXP6-1 [UniParc]FASTAAdd to Basket

« Hide

MKDVQNEKDP RMVPLKKVGI KDLHWPLKVI LKEDGYQSTV AQISCSVDLH    50
REKRGIHMSR FIEVLNKLEV ITPQIFEEIL DDLIEIMEAK RAHLEIHFPY 100
FIWKESPVSR KKSPLKVDCF VEAEKEKNFS FKIGVRTPVH TLCPCSKEIS 150
DYGAHNQRAF VEITVKTRKF IWFEDLVEIA EKNASSPLYT LLKRPDEKFV 200
TEKAYENPRF VEDVARDVAL ELEKDPRITW YRVYVESMES IHNHNAFACV 250
EKGDFVLEG 259
Length:259
Mass (Da):30,309
Last modified:November 1, 1999 - v1
Checksum:i89A5C0EA52EEF34D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35133.1.
PIRiD72425.
RefSeqiNP_227855.1. NC_000853.1.
YP_007976387.1. NC_021214.1.
YP_008990984.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35133; AAD35133; TM_0039.
GeneIDi896863.
KEGGitma:TM0039.
tmi:THEMA_04605.
tmm:Tmari_0036.
PATRICi23934918. VBITheMar51294_0037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000512 Genomic DNA. Translation: AAD35133.1 .
PIRi D72425.
RefSeqi NP_227855.1. NC_000853.1.
YP_007976387.1. NC_021214.1.
YP_008990984.1. NC_023151.1.

3D structure databases

ProteinModelPortali Q9WXP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35133 ; AAD35133 ; TM_0039 .
GeneIDi 896863.
KEGGi tma:TM0039.
tmi:THEMA_04605.
tmm:Tmari_0036.
PATRICi 23934918. VBITheMar51294_0037.

Phylogenomic databases

eggNOGi COG1469.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiGCH4_THEMA
AccessioniPrimary (citable) accession number: Q9WXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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