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Q9WXP6 (GCH4_THEMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase 1B
Gene names
Name:folE2
Ordered Locus Names:TM_0039
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate. Ref.2

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. Ref.2

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527_B

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527_B
PRO_0000147732

Sites

Site1431May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WXP6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 89A5C0EA52EEF34D

FASTA25930,309
        10         20         30         40         50         60 
MKDVQNEKDP RMVPLKKVGI KDLHWPLKVI LKEDGYQSTV AQISCSVDLH REKRGIHMSR 

        70         80         90        100        110        120 
FIEVLNKLEV ITPQIFEEIL DDLIEIMEAK RAHLEIHFPY FIWKESPVSR KKSPLKVDCF 

       130        140        150        160        170        180 
VEAEKEKNFS FKIGVRTPVH TLCPCSKEIS DYGAHNQRAF VEITVKTRKF IWFEDLVEIA 

       190        200        210        220        230        240 
EKNASSPLYT LLKRPDEKFV TEKAYENPRF VEDVARDVAL ELEKDPRITW YRVYVESMES 

       250 
IHNHNAFACV EKGDFVLEG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000512 Genomic DNA. Translation: AAD35133.1.
PIRD72425.
RefSeqNP_227855.1. NC_000853.1.
YP_007976387.1. NC_021214.1.
YP_008990984.1. NC_023151.1.

3D structure databases

ProteinModelPortalQ9WXP6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243274.TM0039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD35133; AAD35133; TM_0039.
GeneID896863.
KEGGtma:TM0039.
tmi:THEMA_04605.
tmm:Tmari_0036.
PATRIC23934918. VBITheMar51294_0037.

Phylogenomic databases

eggNOGCOG1469.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_THEMA
AccessionPrimary (citable) accession number: Q9WXP6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways