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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.1 Publication

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1431May be catalytically importantBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase 1B
Gene namesi
Name:folE2
Ordered Locus Names:TM_0039
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259GTP cyclohydrolase FolE2PRO_0000147732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0039.

Structurei

3D structure databases

ProteinModelPortaliQ9WXP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.Curated

Phylogenomic databases

eggNOGiCOG1469.
InParanoidiQ9WXP6.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WXP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVQNEKDP RMVPLKKVGI KDLHWPLKVI LKEDGYQSTV AQISCSVDLH
60 70 80 90 100
REKRGIHMSR FIEVLNKLEV ITPQIFEEIL DDLIEIMEAK RAHLEIHFPY
110 120 130 140 150
FIWKESPVSR KKSPLKVDCF VEAEKEKNFS FKIGVRTPVH TLCPCSKEIS
160 170 180 190 200
DYGAHNQRAF VEITVKTRKF IWFEDLVEIA EKNASSPLYT LLKRPDEKFV
210 220 230 240 250
TEKAYENPRF VEDVARDVAL ELEKDPRITW YRVYVESMES IHNHNAFACV

EKGDFVLEG
Length:259
Mass (Da):30,309
Last modified:November 1, 1999 - v1
Checksum:i89A5C0EA52EEF34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35133.1.
PIRiD72425.
RefSeqiNP_227855.1. NC_000853.1.
WP_004082504.1. NC_023151.1.
YP_007976387.1. NC_021214.1.
YP_008990984.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35133; AAD35133; TM_0039.
GeneIDi896863.
KEGGitma:TM0039.
tmi:THEMA_04605.
tmm:Tmari_0036.
PATRICi23934918. VBITheMar51294_0037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA. Translation: AAD35133.1.
PIRiD72425.
RefSeqiNP_227855.1. NC_000853.1.
WP_004082504.1. NC_023151.1.
YP_007976387.1. NC_021214.1.
YP_008990984.1. NC_023151.1.

3D structure databases

ProteinModelPortaliQ9WXP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35133; AAD35133; TM_0039.
GeneIDi896863.
KEGGitma:TM0039.
tmi:THEMA_04605.
tmm:Tmari_0036.
PATRICi23934918. VBITheMar51294_0037.

Phylogenomic databases

eggNOGiCOG1469.
InParanoidiQ9WXP6.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiGCH4_THEMA
AccessioniPrimary (citable) accession number: Q9WXP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1999
Last modified: May 27, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.