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Q9WXP6

- GCH4_THEMA

UniProt

Q9WXP6 - GCH4_THEMA

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.1 Publication

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1431May be catalytically importantBy similarity

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 (EC:3.5.4.16)
    Alternative name(s):
    GTP cyclohydrolase 1B
    Gene namesi
    Name:folE2
    Ordered Locus Names:TM_0039
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000008183: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259GTP cyclohydrolase FolE2PRO_0000147732Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243274.TM0039.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WXP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.Curated

    Phylogenomic databases

    eggNOGiCOG1469.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WXP6-1 [UniParc]FASTAAdd to Basket

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    MKDVQNEKDP RMVPLKKVGI KDLHWPLKVI LKEDGYQSTV AQISCSVDLH    50
    REKRGIHMSR FIEVLNKLEV ITPQIFEEIL DDLIEIMEAK RAHLEIHFPY 100
    FIWKESPVSR KKSPLKVDCF VEAEKEKNFS FKIGVRTPVH TLCPCSKEIS 150
    DYGAHNQRAF VEITVKTRKF IWFEDLVEIA EKNASSPLYT LLKRPDEKFV 200
    TEKAYENPRF VEDVARDVAL ELEKDPRITW YRVYVESMES IHNHNAFACV 250
    EKGDFVLEG 259
    Length:259
    Mass (Da):30,309
    Last modified:November 1, 1999 - v1
    Checksum:i89A5C0EA52EEF34D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35133.1.
    PIRiD72425.
    RefSeqiNP_227855.1. NC_000853.1.
    YP_007976387.1. NC_021214.1.
    YP_008990984.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAAD35133; AAD35133; TM_0039.
    GeneIDi896863.
    KEGGitma:TM0039.
    tmi:THEMA_04605.
    tmm:Tmari_0036.
    PATRICi23934918. VBITheMar51294_0037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000512 Genomic DNA. Translation: AAD35133.1 .
    PIRi D72425.
    RefSeqi NP_227855.1. NC_000853.1.
    YP_007976387.1. NC_021214.1.
    YP_008990984.1. NC_023151.1.

    3D structure databases

    ProteinModelPortali Q9WXP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243274.TM0039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD35133 ; AAD35133 ; TM_0039 .
    GeneIDi 896863.
    KEGGi tma:TM0039.
    tmi:THEMA_04605.
    tmm:Tmari_0036.
    PATRICi 23934918. VBITheMar51294_0037.

    Phylogenomic databases

    eggNOGi COG1469.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
    2. Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiGCH4_THEMA
    AccessioniPrimary (citable) accession number: Q9WXP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3