Q9WXP3 (NTPTH_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside-triphosphatase THEP1
Short name=NTPase THEP1
EC=3.6.1.15

Alternative name(s):
Nucleoside triphosphate phosphohydrolase

Gene names

Ordered Locus Names:

TM_0036

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) [Reference proteome] [HAMAP]

Taxonomic identifier

243274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga maritima

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency By similarity. HAMAP-Rule MF_00796
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP-Rule MF_00796
Sequence similarities	Belongs to the THEP1 NTPase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP nucleotide phosphatase activity Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Nucleoside-triphosphatase THEP1 HAMAP-Rule MF_00796		PRO_0000146710
Regions
	Nucleotide binding	7 – 14	8	ATP By similarity
	Nucleotide binding	94 – 101	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WXP3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A739CCA34DF59B52	FASTA	174	20,034
	10 20 30 40 50 60 MKILITGRPG VGKTTLIKKL SRLLQNAGGF YTEEMREGEK RIGFKIITLD GEEGILARTD 70 80 90 100 110 120 LPSPYRVGKY YVNLKDLEEI GVRSLERAFQ EKDLIIVDEI GKMELLSRKF REVVEKIFDS 130 140 150 160 170 EKDVIATIKK SSDPFVEKIK NRNDVVIFEL NEKNRNSLLN EILSVLKFNR GEKQ

References

[1]

"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000512 Genomic DNA. Translation: AAD35130.1.
PIR	A72425.
RefSeq	NP_227852.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WXP3.
ModBase	Search...
Protein-protein interaction databases
STRING	243274.TM0036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD35130; AAD35130; TM_0036.
GeneID	896857.
KEGG	tma:TM0036.
PATRIC	23934912. VBITheMar51294_0034.
Phylogenomic databases
eggNOG	COG1618.
KO	K06928.
OMA	VTKENRN.
ProtClustDB	PRK13695.
Family and domain databases
HAMAP	MF_00796. NTPase_1.
InterPro	IPR003593. AAA+_ATPase. IPR004948. Nuc-triphosphatase_THEP1. [Graphical view]
Pfam	PF03266. NTPase_1. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPTH_THEMA

Accession

Primary (citable) accession number: Q9WXP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program