Q9WXC3 (CYAA_STRGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:	cya
Synonyms:	cyaA

Organism

Streptomyces griseus

Taxonomic identifier

1911 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Adenylate cyclase		PRO_0000195750
Regions
	Domain	198 – 307	110	Guanylate cyclase
Sites
	Metal binding	203	1	Magnesium By similarity
	Metal binding	247	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WXC3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: C38C6A015F9E7685	FASTA	399	43,164
	10 20 30 40 50 60 MTVGDTTSGS GEEPAADSSV HATPHHEVDH TVEPTDDPLA IRLEALILGA DRRYTPFQAA 70 80 90 100 110 120 RTAGVSMDLA SRFWRAMAFA DIGQAKALTE ADVLALRRLA GLVEAGLLSE PMAIQVARST 130 140 150 160 170 180 GQTTARLAEW QIDSFLEGLT EPPEPGMTRT EVTYPLVELL LPELQEFLVY VWRRQLAAAT 190 200 210 220 230 240 GRVVQAADDE EMVDRRPRVR FADLVGFTRL TRRLEEEELG ELVESFETTA ADLVAPTAAG 250 260 270 280 290 300 LVKTLGDEVL FAADDAGTAA EIALRLIEAM SQDETMPALR VGIAFGTVTT RMGDVFGTTV 310 320 330 340 350 360 NLASRLTSIA PKDAVLVDGA FAKELVRHGE APESEAQAAE AVAAAAERVR LAEKEGREPD 370 380 390 DEPPLPTYRF GLQPMWQRPV RGLGVVEPWL LARRGKTGS

References

[1]	"Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus." Kang D.K., Li X.M., Ochi K., Horinouchi S. Microbiology 145:1161-1172(1999) [PubMed: 10376832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018557 Genomic DNA. Translation: BAA76599.1.
3D structure databases
ProteinModelPortal	Q9WXC3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 1 hit.
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_STRGR

Accession

Primary (citable) accession number: Q9WXC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program