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Q9WX76

- RRF_THET8

UniProt

Q9WX76 - RRF_THET8

Protein

Ribosome-recycling factor

Gene

frr

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.UniRule annotation

    GO - Biological processi

    1. translational termination Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-890-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome-recycling factorUniRule annotation
    Short name:
    RRFUniRule annotation
    Alternative name(s):
    Ribosome-releasing factorUniRule annotation
    Gene namesi
    Name:frrUniRule annotation
    Ordered Locus Names:TTHA0858
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Ribosome-recycling factorPRO_0000167567Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA0858.

    Structurei

    Secondary structure

    1
    185
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 2624
    Helixi36 – 383
    Beta strandi42 – 454
    Beta strandi48 – 514
    Helixi52 – 543
    Beta strandi57 – 593
    Beta strandi65 – 695
    Helixi73 – 8311
    Beta strandi84 – 863
    Beta strandi92 – 954
    Beta strandi98 – 1025
    Helixi110 – 14738
    Helixi151 – 18333

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EH1X-ray2.60A1-185[»]
    2QBEX-ray3.3061-185[»]
    2QBGX-ray3.3061-185[»]
    2QBIX-ray4.0061-185[»]
    2QBKX-ray4.0061-185[»]
    2V46X-ray3.80Y1-185[»]
    2V48X-ray3.80Y1-185[»]
    2Z4LX-ray4.4561-185[»]
    2Z4NX-ray4.4561-185[»]
    3J0Delectron microscopy11.10J1-185[»]
    3J0Eelectron microscopy9.90G1-185[»]
    ProteinModelPortaliQ9WX76.
    SMRiQ9WX76. Positions 1-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WX76.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RRF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0233.
    HOGENOMiHOG000040143.
    KOiK02838.
    OMAiEKECTED.
    OrthoDBiEOG6SV5F9.
    PhylomeDBiQ9WX76.

    Family and domain databases

    HAMAPiMF_00040. RRF.
    InterProiIPR002661. Ribosome_recyc_fac.
    IPR023584. Ribosome_recyc_fac_dom.
    [Graphical view]
    PANTHERiPTHR20982. PTHR20982. 1 hit.
    PfamiPF01765. RRF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55194. SSF55194. 1 hit.
    TIGRFAMsiTIGR00496. frr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WX76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLKELYAET RSHMQKSLEV LEHNLAGLRT GRANPALLLH LKVEYYGAHV    50
    PLNQIATVTA PDPRTLVVQS WDQNALKAIE KAIRDSDLGL NPSNKGDALY 100
    INIPPLTEER RKDLVRAVRQ YAEEGRVAIR NIRREALDKL KKLAKELHLS 150
    EDETKRAEAE IQKITDEFIA KADQLAEKKE QEILG 185
    Length:185
    Mass (Da):20,994
    Last modified:November 1, 1999 - v1
    Checksum:iF3135ABF7F813328
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016498 Genomic DNA. Translation: BAA76865.1.
    AP008226 Genomic DNA. Translation: BAD70681.1.
    RefSeqiWP_011172951.1. NC_006461.1.
    YP_144124.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70681; BAD70681; BAD70681.
    GeneIDi3170111.
    KEGGittj:TTHA0858.
    PATRICi23956698. VBITheThe93045_0852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016498 Genomic DNA. Translation: BAA76865.1 .
    AP008226 Genomic DNA. Translation: BAD70681.1 .
    RefSeqi WP_011172951.1. NC_006461.1.
    YP_144124.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EH1 X-ray 2.60 A 1-185 [» ]
    2QBE X-ray 3.30 6 1-185 [» ]
    2QBG X-ray 3.30 6 1-185 [» ]
    2QBI X-ray 4.00 6 1-185 [» ]
    2QBK X-ray 4.00 6 1-185 [» ]
    2V46 X-ray 3.80 Y 1-185 [» ]
    2V48 X-ray 3.80 Y 1-185 [» ]
    2Z4L X-ray 4.45 6 1-185 [» ]
    2Z4N X-ray 4.45 6 1-185 [» ]
    3J0D electron microscopy 11.10 J 1-185 [» ]
    3J0E electron microscopy 9.90 G 1-185 [» ]
    ProteinModelPortali Q9WX76.
    SMRi Q9WX76. Positions 1-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0858.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70681 ; BAD70681 ; BAD70681 .
    GeneIDi 3170111.
    KEGGi ttj:TTHA0858.
    PATRICi 23956698. VBITheThe93045_0852.

    Phylogenomic databases

    eggNOGi COG0233.
    HOGENOMi HOG000040143.
    KOi K02838.
    OMAi EKECTED.
    OrthoDBi EOG6SV5F9.
    PhylomeDBi Q9WX76.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-890-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9WX76.

    Family and domain databases

    HAMAPi MF_00040. RRF.
    InterProi IPR002661. Ribosome_recyc_fac.
    IPR023584. Ribosome_recyc_fac_dom.
    [Graphical view ]
    PANTHERi PTHR20982. PTHR20982. 1 hit.
    Pfami PF01765. RRF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55194. SSF55194. 1 hit.
    TIGRFAMsi TIGR00496. frr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Amber mutations in ribosome recycling factors of Escherichia coli and Thermus thermophilus: evidence for C-terminal modulator element."
      Fujiwara T., Ito K., Nakayashiki T., Nakamura Y.
      FEBS Lett. 447:297-302(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    3. "Crystal structure combined with genetic analysis of the Thermus thermophilus ribosome recycling factor shows that a flexible hinge may act as a functional switch."
      Toyoda T., Tin O.F., Ito K., Fujiwara T., Kumasaka T., Yamamoto M., Garber M.B., Nakamura Y.
      RNA 6:1432-1444(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).

    Entry informationi

    Entry nameiRRF_THET8
    AccessioniPrimary (citable) accession number: Q9WX76
    Secondary accession number(s): Q5SJZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3