Reviewed,
UniProtKB/Swiss-Prot Q9WX75 (BCSA5_ACEXY)
Last modified
June 16, 2009.
Version 54.
History...
Clusters with 100%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative cellulose synthase 3 Including the following 2 domains: 1- Recommended name: Cellulose synthase catalytic subunit [UDP-forming] EC=2.4.1.12 2- Recommended name: Cyclic di-GMP-binding domain Alternative name(s): Cellulose synthase 3 regulatory subunit | ||
| Gene names |
| ||
| Organism | Acetobacter xylinus (Gluconacetobacter xylinus) | ||
| Taxonomic identifier | 28448 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter |
Protein attributes
| Sequence length | 1518 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1). |
| Pathway | |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein Potential. |
| Domain | There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site. |
| Sequence similarities | In the N-terminal section; belongs to the glycosyltransferase 2 family. In the C-terminal section; belongs to the acsB/bcsB family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cellulose biosynthesis |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro cellulose biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to plasma membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1518 | 1518 | Putative cellulose synthase 3 | PRO_0000059266 | |||||
Regions | |||||||||
| Transmembrane | 24 – 44 | 21 | Potential | ||||||
| Transmembrane | 71 – 91 | 21 | Potential | ||||||
| Transmembrane | 105 – 125 | 21 | Potential | ||||||
| Transmembrane | 404 – 424 | 21 | Potential | ||||||
| Transmembrane | 428 – 448 | 21 | Potential | ||||||
| Transmembrane | 465 – 485 | 21 | Potential | ||||||
| Transmembrane | 514 – 534 | 21 | Potential | ||||||
| Transmembrane | 543 – 563 | 21 | Potential | ||||||
| Transmembrane | 1481 – 1501 | 21 | Potential | ||||||
| Region | 1 – 731 | 731 | Catalytic | ||||||
| Region | 144 – 237 | 94 | Catalytic subdomain A | ||||||
| Region | 314 – 374 | 61 | Catalytic subdomain B | ||||||
| Region | 732 – 1518 | 787 | Cyclic di-GMP binding By similarity | ||||||
Sites | |||||||||
| Active site | 186 | 1 | Potential | ||||||
| Active site | 330 | 1 | Potential | ||||||
| Site | 233 | 1 | Important for substrate binding Potential | ||||||
| Site | 235 | 1 | Important for substrate binding Potential | ||||||
Sequences
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References
| [1] | "Cloning of cellulose synthase genes from Acetobacter xylinum JCM 7664: implication of a novel set of cellulose synthase genes." Umeda Y., Hirano A., Ishibashi M., Akiyama H., Onizuka T., Ikeuchi M., Inoue Y. DNA Res. 6:109-115(1999) [PubMed: 10382968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: JCM 7664 / IFO 13693. |
Cross-references
Sequence databases | |
|---|---|
| AB015804 Genomic DNA. Translation: BAA77600.1. | |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT2. Glycosyltransferase Family 2. |
Family and domain databases | |
| InterPro | IPR003920. Cell_synth_B. IPR018513. Cell_synthase_bac. IPR017480. Cellulose_synth_catalytic. IPR001173. Glyco_trans_2. IPR009875. PilZ. [Graphical view] |
| Pfam | PF03170. BcsB. 1 hit. PF00535. Glycos_transf_2. 1 hit. PF07238. PilZ. 1 hit. [Graphical view] |
| PRINTS | PR01440. CELLSNTHASEB. |
| TIGRFAMs | TIGR03030. CelA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | BCSA5_ACEXY | ||||||||
| Accession | Primary (citable) accession number: Q9WX75 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
