Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WX75

- BCSA5_KOMXY

UniProt

Q9WX75 - BCSA5_KOMXY

Protein

Putative cellulose synthase 3

Gene

bcsABII-B

Organism
Komagataeibacter xylinus (Gluconacetobacter xylinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei186 – 1861Sequence Analysis
    Sitei233 – 2331Important for substrate bindingSequence Analysis
    Sitei235 – 2351Important for substrate bindingSequence Analysis
    Active sitei330 – 3301Sequence Analysis

    GO - Molecular functioni

    1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
    2. cyclic-di-GMP binding Source: InterPro

    GO - Biological processi

    1. cellulose biosynthetic process Source: UniProtKB-KW
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cellulose biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00694.

    Protein family/group databases

    CAZyiGT2. Glycosyltransferase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative cellulose synthase 3
    Including the following 2 domains:
    Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
    Cyclic di-GMP-binding domain
    Alternative name(s):
    Cellulose synthase 3 regulatory subunit
    Gene namesi
    Name:bcsABII-B
    OrganismiKomagataeibacter xylinus (Gluconacetobacter xylinus)
    Taxonomic identifieri28448 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15181518Putative cellulose synthase 3PRO_0000059266Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WX75.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei514 – 53421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei543 – 56321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1481 – 150121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini569 – 668100PilZAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 731731CatalyticAdd
    BLAST
    Regioni144 – 23794Catalytic subdomain AAdd
    BLAST
    Regioni314 – 37461Catalytic subdomain BAdd
    BLAST
    Regioni732 – 1518787Cyclic di-GMP bindingBy similarityAdd
    BLAST

    Domaini

    There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 2 family.Curated
    In the C-terminal section; belongs to the AcsB/BcsB family.Curated
    Contains 1 PilZ domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR003919. Cell_synth_A.
    IPR003920. Cell_synth_B.
    IPR018513. Cell_synthase_bac.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR009875. PilZ_domain.
    [Graphical view]
    PfamiPF03170. BcsB. 1 hit.
    PF07238. PilZ. 1 hit.
    [Graphical view]
    PRINTSiPR01440. CELLSNTHASEB.
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR03030. CelA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WX75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGTWFTTGK VTDLLARTGL DRVPVWVPVV LGVVLMAFVG SVRIDPALQG     50
    WVSIGTVTLL LVLNRRRGRG ITVFLMMLSL LVSLRYIVWR LTATVQFSNW 100
    LQTALAVLLL LAEAYALMTL CLSYFQMAWP LRRREHPLPE DMAQWPSVDV 150
    FVPSYNEELS LVRSTVLGAL DLDWPADRLN VYILDDGRRK AFHDFAVEAG 200
    AGYIIRAENN HAKAGNLNHA LAVTDSPFAV IFDCDHVPTR GFLRRTIGWM 250
    MADPNLALLQ TPHHFYAPDP FQRNLAGGMH VPPEGNMFYG LVQDGNDFWD 300
    ATFFCGSCAI IRREAVMGIG GFATETVTED AHTALKMQRR GWGTAYLREP 350
    LAAGLATERL ILHIGQRVRW ARGMIQIMRL DNPMLGAGLR WEQRLCYLSA 400
    MSHFLFAIPR LTFLVSPLAF LFLGQNIIAA SPLAISVYAL PHIFHSVITL 450
    SRIEGRWRYS FWSEIYETSL ALFLVRITIV TLLQPHKGKF NVTDKGGLLA 500
    RGYFDWDAVY PNVILAGVLC AALLRGVFGI VWQFHDRLAL QSFILNTLWV 550
    VISLIIVLAS IAVGRETRQT RNAPRVSVRL PVVVTDAHGR QMEGHTHDIS 600
    LGGLAVGTRL ATPDMVGGEV TVRYDSARDG IHVGVPARVL DARDGTLRLR 650
    WAVRDLEDER QVVSMVFGRN DAWAGWADFA PDRPLRSLAM VFRSIGGLLR 700
    RRPAEAPRAL HEMGEGELPA TEEKLEKQSF VLKPVPRSAR HGATASAALF 750
    VAFTALVPAA MAQEAPSPDQ SGVTAETPFG DSNTGVVPDA LPAIDPAVAD 800
    RISDAEVTRT LTFRNLGATT GPLTLRGYSP LQGLDVVVPA NRVVTHAQLT 850
    LSGALSPSLL PEANAVTVTL NEQYVGTLKV DPQHPQFGPV SFDIDPLYFT 900
    GDNKLNFHFA GEYRRDCNDL FNEILWARIS DMSRITLTTV RITPERKLSR 950
    LPAPFFDPNQ RSTLRVPVVL PATGDRGALR AAGLVASWFG RIADFRKLSF 1000
    PVSTTIPASG NAVEVGVNLP VDAEGGRPAG PMLAEVANPN DRWGTVLVVT 1050
    GRTAQEVEVA ARALVFSPDT LGGVASKVVS DVSLETRHPY DAPAFVPTDR 1100
    PVRFGELVGA ADLQGGGFAP AGMTLPFHLP PDLYTWRGRP FLMNMWVRAP 1150
    GGPVVDLETS RVDVSLNNNY LQSYTLSPPG LWRKWSERLV NQHAGAVGHV 1200
    TALPPWLLFG QNQLQFNFDA RPIDRGACRR TPGDIHMSVD SDSTLDFRRG 1250
    YHFAEMPNLS YFAEAAFPFS RMADLSETTV VLPDHPDTGT TGAFLDLMGF 1300
    FGASTWYPAA GVTVMGADEV AQTPPKGDIV VLGTAAQLGG AASGLLARSP 1350
    YVIHDRHITV GQRMGLQGIW YLFQDHDHAG LKDGVTANLN APIAEAGVLL 1400
    AAQSPYDSQR SVVAFTGDTP ERIHDLVLSL RNKGDLPSLQ GDLVLKNGDR 1450
    FTSYRTAPVY TVGSLPLWLR LDWFLGHHPS ALYLAGLAGA GLAALGVWAW 1500
    LRGWSRRRIA RDDLTGEL 1518
    Length:1,518
    Mass (Da):166,465
    Last modified:November 1, 1999 - v1
    Checksum:i7D7634503183DAB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015804 Genomic DNA. Translation: BAA77600.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015804 Genomic DNA. Translation: BAA77600.1 .

    3D structure databases

    ProteinModelPortali Q9WX75.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT2. Glycosyltransferase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00694 .

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR003919. Cell_synth_A.
    IPR003920. Cell_synth_B.
    IPR018513. Cell_synthase_bac.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR009875. PilZ_domain.
    [Graphical view ]
    Pfami PF03170. BcsB. 1 hit.
    PF07238. PilZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01440. CELLSNTHASEB.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR03030. CelA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cellulose synthase genes from Acetobacter xylinum JCM 7664: implication of a novel set of cellulose synthase genes."
      Umeda Y., Hirano A., Ishibashi M., Akiyama H., Onizuka T., Ikeuchi M., Inoue Y.
      DNA Res. 6:109-115(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JCM 7664 / NBRC 13693.

    Entry informationi

    Entry nameiBCSA5_KOMXY
    AccessioniPrimary (citable) accession number: Q9WX75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3