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Q9WX75

- BCSA5_KOMXY

UniProt

Q9WX75 - BCSA5_KOMXY

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Protein

Putative cellulose synthase 3

Gene

bcsABII-B

Organism
Komagataeibacter xylinus (Gluconacetobacter xylinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861Sequence Analysis
Sitei233 – 2331Important for substrate bindingSequence Analysis
Sitei235 – 2351Important for substrate bindingSequence Analysis
Active sitei330 – 3301Sequence Analysis

GO - Molecular functioni

  1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
  2. cyclic-di-GMP binding Source: InterPro

GO - Biological processi

  1. cellulose biosynthetic process Source: UniProtKB-KW
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cellulose biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00694.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cellulose synthase 3
Including the following 2 domains:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Cyclic di-GMP-binding domain
Alternative name(s):
Cellulose synthase 3 regulatory subunit
Gene namesi
Name:bcsABII-B
OrganismiKomagataeibacter xylinus (Gluconacetobacter xylinus)
Taxonomic identifieri28448 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15181518Putative cellulose synthase 3PRO_0000059266Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9WX75.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence AnalysisAdd
BLAST
Transmembranei514 – 53421HelicalSequence AnalysisAdd
BLAST
Transmembranei543 – 56321HelicalSequence AnalysisAdd
BLAST
Transmembranei1481 – 150121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini569 – 668100PilZAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 731731CatalyticAdd
BLAST
Regioni144 – 23794Catalytic subdomain AAdd
BLAST
Regioni314 – 37461Catalytic subdomain BAdd
BLAST
Regioni732 – 1518787Cyclic di-GMP bindingBy similarityAdd
BLAST

Domaini

There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 2 family.Curated
In the C-terminal section; belongs to the AcsB/BcsB family.Curated
Contains 1 PilZ domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view]
PfamiPF03170. BcsB. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view]
PRINTSiPR01440. CELLSNTHASEB.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03030. CelA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WX75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGTWFTTGK VTDLLARTGL DRVPVWVPVV LGVVLMAFVG SVRIDPALQG
60 70 80 90 100
WVSIGTVTLL LVLNRRRGRG ITVFLMMLSL LVSLRYIVWR LTATVQFSNW
110 120 130 140 150
LQTALAVLLL LAEAYALMTL CLSYFQMAWP LRRREHPLPE DMAQWPSVDV
160 170 180 190 200
FVPSYNEELS LVRSTVLGAL DLDWPADRLN VYILDDGRRK AFHDFAVEAG
210 220 230 240 250
AGYIIRAENN HAKAGNLNHA LAVTDSPFAV IFDCDHVPTR GFLRRTIGWM
260 270 280 290 300
MADPNLALLQ TPHHFYAPDP FQRNLAGGMH VPPEGNMFYG LVQDGNDFWD
310 320 330 340 350
ATFFCGSCAI IRREAVMGIG GFATETVTED AHTALKMQRR GWGTAYLREP
360 370 380 390 400
LAAGLATERL ILHIGQRVRW ARGMIQIMRL DNPMLGAGLR WEQRLCYLSA
410 420 430 440 450
MSHFLFAIPR LTFLVSPLAF LFLGQNIIAA SPLAISVYAL PHIFHSVITL
460 470 480 490 500
SRIEGRWRYS FWSEIYETSL ALFLVRITIV TLLQPHKGKF NVTDKGGLLA
510 520 530 540 550
RGYFDWDAVY PNVILAGVLC AALLRGVFGI VWQFHDRLAL QSFILNTLWV
560 570 580 590 600
VISLIIVLAS IAVGRETRQT RNAPRVSVRL PVVVTDAHGR QMEGHTHDIS
610 620 630 640 650
LGGLAVGTRL ATPDMVGGEV TVRYDSARDG IHVGVPARVL DARDGTLRLR
660 670 680 690 700
WAVRDLEDER QVVSMVFGRN DAWAGWADFA PDRPLRSLAM VFRSIGGLLR
710 720 730 740 750
RRPAEAPRAL HEMGEGELPA TEEKLEKQSF VLKPVPRSAR HGATASAALF
760 770 780 790 800
VAFTALVPAA MAQEAPSPDQ SGVTAETPFG DSNTGVVPDA LPAIDPAVAD
810 820 830 840 850
RISDAEVTRT LTFRNLGATT GPLTLRGYSP LQGLDVVVPA NRVVTHAQLT
860 870 880 890 900
LSGALSPSLL PEANAVTVTL NEQYVGTLKV DPQHPQFGPV SFDIDPLYFT
910 920 930 940 950
GDNKLNFHFA GEYRRDCNDL FNEILWARIS DMSRITLTTV RITPERKLSR
960 970 980 990 1000
LPAPFFDPNQ RSTLRVPVVL PATGDRGALR AAGLVASWFG RIADFRKLSF
1010 1020 1030 1040 1050
PVSTTIPASG NAVEVGVNLP VDAEGGRPAG PMLAEVANPN DRWGTVLVVT
1060 1070 1080 1090 1100
GRTAQEVEVA ARALVFSPDT LGGVASKVVS DVSLETRHPY DAPAFVPTDR
1110 1120 1130 1140 1150
PVRFGELVGA ADLQGGGFAP AGMTLPFHLP PDLYTWRGRP FLMNMWVRAP
1160 1170 1180 1190 1200
GGPVVDLETS RVDVSLNNNY LQSYTLSPPG LWRKWSERLV NQHAGAVGHV
1210 1220 1230 1240 1250
TALPPWLLFG QNQLQFNFDA RPIDRGACRR TPGDIHMSVD SDSTLDFRRG
1260 1270 1280 1290 1300
YHFAEMPNLS YFAEAAFPFS RMADLSETTV VLPDHPDTGT TGAFLDLMGF
1310 1320 1330 1340 1350
FGASTWYPAA GVTVMGADEV AQTPPKGDIV VLGTAAQLGG AASGLLARSP
1360 1370 1380 1390 1400
YVIHDRHITV GQRMGLQGIW YLFQDHDHAG LKDGVTANLN APIAEAGVLL
1410 1420 1430 1440 1450
AAQSPYDSQR SVVAFTGDTP ERIHDLVLSL RNKGDLPSLQ GDLVLKNGDR
1460 1470 1480 1490 1500
FTSYRTAPVY TVGSLPLWLR LDWFLGHHPS ALYLAGLAGA GLAALGVWAW
1510
LRGWSRRRIA RDDLTGEL
Length:1,518
Mass (Da):166,465
Last modified:November 1, 1999 - v1
Checksum:i7D7634503183DAB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015804 Genomic DNA. Translation: BAA77600.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015804 Genomic DNA. Translation: BAA77600.1 .

3D structure databases

ProteinModelPortali Q9WX75.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00694 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view ]
Pfami PF03170. BcsB. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view ]
PRINTSi PR01440. CELLSNTHASEB.
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03030. CelA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of cellulose synthase genes from Acetobacter xylinum JCM 7664: implication of a novel set of cellulose synthase genes."
    Umeda Y., Hirano A., Ishibashi M., Akiyama H., Onizuka T., Ikeuchi M., Inoue Y.
    DNA Res. 6:109-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JCM 7664 / NBRC 13693.

Entry informationi

Entry nameiBCSA5_KOMXY
AccessioniPrimary (citable) accession number: Q9WX75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3