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Q9WX75

- BCSA5_KOMXY

UniProt

Q9WX75 - BCSA5_KOMXY

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Protein

Putative cellulose synthase 3

Gene
bcsABII-B
Organism
Komagataeibacter xylinus (Gluconacetobacter xylinus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861 Reviewed prediction
Sitei233 – 2331Important for substrate binding Reviewed prediction
Sitei235 – 2351Important for substrate binding Reviewed prediction
Active sitei330 – 3301 Reviewed prediction

GO - Molecular functioni

  1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
  2. cyclic-di-GMP binding Source: InterPro

GO - Biological processi

  1. cellulose biosynthetic process Source: UniProtKB-KW
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cellulose biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00694.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cellulose synthase 3
Including the following 2 domains:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Cyclic di-GMP-binding domain
Alternative name(s):
Cellulose synthase 3 regulatory subunit
Gene namesi
Name:bcsABII-B
OrganismiKomagataeibacter xylinus (Gluconacetobacter xylinus)
Taxonomic identifieri28448 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Reviewed predictionAdd
BLAST
Transmembranei71 – 9121Helical; Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Transmembranei404 – 42421Helical; Reviewed predictionAdd
BLAST
Transmembranei428 – 44821Helical; Reviewed predictionAdd
BLAST
Transmembranei465 – 48521Helical; Reviewed predictionAdd
BLAST
Transmembranei514 – 53421Helical; Reviewed predictionAdd
BLAST
Transmembranei543 – 56321Helical; Reviewed predictionAdd
BLAST
Transmembranei1481 – 150121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15181518Putative cellulose synthase 3PRO_0000059266Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9WX75.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini569 – 668100PilZAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 731731CatalyticAdd
BLAST
Regioni144 – 23794Catalytic subdomain AAdd
BLAST
Regioni314 – 37461Catalytic subdomain BAdd
BLAST
Regioni732 – 1518787Cyclic di-GMP binding By similarityAdd
BLAST

Domaini

There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 2 family.
In the C-terminal section; belongs to the AcsB/BcsB family.
Contains 1 PilZ domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view]
PfamiPF03170. BcsB. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view]
PRINTSiPR01440. CELLSNTHASEB.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03030. CelA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WX75-1 [UniParc]FASTAAdd to Basket

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MYGTWFTTGK VTDLLARTGL DRVPVWVPVV LGVVLMAFVG SVRIDPALQG     50
WVSIGTVTLL LVLNRRRGRG ITVFLMMLSL LVSLRYIVWR LTATVQFSNW 100
LQTALAVLLL LAEAYALMTL CLSYFQMAWP LRRREHPLPE DMAQWPSVDV 150
FVPSYNEELS LVRSTVLGAL DLDWPADRLN VYILDDGRRK AFHDFAVEAG 200
AGYIIRAENN HAKAGNLNHA LAVTDSPFAV IFDCDHVPTR GFLRRTIGWM 250
MADPNLALLQ TPHHFYAPDP FQRNLAGGMH VPPEGNMFYG LVQDGNDFWD 300
ATFFCGSCAI IRREAVMGIG GFATETVTED AHTALKMQRR GWGTAYLREP 350
LAAGLATERL ILHIGQRVRW ARGMIQIMRL DNPMLGAGLR WEQRLCYLSA 400
MSHFLFAIPR LTFLVSPLAF LFLGQNIIAA SPLAISVYAL PHIFHSVITL 450
SRIEGRWRYS FWSEIYETSL ALFLVRITIV TLLQPHKGKF NVTDKGGLLA 500
RGYFDWDAVY PNVILAGVLC AALLRGVFGI VWQFHDRLAL QSFILNTLWV 550
VISLIIVLAS IAVGRETRQT RNAPRVSVRL PVVVTDAHGR QMEGHTHDIS 600
LGGLAVGTRL ATPDMVGGEV TVRYDSARDG IHVGVPARVL DARDGTLRLR 650
WAVRDLEDER QVVSMVFGRN DAWAGWADFA PDRPLRSLAM VFRSIGGLLR 700
RRPAEAPRAL HEMGEGELPA TEEKLEKQSF VLKPVPRSAR HGATASAALF 750
VAFTALVPAA MAQEAPSPDQ SGVTAETPFG DSNTGVVPDA LPAIDPAVAD 800
RISDAEVTRT LTFRNLGATT GPLTLRGYSP LQGLDVVVPA NRVVTHAQLT 850
LSGALSPSLL PEANAVTVTL NEQYVGTLKV DPQHPQFGPV SFDIDPLYFT 900
GDNKLNFHFA GEYRRDCNDL FNEILWARIS DMSRITLTTV RITPERKLSR 950
LPAPFFDPNQ RSTLRVPVVL PATGDRGALR AAGLVASWFG RIADFRKLSF 1000
PVSTTIPASG NAVEVGVNLP VDAEGGRPAG PMLAEVANPN DRWGTVLVVT 1050
GRTAQEVEVA ARALVFSPDT LGGVASKVVS DVSLETRHPY DAPAFVPTDR 1100
PVRFGELVGA ADLQGGGFAP AGMTLPFHLP PDLYTWRGRP FLMNMWVRAP 1150
GGPVVDLETS RVDVSLNNNY LQSYTLSPPG LWRKWSERLV NQHAGAVGHV 1200
TALPPWLLFG QNQLQFNFDA RPIDRGACRR TPGDIHMSVD SDSTLDFRRG 1250
YHFAEMPNLS YFAEAAFPFS RMADLSETTV VLPDHPDTGT TGAFLDLMGF 1300
FGASTWYPAA GVTVMGADEV AQTPPKGDIV VLGTAAQLGG AASGLLARSP 1350
YVIHDRHITV GQRMGLQGIW YLFQDHDHAG LKDGVTANLN APIAEAGVLL 1400
AAQSPYDSQR SVVAFTGDTP ERIHDLVLSL RNKGDLPSLQ GDLVLKNGDR 1450
FTSYRTAPVY TVGSLPLWLR LDWFLGHHPS ALYLAGLAGA GLAALGVWAW 1500
LRGWSRRRIA RDDLTGEL 1518
Length:1,518
Mass (Da):166,465
Last modified:November 1, 1999 - v1
Checksum:i7D7634503183DAB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015804 Genomic DNA. Translation: BAA77600.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015804 Genomic DNA. Translation: BAA77600.1 .

3D structure databases

ProteinModelPortali Q9WX75.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00694 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view ]
Pfami PF03170. BcsB. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view ]
PRINTSi PR01440. CELLSNTHASEB.
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03030. CelA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of cellulose synthase genes from Acetobacter xylinum JCM 7664: implication of a novel set of cellulose synthase genes."
    Umeda Y., Hirano A., Ishibashi M., Akiyama H., Onizuka T., Ikeuchi M., Inoue Y.
    DNA Res. 6:109-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JCM 7664 / NBRC 13693.

Entry informationi

Entry nameiBCSA5_KOMXY
AccessioniPrimary (citable) accession number: Q9WX75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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