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Q9WX29 (SYR_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:SCO3304
ORF Names:SCE68.02
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151616

Regions

Motif127 – 13711"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q9WX29 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 6EA6F2158A7CB91D

FASTA58664,704
        10         20         30         40         50         60 
MASVTSLSDS VQQHLASALT ATRPEAAGAD PLLRRSDRAD YQANGILALA KKTKANPREL 

        70         80         90        100        110        120 
AAEVVARITT GDELIEDVEV SGPGFLNITV ADRAITANLA ARLADGERLG VPLKQDAGTT 

       130        140        150        160        170        180 
VVDYAQPNVA KEMHVGHLRS AVIGDALRSM LDFTGEKTIG RHHIGDWGTQ FGMLIQYLFE 

       190        200        210        220        230        240 
HPGELAPAGD IDGEQAMSNL NRVYKASRAV FDTDEEFKER ARRRVVALQS GDKETLDLWQ 

       250        260        270        280        290        300 
QFVDESKVYF YSVFEKLDME IRDEEIVGES AYNDGMPETA RLLEEMGVAV RSEGALVVFF 

       310        320        330        340        350        360 
DEIRGKDDQP VPLIVQKADG GFGYAASDLT AIRNRVQDLH ATTLLYVVDV RQSLHFRMVF 

       370        380        390        400        410        420 
ETARRAGWLG DEVTAHNMGY GTVLGADGKP FKTRAGETVR LEDLLDEAVQ RAAEVVREKA 

       430        440        450        460        470        480 
RDLTEDEIQE RAAQVGIGAV KYADLSTSPN RDYKFDLDQM VSLNGDTSVY LQYAYARIQS 

       490        500        510        520        530        540 
ILRKAGEVRP AAHPELALHE AERALGLHLD AFGPTVFEAA AEYAPHKLAA YLYQLASLYT 

       550        560        570        580 
TFYDKCPVLK AETPEQVENR LFLCDLTART LHRGMALLGI RTPERL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939116 Genomic DNA. Translation: CAB45338.1.
PIRT36252.
RefSeqNP_627514.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9WX29.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO3304.

Proteomic databases

PRIDEQ9WX29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB45338; CAB45338; CAB45338.
GeneID1098738.
KEGGsco:SCO3304.
PATRIC23736354. VBIStrCoe124346_3365.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OMAYVKFHDE.
OrthoDBEOG6JB13C.
PhylomeDBQ9WX29.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_STRCO
AccessionPrimary (citable) accession number: Q9WX29
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries