Q9WW19 (ARGR_THEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine repressor

Gene names

Name:	argR
Ordered Locus Names:	TM_0371

Organism

Thermotoga maritima

Taxonomic identifier

2336 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulates arginine biosynthesis genes By similarity. HAMAP MF_00173
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis. [regulation] HAMAP MF_00173
Subcellular location	Cytoplasm Probable HAMAP MF_00173.
Sequence similarities	Belongs to the ArgR family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Arginine repressor HAMAP MF_00173		PRO_0000205136

Sequences

	Sequence		Length	Mass (Da)
	Q9WW19 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: BCD5384934D490E9	FASTA	152	17,222
	10 20 30 40 50 60 MKISKKRRQE LIRKIIHEKK ISNQFQIVEE LKKYGIKAVQ PTVARDLKEI GAVKIMDESG 70 80 90 100 110 120 NYVYKLLDET PVIDPWKELK RNFKSFVESI DRAGNLIVIK TIPGTASGIA RVIDRLDIDE 130 140 150 IVGTLAGDDT IFVAVRDPES CEKIVEKLSS IL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Thermostability, oligomerization and DNA-binding properties of the regulatory protein ArgR from the hyperthermophilic bacterium Thermotoga neapolitana." Dimova D., Weigel P., Takahashi M., Marc F., Van Duyne G.D., Sakanyan V. Mol. Gen. Genet. 263:119-130(2000) [PubMed: 10732680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]	"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ132286 Genomic DNA. Translation: CAB45262.1. AE000512 Genomic DNA. Translation: AAD35458.1.
PIR	A72385.
RefSeq	NP_228182.1. NC_000853.1.
3D structure databases
ProteinModelPortal	Q9WW19.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	897330.
GenomeReviews	Gene locus TM_0371 in contig AE000512_GR.
KEGG	tma:TM0371.
NMPDR	fig|243274.1.peg.366.
PATRIC	23935623. VBITheMar51294_0376.
TIGR	TM_0371.
Phylogenomic databases
HOGENOM	HBG697909.
OMA	VENVDKM.
PhylomeDB	Q9WW19.
ProtClustDB	CLSK795113.
Enzyme and pathway databases
BioCyc	TMAR243274:TM_0371-MONOMER.
Family and domain databases
HAMAP	MF_00173. Arg_repressor. [Tree]
InterPro	IPR001669. Arg_repress. IPR020899. Arg_repress_C. IPR020900. Arg_repress_DNA-bd. IPR011991. WHTH_trsnscrt_rep_DNA-bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KO	K03402.
Pfam	PF01316. Arg_repressor. 1 hit. PF02863. Arg_repressor_C. 1 hit. [Graphical view]
PRINTS	PR01467. ARGREPRESSOR.
ProDom	PD007402. Arg_repress. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55252. Arg_repress. 1 hit.
TIGRFAMs	TIGR01529. ArgR_whole. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGR_THEMA

Accession

Primary (citable) accession number: Q9WW19

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program