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Q9WVT5

- Q9WVT5_RAT

UniProt

Q9WVT5 - Q9WVT5_RAT

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Protein
Submitted name:

Sterol 12alpha-hydroxylase P450

Gene

Cyp8b1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Heme group.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi438 – 4381Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. heme binding Source: RefGenome
  2. iron ion binding Source: InterPro
  3. sterol 12-alpha-hydroxylase activity Source: RGD

GO - Biological processi

  1. lipid metabolic process Source: RefGenome
Complete GO annotation...

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Sterol 12alpha-hydroxylase P450Imported
Gene namesi
Name:Cyp8b1Imported
Synonyms:CYP8BImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi71016. Cyp8b1.

Subcellular locationi

Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ9WVT5.

PTM databases

PhosphoSiteiQ9WVT5.

Expressioni

Gene expression databases

GenevestigatoriQ9WVT5.

Structurei

3D structure databases

ProteinModelPortaliQ9WVT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG051100.
KOiK07431.
PhylomeDBiQ9WVT5.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSiPR00465. EP450IV.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWGSVLGAL LMAVGCLCLS LLPRHRRPWE PPLDKGFVPW LGHTMAFRKN
60 70 80 90 100
MFEFLKGMRA KHGDVFTLQL GGQYFTFVMD PLSFGPIIKS TQKVLDFVTY
110 120 130 140 150
ARELVFKVFG YQSMDEDHQM LHVASTKHLM GQGLEDLNRA MLDSLSLVML
160 170 180 190 200
GPKGRSLGAR SWCEDGLFHF CYSILFKAGF LSLFGCTKDK EQDLDEADEL
210 220 230 240 250
FRKFRRFDLL FPRFVYSLLG PLEWVEVSQL QRLFHQRLSV EQNLEKDGIS
260 270 280 290 300
NWLGFMLRFL RERGMASSMQ DKFNFMMLWA SQGNTGPTCF WALLFLLKHQ
310 320 330 340 350
DAMKAVREEA TRVLGEARLE AETSFAFTLS ALKCTPVLDS VMEETLRLCA
360 370 380 390 400
TPTLLGVVQE DYVLKMASGQ EYQIRRGDKV ALFPYLSVHM DPDIHPEPTT
410 420 430 440 450
FKYNRFLNPD GTRKVDFYKS GKKIHHYNMP WGSGVSICPG RFFAPSEMKT
460 470 480 490
FVLLMVMYFD FELVDPDMPV PPIDPRRWGF GTSQPSHEVR FRYRLKPMQ
Length:499
Mass (Da):57,585
Last modified:November 1, 1999 - v1
Checksum:i1923F68539C02122
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009686 mRNA. Translation: BAA82169.1.
RefSeqiNP_112520.1. NM_031241.1.
UniGeneiRn.23013.

Genome annotation databases

GeneIDi81924.
KEGGirno:81924.
UCSCiRGD:71016. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009686 mRNA. Translation: BAA82169.1 .
RefSeqi NP_112520.1. NM_031241.1.
UniGenei Rn.23013.

3D structure databases

ProteinModelPortali Q9WVT5.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVT5.

Proteomic databases

PRIDEi Q9WVT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81924.
KEGGi rno:81924.
UCSCi RGD:71016. rat.

Organism-specific databases

CTDi 1582.
RGDi 71016. Cyp8b1.

Phylogenomic databases

HOVERGENi HBG051100.
KOi K07431.
PhylomeDBi Q9WVT5.

Miscellaneous databases

NextBioi 615825.

Gene expression databases

Genevestigatori Q9WVT5.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PIRSFi PIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSi PR00465. EP450IV.
SUPFAMi SSF48264. SSF48264. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)."
    Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M.
    J. Biochem. 126:19-25(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ9WVT5_RAT
AccessioniPrimary (citable) accession number: Q9WVT5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)