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Q9WVT5

- Q9WVT5_RAT

UniProt

Q9WVT5 - Q9WVT5_RAT

Protein
Submitted name:

Sterol 12alpha-hydroxylase P450

Gene

Cyp8b1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Cofactori

    Heme group.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi438 – 4381Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. heme binding Source: RefGenome
    2. iron ion binding Source: InterPro
    3. sterol 12-alpha-hydroxylase activity Source: RGD

    GO - Biological processi

    1. lipid metabolic process Source: RefGenome

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Sterol 12alpha-hydroxylase P450Imported
    Gene namesi
    Name:Cyp8b1Imported
    Synonyms:CYP8BImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi71016. Cyp8b1.

    Subcellular locationi

    Endoplasmic reticulum membrane UniRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9WVT5.

    PTM databases

    PhosphoSiteiQ9WVT5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVT5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG051100.
    InParanoidiQ9WVT5.
    KOiK07431.
    PhylomeDBiQ9WVT5.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR024204. Cyt_P450_CYP7A1-type.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
    PRINTSiPR00465. EP450IV.
    SUPFAMiSSF48264. SSF48264. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WVT5-1 [UniParc]FASTAAdd to Basket

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    MLWGSVLGAL LMAVGCLCLS LLPRHRRPWE PPLDKGFVPW LGHTMAFRKN    50
    MFEFLKGMRA KHGDVFTLQL GGQYFTFVMD PLSFGPIIKS TQKVLDFVTY 100
    ARELVFKVFG YQSMDEDHQM LHVASTKHLM GQGLEDLNRA MLDSLSLVML 150
    GPKGRSLGAR SWCEDGLFHF CYSILFKAGF LSLFGCTKDK EQDLDEADEL 200
    FRKFRRFDLL FPRFVYSLLG PLEWVEVSQL QRLFHQRLSV EQNLEKDGIS 250
    NWLGFMLRFL RERGMASSMQ DKFNFMMLWA SQGNTGPTCF WALLFLLKHQ 300
    DAMKAVREEA TRVLGEARLE AETSFAFTLS ALKCTPVLDS VMEETLRLCA 350
    TPTLLGVVQE DYVLKMASGQ EYQIRRGDKV ALFPYLSVHM DPDIHPEPTT 400
    FKYNRFLNPD GTRKVDFYKS GKKIHHYNMP WGSGVSICPG RFFAPSEMKT 450
    FVLLMVMYFD FELVDPDMPV PPIDPRRWGF GTSQPSHEVR FRYRLKPMQ 499
    Length:499
    Mass (Da):57,585
    Last modified:November 1, 1999 - v1
    Checksum:i1923F68539C02122
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009686 mRNA. Translation: BAA82169.1.
    RefSeqiNP_112520.1. NM_031241.1.
    UniGeneiRn.23013.

    Genome annotation databases

    GeneIDi81924.
    KEGGirno:81924.
    UCSCiRGD:71016. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009686 mRNA. Translation: BAA82169.1 .
    RefSeqi NP_112520.1. NM_031241.1.
    UniGenei Rn.23013.

    3D structure databases

    ProteinModelPortali Q9WVT5.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WVT5.

    Proteomic databases

    PRIDEi Q9WVT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81924.
    KEGGi rno:81924.
    UCSCi RGD:71016. rat.

    Organism-specific databases

    CTDi 1582.
    RGDi 71016. Cyp8b1.

    Phylogenomic databases

    HOVERGENi HBG051100.
    InParanoidi Q9WVT5.
    KOi K07431.
    PhylomeDBi Q9WVT5.

    Miscellaneous databases

    NextBioi 615825.

    Gene expression databases

    Genevestigatori Q9WVT5.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR024204. Cyt_P450_CYP7A1-type.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
    PRINTSi PR00465. EP450IV.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)."
      Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M.
      J. Biochem. 126:19-25(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ9WVT5_RAT
    AccessioniPrimary (citable) accession number: Q9WVT5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)