Q9WVT5 (Q9WVT5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sterol 12alpha-hydroxylase P450 EMBL BAA82169.1

Gene names

Name:	Cyp8b1 RGD 71016
Synonyms:	CYP8B EMBL BAA82169.1

Organism

Rattus norvegicus (Rat) EMBL BAA82169.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor

Heme group By similarity. PIRSR PIRSR000047-1

Ontologies

Keywords
Ligand	Heme PIRSR PIRSR000047-1 SAAS SAAS002403 Iron Metal-binding
Gene Ontology (GO)
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro sterol 12-alpha-hydroxylase activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	438	1	Iron (heme axial ligand) By similarity PIRSR PIRSR000047-1

Sequences

	Sequence		Length	Mass (Da)
	Q9WVT5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 1923F68539C02122	FASTA	499	57,585
	10 20 30 40 50 60 MLWGSVLGAL LMAVGCLCLS LLPRHRRPWE PPLDKGFVPW LGHTMAFRKN MFEFLKGMRA 70 80 90 100 110 120 KHGDVFTLQL GGQYFTFVMD PLSFGPIIKS TQKVLDFVTY ARELVFKVFG YQSMDEDHQM 130 140 150 160 170 180 LHVASTKHLM GQGLEDLNRA MLDSLSLVML GPKGRSLGAR SWCEDGLFHF CYSILFKAGF 190 200 210 220 230 240 LSLFGCTKDK EQDLDEADEL FRKFRRFDLL FPRFVYSLLG PLEWVEVSQL QRLFHQRLSV 250 260 270 280 290 300 EQNLEKDGIS NWLGFMLRFL RERGMASSMQ DKFNFMMLWA SQGNTGPTCF WALLFLLKHQ 310 320 330 340 350 360 DAMKAVREEA TRVLGEARLE AETSFAFTLS ALKCTPVLDS VMEETLRLCA TPTLLGVVQE 370 380 390 400 410 420 DYVLKMASGQ EYQIRRGDKV ALFPYLSVHM DPDIHPEPTT FKYNRFLNPD GTRKVDFYKS 430 440 450 460 470 480 GKKIHHYNMP WGSGVSICPG RFFAPSEMKT FVLLMVMYFD FELVDPDMPV PPIDPRRWGF 490 GTSQPSHEVR FRYRLKPMQ

References

[1]	"Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)." Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M. J. Biochem. 126:19-25(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL BAA82169.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009686 mRNA. Translation: BAA82169.1.
IPI	IPI00393189.
RefSeq	NP_112520.1. NM_031241.1.
UniGene	Rn.23013.
3D structure databases
ProteinModelPortal	Q9WVT5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WVT5.
PTM databases
PhosphoSite	Q9WVT5.
Proteomic databases
PRIDE	Q9WVT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	81924.
KEGG	rno:81924.
UCSC	RGD:71016. rat.
Organism-specific databases
CTD	1582.
RGD	71016. Cyp8b1.
Phylogenomic databases
HOVERGEN	HBG051100.
InParanoid	Q9WVT5.
KO	K07431.
Gene expression databases
ArrayExpress	Q9WVT5.
Genevestigator	Q9WVT5.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR024204. Cyt_P450_CYP7A1-type. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PIRSF	PIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTS	PR00465. EP450IV.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
ProtoNet	Search...
Other
NextBio	615825.

Entry information

Entry name

Q9WVT5_RAT

Accession

Primary (citable) accession number: Q9WVT5

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)