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Protein
Submitted name:

Sterol 12alpha-hydroxylase P450

Gene

Cyp8b1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

hemeUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi438 – 4381Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. heme binding Source: GO_Central
  2. iron ion binding Source: InterPro
  3. sterol 12-alpha-hydroxylase activity Source: RGD

GO - Biological processi

  1. lipid metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Sterol 12alpha-hydroxylase P450Imported
Gene namesi
Name:Cyp8b1Imported
Synonyms:CYP8BImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi71016. Cyp8b1.

Subcellular locationi

Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ9WVT5.

PTM databases

PhosphoSiteiQ9WVT5.

Expressioni

Gene expression databases

GenevestigatoriQ9WVT5.

Structurei

3D structure databases

ProteinModelPortaliQ9WVT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG051100.
KOiK07431.
PhylomeDBiQ9WVT5.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSiPR00465. EP450IV.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWGSVLGAL LMAVGCLCLS LLPRHRRPWE PPLDKGFVPW LGHTMAFRKN
60 70 80 90 100
MFEFLKGMRA KHGDVFTLQL GGQYFTFVMD PLSFGPIIKS TQKVLDFVTY
110 120 130 140 150
ARELVFKVFG YQSMDEDHQM LHVASTKHLM GQGLEDLNRA MLDSLSLVML
160 170 180 190 200
GPKGRSLGAR SWCEDGLFHF CYSILFKAGF LSLFGCTKDK EQDLDEADEL
210 220 230 240 250
FRKFRRFDLL FPRFVYSLLG PLEWVEVSQL QRLFHQRLSV EQNLEKDGIS
260 270 280 290 300
NWLGFMLRFL RERGMASSMQ DKFNFMMLWA SQGNTGPTCF WALLFLLKHQ
310 320 330 340 350
DAMKAVREEA TRVLGEARLE AETSFAFTLS ALKCTPVLDS VMEETLRLCA
360 370 380 390 400
TPTLLGVVQE DYVLKMASGQ EYQIRRGDKV ALFPYLSVHM DPDIHPEPTT
410 420 430 440 450
FKYNRFLNPD GTRKVDFYKS GKKIHHYNMP WGSGVSICPG RFFAPSEMKT
460 470 480 490
FVLLMVMYFD FELVDPDMPV PPIDPRRWGF GTSQPSHEVR FRYRLKPMQ
Length:499
Mass (Da):57,585
Last modified:November 1, 1999 - v1
Checksum:i1923F68539C02122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009686 mRNA. Translation: BAA82169.1.
RefSeqiNP_112520.1. NM_031241.1.
UniGeneiRn.23013.

Genome annotation databases

GeneIDi81924.
KEGGirno:81924.
UCSCiRGD:71016. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009686 mRNA. Translation: BAA82169.1.
RefSeqiNP_112520.1. NM_031241.1.
UniGeneiRn.23013.

3D structure databases

ProteinModelPortaliQ9WVT5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9WVT5.

Proteomic databases

PRIDEiQ9WVT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81924.
KEGGirno:81924.
UCSCiRGD:71016. rat.

Organism-specific databases

CTDi1582.
RGDi71016. Cyp8b1.

Phylogenomic databases

HOVERGENiHBG051100.
KOiK07431.
PhylomeDBiQ9WVT5.

Miscellaneous databases

NextBioi615825.

Gene expression databases

GenevestigatoriQ9WVT5.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSiPR00465. EP450IV.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)."
    Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M.
    J. Biochem. 126:19-25(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ9WVT5_RAT
AccessioniPrimary (citable) accession number: Q9WVT5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.