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Q9WVS0

- ICOS_MOUSE

UniProt

Q9WVS0 - ICOS_MOUSE

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Protein

Inducible T-cell costimulator

Gene

Icos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes By similarity.By similarity

GO - Biological processi

  1. single organismal cell-cell adhesion Source: Ensembl
  2. T cell costimulation Source: Ensembl
  3. T cell tolerance induction Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_225477. Costimulation by the CD28 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible T-cell costimulator
Alternative name(s):
Activation-inducible lymphocyte immunomediatory molecule
CD28 and CTLA-4-like protein
Short name:
CCLP
CD28-related protein 1
Short name:
CRP-1
CD_antigen: CD278
Gene namesi
Name:Icos
Synonyms:Ailim
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1858745. Icos.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 200180Inducible T-cell costimulatorPRO_0000014807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi42 ↔ 109By similarity
Disulfide bondi63 ↔ 83By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WVS0.

PTM databases

PhosphoSiteiQ9WVS0.

Expressioni

Tissue specificityi

Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen.3 Publications

Gene expression databases

BgeeiQ9WVS0.
CleanExiMM_ICOS.
ExpressionAtlasiQ9WVS0. baseline and differential.
GenevestigatoriQ9WVS0.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9WVS0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 144124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini166 – 20035CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG69972.
GeneTreeiENSGT00390000000801.
HOGENOMiHOG000112996.
HOVERGENiHBG052079.
InParanoidiQ9WVS0.
KOiK06713.
OrthoDBiEOG7JMGFN.
TreeFamiTF335679.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPYFCRVFV FCFLIRLLTG EINGSADHRM FSFHNGGVQI SCKYPETVQQ
60 70 80 90 100
LKMRLFRERE VLCELTKTKG SGNAVSIKNP MLCLYHLSNN SVSFFLNNPD
110 120 130 140 150
SSQGSYYFCS LSIFDPPPFQ ERNLSGGYLH IYESQLCCQL KLWLPVGCAA
160 170 180 190 200
FVVVLLFGCI LIIWFSKKKY GSSVHDPNSE YMFMAAVNTN KKSRLAGVTS
Length:200
Mass (Da):22,709
Last modified:July 19, 2004 - v2
Checksum:i87D97F0DC44ADCA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71R → H(PubMed:11006126)Curated
Sequence conflicti7 – 71R → H(PubMed:10760791)Curated
Sequence conflicti7 – 71R → H1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216748 mRNA. Translation: AAF45150.1.
AB023132 mRNA. Translation: BAA82126.1.
AJ250559 mRNA. Translation: CAB71153.1.
AF327185, AF327184 Genomic DNA. Translation: AAG48732.1.
AF257230 mRNA. Translation: AAF70099.1.
BC034852 mRNA. Translation: AAH34852.1.
CCDSiCCDS14994.1.
RefSeqiNP_059508.2. NM_017480.2.
XP_006496201.1. XM_006496138.1.
XP_006496202.1. XM_006496139.1.
XP_006536968.1. XM_006536905.1.
XP_006536969.1. XM_006536906.1.
UniGeneiMm.42044.

Genome annotation databases

EnsembliENSMUST00000102827; ENSMUSP00000099891; ENSMUSG00000026009.
GeneIDi54167.
KEGGimmu:54167.
UCSCiuc011wlz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216748 mRNA. Translation: AAF45150.1 .
AB023132 mRNA. Translation: BAA82126.1 .
AJ250559 mRNA. Translation: CAB71153.1 .
AF327185 , AF327184 Genomic DNA. Translation: AAG48732.1 .
AF257230 mRNA. Translation: AAF70099.1 .
BC034852 mRNA. Translation: AAH34852.1 .
CCDSi CCDS14994.1.
RefSeqi NP_059508.2. NM_017480.2.
XP_006496201.1. XM_006496138.1.
XP_006496202.1. XM_006496139.1.
XP_006536968.1. XM_006536905.1.
XP_006536969.1. XM_006536906.1.
UniGenei Mm.42044.

3D structure databases

ProteinModelPortali Q9WVS0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVS0.

Proteomic databases

PRIDEi Q9WVS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102827 ; ENSMUSP00000099891 ; ENSMUSG00000026009 .
GeneIDi 54167.
KEGGi mmu:54167.
UCSCi uc011wlz.2. mouse.

Organism-specific databases

CTDi 29851.
MGIi MGI:1858745. Icos.

Phylogenomic databases

eggNOGi NOG69972.
GeneTreei ENSGT00390000000801.
HOGENOMi HOG000112996.
HOVERGENi HBG052079.
InParanoidi Q9WVS0.
KOi K06713.
OrthoDBi EOG7JMGFN.
TreeFami TF335679.

Enzyme and pathway databases

Reactomei REACT_225477. Costimulation by the CD28 family.

Miscellaneous databases

NextBioi 311010.
PROi Q9WVS0.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVS0.
CleanExi MM_ICOS.
ExpressionAtlasi Q9WVS0. baseline and differential.
Genevestigatori Q9WVS0.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Intestinal epithelium.
  2. "Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family."
    Tezuka K., Tsuji T., Hirano D., Tamatani T., Sakamaki K., Kobayashi Y., Kamada M.
    Biochem. Biophys. Res. Commun. 276:335-345(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
    Tissue: Spleen.
  3. "Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand."
    Mages H.W., Hutloff A., Heuck C., Buechner K., Himmelbauer H., Oliveri F., Kroczek R.A.
    Eur. J. Immunol. 30:1040-1047(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Spleen.
  4. "The inducible costimulatory (ICOS) molecule is critical for CD40-mediated antibody class switching."
    McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., Sharpe A.H.
    Nature 409:102-105(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION.
    Strain: 129/Ola.
  5. "CCLP, A novel molecule that regulates T cell activation."
    Wu D., Giannoni M.A., Kiesecker C.L., Faas S.J., Mickle A.P., Matis L.A., Rother R.P.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
    Tissue: Spleen.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  7. Cited for: FUNCTION.

Entry informationi

Entry nameiICOS_MOUSE
AccessioniPrimary (citable) accession number: Q9WVS0
Secondary accession number(s): Q9JL17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3