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Q9WVS0

- ICOS_MOUSE

UniProt

Q9WVS0 - ICOS_MOUSE

Protein

Inducible T-cell costimulator

Gene

Icos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. single organismal cell-cell adhesion Source: Ensembl
    2. T cell costimulation Source: Ensembl
    3. T cell tolerance induction Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_225477. Costimulation by the CD28 family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inducible T-cell costimulator
    Alternative name(s):
    Activation-inducible lymphocyte immunomediatory molecule
    CD28 and CTLA-4-like protein
    Short name:
    CCLP
    CD28-related protein 1
    Short name:
    CRP-1
    CD_antigen: CD278
    Gene namesi
    Name:Icos
    Synonyms:Ailim
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1858745. Icos.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 200180Inducible T-cell costimulatorPRO_0000014807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi42 ↔ 109By similarity
    Disulfide bondi63 ↔ 83By similarity
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WVS0.

    PTM databases

    PhosphoSiteiQ9WVS0.

    Expressioni

    Tissue specificityi

    Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen.3 Publications

    Gene expression databases

    ArrayExpressiQ9WVS0.
    BgeeiQ9WVS0.
    CleanExiMM_ICOS.
    GenevestigatoriQ9WVS0.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 144124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20035CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 133104Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG69972.
    GeneTreeiENSGT00390000000801.
    HOGENOMiHOG000112996.
    HOVERGENiHBG052079.
    KOiK06713.
    OrthoDBiEOG7JMGFN.
    TreeFamiTF335679.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVS0-1 [UniParc]FASTAAdd to Basket

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    MKPYFCRVFV FCFLIRLLTG EINGSADHRM FSFHNGGVQI SCKYPETVQQ    50
    LKMRLFRERE VLCELTKTKG SGNAVSIKNP MLCLYHLSNN SVSFFLNNPD 100
    SSQGSYYFCS LSIFDPPPFQ ERNLSGGYLH IYESQLCCQL KLWLPVGCAA 150
    FVVVLLFGCI LIIWFSKKKY GSSVHDPNSE YMFMAAVNTN KKSRLAGVTS 200
    Length:200
    Mass (Da):22,709
    Last modified:July 19, 2004 - v2
    Checksum:i87D97F0DC44ADCA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71R → H(PubMed:11006126)Curated
    Sequence conflicti7 – 71R → H(PubMed:10760791)Curated
    Sequence conflicti7 – 71R → H1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216748 mRNA. Translation: AAF45150.1.
    AB023132 mRNA. Translation: BAA82126.1.
    AJ250559 mRNA. Translation: CAB71153.1.
    AF327185, AF327184 Genomic DNA. Translation: AAG48732.1.
    AF257230 mRNA. Translation: AAF70099.1.
    BC034852 mRNA. Translation: AAH34852.1.
    CCDSiCCDS14994.1.
    RefSeqiNP_059508.2. NM_017480.2.
    XP_006496201.1. XM_006496138.1.
    XP_006496202.1. XM_006496139.1.
    XP_006536968.1. XM_006536905.1.
    XP_006536969.1. XM_006536906.1.
    UniGeneiMm.42044.

    Genome annotation databases

    EnsembliENSMUST00000102827; ENSMUSP00000099891; ENSMUSG00000026009.
    GeneIDi54167.
    KEGGimmu:54167.
    UCSCiuc011wlz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216748 mRNA. Translation: AAF45150.1 .
    AB023132 mRNA. Translation: BAA82126.1 .
    AJ250559 mRNA. Translation: CAB71153.1 .
    AF327185 , AF327184 Genomic DNA. Translation: AAG48732.1 .
    AF257230 mRNA. Translation: AAF70099.1 .
    BC034852 mRNA. Translation: AAH34852.1 .
    CCDSi CCDS14994.1.
    RefSeqi NP_059508.2. NM_017480.2.
    XP_006496201.1. XM_006496138.1.
    XP_006496202.1. XM_006496139.1.
    XP_006536968.1. XM_006536905.1.
    XP_006536969.1. XM_006536906.1.
    UniGenei Mm.42044.

    3D structure databases

    ProteinModelPortali Q9WVS0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WVS0.

    Proteomic databases

    PRIDEi Q9WVS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102827 ; ENSMUSP00000099891 ; ENSMUSG00000026009 .
    GeneIDi 54167.
    KEGGi mmu:54167.
    UCSCi uc011wlz.2. mouse.

    Organism-specific databases

    CTDi 29851.
    MGIi MGI:1858745. Icos.

    Phylogenomic databases

    eggNOGi NOG69972.
    GeneTreei ENSGT00390000000801.
    HOGENOMi HOG000112996.
    HOVERGENi HBG052079.
    KOi K06713.
    OrthoDBi EOG7JMGFN.
    TreeFami TF335679.

    Enzyme and pathway databases

    Reactomei REACT_225477. Costimulation by the CD28 family.

    Miscellaneous databases

    NextBioi 311010.
    PROi Q9WVS0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WVS0.
    Bgeei Q9WVS0.
    CleanExi MM_ICOS.
    Genevestigatori Q9WVS0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Intestinal epithelium.
    2. "Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family."
      Tezuka K., Tsuji T., Hirano D., Tamatani T., Sakamaki K., Kobayashi Y., Kamada M.
      Biochem. Biophys. Res. Commun. 276:335-345(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
      Tissue: Spleen.
    3. "Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand."
      Mages H.W., Hutloff A., Heuck C., Buechner K., Himmelbauer H., Oliveri F., Kroczek R.A.
      Eur. J. Immunol. 30:1040-1047(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Spleen.
    4. "The inducible costimulatory (ICOS) molecule is critical for CD40-mediated antibody class switching."
      McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., Sharpe A.H.
      Nature 409:102-105(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, FUNCTION.
      Strain: 129/Ola.
    5. "CCLP, A novel molecule that regulates T cell activation."
      Wu D., Giannoni M.A., Kiesecker C.L., Faas S.J., Mickle A.P., Matis L.A., Rother R.P.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
      Tissue: Spleen.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    7. Cited for: FUNCTION.

    Entry informationi

    Entry nameiICOS_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVS0
    Secondary accession number(s): Q9JL17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3