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Protein

Menin

Gene

Men1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • cellular response to DNA damage stimulus Source: Ensembl
  • cellular response to glucose stimulus Source: RGD
  • cellular response to peptide hormone stimulus Source: RGD
  • decidualization Source: RGD
  • histone lysine methylation Source: GO_Central
  • MAPK cascade Source: Ensembl
  • mitotic cell cycle Source: RGD
  • negative regulation of cell cycle G1/S phase transition Source: RGD
  • negative regulation of cell-substrate adhesion Source: RGD
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  • negative regulation of epithelial cell proliferation Source: RGD
  • negative regulation of JNK cascade Source: Ensembl
  • negative regulation of osteoblast differentiation Source: Ensembl
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  • negative regulation of telomerase activity Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • osteoblast development Source: Ensembl
  • positive regulation of protein binding Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  • regulation of activin receptor signaling pathway Source: RGD
  • regulation of type B pancreatic cell proliferation Source: RGD
  • response to gamma radiation Source: Ensembl
  • response to transforming growth factor beta Source: RGD
  • response to UV Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
  • type B pancreatic cell differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-201722. Formation of the beta-catenin:TCF transactivating complex.
R-RNO-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.
R-RNO-5626467. RHO GTPases activate IQGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Menin
Gene namesi
Name:Men1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3078. Men1.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: GO_Central
  • cleavage furrow Source: Ensembl
  • cytosol Source: Ensembl
  • histone methyltransferase complex Source: GO_Central
  • nuclear matrix Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610MeninPRO_0000408473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei487 – 4871PhosphoserineBy similarity
Modified residuei543 – 5431PhosphoserineCombined sources
Modified residuei594 – 5941PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WVR8.

PTM databases

iPTMnetiQ9WVR8.
PhosphoSiteiQ9WVR8.

Expressioni

Tissue specificityi

Widely expressed, including in the pituitary, brain, large intestine, spleen, kidney, adrenal gland, ovary, testis, thymus, lung, epididymis, bone marrow, pancreatic islets and placenta.2 Publications

Developmental stagei

In the brain, highest expression at E16 to 18. Expression decreases from E20 onward.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSRNOG00000021054.
GenevisibleiQ9WVR8. RN.

Interactioni

Subunit structurei

Component of the MLL-HCF complex, at least composed of KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 (By similarity). Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 (By similarity). Interacts with POLR2B (By similarity). Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms (By similarity). Interacts with FANCD2 and DBF4 (By similarity). Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA (By similarity). Interacts with JUND (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028592.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 390177Interaction with FANCD2By similarityAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IF2R. Eukaryota.
ENOG410ZNZF. LUCA.
GeneTreeiENSGT00390000014237.
HOGENOMiHOG000007225.
HOVERGENiHBG000208.
InParanoidiQ9WVR8.
KOiK14970.
OMAiCNRNMEV.
OrthoDBiEOG091G066V.
PhylomeDBiQ9WVR8.

Family and domain databases

CDDicd14456. Menin. 1 hit.
InterProiIPR007747. Menin.
[Graphical view]
PANTHERiPTHR12693. PTHR12693. 1 hit.
PfamiPF05053. Menin. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9WVR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV
60 70 80 90 100
NRVIPTNVPE LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA
110 120 130 140 150
VDLSLYPREG GVSSRELVKK VSDVIWNSLS RSYFKDRAHI QSLFSFITGT
160 170 180 190 200
KLDSSGVAFA VVGACQALGL RDVHLALSED HAWVVFGSNG EQTAEVTWHG
210 220 230 240 250
KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV CAINPSIDLH
260 270 280 290 300
TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT
310 320 330 340 350
LYHKGIASAK TYYQDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD
360 370 380 390 400
YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQAQGTQGQ
410 420 430 440 450
GSALQDPECF AHLLRFYDGI CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ
460 470 480 490 500
VRQKVHIVSR EAEAAEAEEP WGDEAREGRR RGPRRESKPE EPPPPKKPAL
510 520 530 540 550
DKGPGSGQSA GSGPPRKTSG TVSGTARGTE VSSAAQAPAP AASPPPEGPV
560 570 580 590 600
LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL
610
SFLKRQRKGL
Length:610
Mass (Da):67,335
Last modified:November 1, 1999 - v1
Checksum:iF9D2078B02363E32
GO
Isoform 2 (identifier: Q9WVR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-450: Missing.

Note: Gene prediction based on similarity to mouse ortholog.
Show »
Length:555
Mass (Da):61,288
Checksum:i54D03E6545FBFB2B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei396 – 45055Missing in isoform 2. CuratedVSP_041103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023400 mRNA. Translation: BAA82134.1.
AF130369 mRNA. Translation: AAF01353.1.
AF130370 mRNA. Translation: AAF01354.1.
CH473953 Genomic DNA. Translation: EDM12593.1.
CH473953 Genomic DNA. Translation: EDM12594.1.
CH473953 Genomic DNA. Translation: EDM12595.1.
RefSeqiNP_062081.1. NM_019208.3. [Q9WVR8-1]
XP_006230832.1. XM_006230770.2. [Q9WVR8-1]
XP_006230833.1. XM_006230771.2. [Q9WVR8-1]
XP_006230834.1. XM_006230772.2. [Q9WVR8-1]
UniGeneiRn.6775.

Genome annotation databases

EnsembliENSRNOT00000028592; ENSRNOP00000028592; ENSRNOG00000021054. [Q9WVR8-1]
GeneIDi29417.
KEGGirno:29417.
UCSCiRGD:3078. rat. [Q9WVR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023400 mRNA. Translation: BAA82134.1.
AF130369 mRNA. Translation: AAF01353.1.
AF130370 mRNA. Translation: AAF01354.1.
CH473953 Genomic DNA. Translation: EDM12593.1.
CH473953 Genomic DNA. Translation: EDM12594.1.
CH473953 Genomic DNA. Translation: EDM12595.1.
RefSeqiNP_062081.1. NM_019208.3. [Q9WVR8-1]
XP_006230832.1. XM_006230770.2. [Q9WVR8-1]
XP_006230833.1. XM_006230771.2. [Q9WVR8-1]
XP_006230834.1. XM_006230772.2. [Q9WVR8-1]
UniGeneiRn.6775.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028592.

PTM databases

iPTMnetiQ9WVR8.
PhosphoSiteiQ9WVR8.

Proteomic databases

PaxDbiQ9WVR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028592; ENSRNOP00000028592; ENSRNOG00000021054. [Q9WVR8-1]
GeneIDi29417.
KEGGirno:29417.
UCSCiRGD:3078. rat. [Q9WVR8-1]

Organism-specific databases

CTDi4221.
RGDi3078. Men1.

Phylogenomic databases

eggNOGiENOG410IF2R. Eukaryota.
ENOG410ZNZF. LUCA.
GeneTreeiENSGT00390000014237.
HOGENOMiHOG000007225.
HOVERGENiHBG000208.
InParanoidiQ9WVR8.
KOiK14970.
OMAiCNRNMEV.
OrthoDBiEOG091G066V.
PhylomeDBiQ9WVR8.

Enzyme and pathway databases

ReactomeiR-RNO-201722. Formation of the beta-catenin:TCF transactivating complex.
R-RNO-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-RNO-3769402. Deactivation of the beta-catenin transactivating complex.
R-RNO-5626467. RHO GTPases activate IQGAPs.

Miscellaneous databases

PROiQ9WVR8.

Gene expression databases

BgeeiENSRNOG00000021054.
GenevisibleiQ9WVR8. RN.

Family and domain databases

CDDicd14456. Menin. 1 hit.
InterProiIPR007747. Menin.
[Graphical view]
PANTHERiPTHR12693. PTHR12693. 1 hit.
PfamiPF05053. Menin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEN1_RAT
AccessioniPrimary (citable) accession number: Q9WVR8
Secondary accession number(s): D3ZCA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.