Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WVR7

- PPM1F_RAT

UniProt

Q9WVR7 - PPM1F_RAT

Protein

Protein phosphatase 1F

Gene

Ppm1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi194 – 1941Manganese 1By similarity
    Metal bindingi194 – 1941Manganese 2By similarity
    Metal bindingi195 – 1951Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi356 – 3561Manganese 2By similarity
    Metal bindingi400 – 4001Manganese 2By similarity

    GO - Molecular functioni

    1. calmodulin-dependent protein phosphatase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoprotein phosphatase activity Source: RGD
    4. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to drug Source: UniProtKB
    2. histone dephosphorylation Source: RGD
    3. intrinsic apoptotic signaling pathway Source: UniProtKB
    4. negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
    5. negative regulation of protein kinase activity Source: UniProtKB
    6. negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. peptidyl-threonine dephosphorylation Source: UniProtKB
    9. positive regulation of cell-substrate adhesion Source: UniProtKB
    10. positive regulation of chemotaxis Source: UniProtKB
    11. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    12. positive regulation of epithelial cell migration Source: UniProtKB
    13. positive regulation of focal adhesion assembly Source: UniProtKB
    14. positive regulation of gene expression Source: UniProtKB
    15. positive regulation of growth Source: UniProtKB
    16. positive regulation of stress fiber assembly Source: Ensembl
    17. protein dephosphorylation Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1F (EC:3.1.3.16)
    Alternative name(s):
    Ca(2+)/calmodulin-dependent protein kinase phosphatase
    Short name:
    CaM-kinase phosphatase
    Short name:
    CaMKPase
    Partner of PIX 2
    Gene namesi
    Name:Ppm1f
    Synonyms:Popx2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi631363. Ppm1f.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. perinuclear region of cytoplasm Source: UniProtKB
    3. protein complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Protein phosphatase 1FPRO_0000057760Add
    BLAST

    Proteomic databases

    PaxDbiQ9WVR7.
    PRIDEiQ9WVR7.

    PTM databases

    PhosphoSiteiQ9WVR7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVR7.

    Interactioni

    Subunit structurei

    Associates with FEM1B.By similarity

    Protein-protein interaction databases

    BioGridi252383. 1 interaction.
    IntActiQ9WVR7. 1 interaction.
    MINTiMINT-4621280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVR7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi99 – 10911Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000232094.
    HOVERGENiHBG053656.
    InParanoidiQ9WVR7.
    KOiK17502.
    OMAiGDVFQKP.
    OrthoDBiEOG7D2FDH.
    PhylomeDBiQ9WVR7.
    TreeFamiTF317617.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGAPQNSS QMACDGEIPG FLDTLLQDFP APLSLESPLP WKVPGTVLGQ    50
    EEVEAELTEL AMGFLGSRNA PPAVAAAVTH EAISQLLQTD LSEFKRLPEQ 100
    EEEEEEEEER VLTTLLDAKG LSRSFFNCLW EVCSQWQKRV PLTAQAPQRK 150
    WLVSIHAIRN TRRKMEDRHV SLPAFNHLFG LSDSVHRAYF AVFDGHGGVD 200
    AARYASVHVH TNASHQPELL TDPAAALKEA FRHTDQMFLQ KAKRERLQSG 250
    TTGVCALITG AALHVAWLGD SQVILVQQGQ VVKLMEPHKP ERQDEKSRIE 300
    ALGGFVSLMD CWRVNGTLAV SRAIGDVFQK PYVSGEADAA SRELTGLEDY 350
    LLLACDGFFD VVPHHEIPGL VHGHLLRQKG SGMHVAEELV AVARDRGSHD 400
    NITVMVVFLR DPLELLEGGG QGAGGAQADV GSQDLSTGLS ELEINTSQRS 450
    Length:450
    Mass (Da):49,165
    Last modified:November 1, 1999 - v1
    Checksum:i67626542F32B2FD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023634 mRNA. Translation: BAA82477.1.
    RefSeqiNP_786931.1. NM_175755.2.
    XP_006248736.1. XM_006248674.1.
    XP_006248737.1. XM_006248675.1.
    UniGeneiRn.91922.

    Genome annotation databases

    EnsembliENSRNOT00000002530; ENSRNOP00000002530; ENSRNOG00000037909.
    GeneIDi287931.
    KEGGirno:287931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023634 mRNA. Translation: BAA82477.1 .
    RefSeqi NP_786931.1. NM_175755.2.
    XP_006248736.1. XM_006248674.1.
    XP_006248737.1. XM_006248675.1.
    UniGenei Rn.91922.

    3D structure databases

    ProteinModelPortali Q9WVR7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 252383. 1 interaction.
    IntActi Q9WVR7. 1 interaction.
    MINTi MINT-4621280.

    PTM databases

    PhosphoSitei Q9WVR7.

    Proteomic databases

    PaxDbi Q9WVR7.
    PRIDEi Q9WVR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002530 ; ENSRNOP00000002530 ; ENSRNOG00000037909 .
    GeneIDi 287931.
    KEGGi rno:287931.

    Organism-specific databases

    CTDi 9647.
    RGDi 631363. Ppm1f.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000232094.
    HOVERGENi HBG053656.
    InParanoidi Q9WVR7.
    KOi K17502.
    OMAi GDVFQKP.
    OrthoDBi EOG7D2FDH.
    PhylomeDBi Q9WVR7.
    TreeFami TF317617.

    Miscellaneous databases

    NextBioi 627246.
    PROi Q9WVR7.

    Gene expression databases

    Genevestigatori Q9WVR7.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of Ca2+/Calmodulin-dependent protein kinase phosphatase."
      Kitani T., Ishida A., Okuno S., Takeuchi M., Kameshita I., Fujisawa H.
      J. Biochem. 125:1022-1028(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPPM1F_RAT
    AccessioniPrimary (citable) accession number: Q9WVR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3