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Q9WVR7

- PPM1F_RAT

UniProt

Q9WVR7 - PPM1F_RAT

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Protein

Protein phosphatase 1F

Gene
Ppm1f, Popx2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi194 – 1941Manganese 1 By similarity
Metal bindingi194 – 1941Manganese 2 By similarity
Metal bindingi195 – 1951Manganese 1; via carbonyl oxygen By similarity
Metal bindingi356 – 3561Manganese 2 By similarity
Metal bindingi400 – 4001Manganese 2 By similarity

GO - Molecular functioni

  1. calmodulin-dependent protein phosphatase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoprotein phosphatase activity Source: RGD
  4. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cellular response to drug Source: UniProtKB
  2. histone dephosphorylation Source: RGD
  3. intrinsic apoptotic signaling pathway Source: UniProtKB
  4. negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
  5. negative regulation of protein kinase activity Source: UniProtKB
  6. negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. peptidyl-threonine dephosphorylation Source: UniProtKB
  9. positive regulation of cell-substrate adhesion Source: UniProtKB
  10. positive regulation of chemotaxis Source: UniProtKB
  11. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  12. positive regulation of epithelial cell migration Source: UniProtKB
  13. positive regulation of focal adhesion assembly Source: UniProtKB
  14. positive regulation of gene expression Source: UniProtKB
  15. positive regulation of growth Source: UniProtKB
  16. positive regulation of stress fiber assembly Source: Ensembl
  17. protein dephosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1F (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase
Short name:
CaM-kinase phosphatase
Short name:
CaMKPase
Partner of PIX 2
Gene namesi
Name:Ppm1f
Synonyms:Popx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi631363. Ppm1f.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. perinuclear region of cytoplasm Source: UniProtKB
  3. protein complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Protein phosphatase 1FPRO_0000057760Add
BLAST

Proteomic databases

PaxDbiQ9WVR7.
PRIDEiQ9WVR7.

PTM databases

PhosphoSiteiQ9WVR7.

Expressioni

Gene expression databases

GenevestigatoriQ9WVR7.

Interactioni

Subunit structurei

Associates with FEM1B By similarity.

Protein-protein interaction databases

BioGridi252383. 1 interaction.
IntActiQ9WVR7. 1 interaction.
MINTiMINT-4621280.

Structurei

3D structure databases

ProteinModelPortaliQ9WVR7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 10911Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000232094.
HOVERGENiHBG053656.
InParanoidiQ9WVR7.
KOiK17502.
OMAiGDVFQKP.
OrthoDBiEOG7D2FDH.
PhylomeDBiQ9WVR7.
TreeFamiTF317617.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVR7-1 [UniParc]FASTAAdd to Basket

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MASGAPQNSS QMACDGEIPG FLDTLLQDFP APLSLESPLP WKVPGTVLGQ    50
EEVEAELTEL AMGFLGSRNA PPAVAAAVTH EAISQLLQTD LSEFKRLPEQ 100
EEEEEEEEER VLTTLLDAKG LSRSFFNCLW EVCSQWQKRV PLTAQAPQRK 150
WLVSIHAIRN TRRKMEDRHV SLPAFNHLFG LSDSVHRAYF AVFDGHGGVD 200
AARYASVHVH TNASHQPELL TDPAAALKEA FRHTDQMFLQ KAKRERLQSG 250
TTGVCALITG AALHVAWLGD SQVILVQQGQ VVKLMEPHKP ERQDEKSRIE 300
ALGGFVSLMD CWRVNGTLAV SRAIGDVFQK PYVSGEADAA SRELTGLEDY 350
LLLACDGFFD VVPHHEIPGL VHGHLLRQKG SGMHVAEELV AVARDRGSHD 400
NITVMVVFLR DPLELLEGGG QGAGGAQADV GSQDLSTGLS ELEINTSQRS 450
Length:450
Mass (Da):49,165
Last modified:November 1, 1999 - v1
Checksum:i67626542F32B2FD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023634 mRNA. Translation: BAA82477.1.
RefSeqiNP_786931.1. NM_175755.2.
XP_006248736.1. XM_006248674.1.
XP_006248737.1. XM_006248675.1.
UniGeneiRn.91922.

Genome annotation databases

EnsembliENSRNOT00000002530; ENSRNOP00000002530; ENSRNOG00000037909.
GeneIDi287931.
KEGGirno:287931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023634 mRNA. Translation: BAA82477.1 .
RefSeqi NP_786931.1. NM_175755.2.
XP_006248736.1. XM_006248674.1.
XP_006248737.1. XM_006248675.1.
UniGenei Rn.91922.

3D structure databases

ProteinModelPortali Q9WVR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 252383. 1 interaction.
IntActi Q9WVR7. 1 interaction.
MINTi MINT-4621280.

PTM databases

PhosphoSitei Q9WVR7.

Proteomic databases

PaxDbi Q9WVR7.
PRIDEi Q9WVR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002530 ; ENSRNOP00000002530 ; ENSRNOG00000037909 .
GeneIDi 287931.
KEGGi rno:287931.

Organism-specific databases

CTDi 9647.
RGDi 631363. Ppm1f.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000114971.
HOGENOMi HOG000232094.
HOVERGENi HBG053656.
InParanoidi Q9WVR7.
KOi K17502.
OMAi GDVFQKP.
OrthoDBi EOG7D2FDH.
PhylomeDBi Q9WVR7.
TreeFami TF317617.

Miscellaneous databases

NextBioi 627246.
PROi Q9WVR7.

Gene expression databases

Genevestigatori Q9WVR7.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of Ca2+/Calmodulin-dependent protein kinase phosphatase."
    Kitani T., Ishida A., Okuno S., Takeuchi M., Kameshita I., Fujisawa H.
    J. Biochem. 125:1022-1028(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPPM1F_RAT
AccessioniPrimary (citable) accession number: Q9WVR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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