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Protein

Protein phosphatase 1F

Gene

Ppm1f

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi194Manganese 1By similarity1
Metal bindingi194Manganese 2By similarity1
Metal bindingi195Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi356Manganese 2By similarity1
Metal bindingi400Manganese 2By similarity1

GO - Molecular functioni

  • calmodulin-dependent protein phosphatase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: RGD
  • protein serine/threonine phosphatase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processApoptosis
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1F (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase
Short name:
CaM-kinase phosphatase
Short name:
CaMKPase
Partner of PIX 2
Gene namesi
Name:Ppm1f
Synonyms:Popx2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi631363 Ppm1f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577601 – 450Protein phosphatase 1FAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei450PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WVR7
PRIDEiQ9WVR7

PTM databases

PhosphoSitePlusiQ9WVR7

Expressioni

Gene expression databases

BgeeiENSRNOG00000037909
ExpressionAtlasiQ9WVR7 baseline and differential
GenevisibleiQ9WVR7 RN

Interactioni

Subunit structurei

Associates with FEM1B.By similarity

Protein-protein interaction databases

BioGridi252383, 1 interactor
IntActiQ9WVR7, 1 interactor
MINTiQ9WVR7
STRINGi10116.ENSRNOP00000002530

Structurei

3D structure databases

ProteinModelPortaliQ9WVR7
SMRiQ9WVR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 409PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 109Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00900000140907
HOGENOMiHOG000232094
HOVERGENiHBG053656
InParanoidiQ9WVR7
KOiK17502
OMAiPLPWKAP
OrthoDBiEOG091G08KG
PhylomeDBiQ9WVR7
TreeFamiTF317617

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGAPQNSS QMACDGEIPG FLDTLLQDFP APLSLESPLP WKVPGTVLGQ
60 70 80 90 100
EEVEAELTEL AMGFLGSRNA PPAVAAAVTH EAISQLLQTD LSEFKRLPEQ
110 120 130 140 150
EEEEEEEEER VLTTLLDAKG LSRSFFNCLW EVCSQWQKRV PLTAQAPQRK
160 170 180 190 200
WLVSIHAIRN TRRKMEDRHV SLPAFNHLFG LSDSVHRAYF AVFDGHGGVD
210 220 230 240 250
AARYASVHVH TNASHQPELL TDPAAALKEA FRHTDQMFLQ KAKRERLQSG
260 270 280 290 300
TTGVCALITG AALHVAWLGD SQVILVQQGQ VVKLMEPHKP ERQDEKSRIE
310 320 330 340 350
ALGGFVSLMD CWRVNGTLAV SRAIGDVFQK PYVSGEADAA SRELTGLEDY
360 370 380 390 400
LLLACDGFFD VVPHHEIPGL VHGHLLRQKG SGMHVAEELV AVARDRGSHD
410 420 430 440 450
NITVMVVFLR DPLELLEGGG QGAGGAQADV GSQDLSTGLS ELEINTSQRS
Length:450
Mass (Da):49,165
Last modified:November 1, 1999 - v1
Checksum:i67626542F32B2FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023634 mRNA Translation: BAA82477.1
RefSeqiNP_786931.1, NM_175755.2
XP_006248736.1, XM_006248674.2
UniGeneiRn.91922

Genome annotation databases

EnsembliENSRNOT00000002530; ENSRNOP00000002530; ENSRNOG00000037909
GeneIDi287931
KEGGirno:287931

Similar proteinsi

Entry informationi

Entry nameiPPM1F_RAT
AccessioniPrimary (citable) accession number: Q9WVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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