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Protein

72 kDa inositol polyphosphate 5-phosphatase

Gene

Inpp5e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Can convert lipid substrates, but also water soluble inositol phosphates.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.1 Publication

GO - Molecular functioni

  • inositol-polyphosphate 5-phosphatase activity Source: RGD
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: InterPro
  • positive regulation of neuron projection development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
72 kDa inositol polyphosphate 5-phosphatase (EC:3.1.3.361 Publication)
Alternative name(s):
5-phosphatase that induces arborization1 Publication
Short name:
Pharbin1 Publication
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Gene namesi
Name:Inpp5e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620478. Inpp5e.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: UniProtKB
  • cytoplasm Source: RGD
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • plasma membrane Source: RGD
  • ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 64464472 kDa inositol polyphosphate 5-phosphataseBy similarityPRO_0000209749Add
BLAST
Propeptidei645 – 6473Removed in mature formBy similarityPRO_0000431691

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei196 – 1961PhosphothreonineBy similarity
Modified residuei244 – 2441PhosphoserineCombined sources
Modified residuei259 – 2591PhosphoserineBy similarity
Modified residuei644 – 6441Cysteine methyl esterBy similarity
Lipidationi644 – 6441S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ9WVR1.

PTM databases

iPTMnetiQ9WVR1.
PhosphoSiteiQ9WVR1.

Interactioni

Subunit structurei

Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025763.

Structurei

3D structure databases

ProteinModelPortaliQ9WVR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 6241
Repeati76 – 7942
Repeati147 – 15043
Repeati239 – 24244

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 2421844 X 4 AA repeats of P-X-X-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 1016Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
HOGENOMiHOG000231541.
HOVERGENiHBG052132.
InParanoidiQ9WVR1.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKSACLRH TEAPGQLEGR MLQGQLSNPE KKLIPTSASL PAADSQSSQT
60 70 80 90 100
NSMPPLSMPA KPSNQNLQAK ANLITPQPPI RPKLERTLSL DDKGWRRRRF
110 120 130 140 150
RGSQEDLTVQ NGASPCRGSL QDSVAQSPAY SRPLPCLSTS LQEIPKPRRP
160 170 180 190 200
QAAREGAHPC GVTVFLEMIS TSWTSCTERV PQVGHSRLAS LRATHTPPAM
210 220 230 240 250
DLNIASSSLR TANKVDPEHT DYKLRMQNRL VRAHSNLGPS RPRSPLAGDD
260 270 280 290 300
HSIHSARSSF SLLAPIRTKD IRSRSYLEGS LLASGALLGA DELARYFPDR
310 320 330 340 350
NMALFVATWN MQGQKELPAS LDEFLLPTEA DYTQDLYVIG VQEGCSDRRE
360 370 380 390 400
WETRLQETLG PQYVLLSSAA HGVLYMSLFI RRDLIWFCSE VEYSTVTTRI
410 420 430 440 450
VSQIKTKGAL GVSFTFFGTS FLFITSHFTS GDGKVAERLL DYNRTIQALA
460 470 480 490 500
LPRNVPDTNP YRSSAGDVTT RFDEVFWFGD FNFRLSGGRV AVEAFLKQDP
510 520 530 540 550
EVDVLALLQH DQLTREMKKG SIFKGFEEAE IHFLPSYKFD IGKDTYDSTS
560 570 580 590 600
KQRTPSYTDR VLYKSRHKGD ICPMKYSSCP GIKTSDHRPV YGLFRVKVRP
610 620 630 640
GRDNIPLAAG KFDRELYLIG IKRRISKEIQ RQEALKSQSS SAVCTVS
Length:647
Mass (Da):72,238
Last modified:March 29, 2004 - v2
Checksum:iDAF4ED31BDD3F972
GO

Sequence cautioni

The sequence BAA82150 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026288 mRNA. Translation: BAA82150.1. Different initiation.
UniGeneiRn.199218.

Genome annotation databases

UCSCiRGD:620478. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026288 mRNA. Translation: BAA82150.1. Different initiation.
UniGeneiRn.199218.

3D structure databases

ProteinModelPortaliQ9WVR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025763.

PTM databases

iPTMnetiQ9WVR1.
PhosphoSiteiQ9WVR1.

Proteomic databases

PaxDbiQ9WVR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620478. rat.

Organism-specific databases

RGDi620478. Inpp5e.

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
HOGENOMiHOG000231541.
HOVERGENiHBG052132.
InParanoidiQ9WVR1.

Miscellaneous databases

PROiQ9WVR1.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINP5E_RAT
AccessioniPrimary (citable) accession number: Q9WVR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The N-terminus was extended using the genomic sequence, in analogy to ortholog sequences.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.