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Protein

Interferon-induced GTP-binding protein Mx2

Gene

Mx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV) and Hantaan virus (HNTV).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778GTPSequence analysis
Nucleotide bindingi171 – 1755GTPSequence analysis
Nucleotide bindingi240 – 2434GTPSequence analysis

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: MGI

GO - Biological processi

  • defense response to virus Source: UniProtKB-KW
  • innate immune response Source: MGI
  • negative regulation of viral genome replication Source: UniProtKB
  • response to type I interferon Source: UniProtKB
  • response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Alternative name(s):
Myxovirus resistance protein 2
Gene namesi
Name:Mx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:97244. Mx2.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Interferon-induced GTP-binding protein Mx2PRO_0000206599Add
BLAST

Proteomic databases

EPDiQ9WVP9.
PaxDbiQ9WVP9.
PRIDEiQ9WVP9.

PTM databases

PhosphoSiteiQ9WVP9.

Expressioni

Inductioni

By type I and type III interferons.2 Publications

Gene expression databases

BgeeiQ9WVP9.
CleanExiMM_MX2.
GenevisibleiQ9WVP9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024112.

Structurei

3D structure databases

ProteinModelPortaliQ9WVP9.
SMRiQ9WVP9. Positions 38-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 333274Dynamin-type GAdd
BLAST
Domaini567 – 65589GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ9WVP9.
KOiK14754.
OrthoDBiEOG7034GF.
PhylomeDBiQ9WVP9.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSTEENTG VDSVNLPSGE TGLGEKDQES VNNLCSQYEE KVRPCIDLID
60 70 80 90 100
SLRALGVEQD LALPAIAVIG DQSSGKSSVL EALSGVALPR GSGIVTRCPL
110 120 130 140 150
VLKLRKLNEG EEWRGKVSYD DIEVELSDPS EVEEAINKGQ NFIAGVGLGI
160 170 180 190 200
SDKLISLDVS SPNVPDLTLI DLPGITRVAV GNQPADIGRQ IKRLIKTYIQ
210 220 230 240 250
KQETINLVVV PSNVDIATTE ALSMAQEVDP EGDRTIGILT KPDLVDRGTE
260 270 280 290 300
DKVVDVVRNL VYHLKKGYMI VKCRGQQDIQ EQLSLTEALQ NEQIFFKEHP
310 320 330 340 350
HFRVLLEDGK ATVPCLAERL TAELISHICK SLPLLENQIK ESHQSASEEL
360 370 380 390 400
QKYGMDIPED DSEKTFFLIE KINAFNQDIT ALVQGEENVA EGECRLFTRL
410 420 430 440 450
RKEFLSWSKE IEKNFAKGYA VLYNEVWAFE KQYRGRELPG FVNYKTFENI
460 470 480 490 500
IRRQIKTLEE PAIEMLHTVT EIVRAAFTSV SEKNFSEFYN LHRTTKSKLE
510 520 530 540 550
DIRLEQEKEA EMSIRLHFKM EQIIYCQDQI YRGALQKVRE EEAEEEKKTK
560 570 580 590 600
HGTSSSSQSQ DLQTSSMAEI FQHLNAYRQE AHNRISSHVP LIIQYFILKM
610 620 630 640 650
FAERLQKGML QLLQDKDSCS WLLKEQSDTS EKRKFLKERL ARLAQARRRL

AKFPG
Length:655
Mass (Da):74,292
Last modified:April 26, 2005 - v2
Checksum:i9F58BD9D0E9349C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3261S → L in BAA82593 (PubMed:10233954).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029920 mRNA. Translation: BAA82593.1.
BC007127 mRNA. Translation: AAH07127.1.
RefSeqiNP_038634.1. NM_013606.1.
UniGeneiMm.14157.

Genome annotation databases

EnsembliENSMUST00000024112; ENSMUSP00000024112; ENSMUSG00000023341.
GeneIDi17858.
KEGGimmu:17858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029920 mRNA. Translation: BAA82593.1.
BC007127 mRNA. Translation: AAH07127.1.
RefSeqiNP_038634.1. NM_013606.1.
UniGeneiMm.14157.

3D structure databases

ProteinModelPortaliQ9WVP9.
SMRiQ9WVP9. Positions 38-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024112.

PTM databases

PhosphoSiteiQ9WVP9.

Proteomic databases

EPDiQ9WVP9.
PaxDbiQ9WVP9.
PRIDEiQ9WVP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024112; ENSMUSP00000024112; ENSMUSG00000023341.
GeneIDi17858.
KEGGimmu:17858.

Organism-specific databases

CTDi4600.
MGIiMGI:97244. Mx2.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ9WVP9.
KOiK14754.
OrthoDBiEOG7034GF.
PhylomeDBiQ9WVP9.
TreeFamiTF331484.

Miscellaneous databases

PROiQ9WVP9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVP9.
CleanExiMM_MX2.
GenevisibleiQ9WVP9. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus."
    Jin H., Takada A., Kon Y., Haller O., Watanabe T.
    J. Virol. 73:4925-4930(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    Strain: NJL.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Mouse Mx2 protein inhibits hantavirus but not influenza virus replication."
    Jin H.K., Yoshimatsu K., Takada A., Ogino M., Asano A., Arikawa J., Watanabe T.
    Arch. Virol. 146:41-49(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The Mx GTPase family of interferon-induced antiviral proteins."
    Haller O., Stertz S., Kochs G.
    Microbes Infect. 9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, INDUCTION.

Entry informationi

Entry nameiMX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVP9
Secondary accession number(s): Q922L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The Mx2 gene is non-functional in all laboratory mouse strains examined. It is functional in feral strains.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.