Reviewed,
UniProtKB/Swiss-Prot Q9WVM8 (AADAT_MOUSE)
Last modified
January 19, 2010.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Alternative name(s): KAT/AadAT EC=2.6.1.7 Kynurenine aminotransferase II Kynurenine--oxoglutarate aminotransferase II Kynurenine--oxoglutarate transaminase II 2-aminoadipate transaminase EC=2.6.1.39 2-aminoadipate aminotransferase Alpha-aminoadipate aminotransferase Short name=AadAT | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Shows activity also towards tryptophan, aspartate and hydroxykinurenine. |
| Catalytic activity | L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate. |
| Cofactor | Pyridoxal phosphate. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Mitochondrion Potential. |
| Tissue specificity | Expressed mainly in kidney and to a lesser amount in liver and brain. |
| Sequence similarities | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Pyridoxal phosphate |
| Molecular function | Aminotransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from direct assay. Source: MGI |
| Molecular function | 2-aminoadipate transaminase activity Inferred from electronic annotation. Source: EC kynurenine-oxoglutarate transaminase activityInferred from electronic annotation. Source: EC pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 29 | 29 | Mitochondrion Potential | ||||||
| Chain | 30 – 425 | 396 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | PRO_0000020603 | |||||
Amino acid modifications | |||||||||
| Modified residue | 263 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease." Yu P., Mosbrook D.M., Tagle D.A. Mamm. Genome 10:845-852(1999) [PubMed: 10441733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF072376 mRNA. Translation: AAD39680.1. AK075578 mRNA. Translation: BAC35833.1. BC012637 mRNA. Translation: AAH12637.1. |
| IPI | IPI00762346. |
| RefSeq | NP_035964.1. |
| UniGene | Mm.35020 |
3D structure databases | |
| SMR | Q9WVM8. Positions 1-425. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9WVM8. |
Proteomic databases | |
| PRIDE | Q9WVM8. |
Genome annotation databases | |
| Ensembl | ENSMUST00000079472; ENSMUSP00000078436; ENSMUSG00000057228; Mus musculus. [Genome view] |
| GeneID | 23923. |
| KEGG | mmu:23923. |
| UCSC | uc009lte.1. mouse. |
Organism-specific databases | |
| CTD | 23923. |
| MGI | MGI:1345167. Aadat. |
Phylogenomic databases | |
| HOVERGEN | Q9WVM8. |
| OrthoDB | EOG9C8BC9. |
| PhylomeDB | Q9WVM8. |
Enzyme and pathway databases | |
| BRENDA | 2.6.1.39. 244. 2.6.1.7. 244. |
Gene expression databases | |
| ArrayExpress | Q9WVM8. |
| Bgee | Q9WVM8. |
| CleanEx | MM_AADAT. |
| Genevestigator | Q9WVM8. |
| GermOnline | ENSMUSG00000057228. Mus musculus. |
Family and domain databases | |
| InterPro | IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| Pfam | PF00155. Aminotran_1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 303709. |
| SOURCE | Search... |
Entry information
| Entry name | AADAT_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9WVM8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


