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Q9WVM4

- ICMT_RAT

UniProt

Q9WVM4 - ICMT_RAT

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Protein
Protein-S-isoprenylcysteine O-methyltransferase
Gene
Icmt
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Cofactori

Divalent cations. Probably zinc.

GO - Molecular functioni

  1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. C-terminal protein methylation Source: RGD
  2. S-adenosylhomocysteine metabolic process Source: RGD
  3. S-adenosylmethioninamine metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ9WVM4.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Farnesyl cysteine carboxyl methyltransferase
Short name:
FCMT
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:Icmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621618. Icmt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 7›7Helical; Reviewed prediction
Topological domaini8 – 1710Cytoplasmic Reviewed prediction
Transmembranei18 – 3518Helical; Reviewed prediction
Add
BLAST
Topological domaini36 – 405Lumenal Reviewed prediction
Transmembranei41 – 6020Helical; Reviewed prediction
Add
BLAST
Topological domaini61 – 7919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei80 – 9718Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 1025Lumenal Reviewed prediction
Transmembranei103 – 12220Helical; Reviewed prediction
Add
BLAST
Topological domaini123 – 16038Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei161 – 17616Helical; Reviewed prediction
Add
BLAST
Topological domaini177 – 1771Lumenal Reviewed prediction
Transmembranei178 – 19215Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 23240Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 232›232Protein-S-isoprenylcysteine O-methyltransferase
PRO_0000209896Add
BLAST

Proteomic databases

PRIDEiQ9WVM4.

PTM databases

PhosphoSiteiQ9WVM4.

Expressioni

Gene expression databases

GenevestigatoriQ9WVM4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2020.
HOGENOMiHOG000213961.
HOVERGENiHBG019034.
InParanoidiQ9WVM4.
PhylomeDBiQ9WVM4.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9WVM4-1 [UniParc]FASTAAdd to Basket

« Hide

ALLLLLYRPP HYQIAIRACF LGFVFGCGVL LSFSQSSWNH FGWYVCSLSL    50
FHYSEYLVTT VNNPKSLSLD SFLLNHSLEY TVAALSSWIE FTLENIFWPE 100
LKQITWLSAA GLLMVIFGEC LRKVAMFTAG SNFNHVVQSE KSDTHTLVTS 150
GVYAWCRHPS YVGWFYWSIG TQVMLCNPIC GVVYALTVWR FFRDRTEEEE 200
ISLIHFFGEE YLDYKKRVPT GLPFIKGVKV GL 232
Length:232
Mass (Da):26,661
Last modified:November 1, 1999 - v1
Checksum:iBBB6D1CC14A8704E
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075595 mRNA. Translation: AAD42926.1.
UniGeneiRn.48709.

Genome annotation databases

UCSCiRGD:621618. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075595 mRNA. Translation: AAD42926.1 .
UniGenei Rn.48709.

3D structure databases

ModBasei Search...

Chemistry

ChEMBLi CHEMBL2298.

PTM databases

PhosphoSitei Q9WVM4.

Proteomic databases

PRIDEi Q9WVM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621618. rat.

Organism-specific databases

RGDi 621618. Icmt.

Phylogenomic databases

eggNOGi COG2020.
HOGENOMi HOG000213961.
HOVERGENi HBG019034.
InParanoidi Q9WVM4.
PhylomeDBi Q9WVM4.

Enzyme and pathway databases

SABIO-RK Q9WVM4.

Miscellaneous databases

PROi Q9WVM4.

Gene expression databases

Genevestigatori Q9WVM4.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of farnesyl cysteine carboxyl methyltransferase gene from rat olfactory bulb."
    Otaki J.M., Firestein S.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "The carboxyl methyltransferase modifying G proteins is a metalloenzyme."
    Desrosiers R.R., Nguyen Q.T., Beliveau R.
    Biochem. Biophys. Res. Commun. 261:790-797(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiICMT_RAT
AccessioniPrimary (citable) accession number: Q9WVM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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