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Q9WVM4

- ICMT_RAT

UniProt

Q9WVM4 - ICMT_RAT

Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

Icmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

    Catalytic activityi

    S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

    Cofactori

    Divalent cations. Probably zinc.

    GO - Molecular functioni

    1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: RGD

    GO - Biological processi

    1. C-terminal protein methylation Source: RGD
    2. S-adenosylhomocysteine metabolic process Source: RGD
    3. S-adenosylmethioninamine metabolic process Source: RGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    SABIO-RKQ9WVM4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
    Alternative name(s):
    Farnesyl cysteine carboxyl methyltransferase
    Short name:
    FCMT
    Isoprenylcysteine carboxylmethyltransferase
    Prenylated protein carboxyl methyltransferase
    Short name:
    PPMT
    Prenylcysteine carboxyl methyltransferase
    Short name:
    pcCMT
    Gene namesi
    Name:Icmt
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621618. Icmt.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 232›232Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209896Add
    BLAST

    Proteomic databases

    PRIDEiQ9WVM4.

    PTM databases

    PhosphoSiteiQ9WVM4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVM4.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini8 – 1710CytoplasmicSequence Analysis
    Topological domaini36 – 405LumenalSequence Analysis
    Topological domaini61 – 7919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025LumenalSequence Analysis
    Topological domaini123 – 16038CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 1771LumenalSequence Analysis
    Topological domaini193 – 23240CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei‹1 – 7›7HelicalSequence Analysis
    Transmembranei18 – 3518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei41 – 6020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 9718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 17616HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19215HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2020.
    HOGENOMiHOG000213961.
    HOVERGENiHBG019034.
    InParanoidiQ9WVM4.
    PhylomeDBiQ9WVM4.

    Family and domain databases

    InterProiIPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view]
    PfamiPF04140. ICMT. 1 hit.
    [Graphical view]
    PROSITEiPS51564. SAM_ICMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9WVM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    ALLLLLYRPP HYQIAIRACF LGFVFGCGVL LSFSQSSWNH FGWYVCSLSL    50
    FHYSEYLVTT VNNPKSLSLD SFLLNHSLEY TVAALSSWIE FTLENIFWPE 100
    LKQITWLSAA GLLMVIFGEC LRKVAMFTAG SNFNHVVQSE KSDTHTLVTS 150
    GVYAWCRHPS YVGWFYWSIG TQVMLCNPIC GVVYALTVWR FFRDRTEEEE 200
    ISLIHFFGEE YLDYKKRVPT GLPFIKGVKV GL 232
    Length:232
    Mass (Da):26,661
    Last modified:November 1, 1999 - v1
    Checksum:iBBB6D1CC14A8704E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075595 mRNA. Translation: AAD42926.1.
    UniGeneiRn.48709.

    Genome annotation databases

    UCSCiRGD:621618. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075595 mRNA. Translation: AAD42926.1 .
    UniGenei Rn.48709.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2298.

    PTM databases

    PhosphoSitei Q9WVM4.

    Proteomic databases

    PRIDEi Q9WVM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621618. rat.

    Organism-specific databases

    RGDi 621618. Icmt.

    Phylogenomic databases

    eggNOGi COG2020.
    HOGENOMi HOG000213961.
    HOVERGENi HBG019034.
    InParanoidi Q9WVM4.
    PhylomeDBi Q9WVM4.

    Enzyme and pathway databases

    SABIO-RK Q9WVM4.

    Miscellaneous databases

    PROi Q9WVM4.

    Gene expression databases

    Genevestigatori Q9WVM4.

    Family and domain databases

    InterProi IPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view ]
    Pfami PF04140. ICMT. 1 hit.
    [Graphical view ]
    PROSITEi PS51564. SAM_ICMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of farnesyl cysteine carboxyl methyltransferase gene from rat olfactory bulb."
      Otaki J.M., Firestein S.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Olfactory bulb.
    2. "The carboxyl methyltransferase modifying G proteins is a metalloenzyme."
      Desrosiers R.R., Nguyen Q.T., Beliveau R.
      Biochem. Biophys. Res. Commun. 261:790-797(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiICMT_RAT
    AccessioniPrimary (citable) accession number: Q9WVM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3