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Q9WVM4

- ICMT_RAT

UniProt

Q9WVM4 - ICMT_RAT

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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

Icmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Cofactori

Zn2+Note: Divalent metal cations. Probably Zn(2+).

GO - Molecular functioni

  1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: RGD

GO - Biological processi

  1. C-terminal protein methylation Source: RGD
  2. S-adenosylhomocysteine metabolic process Source: RGD
  3. S-adenosylmethioninamine metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ9WVM4.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Farnesyl cysteine carboxyl methyltransferase
Short name:
FCMT
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:Icmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621618. Icmt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 7›7HelicalSequence Analysis
Topological domaini8 – 1710CytoplasmicSequence Analysis
Transmembranei18 – 3518HelicalSequence AnalysisAdd
BLAST
Topological domaini36 – 405LumenalSequence Analysis
Transmembranei41 – 6020HelicalSequence AnalysisAdd
BLAST
Topological domaini61 – 7919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei80 – 9718HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 1025LumenalSequence Analysis
Transmembranei103 – 12220HelicalSequence AnalysisAdd
BLAST
Topological domaini123 – 16038CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 17616HelicalSequence AnalysisAdd
BLAST
Topological domaini177 – 1771LumenalSequence Analysis
Transmembranei178 – 19215HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 23240CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 232›232Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209896Add
BLAST

Proteomic databases

PRIDEiQ9WVM4.

PTM databases

PhosphoSiteiQ9WVM4.

Expressioni

Gene expression databases

GenevestigatoriQ9WVM4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2020.
HOGENOMiHOG000213961.
HOVERGENiHBG019034.
InParanoidiQ9WVM4.
PhylomeDBiQ9WVM4.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9WVM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ALLLLLYRPP HYQIAIRACF LGFVFGCGVL LSFSQSSWNH FGWYVCSLSL
60 70 80 90 100
FHYSEYLVTT VNNPKSLSLD SFLLNHSLEY TVAALSSWIE FTLENIFWPE
110 120 130 140 150
LKQITWLSAA GLLMVIFGEC LRKVAMFTAG SNFNHVVQSE KSDTHTLVTS
160 170 180 190 200
GVYAWCRHPS YVGWFYWSIG TQVMLCNPIC GVVYALTVWR FFRDRTEEEE
210 220 230
ISLIHFFGEE YLDYKKRVPT GLPFIKGVKV GL
Length:232
Mass (Da):26,661
Last modified:November 1, 1999 - v1
Checksum:iBBB6D1CC14A8704E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075595 mRNA. Translation: AAD42926.1.
UniGeneiRn.48709.

Genome annotation databases

UCSCiRGD:621618. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075595 mRNA. Translation: AAD42926.1 .
UniGenei Rn.48709.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2298.

PTM databases

PhosphoSitei Q9WVM4.

Proteomic databases

PRIDEi Q9WVM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621618. rat.

Organism-specific databases

RGDi 621618. Icmt.

Phylogenomic databases

eggNOGi COG2020.
HOGENOMi HOG000213961.
HOVERGENi HBG019034.
InParanoidi Q9WVM4.
PhylomeDBi Q9WVM4.

Enzyme and pathway databases

SABIO-RK Q9WVM4.

Miscellaneous databases

PROi Q9WVM4.

Gene expression databases

Genevestigatori Q9WVM4.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of farnesyl cysteine carboxyl methyltransferase gene from rat olfactory bulb."
    Otaki J.M., Firestein S.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  2. "The carboxyl methyltransferase modifying G proteins is a metalloenzyme."
    Desrosiers R.R., Nguyen Q.T., Beliveau R.
    Biochem. Biophys. Res. Commun. 261:790-797(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiICMT_RAT
AccessioniPrimary (citable) accession number: Q9WVM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3