Reviewed, UniProtKB/Swiss-Prot Q9WVM3 (APC7_MOUSE)

Names and origin

Protein names

Recommended name:
    Anaphase-promoting complex subunit 7
      Short name=APC7
Alternative name(s):
    Cyclosome subunit 7
    Prediabetic NOD sera-reactive autoantigen

Gene names

Name:	Anapc7
Synonyms:	Apc7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	The APC/C is composed of at least 12 subunits By similarity.
Sequence similarities	Belongs to the APC7 family. Contains 7 TPR repeats.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Domain	Repeat TPR repeat
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW protein K11-linked ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	anaphase-promoting complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Pik3ca	P42337	2	EBI-642653,EBI-641748

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 565	565	Anaphase-promoting complex subunit 7		PRO_0000106262
Regions
	Repeat	43 – 76	34	TPR 1
	Repeat	135 – 168	34	TPR 2
	Repeat	237 – 270	34	TPR 3
	Repeat	339 – 372	34	TPR 4
	Repeat	407 – 441	35	TPR 5
	Repeat	442 – 474	33	TPR 6
	Repeat	475 – 508	34	TPR 7
Experimental info
	Sequence conflict	156	1	T → A in AAD39343. Ref.1
	Sequence conflict	188	1	M → T in AAD39343. Ref.1
	Sequence conflict	288	1	E → K in BAC27131. Ref.2
	Sequence conflict	340	1	Q → K in BAC27131. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9WVM3-1 [UniParc]. Last modified October 3, 2003. Version 3. Checksum: F7DFB8D45FDCD639	FASTA	565	63,021
	10 20 30 40 50 60 MSVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPS QKYQLLVYHA DSLFHDKEYR 70 80 90 100 110 120 NAVSKYAMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS EIEVKYKMAE CYTMLKLDKD 130 140 150 160 170 180 AIAVLDGIPS RQRTPKINMM LANLYKKAGQ ERPSVTSYKE VLRQCPLALD AILGLLSLSV 190 200 210 220 230 240 KGAEVASMTM NVIQTVPNLD WLSVWIKAYA FVHTGDNSRA INTICSLEKK SLLRDNVDLL 250 260 270 280 290 300 GSLADLYFRA GDSKNSVLKF EQAQMLDPYL IRGMDVYGYL LAREGRLEDV ENLGCRLFNI 310 320 330 340 350 360 SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR NMGRVQEAII 370 380 390 400 410 420 HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY KTLGANAQTL TLLATVCLED 430 440 450 460 470 480 PVTQEKAKTL LDKALAQRPD YVKAVVKKAE LLSREQKYED GIALLRNALA NQSDCVLHRI 490 500 510 520 530 540 LGDFLVAVNE YQEAMDQYSI ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG 550 560 EEGDLEGSDS EAAQWADQEQ WFGMQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new autoantigen reactive with prediabetic nonobese diabetic mice sera." Kang Y., Choi K.S., Kim K.H., Kim K.S., Choi S.E., Ko I.Y., Kim H.M., Yoon J.W. Mol. Cells 9:358-364(1999) [PubMed: 10515598] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow and Hippocampus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF076607 mRNA. Translation: AAD39343.2. AK030775 mRNA. Translation: BAC27131.1. AK150764 mRNA. Translation: BAE29831.1. AK150891 mRNA. Translation: BAE29937.1. AK153114 mRNA. Translation: BAE31731.1. AK159523 mRNA. Translation: BAE35152.1. AK164202 mRNA. Translation: BAE37680.1. BC006635 mRNA. Translation: AAH06635.1.
IPI	IPI00331074.
RefSeq	NP_062779.3.
UniGene	Mm.37341
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9WVM3. 2 interactions.
STRING	Q9WVM3.
PTM databases
PhosphoSite	Q9WVM3.
Proteomic databases
PRIDE	Q9WVM3.
Genome annotation databases
Ensembl	ENSMUST00000031422; ENSMUSP00000031422; ENSMUSG00000029466; Mus musculus. [Genome view] ENSMUST00000122010; ENSMUSP00000113928; ENSMUSG00000029466; Mus musculus. [Genome view]
GeneID	56317.
KEGG	mmu:56317.
UCSC	uc008zlg.1. mouse.
Organism-specific databases
CTD	56317.
MGI	MGI:1929711. Anapc7.
Phylogenomic databases
HOGENOM	HBG505401.
HOVERGEN	Q9WVM3.
InParanoid	Q9WVM3.
OMA	QSIPNLD.
OrthoDB	EOG9N5ZGT.
Gene expression databases
ArrayExpress	Q9WVM3.
Bgee	Q9WVM3.
CleanEx	MM_ANAPC7.
Genevestigator	Q9WVM3.
GermOnline	ENSMUSG00000029466. Mus musculus.
Family and domain databases
InterPro	IPR001440. TPR-1. IPR011990. TPR-like_helical. IPR013026. TPR_region. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF00515. TPR_1. 3 hits. [Graphical view]
SMART	SM00028. TPR. 4 hits. [Graphical view]
PROSITE	PS50005. TPR. 5 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	312272.
SOURCE	Search...

Entry information

Entry name

APC7_MOUSE

Accession

Primary (citable) accession number: Q9WVM3
Secondary accession number(s): Q3UBM7, Q8BSR2, Q91W13

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	October 3, 2003
Last modified:	December 15, 2009
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)