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Protein

C-X-C motif chemokine 15

Gene

Cxcl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions.1 Publication

GO - Molecular functioni

  • chemokine activity Source: MGI

GO - Biological processi

  • chemotaxis Source: MGI
  • hemopoiesis Source: MGI
  • immune response Source: InterPro
  • inflammatory response Source: MGI
  • neutrophil chemotaxis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 15
Alternative name(s):
Lungkine
Small-inducible cytokine B15
Gene namesi
Name:Cxcl15
Synonyms:Scyb15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339941. Cxcl15.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and are fertile. They display normal leukocyte subpopulations in peripheral blood and bone marrow, but the amount of neutrophils is reduced in the airspace. Susceptibility to pneumonia induced by K.pneumoniae is increased with decreased survival and increased bacterial burden in lung.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 167142C-X-C motif chemokine 15PRO_0000005117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 73By similarity
Modified residuei157 – 1571PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9WVL7.
PaxDbiQ9WVL7.
PRIDEiQ9WVL7.

PTM databases

PhosphoSiteiQ9WVL7.

Expressioni

Tissue specificityi

Expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. Expressed at low levels in fetal lung.2 Publications

Inductioni

By inflammation; in lung.1 Publication

Gene expression databases

BgeeiQ9WVL7.
CleanExiMM_CXCL15.
GenevisibleiQ9WVL7. MM.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: MGI

Protein-protein interaction databases

IntActiQ9WVL7. 1 interaction.
MINTiMINT-4134001.
STRINGi10090.ENSMUSP00000031322.

Structurei

3D structure databases

ProteinModelPortaliQ9WVL7.
SMRiQ9WVL7. Positions 27-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3HC. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOVERGENiHBG079169.
InParanoidiQ9WVL7.
KOiK10034.
OrthoDBiEOG78SQMT.
PhylomeDBiQ9WVL7.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQGWSMLL LAVLNLGIFV RPCDTQELRC LCIQEHSEFI PLKLIKNIMV
60 70 80 90 100
IFETIYCNRK EVIAVPKNGS MICLDPDAPW VKATVGPITN RFLPEDLKQK
110 120 130 140 150
EFPPAMKLLY SVEHEKPLYL SFGRPENKRI FPFPIRETSR HFADLAHNSD
160
RNFLRDSSEV SLTGSDA
Length:167
Mass (Da):19,091
Last modified:November 1, 1999 - v1
Checksum:iB9A724505FFDA5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082859 mRNA. Translation: AAD38079.1.
AK142955 mRNA. Translation: BAE25229.1.
CH466617 Genomic DNA. Translation: EDL05302.1.
BC061138 mRNA. Translation: AAH61138.1.
CCDSiCCDS19418.1.
RefSeqiNP_035469.1. NM_011339.2.
UniGeneiMm.64326.

Genome annotation databases

EnsembliENSMUST00000031322; ENSMUSP00000031322; ENSMUSG00000029375.
GeneIDi20309.
KEGGimmu:20309.
UCSCiuc008ybk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082859 mRNA. Translation: AAD38079.1.
AK142955 mRNA. Translation: BAE25229.1.
CH466617 Genomic DNA. Translation: EDL05302.1.
BC061138 mRNA. Translation: AAH61138.1.
CCDSiCCDS19418.1.
RefSeqiNP_035469.1. NM_011339.2.
UniGeneiMm.64326.

3D structure databases

ProteinModelPortaliQ9WVL7.
SMRiQ9WVL7. Positions 27-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVL7. 1 interaction.
MINTiMINT-4134001.
STRINGi10090.ENSMUSP00000031322.

PTM databases

PhosphoSiteiQ9WVL7.

Proteomic databases

MaxQBiQ9WVL7.
PaxDbiQ9WVL7.
PRIDEiQ9WVL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031322; ENSMUSP00000031322; ENSMUSG00000029375.
GeneIDi20309.
KEGGimmu:20309.
UCSCiuc008ybk.1. mouse.

Organism-specific databases

CTDi20309.
MGIiMGI:1339941. Cxcl15.

Phylogenomic databases

eggNOGiENOG410J3HC. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOVERGENiHBG079169.
InParanoidiQ9WVL7.
KOiK10034.
OrthoDBiEOG78SQMT.
PhylomeDBiQ9WVL7.
TreeFamiTF333433.

Miscellaneous databases

NextBioi298075.
PROiQ9WVL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVL7.
CleanExiMM_CXCL15.
GenevisibleiQ9WVL7. MM.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells."
    Rossi D.L., Hurst S.D., Xu Y., Wang W., Menon S., Coffman R.L., Zlotnik A.
    J. Immunol. 162:5490-5497(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.
  5. "Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine."
    Chen S.C., Mehrad B., Deng J.C., Vassileva G., Manfra D.J., Cook D.N., Wiekowski M.T., Zlotnik A., Standiford T.J., Lira S.A.
    J. Immunol. 166:3362-3368(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiCXL15_MOUSE
AccessioniPrimary (citable) accession number: Q9WVL7
Secondary accession number(s): Q3UQ15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.