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Q9WVL6 (EXTL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Exostosin-like 3
EC=2.4.1.223
Alternative name(s):
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Multiple exostosis-like protein 3
Gene names
Name:Extl3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length918 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable glycosyltransferase By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.

Pathway

Glycan metabolism; heparan sulfate biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 47 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 918918Exostosin-like 3
PRO_0000149658

Regions

Topological domain1 – 3030Cytoplasmic Potential
Transmembrane31 – 5121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain52 – 918867Lumenal Potential

Sites

Metal binding7451Manganese; catalytic By similarity

Amino acid modifications

Glycosylation2771N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation5911N-linked (GlcNAc...) Potential
Glycosylation7891N-linked (GlcNAc...) Potential
Disulfide bond830 ↔ 878 By similarity

Experimental info

Sequence conflict3021F → L in AAD42040. Ref.1
Sequence conflict4391H → R in AAD42040. Ref.1
Sequence conflict6091P → R in AAD42040. Ref.1
Sequence conflict7581R → W in AAD42040. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9WVL6 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 5A881B9BFCCB8115

FASTA918104,474
        10         20         30         40         50         60 
MTGYTMLRNG GVGNGGQTCM LRWSNRIRLT WLSFTLFIIL VFFPLIAHYY LTTLDEADEA 

        70         80         90        100        110        120 
GKRIFGPRAG SELCEVKHVL DLCRIRESVS EELLQLEAKR QELNSEIAKL NLKIEACKKS 

       130        140        150        160        170        180 
IENAKQDLLQ LKNVISQTEH SYKELMAQNQ PKLSLPIRLL PEKDDAGLPP PKVTRGCRLH 

       190        200        210        220        230        240 
NCFDYSRCPL TSGFPVYVYD SDQFAFGSYL DPLVKQAFQA TVRANVYVTE NAAIACLYVV 

       250        260        270        280        290        300 
LVGEMQEPTV LRPADLEKQL FSLPHWRTDG HNHVIINLSR KSDTQNLLYN VSTGRHVAQS 

       310        320        330        340        350        360 
TFYAAQYRAG FDLVVSPLVH AMSEPNFMEI PPQVPVKRKY LFTFQGEKIE SLRSSLQEAR 

       370        380        390        400        410        420 
SFEEEMEGDP PADYDDRIIA TLKAVQDSKL DQVLVEFTCK NQPKPSLPTE WALCGEREDR 

       430        440        450        460        470        480 
LELLKLSTFA LIITPGDPHL LISSGCATRL FEALEVGAVP VVLGEQVQLP YHDMLQWNEA 

       490        500        510        520        530        540 
ALVVPKPRVT EVHFLLRSLS DSDLLAMRRQ GRFLWETYFS TADSIFNTVL AMIRTRIQIP 

       550        560        570        580        590        600 
AAPIREEVAA EIPHRSGKAA GTDPNMADNG DLDLGPVETE PPYASPKYLR NFTLTVTDCY 

       610        620        630        640        650        660 
RGWNSAPGPF HLFPHTPFDP VLPSEAKFLG SGTGFRPIGG GAGGSGKEFQ AALGGNVQRE 

       670        680        690        700        710        720 
QFTVVMLTYE REEVLMNSLE RLNGLPYLNK VVVVWNSPKL PSEDLLWPDI GVPIMVVRTE 

       730        740        750        760        770        780 
KNSLNNRFLP WNEIETEAIL SIDDDAHLRH DEIMFGFRVW REARDRIVGF PGRYHAWDIP 

       790        800        810        820        830        840 
HQSWLYNSNY SCELSMVLTG AAFFHKYYAY LYSYVMPQAI RDMVDEYINC EDIAMNFLVS 

       850        860        870        880        890        900 
HITRKPPIKV TSRWTFRCPG CPQALSHDDS HFHERHKCIN FFVKVYGYMP LLYTQFRVDS 

       910 
VLFKTRLPHD KTKCFKFI

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the mouse homolog of EXT1L."
Sato T.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - GTase

EXTL3 (Putative GlcNAc Transferase I) [GAG Enzyme]

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF083550 mRNA. Translation: AAD42040.1.
AC155172 Genomic DNA. No translation available.
IPIIPI00126131.
UniGeneMm.103748.

3D structure databases

ProteinModelPortalQ9WVL6.
SMRQ9WVL6. Positions 660-904.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9WVL6.

Protein family/group databases

CAZyGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

PTM databases

PhosphoSiteQ9WVL6.

Proteomic databases

PRIDEQ9WVL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111165; ENSMUSP00000106795; ENSMUSG00000021978.

Organism-specific databases

MGIMGI:1860765. Extl3.

Phylogenomic databases

GeneTreeENSGT00550000074496.
HOVERGENHBG051526.
InParanoidQ9WVL6.
OrthoDBEOG415GCN.

Gene expression databases

ArrayExpressQ9WVL6.
BgeeQ9WVL6.
CleanExMM_EXTL3.
GenevestigatorQ9WVL6.
GermOnlineENSMUSG00000021978. Mus musculus.

Family and domain databases

InterProIPR004263. Exostosin.
IPR015338. HexNAc_Trfase_a.
[Graphical view]
PfamPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameEXTL3_MOUSE
AccessionPrimary (citable) accession number: Q9WVL6
Secondary accession number(s): E9QKN8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 16, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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