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Q9WVL2 (STAT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and activator of transcription 2
Gene names
Name:Stat2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Subunit structure

Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1 and IFNAR2. Interacts with ARL2BP. Ref.3 Ref.4

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Translocated into the nucleus upon activation by IFN-alpha/beta By similarity.

Tissue specificity

Found in the brain, lung, heart, spleen, liver, kidney, muscle and the testis.

Post-translational modification

Tyrosine phosphorylated in response to IFN-alpha By similarity.

Sequence similarities

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Sequence caution

The sequence AAB36230.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAB36231.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 923923Signal transducer and activator of transcription 2
PRO_0000182414

Regions

Domain571 – 66696SH2

Amino acid modifications

Modified residue2841Phosphoserine By similarity
Modified residue6891Phosphotyrosine; by JAK By similarity

Experimental info

Sequence conflict5961T → A in AAB36228. Ref.2
Sequence conflict5961T → A in AAB36231. Ref.2
Sequence conflict6201H → D in AAB36228. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9WVL2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: D50BB54C535B0774

FASTA923105,417
        10         20         30         40         50         60 
MAQWEMLQNL DSPFLDQLHQ VYSQSFLPMD FRQHLASWIE DQNWREAALE SDDAKANMLY 

        70         80         90        100        110        120 
FSILDQLNQW DHYSSDPKSL LLQHNLRKFS RDIQPFPNGP SQLAEMIFNL LLEEQRILIQ 

       130        140        150        160        170        180 
AQRAQEVQPP PAPEAVVESQ QLEIENRIQG LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS 

       190        200        210        220        230        240 
LKKTSSSDPH QSQQAHVVQA TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ 

       250        260        270        280        290        300 
QQKSCIGAPP PVKSAAEQLE QWLTAGAKFL FHLRQLLKQL KEMSCLRYQG DMFAKGVDLR 

       310        320        330        340        350        360 
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL QEGSESLKAE 

       370        380        390        400        410        420 
VSVDRNSDLP GFRKFNILTS NQKTLTPEKG QRQGLIWDFG FLTLVEQRAV GAGKGNNKGP 

       430        440        450        460        470        480 
LAVTEELHVI SFVVEYTYQG LKMKLQTDTL PVVIISNMNQ LSFAWASILW FNMLSPNPKN 

       490        500        510        520        530        540 
QQFFCQAPKA PWSLLGPVLS WQFSSYVARG LDSEQLGMLR TKLFGKSCKM EDALLSWVDF 

       550        560        570        580        590        600 
CKRESPPGKI PFWTWLDKIL ELVHDHLKDL WKDGRIMGFV SRNQERRLLK KMLSGTFLLR 

       610        620        630        640        650        660 
FSETSEGGIT CSWVEHQDDH KVEIYSVQPY TKEVLQSLPL TEIIRHYQVL AEENIPENPL 

       670        680        690        700        710        720 
RFLYPRIPRD EAFGCYYQEK VNLEEQEEYL KHKLIVISNR QVDELQQPLE LKQDSESLEV 

       730        740        750        760        770        780 
NAELLLAHDQ ELPLMMQTGL VLGTELKVDP ILSTAPQVLL EPAPQVLLEP APQVLLEPAP 

       790        800        810        820        830        840 
QVLLEPAPQV LLEPAPQVLL EPAPQVLLEP APQVQLEPAP QVLLELAPQV LLEPAPQVLL 

       850        860        870        880        890        900 
ELAPQVQLEP AHLLQQPSES DLPEDLQQIS VEDLKKLSNP STEYITTNEN PMLAGESSGD 

       910        920 
ETSIPYHSHF DADGLLGWTL DTF 

« Hide

References

[1]"Molecular cloning and characterization of murine Stat2."
Paulson M.S., Mui A., Levy D.E.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"Identification of alternative splicing form of Stat2."
Sugiyama T., Nishio Y., Kishimoto T., Akira S.
FEBS Lett. 381:191-194(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 595-658.
[3]"Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity."
Tenoever B.R., Ng S.L., Chua M.A., McWhirter S.M., Garcia-Sastre A., Maniatis T.
Science 315:1274-1278(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ISGF3 COMPLEX.
[4]"BART is essential for nuclear retention of STAT3."
Muromoto R., Sekine Y., Imoto S., Ikeda O., Okayama T., Sato N., Matsuda T.
Int. Immunol. 20:395-403(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARL2BP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF088862 mRNA. Translation: AAD38329.1.
S81342 Genomic DNA. Translation: AAB36228.2.
S81342 Genomic DNA. Translation: AAB36230.1. Sequence problems.
S81342 Genomic DNA. Translation: AAB36231.1. Sequence problems.
PIRS63681.
S63682.
UniGeneMm.293120.
Mm.471333.

3D structure databases

ProteinModelPortalQ9WVL2.
SMRQ9WVL2. Positions 2-698, 855-908.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000100872.

PTM databases

PhosphoSiteQ9WVL2.

Proteomic databases

PaxDbQ9WVL2.
PRIDEQ9WVL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:103039. Stat2.

Phylogenomic databases

eggNOGNOG303257.
HOVERGENHBG055669.
InParanoidQ9WVL2.
PhylomeDBQ9WVL2.

Gene expression databases

GenevestigatorQ9WVL2.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9WVL2.
SOURCESearch...

Entry information

Entry nameSTAT2_MOUSE
AccessionPrimary (citable) accession number: Q9WVL2
Secondary accession number(s): Q64188, Q64189, Q64250
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot