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Protein

Signal transducer and activator of transcription 2

Gene

Stat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 2
Gene namesi
Name:Stat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103039. Stat2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocated into the nucleus upon activation by IFN-alpha/beta.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824141 – 923Signal transducer and activator of transcription 2Add BLAST923

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284PhosphoserineBy similarity1
Modified residuei689Phosphotyrosine; by JAKBy similarity1

Post-translational modificationi

Tyrosine phosphorylated in response to IFN-alpha.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WVL2.
MaxQBiQ9WVL2.
PaxDbiQ9WVL2.
PeptideAtlasiQ9WVL2.
PRIDEiQ9WVL2.

PTM databases

iPTMnetiQ9WVL2.
PhosphoSitePlusiQ9WVL2.

Expressioni

Tissue specificityi

Found in the brain, lung, heart, spleen, liver, kidney, muscle and the testis.

Interactioni

Subunit structurei

Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1 and IFNAR2. Interacts with ARL2BP.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082855.

Structurei

3D structure databases

ProteinModelPortaliQ9WVL2.
SMRiQ9WVL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini571 – 666SH2PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOVERGENiHBG055669.
InParanoidiQ9WVL2.
PhylomeDBiQ9WVL2.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWEMLQNL DSPFLDQLHQ VYSQSFLPMD FRQHLASWIE DQNWREAALE
60 70 80 90 100
SDDAKANMLY FSILDQLNQW DHYSSDPKSL LLQHNLRKFS RDIQPFPNGP
110 120 130 140 150
SQLAEMIFNL LLEEQRILIQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG
160 170 180 190 200
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAHVVQA
210 220 230 240 250
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP
260 270 280 290 300
PVKSAAEQLE QWLTAGAKFL FHLRQLLKQL KEMSCLRYQG DMFAKGVDLR
310 320 330 340 350
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL
360 370 380 390 400
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEKG QRQGLIWDFG
410 420 430 440 450
FLTLVEQRAV GAGKGNNKGP LAVTEELHVI SFVVEYTYQG LKMKLQTDTL
460 470 480 490 500
PVVIISNMNQ LSFAWASILW FNMLSPNPKN QQFFCQAPKA PWSLLGPVLS
510 520 530 540 550
WQFSSYVARG LDSEQLGMLR TKLFGKSCKM EDALLSWVDF CKRESPPGKI
560 570 580 590 600
PFWTWLDKIL ELVHDHLKDL WKDGRIMGFV SRNQERRLLK KMLSGTFLLR
610 620 630 640 650
FSETSEGGIT CSWVEHQDDH KVEIYSVQPY TKEVLQSLPL TEIIRHYQVL
660 670 680 690 700
AEENIPENPL RFLYPRIPRD EAFGCYYQEK VNLEEQEEYL KHKLIVISNR
710 720 730 740 750
QVDELQQPLE LKQDSESLEV NAELLLAHDQ ELPLMMQTGL VLGTELKVDP
760 770 780 790 800
ILSTAPQVLL EPAPQVLLEP APQVLLEPAP QVLLEPAPQV LLEPAPQVLL
810 820 830 840 850
EPAPQVLLEP APQVQLEPAP QVLLELAPQV LLEPAPQVLL ELAPQVQLEP
860 870 880 890 900
AHLLQQPSES DLPEDLQQIS VEDLKKLSNP STEYITTNEN PMLAGESSGD
910 920
ETSIPYHSHF DADGLLGWTL DTF
Length:923
Mass (Da):105,417
Last modified:November 1, 1999 - v1
Checksum:iD50BB54C535B0774
GO

Sequence cautioni

The sequence AAB36230 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAB36231 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti596T → A in AAB36228 (PubMed:8601453).Curated1
Sequence conflicti596T → A in AAB36231 (PubMed:8601453).Curated1
Sequence conflicti620H → D in AAB36228 (PubMed:8601453).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088862 mRNA. Translation: AAD38329.1.
S81342 Genomic DNA. Translation: AAB36228.2.
S81342 Genomic DNA. Translation: AAB36230.1. Sequence problems.
S81342 Genomic DNA. Translation: AAB36231.1. Sequence problems.
PIRiS63681.
S63682.
UniGeneiMm.293120.
Mm.471333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088862 mRNA. Translation: AAD38329.1.
S81342 Genomic DNA. Translation: AAB36228.2.
S81342 Genomic DNA. Translation: AAB36230.1. Sequence problems.
S81342 Genomic DNA. Translation: AAB36231.1. Sequence problems.
PIRiS63681.
S63682.
UniGeneiMm.293120.
Mm.471333.

3D structure databases

ProteinModelPortaliQ9WVL2.
SMRiQ9WVL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082855.

PTM databases

iPTMnetiQ9WVL2.
PhosphoSitePlusiQ9WVL2.

Proteomic databases

EPDiQ9WVL2.
MaxQBiQ9WVL2.
PaxDbiQ9WVL2.
PeptideAtlasiQ9WVL2.
PRIDEiQ9WVL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103039. Stat2.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
HOVERGENiHBG055669.
InParanoidiQ9WVL2.
PhylomeDBiQ9WVL2.

Miscellaneous databases

PROiQ9WVL2.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAT2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVL2
Secondary accession number(s): Q64188, Q64189, Q64250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.