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Protein

AP-4 complex subunit sigma-1

Gene

Ap4s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.By similarity

GO - Biological processi

  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432720 Lysosome Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-4 complex subunit sigma-1Curated
Alternative name(s):
AP-4 adaptor complex subunit sigma-1
Adaptor-related protein complex 4 subunit sigma-1
Sigma-1 subunit of AP-4
Sigma-4-adaptin
Short name:
Sigma4-adaptin
Gene namesi
Name:Ap4s1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1337065 Ap4s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938211 – 144AP-4 complex subunit sigma-1Add BLAST144

Proteomic databases

EPDiQ9WVL1
MaxQBiQ9WVL1
PaxDbiQ9WVL1
PeptideAtlasiQ9WVL1
PRIDEiQ9WVL1

PTM databases

PhosphoSitePlusiQ9WVL1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020955
CleanExiMM_AP4S1
ExpressionAtlasiQ9WVL1 baseline and differential
GenevisibleiQ9WVL1 MM

Interactioni

Subunit structurei

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021338

Structurei

3D structure databases

ProteinModelPortaliQ9WVL1
SMRiQ9WVL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0934 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00530000062839
HOGENOMiHOG000185227
HOVERGENiHBG050517
InParanoidiQ9WVL1
KOiK12403
OMAiENEMAVY
OrthoDBiEOG091G0OOD
PhylomeDBiQ9WVL1
TreeFamiTF331913

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKFFLMVNK QGQTRLSKYY EHVDINKRAL LETEVSKSCL SRSSEQCSFI
60 70 80 90 100
EYKDFKLIYR QYAALFVVVG VNDTENEMAI YEFIHNFVEV LDGYFSRVSE
110 120 130 140
LDIMFNLDKV HIILDEMVLN GCIVETNRAR ILAPLLILDK LSES
Length:144
Mass (Da):16,818
Last modified:November 1, 1999 - v1
Checksum:i8EC280834976B430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092093 mRNA Translation: AAD20447.1
AK005283 mRNA Translation: BAB23931.1
BC053339 mRNA Translation: AAH53339.1
CCDSiCCDS36441.1
RefSeqiNP_068356.1, NM_021710.4
XP_017170429.1, XM_017314940.1
XP_017170430.1, XM_017314941.1
UniGeneiMm.386749

Genome annotation databases

EnsembliENSMUST00000021338; ENSMUSP00000021338; ENSMUSG00000020955
GeneIDi11782
KEGGimmu:11782
UCSCiuc007nmv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAP4S1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health