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Q9WVK7

- HCDH_RAT

UniProt

Q9WVK7 - HCDH_RAT

Protein

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Gene

Hadh

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571NADBy similarity
    Binding sitei73 – 731Coenzyme ABy similarity
    Binding sitei80 – 801Coenzyme ABy similarity
    Binding sitei122 – 1221NADBy similarity
    Binding sitei127 – 1271NADBy similarity
    Binding sitei149 – 1491Coenzyme ABy similarity
    Binding sitei149 – 1491NADBy similarity
    Sitei170 – 1701Important for catalytic activityBy similarity
    Binding sitei173 – 1731NADBy similarity
    Binding sitei305 – 3051NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 396NADBy similarity

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: RGD
    2. NAD+ binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation Source: RGD
    2. negative regulation of insulin secretion Source: RGD
    3. response to activity Source: RGD
    4. response to drug Source: RGD
    5. response to hormone Source: RGD
    6. response to insulin Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    SABIO-RKQ9WVK7.
    UniPathwayiUPA00659.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (EC:1.1.1.35)
    Short name:
    HCDH
    Alternative name(s):
    Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
    Short-chain 3-hydroxyacyl-CoA dehydrogenase
    Gene namesi
    Name:Hadh
    Synonyms:Had, Hadhsc, Schad
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi69321. Hadh.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1212MitochondrionBy similarityAdd
    BLAST
    Chaini13 – 314302Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialPRO_0000007409Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751N6-acetyllysineBy similarity
    Modified residuei80 – 801N6-succinyllysineBy similarity
    Modified residuei81 – 811N6-acetyllysine; alternateBy similarity
    Modified residuei81 – 811N6-succinyllysine; alternateBy similarity
    Modified residuei87 – 871N6-acetyllysine; alternateBy similarity
    Modified residuei87 – 871N6-succinyllysine; alternateBy similarity
    Modified residuei125 – 1251N6-acetyllysineBy similarity
    Modified residuei136 – 1361N6-acetyllysine; alternateBy similarity
    Modified residuei136 – 1361N6-succinyllysine; alternateBy similarity
    Modified residuei179 – 1791N6-acetyllysineBy similarity
    Modified residuei185 – 1851N6-acetyllysine; alternateBy similarity
    Modified residuei185 – 1851N6-succinyllysine; alternateBy similarity
    Modified residuei192 – 1921N6-acetyllysine; alternateBy similarity
    Modified residuei192 – 1921N6-succinyllysine; alternateBy similarity
    Modified residuei202 – 2021N6-acetyllysine; alternateBy similarity
    Modified residuei202 – 2021N6-succinyllysine; alternateBy similarity
    Modified residuei206 – 2061N6-succinyllysineBy similarity
    Modified residuei212 – 2121N6-acetyllysine; alternateBy similarity
    Modified residuei212 – 2121N6-succinyllysine; alternateBy similarity
    Modified residuei241 – 2411N6-acetyllysine; alternateBy similarity
    Modified residuei241 – 2411N6-succinyllysine; alternateBy similarity
    Modified residuei312 – 3121N6-acetyllysine; alternateBy similarity
    Modified residuei312 – 3121N6-succinyllysine; alternateBy similarity

    Post-translational modificationi

    Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 By similarity.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9WVK7.
    PRIDEiQ9WVK7.

    PTM databases

    PhosphoSiteiQ9WVK7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVK7.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9WVK7. 1 interaction.
    STRINGi10116.ENSRNOP00000014658.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVK7.
    SMRiQ9WVK7. Positions 24-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1250.
    GeneTreeiENSGT00720000108673.
    HOGENOMiHOG000141498.
    HOVERGENiHBG000832.
    InParanoidiQ9WVK7.
    KOiK00022.
    OMAiVARKKFA.
    OrthoDBiEOG7K3TMS.
    PhylomeDBiQ9WVK7.
    TreeFamiTF300886.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000105. HCDH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00067. 3HCDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVK7-1 [UniParc]FASTAAdd to Basket

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    MAFVTRQFVR SMSSSSSASA AAKKILIKHV TVIGGGLMGA GIAQVAAATG    50
    HTVVLVDQTE DILAKSKKGI EESLKRMAKK KFTENPKAAD EFVEKTLSSL 100
    STSTDAASVV HSTDLVVEAI VENLKLKNEL FQRLDKFAAE HTIFASNTSS 150
    LQITNIANAT TRQDRFAGLH FFNPVPMMKL VEVIKTPMTS QKTFESLVDF 200
    CKTLGKHPVS CKDTPGFIVN RLLVPYLIEA IRLHERGDAS KEDIDTAMKL 250
    GAGYPMGPFE LLDYVGLDTT KFILDGWHEM DPENPLFQPS PSMNNLVAQK 300
    KLGKKTGEGF YKYK 314
    Length:314
    Mass (Da):34,448
    Last modified:November 1, 1999 - v1
    Checksum:iB36518766D6C3828
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095449 mRNA. Translation: AAD42162.1.
    PIRiS74114.
    RefSeqiNP_476534.1. NM_057186.2.
    UniGeneiRn.92789.

    Genome annotation databases

    EnsembliENSRNOT00000014658; ENSRNOP00000014658; ENSRNOG00000010697.
    GeneIDi113965.
    KEGGirno:113965.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095449 mRNA. Translation: AAD42162.1 .
    PIRi S74114.
    RefSeqi NP_476534.1. NM_057186.2.
    UniGenei Rn.92789.

    3D structure databases

    ProteinModelPortali Q9WVK7.
    SMRi Q9WVK7. Positions 24-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WVK7. 1 interaction.
    STRINGi 10116.ENSRNOP00000014658.

    Chemistry

    ChEMBLi CHEMBL2176821.

    PTM databases

    PhosphoSitei Q9WVK7.

    Proteomic databases

    PaxDbi Q9WVK7.
    PRIDEi Q9WVK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014658 ; ENSRNOP00000014658 ; ENSRNOG00000010697 .
    GeneIDi 113965.
    KEGGi rno:113965.

    Organism-specific databases

    CTDi 3033.
    RGDi 69321. Hadh.

    Phylogenomic databases

    eggNOGi COG1250.
    GeneTreei ENSGT00720000108673.
    HOGENOMi HOG000141498.
    HOVERGENi HBG000832.
    InParanoidi Q9WVK7.
    KOi K00022.
    OMAi VARKKFA.
    OrthoDBi EOG7K3TMS.
    PhylomeDBi Q9WVK7.
    TreeFami TF300886.

    Enzyme and pathway databases

    UniPathwayi UPA00659 .
    SABIO-RK Q9WVK7.

    Miscellaneous databases

    NextBioi 618105.
    PROi Q9WVK7.

    Gene expression databases

    Genevestigatori Q9WVK7.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000105. HCDH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00067. 3HCDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identity of heart and liver L-3-hydroxyacyl coenzyme A dehydrogenase."
      He X.-Y., Zhang G., Blecha F., Yang S.-Y.
      Biochim. Biophys. Acta 1437:119-123(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Heart muscle and Liver.

    Entry informationi

    Entry nameiHCDH_RAT
    AccessioniPrimary (citable) accession number: Q9WVK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3