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Q9WVK3

- PECR_RAT

UniProt

Q9WVK3 - PECR_RAT

Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

Pecr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 4725NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
    Short name:
    TERP
    Alternative name(s):
    PX-2,4-DCR1
    Peroxisomal 2,4-dienoyl-CoA reductase
    RLF98
    Gene namesi
    Name:Pecr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi70925. Pecr.

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: UniProtKB
    2. mitochondrion Source: UniProtKB
    3. peroxisomal membrane Source: UniProtKB
    4. peroxisome Source: HGNC

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 303302Peroxisomal trans-2-enoyl-CoA reductasePRO_0000054743Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei5 – 51N6-succinyllysineBy similarity
    Modified residuei32 – 321N6-succinyllysineBy similarity
    Modified residuei83 – 831N6-acetyllysineBy similarity
    Modified residuei97 – 971N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9WVK3.
    PRIDEiQ9WVK3.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and kidney. Weakly expressed in other tissues.1 Publication

    Inductioni

    Up-regulated by fasting.1 Publication

    Gene expression databases

    GenevestigatoriQ9WVK3.

    Interactioni

    Subunit structurei

    Interacts with PEX5, probably required to target it into peroxisomes.By similarity

    Protein-protein interaction databases

    IntActiQ9WVK3. 1 interaction.
    STRINGi10116.ENSRNOP00000021512.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVK3.
    SMRiQ9WVK3. Positions 7-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi301 – 3033Microbody targeting signalBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG105268.
    InParanoidiQ9WVK3.
    KOiK07753.
    OrthoDBiEOG7Q5HFK.
    PhylomeDBiQ9WVK3.
    TreeFamiTF315256.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSWKSGQSY LAAGLLQNQV AVVTGGATGI GKAISRELLH LGCNVVIASR    50
    KLDRLTAAVD ELRASQPPSS STQVTAIQCN IRKEEEVNNL VKSTLAKYGK 100
    INFLVNNAGG QFMAPAEDIT AKGWQAVIET NLTGTFYMCK AVYNSWMKDH 150
    GGSIVNIIVL LNNGFPTAAH SGAARAGVYN LTKTMALTWA SSGVRINCVA 200
    PGTIYSQTAV DNYGELGQTM FEMAFENIPA KRVGLPEEIS PLVCFLLSPA 250
    ASFITGQLIN VDGGQALYTR NFTIPDHDNW PVGAGDSSFI KKVKESLKKQ 300
    ARL 303
    Length:303
    Mass (Da):32,433
    Last modified:November 1, 1999 - v1
    Checksum:iF137C5517D655D7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF099742 mRNA. Translation: AAD38447.1.
    AF021854 mRNA. Translation: AAF14047.1.
    BC060546 mRNA. Translation: AAH60546.1.
    RefSeqiNP_579833.1. NM_133299.2.
    UniGeneiRn.163081.

    Genome annotation databases

    GeneIDi113956.
    KEGGirno:113956.
    UCSCiRGD:70925. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF099742 mRNA. Translation: AAD38447.1 .
    AF021854 mRNA. Translation: AAF14047.1 .
    BC060546 mRNA. Translation: AAH60546.1 .
    RefSeqi NP_579833.1. NM_133299.2.
    UniGenei Rn.163081.

    3D structure databases

    ProteinModelPortali Q9WVK3.
    SMRi Q9WVK3. Positions 7-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WVK3. 1 interaction.
    STRINGi 10116.ENSRNOP00000021512.

    Proteomic databases

    PaxDbi Q9WVK3.
    PRIDEi Q9WVK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 113956.
    KEGGi rno:113956.
    UCSCi RGD:70925. rat.

    Organism-specific databases

    CTDi 55825.
    RGDi 70925. Pecr.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG105268.
    InParanoidi Q9WVK3.
    KOi K07753.
    OrthoDBi EOG7Q5HFK.
    PhylomeDBi Q9WVK3.
    TreeFami TF315256.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    NextBioi 618083.
    PROi Q9WVK3.

    Gene expression databases

    Genevestigatori Q9WVK3.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a new fasting-inducible short-chain dehydrogenase/reductase from rat liver."
      Zhang J., Underwood L.E.
      Biochim. Biophys. Acta 1435:184-190(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Mitochondria and peroxisomes contain distinct isoforms of 2,4-dienoyl CoA reductase that interact with an Hsp70 member: isolation and characterisation of a cDNA encoding rat peroxisomal 2,4-dienoyl CoA reductase."
      Naylor D.J., Koivurantac K.T., Stines A.P., Hiltunen J.K., Hoogenraad N.J., Hoj P.B.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiPECR_RAT
    AccessioniPrimary (citable) accession number: Q9WVK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3