Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WVK3

- PECR_RAT

UniProt

Q9WVK3 - PECR_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

Pecr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 4725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Short name:
TERP
Alternative name(s):
PX-2,4-DCR1
Peroxisomal 2,4-dienoyl-CoA reductase
RLF98
Gene namesi
Name:Pecr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70925. Pecr.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. peroxisomal membrane Source: UniProtKB
  4. peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 303302Peroxisomal trans-2-enoyl-CoA reductasePRO_0000054743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei5 – 51N6-succinyllysineBy similarity
Modified residuei32 – 321N6-succinyllysineBy similarity
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei97 – 971N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9WVK3.
PRIDEiQ9WVK3.

Expressioni

Tissue specificityi

Highly expressed in liver and kidney. Weakly expressed in other tissues.1 Publication

Inductioni

Up-regulated by fasting.1 Publication

Gene expression databases

GenevestigatoriQ9WVK3.

Interactioni

Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.By similarity

Protein-protein interaction databases

IntActiQ9WVK3. 1 interaction.
STRINGi10116.ENSRNOP00000021512.

Structurei

3D structure databases

ProteinModelPortaliQ9WVK3.
SMRiQ9WVK3. Positions 7-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi301 – 3033Microbody targeting signalBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG105268.
InParanoidiQ9WVK3.
KOiK07753.
OrthoDBiEOG7Q5HFK.
PhylomeDBiQ9WVK3.
TreeFamiTF315256.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSWKSGQSY LAAGLLQNQV AVVTGGATGI GKAISRELLH LGCNVVIASR
60 70 80 90 100
KLDRLTAAVD ELRASQPPSS STQVTAIQCN IRKEEEVNNL VKSTLAKYGK
110 120 130 140 150
INFLVNNAGG QFMAPAEDIT AKGWQAVIET NLTGTFYMCK AVYNSWMKDH
160 170 180 190 200
GGSIVNIIVL LNNGFPTAAH SGAARAGVYN LTKTMALTWA SSGVRINCVA
210 220 230 240 250
PGTIYSQTAV DNYGELGQTM FEMAFENIPA KRVGLPEEIS PLVCFLLSPA
260 270 280 290 300
ASFITGQLIN VDGGQALYTR NFTIPDHDNW PVGAGDSSFI KKVKESLKKQ

ARL
Length:303
Mass (Da):32,433
Last modified:November 1, 1999 - v1
Checksum:iF137C5517D655D7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF099742 mRNA. Translation: AAD38447.1.
AF021854 mRNA. Translation: AAF14047.1.
BC060546 mRNA. Translation: AAH60546.1.
RefSeqiNP_579833.1. NM_133299.2.
UniGeneiRn.163081.

Genome annotation databases

GeneIDi113956.
KEGGirno:113956.
UCSCiRGD:70925. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF099742 mRNA. Translation: AAD38447.1 .
AF021854 mRNA. Translation: AAF14047.1 .
BC060546 mRNA. Translation: AAH60546.1 .
RefSeqi NP_579833.1. NM_133299.2.
UniGenei Rn.163081.

3D structure databases

ProteinModelPortali Q9WVK3.
SMRi Q9WVK3. Positions 7-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WVK3. 1 interaction.
STRINGi 10116.ENSRNOP00000021512.

Proteomic databases

PaxDbi Q9WVK3.
PRIDEi Q9WVK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 113956.
KEGGi rno:113956.
UCSCi RGD:70925. rat.

Organism-specific databases

CTDi 55825.
RGDi 70925. Pecr.

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG105268.
InParanoidi Q9WVK3.
KOi K07753.
OrthoDBi EOG7Q5HFK.
PhylomeDBi Q9WVK3.
TreeFami TF315256.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Miscellaneous databases

NextBioi 618083.
PROi Q9WVK3.

Gene expression databases

Genevestigatori Q9WVK3.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a new fasting-inducible short-chain dehydrogenase/reductase from rat liver."
    Zhang J., Underwood L.E.
    Biochim. Biophys. Acta 1435:184-190(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Mitochondria and peroxisomes contain distinct isoforms of 2,4-dienoyl CoA reductase that interact with an Hsp70 member: isolation and characterisation of a cDNA encoding rat peroxisomal 2,4-dienoyl CoA reductase."
    Naylor D.J., Koivurantac K.T., Stines A.P., Hiltunen J.K., Hoogenraad N.J., Hoj P.B.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiPECR_RAT
AccessioniPrimary (citable) accession number: Q9WVK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 1, 1999
Last modified: October 1, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3