Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9WVK3 (PECR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal trans-2-enoyl-CoA reductase

Short name=TERP
EC=1.3.1.38
Alternative name(s):
PX-2,4-DCR1
Peroxisomal 2,4-dienoyl-CoA reductase
RLF98
Gene names
Name:Pecr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Interacts with PEX5, probably required to target it into peroxisomes By similarity.

Subcellular location

Peroxisome By similarity.

Tissue specificity

Highly expressed in liver and kidney. Weakly expressed in other tissues. Ref.1

Induction

Up-regulated by fasting. Ref.1

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 303302Peroxisomal trans-2-enoyl-CoA reductase
PRO_0000054743

Regions

Nucleotide binding23 – 4725NADP By similarity
Motif301 – 3033Microbody targeting signal By similarity

Sites

Active site1791Proton acceptor By similarity

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue51N6-succinyllysine By similarity
Modified residue321N6-succinyllysine By similarity
Modified residue831N6-acetyllysine By similarity
Modified residue971N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVK3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F137C5517D655D7B

FASTA30332,433
        10         20         30         40         50         60 
MGSWKSGQSY LAAGLLQNQV AVVTGGATGI GKAISRELLH LGCNVVIASR KLDRLTAAVD 

        70         80         90        100        110        120 
ELRASQPPSS STQVTAIQCN IRKEEEVNNL VKSTLAKYGK INFLVNNAGG QFMAPAEDIT 

       130        140        150        160        170        180 
AKGWQAVIET NLTGTFYMCK AVYNSWMKDH GGSIVNIIVL LNNGFPTAAH SGAARAGVYN 

       190        200        210        220        230        240 
LTKTMALTWA SSGVRINCVA PGTIYSQTAV DNYGELGQTM FEMAFENIPA KRVGLPEEIS 

       250        260        270        280        290        300 
PLVCFLLSPA ASFITGQLIN VDGGQALYTR NFTIPDHDNW PVGAGDSSFI KKVKESLKKQ 


ARL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a new fasting-inducible short-chain dehydrogenase/reductase from rat liver."
Zhang J., Underwood L.E.
Biochim. Biophys. Acta 1435:184-190(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"Mitochondria and peroxisomes contain distinct isoforms of 2,4-dienoyl CoA reductase that interact with an Hsp70 member: isolation and characterisation of a cDNA encoding rat peroxisomal 2,4-dienoyl CoA reductase."
Naylor D.J., Koivurantac K.T., Stines A.P., Hiltunen J.K., Hoogenraad N.J., Hoj P.B.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF099742 mRNA. Translation: AAD38447.1.
AF021854 mRNA. Translation: AAF14047.1.
BC060546 mRNA. Translation: AAH60546.1.
RefSeqNP_579833.1. NM_133299.2.
UniGeneRn.163081.

3D structure databases

ProteinModelPortalQ9WVK3.
SMRQ9WVK3. Positions 7-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9WVK3. 1 interaction.
STRING10116.ENSRNOP00000021512.

Proteomic databases

PaxDbQ9WVK3.
PRIDEQ9WVK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID113956.
KEGGrno:113956.
UCSCRGD:70925. rat.

Organism-specific databases

CTD55825.
RGD70925. Pecr.

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG105268.
InParanoidQ9WVK3.
KOK07753.
OrthoDBEOG7Q5HFK.
PhylomeDBQ9WVK3.
TreeFamTF315256.

Enzyme and pathway databases

UniPathwayUPA00094.

Gene expression databases

GenevestigatorQ9WVK3.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Other

NextBio618083.
PROQ9WVK3.

Entry information

Entry namePECR_RAT
AccessionPrimary (citable) accession number: Q9WVK3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways