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Q9WVK0 (ATRAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene names
Name:Agtrap
Synonyms:Atrap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Ref.1 Ref.6

Subunit structure

Interacts with GNB2L1/RACK1 By similarity, and with the C-terminal region of AGTR1. Ref.1

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity. Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles By similarity.

Tissue specificity

Ubiquitous but more abundant in kidney, testis and heart. Ref.1

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Agtr1aP297545EBI-645964,EBI-765178

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Type-1 angiotensin II receptor-associated protein
PRO_0000064736

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 536Cytoplasmic Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 8612Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 16154Cytoplasmic Potential
Region110 – 12213Interaction with AGTR1 By similarity

Experimental info

Sequence conflict351F → L in BAB25074. Ref.2
Sequence conflict1571V → A in AAD25997. Ref.1
Sequence conflict1571V → A in CAQ51920. Ref.3
Sequence conflict1571V → A in AAH57196. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9WVK0 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 42094CBD40A2F97C

FASTA16117,525
        10         20         30         40         50         60 
MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS IDAIGMFLGG 

        70         80         90        100        110        120 
LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP FSCCLVYHMH RERGGELPLR 

       130        140        150        160 
PDFFGPSQEH SAYQTIDSSS DAAADPFASL ENKGQAVPRG Y 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor."
Daviet L., Lehtonen J.Y.A., Tamura K., Griese D.P., Horiuchi M., Dzau V.J.
J. Biol. Chem. 274:17058-17062(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AGTR1.
Strain: DBA/2J.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone, Bone marrow and Pancreas.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Mammary tumor.
[6]"The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy."
Tanaka Y., Tamura K., Koide Y., Sakai M., Tsurumi Y., Noda Y., Umemura M., Ishigami T., Uchino K., Kimura K., Horiuchi M., Umemura S.
FEBS Lett. 579:1579-1586(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSCCDS18930.1.
RefSeqNP_033772.2. NM_009642.4.
UniGeneMm.46247.

3D structure databases

ProteinModelPortalQ9WVK0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198032. 2 interactions.
IntActQ9WVK0. 2 interactions.
MINTMINT-1339593.
STRING10090.ENSMUSP00000030865.

PTM databases

PhosphoSiteQ9WVK0.

Proteomic databases

MaxQBQ9WVK0.
PaxDbQ9WVK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneID11610.
KEGGmmu:11610.
UCSCuc008vtz.1. mouse.

Organism-specific databases

CTD57085.
MGIMGI:1339977. Agtrap.

Phylogenomic databases

eggNOGNOG45277.
GeneTreeENSGT00390000017402.
HOGENOMHOG000034218.
HOVERGENHBG080881.
InParanoidB2KFL8.
OMAVHISIFY.
OrthoDBEOG7S4X7K.
TreeFamTF324477.

Gene expression databases

GenevestigatorQ9WVK0.

Family and domain databases

InterProIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279156.
PROQ9WVK0.
SOURCESearch...

Entry information

Entry nameATRAP_MOUSE
AccessionPrimary (citable) accession number: Q9WVK0
Secondary accession number(s): B2KFL8 expand/collapse secondary AC list , Q3U7X6, Q9D8Z8, Q9D940
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot