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Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.2 Publications

GO - Molecular functioni

  • angiotensin type II receptor activity Source: MGI

GO - Biological processi

  • regulation of blood pressure Source: MGI
  • response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1339977. Agtrap.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 53CytoplasmicSequence analysis6
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 86ExtracellularSequence analysisAdd BLAST12
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 161CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647361 – 161Type-1 angiotensin II receptor-associated proteinAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WVK0.
PaxDbiQ9WVK0.
PeptideAtlasiQ9WVK0.
PRIDEiQ9WVK0.

PTM databases

iPTMnetiQ9WVK0.
PhosphoSitePlusiQ9WVK0.

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, testis and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000029007.
GenevisibleiQ9WVK0. MM.

Interactioni

Subunit structurei

Interacts with RACK1 (By similarity), and with the C-terminal region of AGTR1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Agtr1aP297545EBI-645964,EBI-765178

Protein-protein interaction databases

BioGridi198032. 2 interactors.
IntActiQ9WVK0. 2 interactors.
MINTiMINT-1339593.
STRINGi10090.ENSMUSP00000030865.

Structurei

3D structure databases

ProteinModelPortaliQ9WVK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 122Interaction with AGTR1By similarityAdd BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYP8. Eukaryota.
ENOG4111P37. LUCA.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ9WVK0.
OMAiFAVPEGR.
OrthoDBiEOG091G0TSZ.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. AGTRAP.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS
60 70 80 90 100
IDAIGMFLGG LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP
110 120 130 140 150
FSCCLVYHMH RERGGELPLR PDFFGPSQEH SAYQTIDSSS DAAADPFASL
160
ENKGQAVPRG Y
Length:161
Mass (Da):17,525
Last modified:October 3, 2012 - v2
Checksum:i42094CBD40A2F97C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35F → L in BAB25074 (PubMed:16141072).Curated1
Sequence conflicti157V → A in AAD25997 (PubMed:10358057).Curated1
Sequence conflicti157V → A in CAQ51920 (PubMed:19468303).Curated1
Sequence conflicti157V → A in AAH57196 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSiCCDS18930.1.
RefSeqiNP_033772.2. NM_009642.5.
UniGeneiMm.46247.

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneIDi11610.
KEGGimmu:11610.
UCSCiuc008vtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSiCCDS18930.1.
RefSeqiNP_033772.2. NM_009642.5.
UniGeneiMm.46247.

3D structure databases

ProteinModelPortaliQ9WVK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198032. 2 interactors.
IntActiQ9WVK0. 2 interactors.
MINTiMINT-1339593.
STRINGi10090.ENSMUSP00000030865.

PTM databases

iPTMnetiQ9WVK0.
PhosphoSitePlusiQ9WVK0.

Proteomic databases

MaxQBiQ9WVK0.
PaxDbiQ9WVK0.
PeptideAtlasiQ9WVK0.
PRIDEiQ9WVK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneIDi11610.
KEGGimmu:11610.
UCSCiuc008vtz.1. mouse.

Organism-specific databases

CTDi57085.
MGIiMGI:1339977. Agtrap.

Phylogenomic databases

eggNOGiENOG410IYP8. Eukaryota.
ENOG4111P37. LUCA.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ9WVK0.
OMAiFAVPEGR.
OrthoDBiEOG091G0TSZ.
TreeFamiTF324477.

Miscellaneous databases

PROiQ9WVK0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029007.
GenevisibleiQ9WVK0. MM.

Family and domain databases

InterProiIPR009436. AGTRAP.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9WVK0
Secondary accession number(s): B2KFL8
, Q3U7X6, Q9D8Z8, Q9D940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.