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Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.2 Publications

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: MGI

GO - Biological processi

  1. angiotensin-activated signaling pathway Source: GOC
  2. regulation of blood pressure Source: MGI
  3. response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1339977. Agtrap.

Subcellular locationi

  1. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  2. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
  3. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity

  4. Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 536CytoplasmicSequence Analysis
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 8612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 16154CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: UniProtKB
  2. cytoplasm Source: MGI
  3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  5. Golgi membrane Source: UniProtKB-SubCell
  6. integral component of membrane Source: UniProtKB-KW
  7. intracellular membrane-bounded organelle Source: MGI
  8. nucleoplasm Source: MGI
  9. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Type-1 angiotensin II receptor-associated proteinPRO_0000064736Add
BLAST

Proteomic databases

MaxQBiQ9WVK0.
PaxDbiQ9WVK0.

PTM databases

PhosphoSiteiQ9WVK0.

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, testis and heart.1 Publication

Gene expression databases

GenevestigatoriQ9WVK0.

Interactioni

Subunit structurei

Interacts with GNB2L1/RACK1 (By similarity), and with the C-terminal region of AGTR1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Agtr1aP297545EBI-645964,EBI-765178

Protein-protein interaction databases

BioGridi198032. 2 interactions.
IntActiQ9WVK0. 2 interactions.
MINTiMINT-1339593.
STRINGi10090.ENSMUSP00000030865.

Structurei

3D structure databases

ProteinModelPortaliQ9WVK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12213Interaction with AGTR1By similarityAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ9WVK0.
OMAiWANFTIL.
OrthoDBiEOG7S4X7K.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS
60 70 80 90 100
IDAIGMFLGG LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP
110 120 130 140 150
FSCCLVYHMH RERGGELPLR PDFFGPSQEH SAYQTIDSSS DAAADPFASL
160
ENKGQAVPRG Y
Length:161
Mass (Da):17,525
Last modified:October 3, 2012 - v2
Checksum:i42094CBD40A2F97C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351F → L in BAB25074 (PubMed:16141072).Curated
Sequence conflicti157 – 1571V → A in AAD25997 (PubMed:10358057).Curated
Sequence conflicti157 – 1571V → A in CAQ51920 (PubMed:19468303).Curated
Sequence conflicti157 – 1571V → A in AAH57196 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSiCCDS18930.1.
RefSeqiNP_033772.2. NM_009642.4.
UniGeneiMm.46247.

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneIDi11610.
KEGGimmu:11610.
UCSCiuc008vtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSiCCDS18930.1.
RefSeqiNP_033772.2. NM_009642.4.
UniGeneiMm.46247.

3D structure databases

ProteinModelPortaliQ9WVK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198032. 2 interactions.
IntActiQ9WVK0. 2 interactions.
MINTiMINT-1339593.
STRINGi10090.ENSMUSP00000030865.

PTM databases

PhosphoSiteiQ9WVK0.

Proteomic databases

MaxQBiQ9WVK0.
PaxDbiQ9WVK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneIDi11610.
KEGGimmu:11610.
UCSCiuc008vtz.1. mouse.

Organism-specific databases

CTDi57085.
MGIiMGI:1339977. Agtrap.

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ9WVK0.
OMAiWANFTIL.
OrthoDBiEOG7S4X7K.
TreeFamiTF324477.

Miscellaneous databases

NextBioi279156.
PROiQ9WVK0.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9WVK0.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor."
    Daviet L., Lehtonen J.Y.A., Tamura K., Griese D.P., Horiuchi M., Dzau V.J.
    J. Biol. Chem. 274:17058-17062(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AGTR1.
    Strain: DBA/2J.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Bone marrow and Pancreas.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Mammary tumor.
  6. "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy."
    Tanaka Y., Tamura K., Koide Y., Sakai M., Tsurumi Y., Noda Y., Umemura M., Ishigami T., Uchino K., Kimura K., Horiuchi M., Umemura S.
    FEBS Lett. 579:1579-1586(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9WVK0
Secondary accession number(s): B2KFL8
, Q3U7X6, Q9D8Z8, Q9D940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: March 4, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.