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Q9WVK0

- ATRAP_MOUSE

UniProt

Q9WVK0 - ATRAP_MOUSE

Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.2 Publications

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. angiotensin-activated signaling pathway Source: GOC
    2. regulation of blood pressure Source: MGI
    3. response to hypoxia Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Alternative name(s):
    AT1 receptor-associated protein
    Gene namesi
    Name:Agtrap
    Synonyms:Atrap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1339977. Agtrap.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Type-1 angiotensin II receptor-associated proteinPRO_0000064736Add
    BLAST

    Proteomic databases

    MaxQBiQ9WVK0.
    PaxDbiQ9WVK0.

    PTM databases

    PhosphoSiteiQ9WVK0.

    Expressioni

    Tissue specificityi

    Ubiquitous but more abundant in kidney, testis and heart.1 Publication

    Gene expression databases

    GenevestigatoriQ9WVK0.

    Interactioni

    Subunit structurei

    Interacts with GNB2L1/RACK1 By similarity, and with the C-terminal region of AGTR1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Agtr1aP297545EBI-645964,EBI-765178

    Protein-protein interaction databases

    BioGridi198032. 2 interactions.
    IntActiQ9WVK0. 2 interactions.
    MINTiMINT-1339593.
    STRINGi10090.ENSMUSP00000030865.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 536CytoplasmicSequence Analysis
    Topological domaini75 – 8612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 16154CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12213Interaction with AGTR1By similarityAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45277.
    GeneTreeiENSGT00390000017402.
    HOGENOMiHOG000034218.
    HOVERGENiHBG080881.
    InParanoidiB2KFL8.
    OMAiVHISIFY.
    OrthoDBiEOG7S4X7K.
    TreeFamiTF324477.

    Family and domain databases

    InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view]
    PfamiPF06396. AGTRAP. 1 hit.
    [Graphical view]
    ProDomiPD357679. PD357679. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00805. AGTRAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS    50
    IDAIGMFLGG LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP 100
    FSCCLVYHMH RERGGELPLR PDFFGPSQEH SAYQTIDSSS DAAADPFASL 150
    ENKGQAVPRG Y 161
    Length:161
    Mass (Da):17,525
    Last modified:October 3, 2012 - v2
    Checksum:i42094CBD40A2F97C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351F → L in BAB25074. (PubMed:16141072)Curated
    Sequence conflicti157 – 1571V → A in AAD25997. (PubMed:10358057)Curated
    Sequence conflicti157 – 1571V → A in CAQ51920. (PubMed:19468303)Curated
    Sequence conflicti157 – 1571V → A in AAH57196. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102548 mRNA. Translation: AAD25997.1.
    AK007383 mRNA. Translation: BAB25001.1.
    AK007502 mRNA. Translation: BAB25074.1.
    AK036598 mRNA. Translation: BAC29501.1.
    AK152467 mRNA. Translation: BAE31243.1.
    CU207376 Genomic DNA. Translation: CAQ51920.1.
    AL606929 Genomic DNA. Translation: CAM14899.1.
    CH466594 Genomic DNA. Translation: EDL14800.1.
    BC046820 mRNA. Translation: AAH46820.1.
    BC057196 mRNA. Translation: AAH57196.1.
    CCDSiCCDS18930.1.
    RefSeqiNP_033772.2. NM_009642.4.
    UniGeneiMm.46247.

    Genome annotation databases

    EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
    GeneIDi11610.
    KEGGimmu:11610.
    UCSCiuc008vtz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF102548 mRNA. Translation: AAD25997.1 .
    AK007383 mRNA. Translation: BAB25001.1 .
    AK007502 mRNA. Translation: BAB25074.1 .
    AK036598 mRNA. Translation: BAC29501.1 .
    AK152467 mRNA. Translation: BAE31243.1 .
    CU207376 Genomic DNA. Translation: CAQ51920.1 .
    AL606929 Genomic DNA. Translation: CAM14899.1 .
    CH466594 Genomic DNA. Translation: EDL14800.1 .
    BC046820 mRNA. Translation: AAH46820.1 .
    BC057196 mRNA. Translation: AAH57196.1 .
    CCDSi CCDS18930.1.
    RefSeqi NP_033772.2. NM_009642.4.
    UniGenei Mm.46247.

    3D structure databases

    ProteinModelPortali Q9WVK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198032. 2 interactions.
    IntActi Q9WVK0. 2 interactions.
    MINTi MINT-1339593.
    STRINGi 10090.ENSMUSP00000030865.

    PTM databases

    PhosphoSitei Q9WVK0.

    Proteomic databases

    MaxQBi Q9WVK0.
    PaxDbi Q9WVK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030865 ; ENSMUSP00000030865 ; ENSMUSG00000029007 .
    GeneIDi 11610.
    KEGGi mmu:11610.
    UCSCi uc008vtz.1. mouse.

    Organism-specific databases

    CTDi 57085.
    MGIi MGI:1339977. Agtrap.

    Phylogenomic databases

    eggNOGi NOG45277.
    GeneTreei ENSGT00390000017402.
    HOGENOMi HOG000034218.
    HOVERGENi HBG080881.
    InParanoidi B2KFL8.
    OMAi VHISIFY.
    OrthoDBi EOG7S4X7K.
    TreeFami TF324477.

    Miscellaneous databases

    NextBioi 279156.
    PROi Q9WVK0.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9WVK0.

    Family and domain databases

    InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view ]
    Pfami PF06396. AGTRAP. 1 hit.
    [Graphical view ]
    ProDomi PD357679. PD357679. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00805. AGTRAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor."
      Daviet L., Lehtonen J.Y.A., Tamura K., Griese D.P., Horiuchi M., Dzau V.J.
      J. Biol. Chem. 274:17058-17062(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AGTR1.
      Strain: DBA/2J.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone, Bone marrow and Pancreas.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Mammary tumor.
    6. "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy."
      Tanaka Y., Tamura K., Koide Y., Sakai M., Tsurumi Y., Noda Y., Umemura M., Ishigami T., Uchino K., Kimura K., Horiuchi M., Umemura S.
      FEBS Lett. 579:1579-1586(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATRAP_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVK0
    Secondary accession number(s): B2KFL8
    , Q3U7X6, Q9D8Z8, Q9D940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3