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Q9WVK0

- ATRAP_MOUSE

UniProt

Q9WVK0 - ATRAP_MOUSE

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Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.2 Publications

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: MGI

GO - Biological processi

  1. angiotensin-activated signaling pathway Source: GOC
  2. regulation of blood pressure Source: MGI
  3. response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1339977. Agtrap.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.By similarity

GO - Cellular componenti

  1. cell cortex Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. Golgi apparatus Source: UniProtKB-KW
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Type-1 angiotensin II receptor-associated proteinPRO_0000064736Add
BLAST

Proteomic databases

MaxQBiQ9WVK0.
PaxDbiQ9WVK0.

PTM databases

PhosphoSiteiQ9WVK0.

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, testis and heart.1 Publication

Gene expression databases

GenevestigatoriQ9WVK0.

Interactioni

Subunit structurei

Interacts with GNB2L1/RACK1 (By similarity), and with the C-terminal region of AGTR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Agtr1aP297545EBI-645964,EBI-765178

Protein-protein interaction databases

BioGridi198032. 2 interactions.
IntActiQ9WVK0. 2 interactions.
MINTiMINT-1339593.
STRINGi10090.ENSMUSP00000030865.

Structurei

3D structure databases

ProteinModelPortaliQ9WVK0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 536CytoplasmicSequence Analysis
Topological domaini75 – 8612ExtracellularSequence AnalysisAdd
BLAST
Topological domaini108 – 16154CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12213Interaction with AGTR1By similarityAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ9WVK0.
OMAiVHISIFY.
OrthoDBiEOG7S4X7K.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS
60 70 80 90 100
IDAIGMFLGG LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP
110 120 130 140 150
FSCCLVYHMH RERGGELPLR PDFFGPSQEH SAYQTIDSSS DAAADPFASL
160
ENKGQAVPRG Y
Length:161
Mass (Da):17,525
Last modified:October 3, 2012 - v2
Checksum:i42094CBD40A2F97C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351F → L in BAB25074. (PubMed:16141072)Curated
Sequence conflicti157 – 1571V → A in AAD25997. (PubMed:10358057)Curated
Sequence conflicti157 – 1571V → A in CAQ51920. (PubMed:19468303)Curated
Sequence conflicti157 – 1571V → A in AAH57196. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102548 mRNA. Translation: AAD25997.1.
AK007383 mRNA. Translation: BAB25001.1.
AK007502 mRNA. Translation: BAB25074.1.
AK036598 mRNA. Translation: BAC29501.1.
AK152467 mRNA. Translation: BAE31243.1.
CU207376 Genomic DNA. Translation: CAQ51920.1.
AL606929 Genomic DNA. Translation: CAM14899.1.
CH466594 Genomic DNA. Translation: EDL14800.1.
BC046820 mRNA. Translation: AAH46820.1.
BC057196 mRNA. Translation: AAH57196.1.
CCDSiCCDS18930.1.
RefSeqiNP_033772.2. NM_009642.4.
UniGeneiMm.46247.

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007.
GeneIDi11610.
KEGGimmu:11610.
UCSCiuc008vtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF102548 mRNA. Translation: AAD25997.1 .
AK007383 mRNA. Translation: BAB25001.1 .
AK007502 mRNA. Translation: BAB25074.1 .
AK036598 mRNA. Translation: BAC29501.1 .
AK152467 mRNA. Translation: BAE31243.1 .
CU207376 Genomic DNA. Translation: CAQ51920.1 .
AL606929 Genomic DNA. Translation: CAM14899.1 .
CH466594 Genomic DNA. Translation: EDL14800.1 .
BC046820 mRNA. Translation: AAH46820.1 .
BC057196 mRNA. Translation: AAH57196.1 .
CCDSi CCDS18930.1.
RefSeqi NP_033772.2. NM_009642.4.
UniGenei Mm.46247.

3D structure databases

ProteinModelPortali Q9WVK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198032. 2 interactions.
IntActi Q9WVK0. 2 interactions.
MINTi MINT-1339593.
STRINGi 10090.ENSMUSP00000030865.

PTM databases

PhosphoSitei Q9WVK0.

Proteomic databases

MaxQBi Q9WVK0.
PaxDbi Q9WVK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030865 ; ENSMUSP00000030865 ; ENSMUSG00000029007 .
GeneIDi 11610.
KEGGi mmu:11610.
UCSCi uc008vtz.1. mouse.

Organism-specific databases

CTDi 57085.
MGIi MGI:1339977. Agtrap.

Phylogenomic databases

eggNOGi NOG45277.
GeneTreei ENSGT00390000017402.
HOGENOMi HOG000034218.
HOVERGENi HBG080881.
InParanoidi Q9WVK0.
OMAi VHISIFY.
OrthoDBi EOG7S4X7K.
TreeFami TF324477.

Miscellaneous databases

NextBioi 279156.
PROi Q9WVK0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9WVK0.

Family and domain databases

InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view ]
Pfami PF06396. AGTRAP. 1 hit.
[Graphical view ]
ProDomi PD357679. PD357679. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00805. AGTRAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor."
    Daviet L., Lehtonen J.Y.A., Tamura K., Griese D.P., Horiuchi M., Dzau V.J.
    J. Biol. Chem. 274:17058-17062(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AGTR1.
    Strain: DBA/2J.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Bone marrow and Pancreas.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Mammary tumor.
  6. "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy."
    Tanaka Y., Tamura K., Koide Y., Sakai M., Tsurumi Y., Noda Y., Umemura M., Ishigami T., Uchino K., Kimura K., Horiuchi M., Umemura S.
    FEBS Lett. 579:1579-1586(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9WVK0
Secondary accession number(s): B2KFL8
, Q3U7X6, Q9D8Z8, Q9D940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3