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Q9WVJ9

- FBLN4_MOUSE

UniProt

Q9WVJ9 - FBLN4_MOUSE

Protein

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: InterPro

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF-containing fibulin-like extracellular matrix protein 2
    Alternative name(s):
    Fibulin-4
    Short name:
    FIBL-4
    Mutant p53-binding protein 1
    Gene namesi
    Name:Efemp2
    Synonyms:Fbln4, Mbp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1891209. Efemp2.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro
    2. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 443418EGF-containing fibulin-like extracellular matrix protein 2PRO_0000007576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 121PROSITE-ProRule annotation
    Disulfide bondi65 ↔ 80PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi127 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi134 ↔ 149PROSITE-ProRule annotation
    Disulfide bondi151 ↔ 162PROSITE-ProRule annotation
    Disulfide bondi168 ↔ 177PROSITE-ProRule annotation
    Disulfide bondi173 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi188 ↔ 201PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi207 ↔ 217PROSITE-ProRule annotation
    Disulfide bondi213 ↔ 226PROSITE-ProRule annotation
    Disulfide bondi228 ↔ 241PROSITE-ProRule annotation
    Disulfide bondi247 ↔ 258PROSITE-ProRule annotation
    Disulfide bondi254 ↔ 267PROSITE-ProRule annotation
    Disulfide bondi269 ↔ 281PROSITE-ProRule annotation
    Disulfide bondi287 ↔ 300PROSITE-ProRule annotation
    Disulfide bondi294 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi315 ↔ 327PROSITE-ProRule annotation
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WVJ9.

    PTM databases

    PhosphoSiteiQ9WVJ9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WVJ9.
    BgeeiQ9WVJ9.
    GenevestigatoriQ9WVJ9.

    Interactioni

    Subunit structurei

    Binds preferentially to p53 mutants.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVJ9.
    SMRiQ9WVJ9. Positions 54-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 8146EGF-like 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini123 – 16341EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 20239EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 24240EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 28240EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 32846EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the fibulin family.Curated
    Contains 6 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG254862.
    GeneTreeiENSGT00740000115418.
    HOGENOMiHOG000234337.
    HOVERGENiHBG051560.
    InParanoidiQ9WVJ9.
    PhylomeDBiQ9WVJ9.

    Family and domain databases

    InterProiIPR026823. cEGF.
    IPR026824. Efemp2.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001491. Thrombomodulin.
    [Graphical view]
    PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
    PfamiPF12662. cEGF. 2 hits.
    PF07645. EGF_CA. 3 hits.
    [Graphical view]
    PRINTSiPR00907. THRMBOMODULN.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVJ9-1 [UniParc]FASTAAdd to Basket

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    MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ    50
    HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA 100
    AHAQQPNPCP QGYEPDEQES CVDVDECTQA LHDCRPSQDC HNLPGSYQCT 150
    CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS 200
    CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS 250
    SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC 300
    VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI 350
    TSERSVPADV FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV 400
    LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF 443
    Length:443
    Mass (Da):49,425
    Last modified:November 1, 1999 - v1
    Checksum:i4969C0328A23DD88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104223 mRNA. Translation: AAD45219.1.
    BC012269 mRNA. Translation: AAH12269.1.
    CCDSiCCDS29466.1.
    RefSeqiNP_067449.3. NM_021474.3.
    XP_006531871.1. XM_006531808.1.
    UniGeneiMm.276367.

    Genome annotation databases

    EnsembliENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909.
    GeneIDi58859.
    KEGGimmu:58859.
    UCSCiuc008gdl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104223 mRNA. Translation: AAD45219.1 .
    BC012269 mRNA. Translation: AAH12269.1 .
    CCDSi CCDS29466.1.
    RefSeqi NP_067449.3. NM_021474.3.
    XP_006531871.1. XM_006531808.1.
    UniGenei Mm.276367.

    3D structure databases

    ProteinModelPortali Q9WVJ9.
    SMRi Q9WVJ9. Positions 54-322.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WVJ9.

    Proteomic databases

    PRIDEi Q9WVJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000165485 ; ENSMUSP00000133016 ; ENSMUSG00000024909 .
    GeneIDi 58859.
    KEGGi mmu:58859.
    UCSCi uc008gdl.2. mouse.

    Organism-specific databases

    CTDi 30008.
    MGIi MGI:1891209. Efemp2.

    Phylogenomic databases

    eggNOGi NOG254862.
    GeneTreei ENSGT00740000115418.
    HOGENOMi HOG000234337.
    HOVERGENi HBG051560.
    InParanoidi Q9WVJ9.
    PhylomeDBi Q9WVJ9.

    Enzyme and pathway databases

    Reactomei REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    ChiTaRSi EFEMP2. mouse.
    NextBioi 314408.
    PROi Q9WVJ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WVJ9.
    Bgeei Q9WVJ9.
    Genevestigatori Q9WVJ9.

    Family and domain databases

    InterProi IPR026823. cEGF.
    IPR026824. Efemp2.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001491. Thrombomodulin.
    [Graphical view ]
    PANTHERi PTHR24048:SF2. PTHR24048:SF2. 1 hit.
    Pfami PF12662. cEGF. 2 hits.
    PF07645. EGF_CA. 3 hits.
    [Graphical view ]
    PRINTSi PR00907. THRMBOMODULN.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MBP1: a novel mutant p53-specific protein partner with oncogenic properties."
      Gallagher W.M., Argentini M., Sierra V., Bracco L., Debussche L., Conseiller E.
      Oncogene 18:3608-3616(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiFBLN4_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3