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Q9WVJ9 (FBLN4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
EGF-containing fibulin-like extracellular matrix protein 2
Alternative name(s):
Fibulin-4
Short name=FIBL-4
Mutant p53-binding protein 1
Gene names
Name:Efemp2
Synonyms:Fbln4, Mbp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Binds preferentially to p53 mutants.

Subcellular location

Secreted.

Sequence similarities

Belongs to the fibulin family.

Contains 6 EGF-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 443418EGF-containing fibulin-like extracellular matrix protein 2
PRO_0000007576

Regions

Domain36 – 8146EGF-like 1; atypical
Domain123 – 16341EGF-like 2; calcium-binding Potential
Domain164 – 20239EGF-like 3; calcium-binding Potential
Domain203 – 24240EGF-like 4; calcium-binding Potential
Domain243 – 28240EGF-like 5; calcium-binding Potential
Domain283 – 32846EGF-like 6; calcium-binding Potential

Amino acid modifications

Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 121 By similarity
Disulfide bond65 ↔ 80 By similarity
Disulfide bond71 ↔ 109 By similarity
Disulfide bond127 ↔ 140 By similarity
Disulfide bond134 ↔ 149 By similarity
Disulfide bond151 ↔ 162 By similarity
Disulfide bond168 ↔ 177 By similarity
Disulfide bond173 ↔ 186 By similarity
Disulfide bond188 ↔ 201 By similarity
Disulfide bond207 ↔ 217 By similarity
Disulfide bond213 ↔ 226 By similarity
Disulfide bond228 ↔ 241 By similarity
Disulfide bond247 ↔ 258 By similarity
Disulfide bond254 ↔ 267 By similarity
Disulfide bond269 ↔ 281 By similarity
Disulfide bond287 ↔ 300 By similarity
Disulfide bond294 ↔ 309 By similarity
Disulfide bond315 ↔ 327 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVJ9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4969C0328A23DD88

FASTA44349,425
        10         20         30         40         50         60 
MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ HCRDVNECLT 

        70         80         90        100        110        120 
IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA AHAQQPNPCP QGYEPDEQES 

       130        140        150        160        170        180 
CVDVDECTQA LHDCRPSQDC HNLPGSYQCT CPDGYRKIGP ECVDIDECRY RYCQHRCVNL 

       190        200        210        220        230        240 
PGSFRCQCEP GFQLGPNNRS CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS 

       250        260        270        280        290        300 
CSDIDECGYS SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC 

       310        320        330        340        350        360 
VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI TSERSVPADV 

       370        380        390        400        410        420 
FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV LARPVTGPRE YVLDLEMVTM 

       430        440 
NSLMSYRASS VLRLTVFVGA YTF

« Hide

References

« Hide 'large scale' references
[1]"MBP1: a novel mutant p53-specific protein partner with oncogenic properties."
Gallagher W.M., Argentini M., Sierra V., Bracco L., Debussche L., Conseiller E.
Oncogene 18:3608-3616(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF104223 mRNA. Translation: AAD45219.1.
BC012269 mRNA. Translation: AAH12269.1.
IPIIPI00126055.
RefSeqNP_067449.3. NM_021474.3.
UniGeneMm.276367.

3D structure databases

ProteinModelPortalQ9WVJ9.
SMRQ9WVJ9. Positions 54-323.
ModBaseSearch...

PTM databases

PhosphoSiteQ9WVJ9.

Proteomic databases

PRIDEQ9WVJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909.
GeneID58859.
KEGGmmu:58859.

Organism-specific databases

CTD30008.
MGIMGI:1891209. Efemp2.

Phylogenomic databases

eggNOGNOG254862.
GeneTreeENSGT00700000104291.
HOGENOMHOG000234337.
HOVERGENHBG051560.
InParanoidQ9WVJ9.
OrthoDBEOG4K6G47.

Gene expression databases

ArrayExpressQ9WVJ9.
BgeeQ9WVJ9.
GenevestigatorQ9WVJ9.
GermOnlineENSMUSG00000024909. Mus musculus.

Family and domain databases

InterProIPR026823. cEGF.
IPR026824. Efemp1/Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001491. Thrombomodulin.
[Graphical view]
PANTHERPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
[Graphical view]
PRINTSPR00907. THRMBOMODULN.
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 4 hits.
[Graphical view]
PROSITEPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. False negative.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEFEMP2. mouse.
NextBio314408.
SOURCESearch...

Entry information

Entry nameFBLN4_MOUSE
AccessionPrimary (citable) accession number: Q9WVJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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