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Protein

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-containing fibulin-like extracellular matrix protein 2
Alternative name(s):
Fibulin-4
Short name:
FIBL-4
Mutant p53-binding protein 1
Gene namesi
Name:Efemp2
Synonyms:Fbln4, Mbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1891209 Efemp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000757626 – 443EGF-containing fibulin-like extracellular matrix protein 2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 121PROSITE-ProRule annotation
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation
Disulfide bondi71 ↔ 109PROSITE-ProRule annotation
Disulfide bondi127 ↔ 140PROSITE-ProRule annotation
Disulfide bondi134 ↔ 149PROSITE-ProRule annotation
Disulfide bondi151 ↔ 162PROSITE-ProRule annotation
Disulfide bondi168 ↔ 177PROSITE-ProRule annotation
Disulfide bondi173 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 201PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi207 ↔ 217PROSITE-ProRule annotation
Disulfide bondi213 ↔ 226PROSITE-ProRule annotation
Disulfide bondi228 ↔ 241PROSITE-ProRule annotation
Disulfide bondi247 ↔ 258PROSITE-ProRule annotation
Disulfide bondi254 ↔ 267PROSITE-ProRule annotation
Disulfide bondi269 ↔ 281PROSITE-ProRule annotation
Disulfide bondi287 ↔ 300PROSITE-ProRule annotation
Disulfide bondi294 ↔ 309PROSITE-ProRule annotation
Disulfide bondi315 ↔ 327PROSITE-ProRule annotation
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WVJ9
PaxDbiQ9WVJ9
PRIDEiQ9WVJ9

PTM databases

PhosphoSitePlusiQ9WVJ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000024909
ExpressionAtlasiQ9WVJ9 baseline and differential
GenevisibleiQ9WVJ9 MM

Interactioni

Subunit structurei

Binds preferentially to p53 mutants (PubMed:10380882). Interacts with FBN1 (via N-terminal domain) (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064719

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ9
SMRiQ9WVJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 81EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Domaini123 – 163EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini164 – 202EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini203 – 242EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini243 – 282EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini283 – 328EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR6U Eukaryota
ENOG410ZNNG LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000234337
HOVERGENiHBG051560
InParanoidiQ9WVJ9
KOiK19866
PhylomeDBiQ9WVJ9

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR026824 Efemp2
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF3 PTHR44074:SF3, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ
60 70 80 90 100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA
110 120 130 140 150
AHAQQPNPCP QGYEPDEQES CVDVDECTQA LHDCRPSQDC HNLPGSYQCT
160 170 180 190 200
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS
210 220 230 240 250
CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS
260 270 280 290 300
SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC
310 320 330 340 350
VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI
360 370 380 390 400
TSERSVPADV FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV
410 420 430 440
LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF
Length:443
Mass (Da):49,425
Last modified:November 1, 1999 - v1
Checksum:i4969C0328A23DD88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104223 mRNA Translation: AAD45219.1
BC012269 mRNA Translation: AAH12269.1
CCDSiCCDS29466.1
RefSeqiNP_067449.3, NM_021474.3
XP_006531871.1, XM_006531808.1
UniGeneiMm.276367

Genome annotation databases

EnsembliENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909
GeneIDi58859
KEGGimmu:58859
UCSCiuc008gdl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFBLN4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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