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Q9WVJ9

- FBLN4_MOUSE

UniProt

Q9WVJ9 - FBLN4_MOUSE

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Protein

EGF-containing fibulin-like extracellular matrix protein 2

Gene
Efemp2, Fbln4, Mbp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_198998. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF-containing fibulin-like extracellular matrix protein 2
Alternative name(s):
Fibulin-4
Short name:
FIBL-4
Mutant p53-binding protein 1
Gene namesi
Name:Efemp2
Synonyms:Fbln4, Mbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
  2. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 443418EGF-containing fibulin-like extracellular matrix protein 2PRO_0000007576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 121 By similarity
Disulfide bondi65 ↔ 80 By similarity
Disulfide bondi71 ↔ 109 By similarity
Disulfide bondi127 ↔ 140 By similarity
Disulfide bondi134 ↔ 149 By similarity
Disulfide bondi151 ↔ 162 By similarity
Disulfide bondi168 ↔ 177 By similarity
Disulfide bondi173 ↔ 186 By similarity
Disulfide bondi188 ↔ 201 By similarity
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi207 ↔ 217 By similarity
Disulfide bondi213 ↔ 226 By similarity
Disulfide bondi228 ↔ 241 By similarity
Disulfide bondi247 ↔ 258 By similarity
Disulfide bondi254 ↔ 267 By similarity
Disulfide bondi269 ↔ 281 By similarity
Disulfide bondi287 ↔ 300 By similarity
Disulfide bondi294 ↔ 309 By similarity
Disulfide bondi315 ↔ 327 By similarity
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WVJ9.

PTM databases

PhosphoSiteiQ9WVJ9.

Expressioni

Gene expression databases

ArrayExpressiQ9WVJ9.
BgeeiQ9WVJ9.
GenevestigatoriQ9WVJ9.

Interactioni

Subunit structurei

Binds preferentially to p53 mutants.

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ9.
SMRiQ9WVJ9. Positions 54-322.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 8146EGF-like 1; atypicalAdd
BLAST
Domaini123 – 16341EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini164 – 20239EGF-like 3; calcium-binding Reviewed predictionAdd
BLAST
Domaini203 – 24240EGF-like 4; calcium-binding Reviewed predictionAdd
BLAST
Domaini243 – 28240EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini283 – 32846EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the fibulin family.
Contains 6 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG254862.
GeneTreeiENSGT00740000115418.
HOGENOMiHOG000234337.
HOVERGENiHBG051560.
InParanoidiQ9WVJ9.
PhylomeDBiQ9WVJ9.

Family and domain databases

InterProiIPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001491. Thrombomodulin.
[Graphical view]
PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
[Graphical view]
PRINTSiPR00907. THRMBOMODULN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ    50
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA 100
AHAQQPNPCP QGYEPDEQES CVDVDECTQA LHDCRPSQDC HNLPGSYQCT 150
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS 200
CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS 250
SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC 300
VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI 350
TSERSVPADV FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV 400
LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF 443
Length:443
Mass (Da):49,425
Last modified:November 1, 1999 - v1
Checksum:i4969C0328A23DD88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104223 mRNA. Translation: AAD45219.1.
BC012269 mRNA. Translation: AAH12269.1.
CCDSiCCDS29466.1.
RefSeqiNP_067449.3. NM_021474.3.
XP_006531871.1. XM_006531808.1.
UniGeneiMm.276367.

Genome annotation databases

EnsembliENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909.
GeneIDi58859.
KEGGimmu:58859.
UCSCiuc008gdl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104223 mRNA. Translation: AAD45219.1 .
BC012269 mRNA. Translation: AAH12269.1 .
CCDSi CCDS29466.1.
RefSeqi NP_067449.3. NM_021474.3.
XP_006531871.1. XM_006531808.1.
UniGenei Mm.276367.

3D structure databases

ProteinModelPortali Q9WVJ9.
SMRi Q9WVJ9. Positions 54-322.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVJ9.

Proteomic databases

PRIDEi Q9WVJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000165485 ; ENSMUSP00000133016 ; ENSMUSG00000024909 .
GeneIDi 58859.
KEGGi mmu:58859.
UCSCi uc008gdl.2. mouse.

Organism-specific databases

CTDi 30008.
MGIi MGI:1891209. Efemp2.

Phylogenomic databases

eggNOGi NOG254862.
GeneTreei ENSGT00740000115418.
HOGENOMi HOG000234337.
HOVERGENi HBG051560.
InParanoidi Q9WVJ9.
PhylomeDBi Q9WVJ9.

Enzyme and pathway databases

Reactomei REACT_198998. Molecules associated with elastic fibres.

Miscellaneous databases

ChiTaRSi EFEMP2. mouse.
NextBioi 314408.
PROi Q9WVJ9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WVJ9.
Bgeei Q9WVJ9.
Genevestigatori Q9WVJ9.

Family and domain databases

InterProi IPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001491. Thrombomodulin.
[Graphical view ]
PANTHERi PTHR24048:SF2. PTHR24048:SF2. 1 hit.
Pfami PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
[Graphical view ]
PRINTSi PR00907. THRMBOMODULN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 4 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MBP1: a novel mutant p53-specific protein partner with oncogenic properties."
    Gallagher W.M., Argentini M., Sierra V., Bracco L., Debussche L., Conseiller E.
    Oncogene 18:3608-3616(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiFBLN4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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