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Q9WVJ6 (Q9WVJ6_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Tissue-type transglutaminase EMBL AAD42046.1

Transglutaminase 2, C polypeptide, isoform CRA_a EMBL EDL96658.1
Gene names
Name:Tgm2 Ensembl ENSRNOP00000018328 RGD 621081 EMBL EDL96658.1
Synonyms:TgaseII EMBL AAD42046.1
ORF Names:rCG_32083 EMBL EDL96658.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 1 calcium ion per subunit By similarity. PIRSR PIRSR000459-2

Ontologies

Keywords
   LigandCalcium PIRSR PIRSR000459-2
Metal-binding PIRSR PIRSR000459-2
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Inferred from mutant phenotype PubMed 15550691. Source: RGD

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

Inferred from direct assay PubMed 16341586. Source: RGD

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 7911253. Source: MGI

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from mutant phenotype PubMed 15471861. Source: RGD

positive regulation of apoptotic process

Inferred from mutant phenotype Ref.1. Source: RGD

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from mutant phenotype PubMed 12054611. Source: RGD

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 15471861. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 14970202. Source: RGD

protein homooligomerization

Inferred from direct assay PubMed 12469910PubMed 16341586. Source: RGD

salivary gland cavitation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 7911253. Source: MGI

mitochondrion

Inferred from direct assay PubMed 16341586. Source: RGD

plasma membrane

Inferred from direct assay PubMed 14970202. Source: RGD

   Molecular_functionGTP binding

Inferred from direct assay PubMed 14970202. Source: RGD

enzyme binding

Inferred by curator PubMed 16341586. Source: RGD

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 16709602. Source: RGD

protein domain specific binding

Inferred from physical interaction PubMed 12054611. Source: RGD

protein-glutamine gamma-glutamyltransferase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2771 By similarity PIRSR PIRSR000459-1
Active site3351 By similarity PIRSR PIRSR000459-1
Active site3581 By similarity PIRSR PIRSR000459-1
Metal binding3981Calcium By similarity
Metal binding4001Calcium By similarity
Metal binding4471Calcium By similarity
Metal binding4521Calcium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVJ6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4CD3D377FA86EC1A

FASTA68676,935
        10         20         30         40         50         60 
MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY EASVDRLTFG 

        70         80         90        100        110        120 
AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL SLQLCTPANA PVGQYRLSLE 

       130        140        150        160        170        180 
TSTGYQGSSF MLGHFILLFN AWCPADDVYL DSEAERREYV LTQQGFIYQG SVKFIKSVPW 

       190        200        210        220        230        240 
NFGQFEDGIL DACLMLLDVN PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR 

       250        260        270        280        290        300 
WDNNYGDGIS PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 

       310        320        330        340        350        360 
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG YEGWQAIDPT 

       370        380        390        400        410        420 
PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD VVDWIRQSDG SVLKSINNSL 

       430        440        450        460        470        480 
VVGQKISTKS VGRDDREDIT YTYKYPEGSP EEREVFTRAN HLNKLAEKEE TGVAMRIRVG 

       490        500        510        520        530        540 
DGMSLGNDFD VFAHIGNDTS ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS 

       550        560        570        580        590        600 
IPLRILYEKY SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 

       610        620        630        640        650        660 
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR VDLFPTDIGL 

       670        680 
HKLVVNFQCD KLKSVKGYRN IIIGPA 

« Hide

References

« Hide 'large scale' references
[1]"Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells."
Ou H., Haendeler J., Aebly M.R., Kelly L.A., Cholewa B.C., Koike G., Kwitek-Black A., Jacob H.J., Berk B.C., Miano J.M.
Circ. Res. 87:881-887(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAD42046.1.
Tissue: Aortic smooth muscle EMBL AAD42046.1.
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000018328.
[3]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL96658.1.
[4]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL96658.1.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000018328.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06027324 Genomic DNA. No translation available.
AABR06027325 Genomic DNA. No translation available.
AABR06027326 Genomic DNA. No translation available.
AABR06027327 Genomic DNA. No translation available.
AF106325 mRNA. Translation: AAD42046.1.
CH474005 Genomic DNA. Translation: EDL96658.1.
UniGeneRn.10.

3D structure databases

ProteinModelPortalQ9WVJ6.
SMRQ9WVJ6. Positions 15-686.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018328; ENSRNOP00000018328; ENSRNOG00000012956.
UCSCRGD:621081. rat.

Organism-specific databases

RGD621081. Tgm2.

Phylogenomic databases

GeneTreeENSGT00740000115156.
HOVERGENHBG004342.
InParanoidQ9WVJ6.
OMAANGRDHH.
OrthoDBEOG7WT40M.
PhylomeDBQ9WVJ6.
TreeFamTF324278.

Gene expression databases

GenevestigatorQ9WVJ6.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9WVJ6.

Entry information

Entry nameQ9WVJ6_RAT
AccessionPrimary (citable) accession number: Q9WVJ6
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)