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Q9WVJ6

- Q9WVJ6_RAT

UniProt

Q9WVJ6 - Q9WVJ6_RAT

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Protein
Submitted name: Protein Tgm2
Gene
Tgm2, TgaseII, rCG_32083
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei277 – 2771 By similarityUniRule annotation
Active sitei335 – 3351 By similarityUniRule annotation
Active sitei358 – 3581 By similarityUniRule annotation
Metal bindingi398 – 3981Calcium By similarityUniRule annotation
Metal bindingi400 – 4001Calcium By similarityUniRule annotation
Metal bindingi447 – 4471Calcium By similarityUniRule annotation
Metal bindingi452 – 4521Calcium By similarityUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: RGD
  2. enzyme binding Source: RGD
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: RGD
  5. protein domain specific binding Source: RGD
  6. protein-glutamine gamma-glutamyltransferase activity Source: Ensembl

GO - Biological processi

  1. apoptotic cell clearance Source: Ensembl
  2. blood vessel remodeling Source: RGD
  3. branching involved in salivary gland morphogenesis Source: Ensembl
  4. isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: RGD
  5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  7. positive regulation of apoptotic process Source: RGD
  8. positive regulation of cell adhesion Source: Ensembl
  9. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  10. positive regulation of inflammatory response Source: RGD
  11. positive regulation of smooth muscle cell proliferation Source: RGD
  12. protein homooligomerization Source: RGD
  13. salivary gland cavitation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tgm2Imported
Submitted name:
Tissue-type transglutaminaseImported
Submitted name:
Transglutaminase 2, C polypeptide, isoform CRA_aImported
Gene namesi
Name:Tgm2Imported
Synonyms:TgaseIIImported
ORF Names:rCG_32083Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi621081. Tgm2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. mitochondrion Source: RGD
  3. plasma membrane Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9WVJ6.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00740000115156.
HOVERGENiHBG004342.
InParanoidiQ9WVJ6.
OMAiANGRDHH.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVJ6-1 [UniParc]FASTAAdd to Basket

« Hide

MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY    50
EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL 100
SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL 150
DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN 200
PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS 250
PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG 350
YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD 400
VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP 450
EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS 500
ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY 550
SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 600
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR 650
VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA 686
Length:686
Mass (Da):76,935
Last modified:November 1, 1999 - v1
Checksum:i4CD3D377FA86EC1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06027324 Genomic DNA. No translation available.
AABR06027325 Genomic DNA. No translation available.
AABR06027326 Genomic DNA. No translation available.
AABR06027327 Genomic DNA. No translation available.
AF106325 mRNA. Translation: AAD42046.1.
CH474005 Genomic DNA. Translation: EDL96658.1.
UniGeneiRn.10.

Genome annotation databases

EnsembliENSRNOT00000018328; ENSRNOP00000018328; ENSRNOG00000012956.
UCSCiRGD:621081. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06027324 Genomic DNA. No translation available.
AABR06027325 Genomic DNA. No translation available.
AABR06027326 Genomic DNA. No translation available.
AABR06027327 Genomic DNA. No translation available.
AF106325 mRNA. Translation: AAD42046.1 .
CH474005 Genomic DNA. Translation: EDL96658.1 .
UniGenei Rn.10.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018328 ; ENSRNOP00000018328 ; ENSRNOG00000012956 .
UCSCi RGD:621081. rat.

Organism-specific databases

RGDi 621081. Tgm2.

Phylogenomic databases

GeneTreei ENSGT00740000115156.
HOVERGENi HBG004342.
InParanoidi Q9WVJ6.
OMAi ANGRDHH.
OrthoDBi EOG7WT40M.
TreeFami TF324278.

Miscellaneous databases

PROi Q9WVJ6.

Gene expression databases

Genevestigatori Q9WVJ6.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells."
    Ou H., Haendeler J., Aebly M.R., Kelly L.A., Cholewa B.C., Koike G., Kwitek-Black A., Jacob H.J., Berk B.C., Miano J.M.
    Circ. Res. 87:881-887(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Aortic smooth muscleImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9WVJ6_RAT
AccessioniPrimary (citable) accession number: Q9WVJ6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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