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Q9WVJ6

- Q9WVJ6_RAT

UniProt

Q9WVJ6 - Q9WVJ6_RAT

Protein
Submitted name:

Protein Tgm2

Gene

Tgm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 calcium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei277 – 2771UniRule annotation
    Active sitei335 – 3351UniRule annotation
    Active sitei358 – 3581UniRule annotation
    Metal bindingi398 – 3981CalciumUniRule annotation
    Metal bindingi400 – 4001CalciumUniRule annotation
    Metal bindingi447 – 4471CalciumUniRule annotation
    Metal bindingi452 – 4521CalciumUniRule annotation

    GO - Molecular functioni

    1. enzyme binding Source: RGD
    2. GTP binding Source: RGD
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: RGD
    5. protein domain specific binding Source: RGD
    6. protein-glutamine gamma-glutamyltransferase activity Source: Ensembl

    GO - Biological processi

    1. apoptotic cell clearance Source: Ensembl
    2. blood vessel remodeling Source: RGD
    3. branching involved in salivary gland morphogenesis Source: Ensembl
    4. isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: RGD
    5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    6. positive regulation of apoptotic process Source: RGD
    7. positive regulation of cell adhesion Source: Ensembl
    8. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
    9. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
    10. positive regulation of inflammatory response Source: RGD
    11. positive regulation of smooth muscle cell proliferation Source: RGD
    12. protein homooligomerization Source: RGD
    13. salivary gland cavitation Source: Ensembl

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Tgm2Imported
    Submitted name:
    Tissue-type transglutaminaseImported
    Submitted name:
    Transglutaminase 2, C polypeptide, isoform CRA_aImported
    Gene namesi
    Name:Tgm2Imported
    Synonyms:TgaseIIImported
    ORF Names:rCG_32083Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi621081. Tgm2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. mitochondrion Source: RGD
    3. plasma membrane Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WVJ6.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00740000115156.
    HOVERGENiHBG004342.
    InParanoidiQ9WVJ6.
    OMAiANGRDHH.
    OrthoDBiEOG7WT40M.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY    50
    EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL 100
    SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL 150
    DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN 200
    PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS 250
    PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN 300
    YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG 350
    YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD 400
    VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP 450
    EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS 500
    ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY 550
    SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR 600
    KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR 650
    VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA 686
    Length:686
    Mass (Da):76,935
    Last modified:November 1, 1999 - v1
    Checksum:i4CD3D377FA86EC1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06027324 Genomic DNA. No translation available.
    AABR06027325 Genomic DNA. No translation available.
    AABR06027326 Genomic DNA. No translation available.
    AABR06027327 Genomic DNA. No translation available.
    AF106325 mRNA. Translation: AAD42046.1.
    CH474005 Genomic DNA. Translation: EDL96658.1.
    UniGeneiRn.10.

    Genome annotation databases

    EnsembliENSRNOT00000018328; ENSRNOP00000018328; ENSRNOG00000012956.
    UCSCiRGD:621081. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06027324 Genomic DNA. No translation available.
    AABR06027325 Genomic DNA. No translation available.
    AABR06027326 Genomic DNA. No translation available.
    AABR06027327 Genomic DNA. No translation available.
    AF106325 mRNA. Translation: AAD42046.1 .
    CH474005 Genomic DNA. Translation: EDL96658.1 .
    UniGenei Rn.10.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018328 ; ENSRNOP00000018328 ; ENSRNOG00000012956 .
    UCSCi RGD:621081. rat.

    Organism-specific databases

    RGDi 621081. Tgm2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115156.
    HOVERGENi HBG004342.
    InParanoidi Q9WVJ6.
    OMAi ANGRDHH.
    OrthoDBi EOG7WT40M.
    TreeFami TF324278.

    Miscellaneous databases

    PROi Q9WVJ6.

    Gene expression databases

    Genevestigatori Q9WVJ6.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells."
      Ou H., Haendeler J., Aebly M.R., Kelly L.A., Cholewa B.C., Koike G., Kwitek-Black A., Jacob H.J., Berk B.C., Miano J.M.
      Circ. Res. 87:881-887(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: Aortic smooth muscleImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9WVJ6_RAT
    AccessioniPrimary (citable) accession number: Q9WVJ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3