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Protein
Submitted name:

Tissue-type transglutaminase

Gene

Tgm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277UniRule annotation1
Active sitei335UniRule annotation1
Active sitei358UniRule annotation1

GO - Molecular functioni

  • enzyme binding Source: RGD
  • GTP binding Source: RGD
  • protein domain specific binding Source: RGD
  • protein-glutamine gamma-glutamyltransferase activity Source: RGD

GO - Biological processi

  • apoptotic cell clearance Source: RGD
  • blood vessel remodeling Source: RGD
  • branching involved in salivary gland morphogenesis Source: RGD
  • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine Source: RGD
  • negative regulation of endoplasmic reticulum calcium ion concentration Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of cell adhesion Source: RGD
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of mitochondrial calcium ion concentration Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • protein homooligomerization Source: RGD
  • salivary gland cavitation Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue-type transglutaminaseImported
Submitted name:
Transglutaminase 2Imported
Submitted name:
Transglutaminase 2, C polypeptide, isoform CRA_aImported
Gene namesi
Name:Tgm2Imported
Synonyms:TgaseIIImported
ORF Names:rCG_32083Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621081. Tgm2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000012956.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018328.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 361TGcInterPro annotationAdd BLAST93

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOVERGENiHBG004342.
OMAiAHITNNT.
OrthoDBiEOG091G030K.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR036985. Transglutaminase-like_sf.
IPR023608. Transglutaminase_animal.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR036238. Transglutaminase_C_sf.
IPR001102. Transglutaminase_N.
PfamiView protein in Pfam
PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiView protein in SMART
SM00460. TGc. 1 hit.
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiView protein in PROSITE
PS00547. TRANSGLUTAMINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELNLERC DLEIQANGRD HHTADLCQQK LVLRRGQRFR LTLYFEGRGY
60 70 80 90 100
EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL
110 120 130 140 150
SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL
160 170 180 190 200
DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN
210 220 230 240 250
PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS
260 270 280 290 300
PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG
360 370 380 390 400
YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD
410 420 430 440 450
VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP
460 470 480 490 500
EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS
510 520 530 540 550
ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY
560 570 580 590 600
SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR
610 620 630 640 650
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR
660 670 680
VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA
Length:686
Mass (Da):76,935
Last modified:November 1, 1999 - v1
Checksum:i4CD3D377FA86EC1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054457 Genomic DNA. No translation available.
AF106325 mRNA. Translation: AAD42046.1.
CH474005 Genomic DNA. Translation: EDL96658.1.
UniGeneiRn.10.

Genome annotation databases

EnsembliENSRNOT00000018328; ENSRNOP00000018328; ENSRNOG00000012956.
UCSCiRGD:621081. rat.

Similar proteinsi

Entry informationi

Entry nameiQ9WVJ6_RAT
AccessioniPrimary (citable) accession number: Q9WVJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported