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Protein

Synaptojanin-2-binding protein

Gene

Synj2bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-2-binding protein
Alternative name(s):
Mitochondrial outer membrane protein 25
NPW16
Gene namesi
Name:Synj2bp
Synonyms:Omp25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi69400. Synj2bp.

Subcellular locationi

  • Mitochondrion outer membrane 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 145Mitochondrial intermembraneSequence analysis7

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: RGD

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723841 – 145Synaptojanin-2-binding proteinAdd BLAST145

Proteomic databases

PaxDbiQ9WVJ4.
PRIDEiQ9WVJ4.

PTM databases

iPTMnetiQ9WVJ4.
PhosphoSitePlusiQ9WVJ4.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSRNOG00000006399.
GenevisibleiQ9WVJ4. RN.

Interactioni

Subunit structurei

Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (PubMed:10357812). Interacts (via C-terminus) with RALBP1. Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus). Forms a ternary complex with ACVR2A and RALBP1 (By similarity). Interacts with MAPK12 (PubMed:15878399). Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Synj2O55207-39EBI-7007454,EBI-7007476

GO - Molecular functioni

  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi249115. 1 interactor.
ELMiQ9WVJ4.
IntActiQ9WVJ4. 1 interactor.
MINTiMINT-1216281.
STRINGi10116.ENSRNOP00000009119.

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ4.
SMRiQ9WVJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 100PDZPROSITE-ProRule annotationAdd BLAST88

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDNK. Eukaryota.
ENOG4111VAQ. LUCA.
GeneTreeiENSGT00830000128402.
HOGENOMiHOG000146436.
HOVERGENiHBG061461.
InParanoidiQ9WVJ4.
KOiK20057.
OMAiQNGPVGH.
OrthoDBiEOG091G0G6P.

Family and domain databases

InterProiView protein in InterPro
IPR001478. PDZ.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGRVDYLVS EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKED
60 70 80 90 100
GAAARDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
PVQNGPIVHR GDGEPSGVPV AVVLLPVFAL TLVAVWAFVR YRKQL
Length:145
Mass (Da):15,825
Last modified:November 25, 2008 - v2
Checksum:i846CD232A73FE266
GO

Sequence cautioni

The sequence AAD39893 differs from that shown. Chimeric cDNA.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107295 mRNA. Translation: AAD39893.1. Sequence problems.
AF260258 mRNA. Translation: AAF70306.1.
BC126067 mRNA. Translation: AAI26068.2.
RefSeqiNP_072121.2. NM_022599.2.
UniGeneiRn.6258.

Genome annotation databases

EnsembliENSRNOT00000009122; ENSRNOP00000009119; ENSRNOG00000006399.
GeneIDi64531.
KEGGirno:64531.
UCSCiRGD:69400. rat.

Similar proteinsi

Entry informationi

Entry nameiSYJ2B_RAT
AccessioniPrimary (citable) accession number: Q9WVJ4
Secondary accession number(s): A0JN00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: August 30, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome