Kcnh3

Functionⁱ

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	585 – 700	cNMPAdd BLAST		116

GO - Molecular functionⁱ

phosphorelay sensor kinase activity Source: InterPro
voltage-gated potassium channel activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

regulation of membrane potential Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium voltage-gated channel subfamily H member 3 Alternative name(s): Ether-a-go-go-like potassium channel 2 Short name: ELK channel 2 Short name: mElk2 Voltage-gated potassium channel subunit Kv12.2
Gene namesⁱ	Name:Kcnh3 Synonyms:Elk2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1341723. Kcnh3.

Subcellular locationⁱ

Membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 228	CytoplasmicSequence analysisAdd BLAST	228
Transmembraneⁱ	229 – 249	Helical; Name=Segment S1Sequence analysisAdd BLAST	21
Topological domainⁱ	250 – 259	ExtracellularSequence analysis	10
Transmembraneⁱ	260 – 280	Helical; Name=Segment S2Sequence analysisAdd BLAST	21
Topological domainⁱ	281 – 302	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	303 – 323	Helical; Name=Segment S3Sequence analysisAdd BLAST	21
Topological domainⁱ	324 – 331	ExtracellularSequence analysis	8
Transmembraneⁱ	332 – 352	Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST	21
Topological domainⁱ	353 – 361	CytoplasmicSequence analysis	9
Transmembraneⁱ	362 – 382	Helical; Name=Segment S5Sequence analysisAdd BLAST	21
Topological domainⁱ	383 – 456	ExtracellularSequence analysisAdd BLAST	74
Intramembraneⁱ	457 – 477	Pore-forming; Name=Segment H5Sequence analysisAdd BLAST	21
Topological domainⁱ	478 – 482	ExtracellularSequence analysis	5
Transmembraneⁱ	483 – 503	Helical; Name=Segment S6Sequence analysisAdd BLAST	21
Topological domainⁱ	504 – 1087	CytoplasmicSequence analysisAdd BLAST	584

GO - Cellular componentⁱ

integral component of plasma membrane Source: GO_Central
intracellular Source: GOC

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	576.

GuidetoPHARMACOLOGYⁱ

576.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000054006	1 – 1087	Potassium voltage-gated channel subfamily H member 3Add BLAST		1087

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	421	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	428	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	439	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9WVJ0.
PRIDEⁱ	Q9WVJ0.

PTM databases

iPTMnetⁱ	Q9WVJ0.
PhosphoSitePlusⁱ	Q9WVJ0.

Expressionⁱ

Tissue specificityⁱ

Detected in brain, but not in other tissues.

Interactionⁱ

Subunit structureⁱ

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000040548.

STRINGⁱ

10090.ENSMUSP00000040548.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WVJ0.
SMRⁱ	Q9WVJ0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 90	PASPROSITE-ProRule annotationAdd BLAST		73
Domainⁱ	93 – 145	PACPROSITE-ProRule annotationAdd BLAST		53

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	468 – 473	Selectivity filterBy similarity		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	954 – 1061	Pro-richAdd BLAST		108

Domainⁱ

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesⁱ

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0498. Eukaryota. ENOG410XPSE. LUCA.
HOGENOMⁱ	HOG000230794.
HOVERGENⁱ	HBG052232.
InParanoidⁱ	Q9WVJ0.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00130. PAS. 1 hit.
Gene3Dⁱ	2.60.120.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003950. K_chnl_volt-dep_ELK. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR014710. RmlC-like_jellyroll.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. PF13426. PAS_9. 1 hit.
PRINTSⁱ	PR01463. EAGCHANLFMLY. PR01465. ELKCHANNEL.
SMARTⁱ	View protein in SMART SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit.
SUPFAMⁱ	SSF51206. SSF51206. 1 hit. SSF55785. SSF55785. 1 hit.
TIGRFAMsⁱ	TIGR00229. sensory_box. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9WVJ0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC 
        60         70         80         90        100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 
       110        120        130        140        150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 
       160        170        180        190        200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 
       210        220        230        240        250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 
       260        270        280        290        300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 
       310        320        330        340        350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 
       360        370        380        390        400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ 
       410        420        430        440        450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSRGSEANG TGLELLGGPS 
       460        470        480        490        500
LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 
       510        520        530        540        550
GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 
       560        570        580        590        600
VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 
       610        620        630        640        650
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 
       660        670        680        690        700
ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 
       710        720        730        740        750
GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTVSPAPAD 
       760        770        780        790        800
EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 
       810        820        830        840        850
SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP KFSFRVGQSG 
       860        870        880        890        900
PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 
       910        920        930        940        950
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY 
       960        970        980        990       1000
CLQPPAGSVL SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS 
      1010       1020       1030       1040       1050
TSDSEPPGSG DLCSEPSTPA SPPPSEEGAR TGTPAPVSQA EATSTGEPPP 
      1060       1070       1080 
GPGGRALPWD PHSLEMVLIG CHGPGTVQWT QEEGTGV

Length:1,087

Mass (Da):117,667

Last modified:July 27, 2011 - v2

Checksum:ⁱ05D419F7812E9D0A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	R → P in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	388	S → N in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	433 – 434	SR → GG in AAD40578 (PubMed:10191308).Curated	2
Sequence conflictⁱ	744	V → I in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	806	S → T in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	836	S → G in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	840	P → H in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	871	G → V in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	889	M → T in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	924	G → V in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	928	E → G in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	935	S → C in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	971	Q → H in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	1025	S → P in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	1052	P → S in AAD40578 (PubMed:10191308).Curated	1
Sequence conflictⁱ	1076	T → S in AAD40578 (PubMed:10191308).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF109143 mRNA. Translation: AAD40578.1. AC161198 Genomic DNA. No translation available.
UniGeneⁱ	Mm.374793.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9WVJ0	Q9ULD8 Q8N500 UPI00024D1547 UPI0007DC516F UPI0005F461F7 UPI000626D160 UPI0006262888 UPI000A321530 UPI000A31F920 UPI000A321011 +171	Homo sapiens (Human) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Aotus nancymaae (Ma's night monkey) Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) Tupaia chinensis (Chinese tree shrew) Tarsius syrichta (Philippine tarsier) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	1,083	UniRef90_Q9ULD8	Cluster: Potassium voltage-gated channel subfamily H member 3	182

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9WVJ0	Q9ULD8 Q8N500 UPI00024D1547 UPI0007DC516F UPI0005F461F7 UPI000626D160 UPI0006262888 UPI000A321530 UPI000A31F920 UPI000A321011 +174	Homo sapiens (Human) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Aotus nancymaae (Ma's night monkey) Mesocricetus auratus (Golden hamster) Mus musculus (Mouse) Tupaia chinensis (Chinese tree shrew) Tarsius syrichta (Philippine tarsier) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) And more	1,083	UniRef50_Q9ULD8	Cluster: Potassium voltage-gated channel subfamily H member 3	185

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF109143 mRNA. Translation: AAD40578.1. AC161198 Genomic DNA. No translation available.
UniGeneⁱ	Mm.374793.

3D structure databases

ProteinModelPortalⁱ	Q9WVJ0.
SMRⁱ	Q9WVJ0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000040548.

STRINGⁱ

10090.ENSMUSP00000040548.

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	576.

GuidetoPHARMACOLOGYⁱ

576.

PTM databases

iPTMnetⁱ	Q9WVJ0.
PhosphoSitePlusⁱ	Q9WVJ0.

Proteomic databases

PaxDbⁱ	Q9WVJ0.
PRIDEⁱ	Q9WVJ0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:1341723. Kcnh3.

Phylogenomic databases

eggNOGⁱ	KOG0498. Eukaryota. ENOG410XPSE. LUCA.
HOGENOMⁱ	HOG000230794.
HOVERGENⁱ	HBG052232.
InParanoidⁱ	Q9WVJ0.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WVJ0.
SOURCEⁱ	Search...

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00130. PAS. 1 hit.
Gene3Dⁱ	2.60.120.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003950. K_chnl_volt-dep_ELK. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR014710. RmlC-like_jellyroll.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. PF13426. PAS_9. 1 hit.
PRINTSⁱ	PR01463. EAGCHANLFMLY. PR01465. ELKCHANNEL.
SMARTⁱ	View protein in SMART SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit.
SUPFAMⁱ	SSF51206. SSF51206. 1 hit. SSF55785. SSF55785. 1 hit.
TIGRFAMsⁱ	TIGR00229. sensory_box. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNH3_MOUSE
Accessionⁱ	Q9WVJ0Primary (citable) accession number: Q9WVJ0 Secondary accession number(s): E9QMZ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
	Last sequence update:	July 27, 2011
	Last modified:	August 30, 2017
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WVJ0 (KCNH3_MOUSE)

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Potassium voltage-gated channel subfamily H member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ