UniProtKB - Q9WVJ0 (KCNH3_MOUSE)
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Protein
Potassium voltage-gated channel subfamily H member 3
Gene
Kcnh3
Organism
Mus musculus (Mouse)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 593 – 708 | cNMPAdd BLAST | 116 |
GO - Molecular functioni
- phosphorelay sensor kinase activity Source: InterPro
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-1296072 Voltage gated Potassium channels |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily H member 3Alternative name(s): Ether-a-go-go-like potassium channel 2 Short name: ELK channel 2 Short name: mElk2 Voltage-gated potassium channel subunit Kv12.2 |
Gene namesi | Name:Kcnh3 Synonyms:Elk2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341723 Kcnh3 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 228 | CytoplasmicSequence analysisAdd BLAST | 228 | |
Transmembranei | 229 – 249 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 259 | ExtracellularSequence analysis | 10 | |
Transmembranei | 260 – 280 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 302 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 303 – 323 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 331 | ExtracellularSequence analysis | 8 | |
Transmembranei | 332 – 352 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 361 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 362 – 382 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 464 | ExtracellularSequence analysisAdd BLAST | 82 | |
Intramembranei | 465 – 485 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 486 – 490 | ExtracellularSequence analysis | 5 | |
Transmembranei | 491 – 511 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 512 – 1095 | CytoplasmicSequence analysisAdd BLAST | 584 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054006 | 1 – 1095 | Potassium voltage-gated channel subfamily H member 3Add BLAST | 1095 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 421 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 428 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 447 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9WVJ0 |
PRIDEi | Q9WVJ0 |
PTM databases
iPTMneti | Q9WVJ0 |
PhosphoSitePlusi | Q9WVJ0 |
Expressioni
Tissue specificityi
Detected in brain, but not in other tissues.
Gene expression databases
Bgeei | ENSMUSG00000037579 |
Genevisiblei | Q6U1M1 MM |
Interactioni
Subunit structurei
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040548 |
Structurei
3D structure databases
ProteinModelPortali | Q9WVJ0 |
SMRi | Q9WVJ0 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 90 | PASPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 93 – 145 | PACPROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 476 – 481 | Selectivity filterBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 962 – 1069 | Pro-richAdd BLAST | 108 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0498 Eukaryota ENOG410XPSE LUCA |
GeneTreei | ENSGT00900000140833 |
HOGENOMi | HOG000230794 |
HOVERGENi | HBG052232 |
InParanoidi | Q9WVJ0 |
KOi | K04906 |
OMAi | PLMAPWP |
OrthoDBi | EOG091G0OXR |
TreeFami | TF313130 |
Family and domain databases
CDDi | cd00038 CAP_ED, 1 hit cd00130 PAS, 1 hit |
Gene3Di | 2.60.120.101 hit |
InterProi | View protein in InterPro IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR005821 Ion_trans_dom IPR003938 K_chnl_volt-dep_EAG/ELK/ERG IPR003950 K_chnl_volt-dep_ELK IPR001610 PAC IPR000014 PAS IPR000700 PAS-assoc_C IPR035965 PAS-like_dom_sf IPR014710 RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027 cNMP_binding, 1 hit PF00520 Ion_trans, 1 hit PF13426 PAS_9, 1 hit |
PRINTSi | PR01463 EAGCHANLFMLY PR01465 ELKCHANNEL |
SMARTi | View protein in SMART SM00100 cNMP, 1 hit SM00086 PAC, 1 hit |
SUPFAMi | SSF51206 SSF51206, 1 hit SSF55785 SSF55785, 1 hit |
TIGRFAMsi | TIGR00229 sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042 CNMP_BINDING_3, 1 hit PS50113 PAC, 1 hit PS50112 PAS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9WVJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG
160 170 180 190 200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSSSSGSGG GRGSEANGTG
460 470 480 490 500
LELLGGPSLR SAYITSLYFA LSSLTSVGFG NVSANTDTEK IFSICTMLIG
510 520 530 540 550
ALMHAVVFGN VTAIIQRMYA RRFLYHSRTR DLRDYIRIHR IPKPLKQRML
560 570 580 590 600
EYFQATWAVN NGIDTTELLQ SLPDELRADI AMHLHKEVLQ LPLFEAASRG
610 620 630 640 650
CLRALSLALR PAFCTPGEYL IHQGDALQAL YFVCSGSMEV LKGGTVLAIL
660 670 680 690 700
GKGDLIGCEL PQREQVVKAN ADVKGLTYCV LQCLQLAGLH ESLALYPEFA
710 720 730 740 750
PRFSRGLRGE LSYNLGAGGV SAEVDTSSLS GDNTLMSTLE EKETDGEQGH
760 770 780 790 800
TVSPAPADEP SSPLLSPGCT SSSSAAKLLS PRRTAPRPRL GGRGRPSRAG
810 820 830 840 850
VLKPEAGPSA HPRSLDGLQL PPMPWNVPPD LSPRVVDGIE DGCSSDQPKF
860 870 880 890 900
SFRVGQSGPE CSSSPSPGTE SGLLTVPLGP SEARNTDTLD KLRQAVMELS
910 920 930 940 950
EQVLQMREGL QSLRQAVQLI LVPQGEGQCP RGSGEEPCPA TASGLLQPLR
960 970 980 990 1000
VDTGASSYCL QPPAGSVLSG TWPHPRPGQP PPLMAPWPWG PPASQSSPWP
1010 1020 1030 1040 1050
RATALWTSTS DSEPPGSGDL CSEPSTPASP PPSEEGARTG TPAPVSQAEA
1060 1070 1080 1090
TSTGEPPPGP GGRALPWDPH SLEMVLIGCH GPGTVQWTQE EGTGV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | R → P in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 388 | S → N in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 433 – 442 | SSSSGSGGGR → GG in AAD40578 (PubMed:10191308).Curated | 10 | |
Sequence conflicti | 472 | S → G in AAQ90188 (Ref. 2) Curated | 1 | |
Sequence conflicti | 497 | M → T in AAQ90188 (Ref. 2) Curated | 1 | |
Sequence conflicti | 500 | G → A in AAQ90188 (Ref. 2) Curated | 1 | |
Sequence conflicti | 752 | V → I in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 814 | S → T in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 844 | S → G in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 848 | P → H in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 879 | G → V in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 897 | M → T in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 932 | G → V in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 936 | E → G in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 943 | S → C in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 979 | Q → H in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 1033 | S → P in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 1060 | P → S in AAD40578 (PubMed:10191308).Curated | 1 | |
Sequence conflicti | 1084 | T → S in AAD40578 (PubMed:10191308).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109143 mRNA Translation: AAD40578.1 AY380579 mRNA Translation: AAQ90188.1 AC161198 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL04139.1 BC141013 mRNA Translation: AAI41014.1 BC145145 mRNA Translation: AAI45146.1 |
CCDSi | CCDS27817.1 |
RefSeqi | NP_034731.3, NM_010601.3 |
UniGenei | Mm.374793 |
Genome annotation databases
Ensembli | ENSMUST00000041415; ENSMUSP00000040548; ENSMUSG00000037579 |
GeneIDi | 16512 |
KEGGi | mmu:16512 |
UCSCi | uc011zzc.1 mouse |
Similar proteinsi
Entry informationi
Entry namei | KCNH3_MOUSE | |
Accessioni | Q9WVJ0Primary (citable) accession number: Q9WVJ0 Secondary accession number(s): B2RU85, E9QMZ8, Q6U1M1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | December 20, 2017 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |