Potassium voltage-gated channel subfamily H member 3

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Q9WVJ0 (KCNH3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily H member 3

Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name=ELK channel 2
Short name=mElk2
Voltage-gated potassium channel subunit Kv12.2

Gene names

Name:	Kcnh3
Synonyms:	Elk2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1087 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in brain, but not in other tissues.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification] Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of membrane potential Inferred from Biological aspect of Ancestor. Source: RefGenome signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1087

1087

Potassium voltage-gated channel subfamily H member 3

PRO_0000054006

Regions

Topological domain

1 – 228

228

Cytoplasmic Potential

Transmembrane

229 – 249

Helical; Name=Segment S1; Potential

Topological domain

250 – 259

Extracellular Potential

Transmembrane

260 – 280

Helical; Name=Segment S2; Potential

Topological domain

281 – 302

Cytoplasmic Potential

Transmembrane

303 – 323

Helical; Name=Segment S3; Potential

Topological domain

324 – 331

Extracellular Potential

Transmembrane

332 – 352

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

353 – 361

Cytoplasmic Potential

Transmembrane

362 – 382

Helical; Name=Segment S5; Potential

Topological domain

383 – 456

Extracellular Potential

Intramembrane

457 – 477

Pore-forming; Name=Segment H5; Potential

Topological domain

478 – 482

Extracellular Potential

Transmembrane

483 – 503

Helical; Name=Segment S6; Potential

Topological domain

504 – 1087

584

Cytoplasmic Potential

Domain

18 – 90

PAS

Domain

93 – 145

PAC

Nucleotide binding

585 – 700

116

cNMP

Motif

468 – 473

Selectivity filter By similarity

Compositional bias

954 – 1061

108

Pro-rich

Amino acid modifications

Glycosylation

421

N-linked (GlcNAc...) Potential

Glycosylation

428

N-linked (GlcNAc...) Potential

Glycosylation

439

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

R → P in AAD40578. Ref.1

Sequence conflict

388

S → N in AAD40578. Ref.1

Sequence conflict

433 – 434

SR → GG in AAD40578. Ref.1

Sequence conflict

744

V → I in AAD40578. Ref.1

Sequence conflict

806

S → T in AAD40578. Ref.1

Sequence conflict

836

S → G in AAD40578. Ref.1

Sequence conflict

840

P → H in AAD40578. Ref.1

Sequence conflict

871

G → V in AAD40578. Ref.1

Sequence conflict

889

M → T in AAD40578. Ref.1

Sequence conflict

924

G → V in AAD40578. Ref.1

Sequence conflict

928

E → G in AAD40578. Ref.1

Sequence conflict

935

S → C in AAD40578. Ref.1

Sequence conflict

971

Q → H in AAD40578. Ref.1

Sequence conflict

1025

S → P in AAD40578. Ref.1

Sequence conflict

1052

P → S in AAD40578. Ref.1

Sequence conflict

1076

T → S in AAD40578. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WVJ0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 05D419F7812E9D0A
Show »

FASTA

1,087

117,667

        10         20         30         40         50         60 
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV 

        70         80         90        100        110        120 
MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK 

       130        140        150        160        170        180 
GEVALFLVSH KDISETKNRG GPDNWKERGG GRRRYGRAGS KGFNANRRRS RAVLYHLSGH 

       190        200        210        220        230        240 
LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV 

       250        260        270        280        290        300 
TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 

       310        320        330        340        350        360 
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL 

       370        380        390        400        410        420 
TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ ELARRLETPY YLVSRSPDGG 

       430        440        450        460        470        480 
NSSGQSENCS SSSRGSEANG TGLELLGGPS LRSAYITSLY FALSSLTSVG FGNVSANTDT 

       490        500        510        520        530        540 
EKIFSICTML IGALMHAVVF GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR 

       550        560        570        580        590        600 
MLEYFQATWA VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 

       610        620        630        640        650        660 
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC ELPQREQVVK 

       670        680        690        700        710        720 
ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR GELSYNLGAG GVSAEVDTSS 

       730        740        750        760        770        780 
LSGDNTLMST LEEKETDGEQ GHTVSPAPAD EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP 

       790        800        810        820        830        840 
RLGGRGRPSR AGVLKPEAGP SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP 

       850        860        870        880        890        900 
KFSFRVGQSG PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 

       910        920        930        940        950        960 
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY CLQPPAGSVL 

       970        980        990       1000       1010       1020 
SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS TSDSEPPGSG DLCSEPSTPA 

      1030       1040       1050       1060       1070       1080 
SPPPSEEGAR TGTPAPVSQA EATSTGEPPP GPGGRALPWD PHSLEMVLIG CHGPGTVQWT 


QEEGTGV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional analysis of a mouse brain Elk-type K+ channel." Trudeau M.C., Titus S.A., Branchaw J.L., Ganetzky B., Robertson G.A. J. Neurosci. 19:2906-2918(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF109143 mRNA. Translation: AAD40578.1. AC161198 Genomic DNA. No translation available.
IPI	IPI00126045.
UniGene	Mm.374793.
3D structure databases
ProteinModelPortal	Q9WVJ0.
SMR	Q9WVJ0. Positions 11-136, 516-685.
ModBase	Search...
PTM databases
PhosphoSite	Q9WVJ0.
Proteomic databases
PRIDE	Q9WVJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1341723. Kcnh3.
Phylogenomic databases
eggNOG	COG2202.
HOGENOM	HOG000230794.
HOVERGEN	HBG052232.
Gene expression databases
ArrayExpress	Q9WVJ0.
Bgee	Q9WVJ0.
Genevestigator	Q9WVJ0.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003950. K_chnl_volt-dep_ELK. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. PF13426. PAS_9. 1 hit. [Graphical view]
PRINTS	PR01463. EAGCHANLFMLY. PR01465. ELKCHANNEL.
SMART	SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF51206. SSF51206. 1 hit. SSF55785. SSF55785. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
PRO	Q9WVJ0.
SOURCE	Search...

Entry information

Entry name

KCNH3_MOUSE

Accession

Primary (citable) accession number: Q9WVJ0
Secondary accession number(s): E9QMZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	July 27, 2011
Last modified:	November 13, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents