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Q9WVJ0

- KCNH3_MOUSE

UniProt

Q9WVJ0 - KCNH3_MOUSE

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Protein
Potassium voltage-gated channel subfamily H member 3
Gene
Kcnh3, Elk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi585 – 700116cNMP
Add
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
mElk2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:Kcnh3
Synonyms:Elk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1341723. Kcnh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 228228Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini250 – 25910Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini281 – 30222Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini324 – 3318Extracellular Reviewed prediction
Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini353 – 3619Cytoplasmic Reviewed prediction
Transmembranei362 – 38221Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini383 – 45674Extracellular Reviewed prediction
Add
BLAST
Intramembranei457 – 47721Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini478 – 4825Extracellular Reviewed prediction
Transmembranei483 – 50321Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini504 – 1087584Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Potassium voltage-gated channel subfamily H member 3
PRO_0000054006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9WVJ0.

PTM databases

PhosphoSiteiQ9WVJ0.

Expressioni

Tissue specificityi

Detected in brain, but not in other tissues.

Gene expression databases

BgeeiQ9WVJ0.
GenevestigatoriQ9WVJ0.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ0.
SMRiQ9WVJ0. Positions 11-136, 454-509, 516-685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 9073PAS
Add
BLAST
Domaini93 – 14553PAC
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi468 – 4736Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi954 – 1061108Pro-rich
Add
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC     50
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 100
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 150
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 200
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 250
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 300
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 350
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ 400
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSRGSEANG TGLELLGGPS 450
LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 500
GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 550
VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 600
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 650
ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 700
GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTVSPAPAD 750
EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 800
SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP KFSFRVGQSG 850
PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 900
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY 950
CLQPPAGSVL SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS 1000
TSDSEPPGSG DLCSEPSTPA SPPPSEEGAR TGTPAPVSQA EATSTGEPPP 1050
GPGGRALPWD PHSLEMVLIG CHGPGTVQWT QEEGTGV 1087
Length:1,087
Mass (Da):117,667
Last modified:July 27, 2011 - v2
Checksum:i05D419F7812E9D0A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → P in AAD40578. 1 Publication
Sequence conflicti388 – 3881S → N in AAD40578. 1 Publication
Sequence conflicti433 – 4342SR → GG in AAD40578. 1 Publication
Sequence conflicti744 – 7441V → I in AAD40578. 1 Publication
Sequence conflicti806 – 8061S → T in AAD40578. 1 Publication
Sequence conflicti836 – 8361S → G in AAD40578. 1 Publication
Sequence conflicti840 – 8401P → H in AAD40578. 1 Publication
Sequence conflicti871 – 8711G → V in AAD40578. 1 Publication
Sequence conflicti889 – 8891M → T in AAD40578. 1 Publication
Sequence conflicti924 – 9241G → V in AAD40578. 1 Publication
Sequence conflicti928 – 9281E → G in AAD40578. 1 Publication
Sequence conflicti935 – 9351S → C in AAD40578. 1 Publication
Sequence conflicti971 – 9711Q → H in AAD40578. 1 Publication
Sequence conflicti1025 – 10251S → P in AAD40578. 1 Publication
Sequence conflicti1052 – 10521P → S in AAD40578. 1 Publication
Sequence conflicti1076 – 10761T → S in AAD40578. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109143 mRNA. Translation: AAD40578.1.
AC161198 Genomic DNA. No translation available.
UniGeneiMm.374793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109143 mRNA. Translation: AAD40578.1 .
AC161198 Genomic DNA. No translation available.
UniGenei Mm.374793.

3D structure databases

ProteinModelPortali Q9WVJ0.
SMRi Q9WVJ0. Positions 11-136, 454-509, 516-685.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVJ0.

Proteomic databases

PRIDEi Q9WVJ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1341723. Kcnh3.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230794.
HOVERGENi HBG052232.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

PROi Q9WVJ0.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVJ0.
Genevestigatori Q9WVJ0.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of a mouse brain Elk-type K+ channel."
    Trudeau M.C., Titus S.A., Branchaw J.L., Ganetzky B., Robertson G.A.
    J. Neurosci. 19:2906-2918(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiKCNH3_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): E9QMZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi