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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi593 – 708cNMPAdd BLAST116

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
mElk2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:Kcnh3
Synonyms:Elk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1341723 Kcnh3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 228CytoplasmicSequence analysisAdd BLAST228
Transmembranei229 – 249Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini250 – 259ExtracellularSequence analysis10
Transmembranei260 – 280Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini281 – 302CytoplasmicSequence analysisAdd BLAST22
Transmembranei303 – 323Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini324 – 331ExtracellularSequence analysis8
Transmembranei332 – 352Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini353 – 361CytoplasmicSequence analysis9
Transmembranei362 – 382Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini383 – 464ExtracellularSequence analysisAdd BLAST82
Intramembranei465 – 485Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini486 – 490ExtracellularSequence analysis5
Transmembranei491 – 511Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini512 – 1095CytoplasmicSequence analysisAdd BLAST584

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540061 – 1095Potassium voltage-gated channel subfamily H member 3Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WVJ0
PRIDEiQ9WVJ0

PTM databases

iPTMnetiQ9WVJ0
PhosphoSitePlusiQ9WVJ0

Expressioni

Tissue specificityi

Detected in brain, but not in other tissues.

Gene expression databases

BgeeiENSMUSG00000037579
GenevisibleiQ6U1M1 MM

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040548

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ0
SMRiQ9WVJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 90PASPROSITE-ProRule annotationAdd BLAST73
Domaini93 – 145PACPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi476 – 481Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi962 – 1069Pro-richAdd BLAST108

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140833
HOGENOMiHOG000230794
HOVERGENiHBG052232
InParanoidiQ9WVJ0
KOiK04906
OMAiPLMAPWP
OrthoDBiEOG091G0OXR
TreeFamiTF313130

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di2.60.120.101 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003950 K_chnl_volt-dep_ELK
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01465 ELKCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00086 PAC, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG
160 170 180 190 200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSSSSGSGG GRGSEANGTG
460 470 480 490 500
LELLGGPSLR SAYITSLYFA LSSLTSVGFG NVSANTDTEK IFSICTMLIG
510 520 530 540 550
ALMHAVVFGN VTAIIQRMYA RRFLYHSRTR DLRDYIRIHR IPKPLKQRML
560 570 580 590 600
EYFQATWAVN NGIDTTELLQ SLPDELRADI AMHLHKEVLQ LPLFEAASRG
610 620 630 640 650
CLRALSLALR PAFCTPGEYL IHQGDALQAL YFVCSGSMEV LKGGTVLAIL
660 670 680 690 700
GKGDLIGCEL PQREQVVKAN ADVKGLTYCV LQCLQLAGLH ESLALYPEFA
710 720 730 740 750
PRFSRGLRGE LSYNLGAGGV SAEVDTSSLS GDNTLMSTLE EKETDGEQGH
760 770 780 790 800
TVSPAPADEP SSPLLSPGCT SSSSAAKLLS PRRTAPRPRL GGRGRPSRAG
810 820 830 840 850
VLKPEAGPSA HPRSLDGLQL PPMPWNVPPD LSPRVVDGIE DGCSSDQPKF
860 870 880 890 900
SFRVGQSGPE CSSSPSPGTE SGLLTVPLGP SEARNTDTLD KLRQAVMELS
910 920 930 940 950
EQVLQMREGL QSLRQAVQLI LVPQGEGQCP RGSGEEPCPA TASGLLQPLR
960 970 980 990 1000
VDTGASSYCL QPPAGSVLSG TWPHPRPGQP PPLMAPWPWG PPASQSSPWP
1010 1020 1030 1040 1050
RATALWTSTS DSEPPGSGDL CSEPSTPASP PPSEEGARTG TPAPVSQAEA
1060 1070 1080 1090
TSTGEPPPGP GGRALPWDPH SLEMVLIGCH GPGTVQWTQE EGTGV
Length:1,095
Mass (Da):118,244
Last modified:December 20, 2017 - v3
Checksum:iC2C3A26090E37A50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti388S → N in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti433 – 442SSSSGSGGGR → GG in AAD40578 (PubMed:10191308).Curated10
Sequence conflicti472S → G in AAQ90188 (Ref. 2) Curated1
Sequence conflicti497M → T in AAQ90188 (Ref. 2) Curated1
Sequence conflicti500G → A in AAQ90188 (Ref. 2) Curated1
Sequence conflicti752V → I in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti814S → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti844S → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti848P → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti879G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti897M → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti932G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti936E → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti943S → C in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti979Q → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1033S → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1060P → S in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1084T → S in AAD40578 (PubMed:10191308).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109143 mRNA Translation: AAD40578.1
AY380579 mRNA Translation: AAQ90188.1
AC161198 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04139.1
BC141013 mRNA Translation: AAI41014.1
BC145145 mRNA Translation: AAI45146.1
CCDSiCCDS27817.1
RefSeqiNP_034731.3, NM_010601.3
UniGeneiMm.374793

Genome annotation databases

EnsembliENSMUST00000041415; ENSMUSP00000040548; ENSMUSG00000037579
GeneIDi16512
KEGGimmu:16512
UCSCiuc011zzc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNH3_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): B2RU85, E9QMZ8, Q6U1M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 20, 2017
Last modified: March 28, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome