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UniProtKB - Q9WVJ0 (KCNH3_MOUSE)

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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi585 – 700cNMPAdd BLAST116

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
mElk2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:Kcnh3
Synonyms:Elk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1341723. Kcnh3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 228CytoplasmicSequence analysisAdd BLAST228
Transmembranei229 – 249Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini250 – 259ExtracellularSequence analysis10
Transmembranei260 – 280Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini281 – 302CytoplasmicSequence analysisAdd BLAST22
Transmembranei303 – 323Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini324 – 331ExtracellularSequence analysis8
Transmembranei332 – 352Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini353 – 361CytoplasmicSequence analysis9
Transmembranei362 – 382Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini383 – 456ExtracellularSequence analysisAdd BLAST74
Intramembranei457 – 477Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini478 – 482ExtracellularSequence analysis5
Transmembranei483 – 503Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini504 – 1087CytoplasmicSequence analysisAdd BLAST584

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540061 – 1087Potassium voltage-gated channel subfamily H member 3Add BLAST1087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WVJ0.
PRIDEiQ9WVJ0.

PTM databases

iPTMnetiQ9WVJ0.
PhosphoSitePlusiQ9WVJ0.

Expressioni

Tissue specificityi

Detected in brain, but not in other tissues.

Gene expression databases

BgeeiENSMUSG00000037579.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040548.

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ0.
SMRiQ9WVJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 90PASPROSITE-ProRule annotationAdd BLAST73
Domaini93 – 145PACPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi468 – 473Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi954 – 1061Pro-richAdd BLAST108

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9WVJ0.

Family and domain databases

CDDicd00130. PAS. 1 hit.
Gene3Di2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WVJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC 
        60         70         80         90        100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 
       110        120        130        140        150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 
       160        170        180        190        200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 
       210        220        230        240        250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 
       260        270        280        290        300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 
       310        320        330        340        350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 
       360        370        380        390        400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ 
       410        420        430        440        450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSRGSEANG TGLELLGGPS 
       460        470        480        490        500
LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 
       510        520        530        540        550
GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 
       560        570        580        590        600
VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 
       610        620        630        640        650
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 
       660        670        680        690        700
ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 
       710        720        730        740        750
GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTVSPAPAD 
       760        770        780        790        800
EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 
       810        820        830        840        850
SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP KFSFRVGQSG 
       860        870        880        890        900
PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 
       910        920        930        940        950
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY 
       960        970        980        990       1000
CLQPPAGSVL SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS 
      1010       1020       1030       1040       1050
TSDSEPPGSG DLCSEPSTPA SPPPSEEGAR TGTPAPVSQA EATSTGEPPP 
      1060       1070       1080 
GPGGRALPWD PHSLEMVLIG CHGPGTVQWT QEEGTGV
Length:1,087
Mass (Da):117,667
Last modified:July 27, 2011 - v2
Checksum:i05D419F7812E9D0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti388S → N in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti433 – 434SR → GG in AAD40578 (PubMed:10191308).Curated2
Sequence conflicti744V → I in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti806S → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti836S → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti840P → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti871G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti889M → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti924G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti928E → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti935S → C in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti971Q → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1025S → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1052P → S in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1076T → S in AAD40578 (PubMed:10191308).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109143 mRNA. Translation: AAD40578.1.
AC161198 Genomic DNA. No translation available.
UniGeneiMm.374793.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCNH3_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): E9QMZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: May 10, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families