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Q9WVJ0

- KCNH3_MOUSE

UniProt

Q9WVJ0 - KCNH3_MOUSE

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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi585 – 700116cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
mElk2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:Kcnh3
Synonyms:Elk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1341723. Kcnh3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Potassium voltage-gated channel subfamily H member 3PRO_0000054006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9WVJ0.

PTM databases

PhosphoSiteiQ9WVJ0.

Expressioni

Tissue specificityi

Detected in brain, but not in other tissues.

Gene expression databases

BgeeiQ9WVJ0.
ExpressionAtlasiQ9WVJ0. baseline and differential.
GenevestigatoriQ9WVJ0.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ0.
SMRiQ9WVJ0. Positions 11-136, 454-509, 516-685.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 228228CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini250 – 25910ExtracellularSequence Analysis
Topological domaini281 – 30222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini324 – 3318ExtracellularSequence Analysis
Topological domaini353 – 3619CytoplasmicSequence Analysis
Topological domaini383 – 45674ExtracellularSequence AnalysisAdd
BLAST
Topological domaini478 – 4825ExtracellularSequence Analysis
Topological domaini504 – 1087584CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei457 – 47721Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei229 – 24921Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei483 – 50321Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 9073PASPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 14553PACPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi468 – 4736Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi954 – 1061108Pro-richAdd
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9WVJ0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVJ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG
160 170 180 190 200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSRGSEANG TGLELLGGPS
460 470 480 490 500
LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF
510 520 530 540 550
GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA
560 570 580 590 600
VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA
610 620 630 640 650
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC
660 670 680 690 700
ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR
710 720 730 740 750
GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTVSPAPAD
760 770 780 790 800
EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP
810 820 830 840 850
SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP KFSFRVGQSG
860 870 880 890 900
PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE
910 920 930 940 950
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY
960 970 980 990 1000
CLQPPAGSVL SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS
1010 1020 1030 1040 1050
TSDSEPPGSG DLCSEPSTPA SPPPSEEGAR TGTPAPVSQA EATSTGEPPP
1060 1070 1080
GPGGRALPWD PHSLEMVLIG CHGPGTVQWT QEEGTGV
Length:1,087
Mass (Da):117,667
Last modified:July 27, 2011 - v2
Checksum:i05D419F7812E9D0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → P in AAD40578. (PubMed:10191308)Curated
Sequence conflicti388 – 3881S → N in AAD40578. (PubMed:10191308)Curated
Sequence conflicti433 – 4342SR → GG in AAD40578. (PubMed:10191308)Curated
Sequence conflicti744 – 7441V → I in AAD40578. (PubMed:10191308)Curated
Sequence conflicti806 – 8061S → T in AAD40578. (PubMed:10191308)Curated
Sequence conflicti836 – 8361S → G in AAD40578. (PubMed:10191308)Curated
Sequence conflicti840 – 8401P → H in AAD40578. (PubMed:10191308)Curated
Sequence conflicti871 – 8711G → V in AAD40578. (PubMed:10191308)Curated
Sequence conflicti889 – 8891M → T in AAD40578. (PubMed:10191308)Curated
Sequence conflicti924 – 9241G → V in AAD40578. (PubMed:10191308)Curated
Sequence conflicti928 – 9281E → G in AAD40578. (PubMed:10191308)Curated
Sequence conflicti935 – 9351S → C in AAD40578. (PubMed:10191308)Curated
Sequence conflicti971 – 9711Q → H in AAD40578. (PubMed:10191308)Curated
Sequence conflicti1025 – 10251S → P in AAD40578. (PubMed:10191308)Curated
Sequence conflicti1052 – 10521P → S in AAD40578. (PubMed:10191308)Curated
Sequence conflicti1076 – 10761T → S in AAD40578. (PubMed:10191308)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109143 mRNA. Translation: AAD40578.1.
AC161198 Genomic DNA. No translation available.
UniGeneiMm.374793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109143 mRNA. Translation: AAD40578.1 .
AC161198 Genomic DNA. No translation available.
UniGenei Mm.374793.

3D structure databases

ProteinModelPortali Q9WVJ0.
SMRi Q9WVJ0. Positions 11-136, 454-509, 516-685.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WVJ0.

Proteomic databases

PRIDEi Q9WVJ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1341723. Kcnh3.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230794.
HOVERGENi HBG052232.
InParanoidi Q9WVJ0.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

PROi Q9WVJ0.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVJ0.
ExpressionAtlasi Q9WVJ0. baseline and differential.
Genevestigatori Q9WVJ0.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of a mouse brain Elk-type K+ channel."
    Trudeau M.C., Titus S.A., Branchaw J.L., Ganetzky B., Robertson G.A.
    J. Neurosci. 19:2906-2918(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiKCNH3_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): E9QMZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3