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Q9WVJ0 (KCNH3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name=ELK channel 2
Short name=mElk2
Voltage-gated potassium channel subunit Kv12.2
Gene names
Name:Kcnh3
Synonyms:Elk2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1087 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in brain, but not in other tissues.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10871087Potassium voltage-gated channel subfamily H member 3
PRO_0000054006

Regions

Topological domain1 – 228228Cytoplasmic Potential
Transmembrane229 – 24921Helical; Name=Segment S1; Potential
Topological domain250 – 25910Extracellular Potential
Transmembrane260 – 28021Helical; Name=Segment S2; Potential
Topological domain281 – 30222Cytoplasmic Potential
Transmembrane303 – 32321Helical; Name=Segment S3; Potential
Topological domain324 – 3318Extracellular Potential
Transmembrane332 – 35221Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain353 – 3619Cytoplasmic Potential
Transmembrane362 – 38221Helical; Name=Segment S5; Potential
Topological domain383 – 45674Extracellular Potential
Intramembrane457 – 47721Pore-forming; Name=Segment H5; Potential
Topological domain478 – 4825Extracellular Potential
Transmembrane483 – 50321Helical; Name=Segment S6; Potential
Topological domain504 – 1087584Cytoplasmic Potential
Domain18 – 9073PAS
Domain93 – 14553PAC
Nucleotide binding585 – 700116cNMP
Motif468 – 4736Selectivity filter By similarity
Compositional bias954 – 1061108Pro-rich

Amino acid modifications

Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict51R → P in AAD40578. Ref.1
Sequence conflict3881S → N in AAD40578. Ref.1
Sequence conflict433 – 4342SR → GG in AAD40578. Ref.1
Sequence conflict7441V → I in AAD40578. Ref.1
Sequence conflict8061S → T in AAD40578. Ref.1
Sequence conflict8361S → G in AAD40578. Ref.1
Sequence conflict8401P → H in AAD40578. Ref.1
Sequence conflict8711G → V in AAD40578. Ref.1
Sequence conflict8891M → T in AAD40578. Ref.1
Sequence conflict9241G → V in AAD40578. Ref.1
Sequence conflict9281E → G in AAD40578. Ref.1
Sequence conflict9351S → C in AAD40578. Ref.1
Sequence conflict9711Q → H in AAD40578. Ref.1
Sequence conflict10251S → P in AAD40578. Ref.1
Sequence conflict10521P → S in AAD40578. Ref.1
Sequence conflict10761T → S in AAD40578. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9WVJ0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 05D419F7812E9D0A

FASTA1,087117,667
        10         20         30         40         50         60 
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV 

        70         80         90        100        110        120 
MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK 

       130        140        150        160        170        180 
GEVALFLVSH KDISETKNRG GPDNWKERGG GRRRYGRAGS KGFNANRRRS RAVLYHLSGH 

       190        200        210        220        230        240 
LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV 

       250        260        270        280        290        300 
TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 

       310        320        330        340        350        360 
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL 

       370        380        390        400        410        420 
TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ ELARRLETPY YLVSRSPDGG 

       430        440        450        460        470        480 
NSSGQSENCS SSSRGSEANG TGLELLGGPS LRSAYITSLY FALSSLTSVG FGNVSANTDT 

       490        500        510        520        530        540 
EKIFSICTML IGALMHAVVF GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR 

       550        560        570        580        590        600 
MLEYFQATWA VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 

       610        620        630        640        650        660 
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC ELPQREQVVK 

       670        680        690        700        710        720 
ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR GELSYNLGAG GVSAEVDTSS 

       730        740        750        760        770        780 
LSGDNTLMST LEEKETDGEQ GHTVSPAPAD EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP 

       790        800        810        820        830        840 
RLGGRGRPSR AGVLKPEAGP SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP 

       850        860        870        880        890        900 
KFSFRVGQSG PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 

       910        920        930        940        950        960 
GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY CLQPPAGSVL 

       970        980        990       1000       1010       1020 
SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS TSDSEPPGSG DLCSEPSTPA 

      1030       1040       1050       1060       1070       1080 
SPPPSEEGAR TGTPAPVSQA EATSTGEPPP GPGGRALPWD PHSLEMVLIG CHGPGTVQWT 


QEEGTGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF109143 mRNA. Translation: AAD40578.1.
AC161198 Genomic DNA. No translation available.
UniGeneMm.374793.

3D structure databases

ProteinModelPortalQ9WVJ0.
SMRQ9WVJ0. Positions 11-136, 455-685.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9WVJ0.

Proteomic databases

PRIDEQ9WVJ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1341723. Kcnh3.

Phylogenomic databases

eggNOGCOG2202.
HOGENOMHOG000230794.
HOVERGENHBG052232.

Gene expression databases

BgeeQ9WVJ0.
GenevestigatorQ9WVJ0.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9WVJ0.
SOURCESearch...

Entry information

Entry nameKCNH3_MOUSE
AccessionPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): E9QMZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot