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Q9WVJ0

- KCNH3_MOUSE

UniProt

Q9WVJ0 - KCNH3_MOUSE

Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi585 – 700116cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 3
    Alternative name(s):
    Ether-a-go-go-like potassium channel 2
    Short name:
    ELK channel 2
    Short name:
    mElk2
    Voltage-gated potassium channel subunit Kv12.2
    Gene namesi
    Name:Kcnh3
    Synonyms:Elk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1341723. Kcnh3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10871087Potassium voltage-gated channel subfamily H member 3PRO_0000054006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9WVJ0.

    PTM databases

    PhosphoSiteiQ9WVJ0.

    Expressioni

    Tissue specificityi

    Detected in brain, but not in other tissues.

    Gene expression databases

    BgeeiQ9WVJ0.
    GenevestigatoriQ9WVJ0.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVJ0.
    SMRiQ9WVJ0. Positions 11-136, 454-509, 516-685.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 228228CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 25910ExtracellularSequence Analysis
    Topological domaini281 – 30222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 3318ExtracellularSequence Analysis
    Topological domaini353 – 3619CytoplasmicSequence Analysis
    Topological domaini383 – 45674ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini478 – 4825ExtracellularSequence Analysis
    Topological domaini504 – 1087584CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei457 – 47721Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9073PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi468 – 4736Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi954 – 1061108Pro-richAdd
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG052232.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVJ0-1 [UniParc]FASTAAdd to Basket

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    MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC     50
    DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 100
    RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 150
    GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 200
    NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 250
    AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 300
    HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 350
    RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ 400
    ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSRGSEANG TGLELLGGPS 450
    LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 500
    GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 550
    VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 600
    LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 650
    ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 700
    GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTVSPAPAD 750
    EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 800
    SAHPRSLDGL QLPPMPWNVP PDLSPRVVDG IEDGCSSDQP KFSFRVGQSG 850
    PECSSSPSPG TESGLLTVPL GPSEARNTDT LDKLRQAVME LSEQVLQMRE 900
    GLQSLRQAVQ LILVPQGEGQ CPRGSGEEPC PATASGLLQP LRVDTGASSY 950
    CLQPPAGSVL SGTWPHPRPG QPPPLMAPWP WGPPASQSSP WPRATALWTS 1000
    TSDSEPPGSG DLCSEPSTPA SPPPSEEGAR TGTPAPVSQA EATSTGEPPP 1050
    GPGGRALPWD PHSLEMVLIG CHGPGTVQWT QEEGTGV 1087
    Length:1,087
    Mass (Da):117,667
    Last modified:July 27, 2011 - v2
    Checksum:i05D419F7812E9D0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51R → P in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti388 – 3881S → N in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti433 – 4342SR → GG in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti744 – 7441V → I in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti806 – 8061S → T in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti836 – 8361S → G in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti840 – 8401P → H in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti871 – 8711G → V in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti889 – 8891M → T in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti924 – 9241G → V in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti928 – 9281E → G in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti935 – 9351S → C in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti971 – 9711Q → H in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti1025 – 10251S → P in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti1052 – 10521P → S in AAD40578. (PubMed:10191308)Curated
    Sequence conflicti1076 – 10761T → S in AAD40578. (PubMed:10191308)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109143 mRNA. Translation: AAD40578.1.
    AC161198 Genomic DNA. No translation available.
    UniGeneiMm.374793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109143 mRNA. Translation: AAD40578.1 .
    AC161198 Genomic DNA. No translation available.
    UniGenei Mm.374793.

    3D structure databases

    ProteinModelPortali Q9WVJ0.
    SMRi Q9WVJ0. Positions 11-136, 454-509, 516-685.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WVJ0.

    Proteomic databases

    PRIDEi Q9WVJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1341723. Kcnh3.

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG052232.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    PROi Q9WVJ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVJ0.
    Genevestigatori Q9WVJ0.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional analysis of a mouse brain Elk-type K+ channel."
      Trudeau M.C., Titus S.A., Branchaw J.L., Ganetzky B., Robertson G.A.
      J. Neurosci. 19:2906-2918(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiKCNH3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVJ0
    Secondary accession number(s): E9QMZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3