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Q9WVI9

- JIP1_MOUSE

UniProt

Q9WVI9 - JIP1_MOUSE

Protein

C-Jun-amino-terminal kinase-interacting protein 1

Gene

Mapk8ip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (05 Dec 2001)
      Previous versions | rss
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    Functioni

    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response By similarity.By similarity

    GO - Molecular functioni

    1. kinesin binding Source: UniProtKB
    2. MAP-kinase scaffold activity Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. JUN phosphorylation Source: MGI
    2. negative regulation of apoptotic process Source: Ensembl
    3. negative regulation of intrinsic apoptotic signaling pathway Source: MGI
    4. negative regulation of JNK cascade Source: Ensembl
    5. negative regulation of JUN kinase activity Source: Ensembl
    6. positive regulation of signal transduction Source: GOC
    7. regulation of JNK cascade Source: UniProtKB
    8. regulation of transcription, DNA-templated Source: MGI
    9. signal transduction Source: MGI
    10. vesicle-mediated transport Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 1
    Short name:
    JIP-1
    Short name:
    JNK-interacting protein 1
    Alternative name(s):
    Islet-brain-1
    Short name:
    IB-1
    JNK MAP kinase scaffold protein 1
    Mitogen-activated protein kinase 8-interacting protein 1
    Gene namesi
    Name:Mapk8ip1
    Synonyms:Ib1, Jip1, Mapk8ip, Prkm8ip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1309464. Mapk8ip1.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Nucleus By similarity. Endoplasmic reticulum membrane By similarity. Mitochondrion membrane By similarity
    Note: Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus By similarity.By similarity

    GO - Cellular componenti

    1. axon Source: MGI
    2. axonal growth cone Source: MGI
    3. cell body Source: MGI
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: MGI
    6. dendrite Source: MGI
    7. dendritic growth cone Source: MGI
    8. dentate gyrus mossy fiber Source: MGI
    9. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    10. membrane Source: UniProtKB
    11. mitochondrial membrane Source: UniProtKB-SubCell
    12. neuron projection Source: MGI
    13. nucleus Source: UniProtKB-SubCell
    14. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    15. synapse Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707C-Jun-amino-terminal kinase-interacting protein 1PRO_0000220629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei103 – 1031Phosphothreonine; by MAPK8, MAPK9 and MAPK10By similarity
    Modified residuei148 – 1481PhosphoserineBy similarity
    Modified residuei177 – 1771PhosphoserineBy similarity
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei189 – 1891PhosphoserineBy similarity
    Modified residuei191 – 1911PhosphoserineBy similarity
    Modified residuei192 – 1921PhosphoserineBy similarity
    Modified residuei201 – 2011Phosphothreonine; by MAPK8, MAPK9 and MAPK10By similarity
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei307 – 3071PhosphoserineBy similarity
    Modified residuei324 – 3241PhosphoserineBy similarity
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei336 – 3361PhosphoserineBy similarity
    Modified residuei351 – 3511PhosphoserineBy similarity
    Modified residuei362 – 3621PhosphoserineBy similarity
    Modified residuei365 – 3651PhosphoserineBy similarity
    Modified residuei403 – 4031PhosphoserineBy similarity
    Modified residuei405 – 4051PhosphoserineBy similarity
    Modified residuei407 – 4071PhosphothreonineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei444 – 4441PhosphothreonineBy similarity
    Modified residuei465 – 4651PhosphoserineBy similarity
    Modified residuei467 – 4671PhosphoserineBy similarity
    Modified residuei468 – 4681PhosphoserineBy similarity
    Modified residuei469 – 4691PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases By similarity.By similarity
    Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9WVI9.
    PRIDEiQ9WVI9.

    PTM databases

    PhosphoSiteiQ9WVI9.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the brain and insulin-secreting cells. In the brain, high expression found in the cerebral cortex and hippocampus. Localizes in the synaptic regions of the olfactory bulb, retina, cerebral and cerebellar cortex and hippocampus. Also expressed in a restricted number of axons, including mossy fibers from the hippocampal dentate gyrus, soma, dendrites and axons of cerebellar Purkinje cells. Also expressed in kidney, testis and prostate. Low levels in heart, ovary and small intestine. Isoform JIP-1b is more predominant in the brain than isoform JIP-1a. Isoform Jip1-a is expressed both in the brain and kidney, isoform JIP-1c, isoform JIP-1d and isoform JIP-1e are brain specific.1 Publication

    Developmental stagei

    Low levels at prenatal stage E15, increased levels during the first postnatal days, with a plateau at postnatal day 15.

    Inductioni

    Upon neuron differentiation.

    Gene expression databases

    BgeeiQ9WVI9.
    GenevestigatoriQ9WVI9.

    Interactioni

    Subunit structurei

    Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9, MAPK10, MAP2K7, MAP3K10, MAP3K11 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2) By similarity. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP By similarity. Interacts, via the PID domain, with ARHGEF28. Interacts with MAP3K7 and VRK2 By similarity. Interacts with DCLK2.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AppP120233EBI-288461,EBI-78814
    AppP12023-22EBI-288461,EBI-286828
    Lrp1Q91ZX72EBI-74515,EBI-300955
    Lrp1bQ9JI183EBI-288461,EBI-8294317
    Lrp2A2ARV42EBI-74515,EBI-300875
    Map3k7Q620734EBI-288464,EBI-1775345
    MAPK8P459832EBI-288461,EBI-286483From a different organism.
    VRK2Q86Y07-22EBI-288464,EBI-1207636From a different organism.

    Protein-protein interaction databases

    BioGridi202375. 4 interactions.
    IntActiQ9WVI9. 17 interactions.
    MINTiMINT-126863.
    STRINGi10090.ENSMUSP00000050773.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UKHX-ray2.35B153-163[»]
    1UKIX-ray2.70B153-163[»]
    3O17X-ray3.00F/G154-163[»]
    3O2MX-ray2.70F/G154-163[»]
    3V3VX-ray2.70B153-163[»]
    ProteinModelPortaliQ9WVI9.
    SMRiQ9WVI9. Positions 486-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9WVI9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini484 – 54562SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini557 – 696140PIDPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 281155JNK-binding domain (JBD)Add
    BLAST
    Regioni153 – 17220Minimal inhibitory domain (MID)Add
    BLAST
    Regioni279 – 467189Interaction with MAP3K7By similarityAdd
    BLAST
    Regioni467 – 656190Interaction with VRK2By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi349 – 3568D-box 1
    Motifi360 – 3689D-box 2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 477Asp/Glu-rich (acidic)
    Compositional biasi107 – 11610Asp/Glu-rich (acidic)
    Compositional biasi355 – 3595Poly-Pro

    Domaini

    The SH3 domain mediates homodimerization.By similarity

    Sequence similaritiesi

    Belongs to the JIP scaffold family.Curated
    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG266073.
    GeneTreeiENSGT00390000003908.
    HOVERGENiHBG018568.
    InParanoidiQ9WVI9.
    KOiK04434.
    OMAiSPCRRSA.
    OrthoDBiEOG74J97M.
    PhylomeDBiQ9WVI9.
    TreeFamiTF325073.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS01179. PID. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform JIP-1b (identifier: Q9WVI9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAERESGLGG GAASPPAASP FLGLHIASPP NFRLTHDISL EEFEDEDLSE    50
    ITDECGISLQ CKDTLSLRPP RAGLLSAGSS GSAGSRLQAE MLQMDLIDAA 100
    GDTPGAEDDE EEEDDELAAQ RPGVGPPKAE SNQDPAPRSQ GQGPGTGSGD 150
    TYRPKRPTTL NLFPQVPRSQ DTLNNNSLGK KHSWQDRVSR SSSPLKTGEQ 200
    TPPHEHICLS DELPPQGSPV PTQDRGTSTD SPCRRSAATQ MAPPSGPPAT 250
    APGGRGHSHR DRIHYQADVR LEATEEIYLT PVQRPPDPAE PTSTFMPPTE 300
    SRMSVSSDPD PAAYSVTAGR PHPSISEEDE GFDCLSSPER AEPPGGGWRG 350
    SLGEPPPPPR ASLSSDTSAL SYDSVKYTLV VDEHAQLELV SLRPCFGDYS 400
    DESDSATVYD NCASASSPYE SAIGEEYEEA PQPRPPTCLS EDSTPDEPDV 450
    HFSKKFLNVF MSGRSRSSSA ESFGLFSCVI NGEEHEQTHR AIFRFVPRHE 500
    DELELEVDDP LLVELQAEDY WYEAYNMRTG ARGVFPAYYA IEVTKEPEHM 550
    AALAKNSDWI DQFRVKFLGS VQVPYHKGND VLCAAMQKIA TTRRLTVHFN 600
    PPSSCVLEIS VRGVKIGVKA DDALEAKGNK CSHFFQLKNI SFCGYHPKNN 650
    KYFGFITKHP ADHRFACHVF VSEDSTKALA ESVGRAFQQF YKQFVEYTCP 700
    TEDIYLE 707
    Length:707
    Mass (Da):77,282
    Last modified:December 5, 2001 - v2
    Checksum:i274013B12D91049D
    GO
    Isoform JIP-1a (identifier: Q9WVI9-2) [UniParc]FASTAAdd to Basket

    Also known as: 1

    The sequence of this isoform differs from the canonical sequence as follows:
         558-604: Missing.

    Show »
    Length:660
    Mass (Da):71,927
    Checksum:iA303DB4A3C9A9775
    GO
    Isoform JIP-1c (identifier: Q9WVI9-3) [UniParc]FASTAAdd to Basket

    Also known as: 2a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: MAERESGLGGGAASPPAASPFLGLHIASPPNFR → MQLVLKMDSSPDNDSWLEDQWEHW

    Show »
    Length:698
    Mass (Da):77,009
    Checksum:i7451CE05C930E9F7
    GO
    Isoform JIP-1d (identifier: Q9WVI9-4) [UniParc]FASTAAdd to Basket

    Also known as: 2B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: MAERESGLGGGAASPPAASPFLGLHIASPPNFR → MQLVLKMDSSPDNDSWLEDQWEHW
         69-93: Missing.

    Show »
    Length:673
    Mass (Da):74,585
    Checksum:iCCB2C92E28D27E23
    GO
    Isoform JIP-1e (identifier: Q9WVI9-5) [UniParc]FASTAAdd to Basket

    Also known as: 3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: Missing.

    Show »
    Length:617
    Mass (Da):68,005
    Checksum:iA22DC803C3DB62DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1452PG → A in AAD38346. (PubMed:10098834)Curated
    Sequence conflicti144 – 1452PG → A in AAD38347. (PubMed:10098834)Curated
    Sequence conflicti144 – 1452PG → A in AAD38348. (PubMed:10098834)Curated
    Sequence conflicti593 – 5931R → RP in AAD38346. (PubMed:10098834)Curated
    Sequence conflicti593 – 5931R → RP in AAD38347. (PubMed:10098834)Curated
    Sequence conflicti593 – 5931R → RP in AAD38348. (PubMed:10098834)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101G → R in strain: ILS. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090Missing in isoform JIP-1e. 1 PublicationVSP_002764Add
    BLAST
    Alternative sequencei1 – 3333MAERE…PPNFR → MQLVLKMDSSPDNDSWLEDQ WEHW in isoform JIP-1c and isoform JIP-1d. 1 PublicationVSP_002763Add
    BLAST
    Alternative sequencei69 – 9325Missing in isoform JIP-1d. 1 PublicationVSP_002765Add
    BLAST
    Alternative sequencei558 – 60447Missing in isoform JIP-1a. 1 PublicationVSP_002766Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003115 mRNA. Translation: AAB66317.1.
    AF109768 mRNA. Translation: AAD38346.1.
    AF109769 mRNA. Translation: AAD38347.1.
    AF109770 mRNA. Translation: AAD38348.1.
    AF109771 mRNA. Translation: AAD38349.1.
    AF054611 mRNA. Translation: AAD22580.1.
    AF332075 mRNA. Translation: AAK56103.1.
    AF332076 mRNA. Translation: AAK56104.1.
    CCDSiCCDS16446.1. [Q9WVI9-1]
    CCDS57180.1. [Q9WVI9-3]
    PIRiT03038.
    RefSeqiNP_035292.2. NM_011162.5. [Q9WVI9-1]
    UniGeneiMm.2720.

    Genome annotation databases

    EnsembliENSMUST00000050312; ENSMUSP00000050773; ENSMUSG00000027223. [Q9WVI9-1]
    ENSMUST00000111279; ENSMUSP00000106910; ENSMUSG00000027223. [Q9WVI9-3]
    GeneIDi19099.
    KEGGimmu:19099.
    UCSCiuc008kxw.2. mouse. [Q9WVI9-4]
    uc008kxx.2. mouse. [Q9WVI9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003115 mRNA. Translation: AAB66317.1 .
    AF109768 mRNA. Translation: AAD38346.1 .
    AF109769 mRNA. Translation: AAD38347.1 .
    AF109770 mRNA. Translation: AAD38348.1 .
    AF109771 mRNA. Translation: AAD38349.1 .
    AF054611 mRNA. Translation: AAD22580.1 .
    AF332075 mRNA. Translation: AAK56103.1 .
    AF332076 mRNA. Translation: AAK56104.1 .
    CCDSi CCDS16446.1. [Q9WVI9-1 ]
    CCDS57180.1. [Q9WVI9-3 ]
    PIRi T03038.
    RefSeqi NP_035292.2. NM_011162.5. [Q9WVI9-1 ]
    UniGenei Mm.2720.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UKH X-ray 2.35 B 153-163 [» ]
    1UKI X-ray 2.70 B 153-163 [» ]
    3O17 X-ray 3.00 F/G 154-163 [» ]
    3O2M X-ray 2.70 F/G 154-163 [» ]
    3V3V X-ray 2.70 B 153-163 [» ]
    ProteinModelPortali Q9WVI9.
    SMRi Q9WVI9. Positions 486-545.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202375. 4 interactions.
    IntActi Q9WVI9. 17 interactions.
    MINTi MINT-126863.
    STRINGi 10090.ENSMUSP00000050773.

    PTM databases

    PhosphoSitei Q9WVI9.

    Proteomic databases

    PaxDbi Q9WVI9.
    PRIDEi Q9WVI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050312 ; ENSMUSP00000050773 ; ENSMUSG00000027223 . [Q9WVI9-1 ]
    ENSMUST00000111279 ; ENSMUSP00000106910 ; ENSMUSG00000027223 . [Q9WVI9-3 ]
    GeneIDi 19099.
    KEGGi mmu:19099.
    UCSCi uc008kxw.2. mouse. [Q9WVI9-4 ]
    uc008kxx.2. mouse. [Q9WVI9-1 ]

    Organism-specific databases

    CTDi 9479.
    MGIi MGI:1309464. Mapk8ip1.

    Phylogenomic databases

    eggNOGi NOG266073.
    GeneTreei ENSGT00390000003908.
    HOVERGENi HBG018568.
    InParanoidi Q9WVI9.
    KOi K04434.
    OMAi SPCRRSA.
    OrthoDBi EOG74J97M.
    PhylomeDBi Q9WVI9.
    TreeFami TF325073.

    Miscellaneous databases

    EvolutionaryTracei Q9WVI9.
    NextBioi 295662.
    PROi Q9WVI9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVI9.
    Genevestigatori Q9WVI9.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS01179. PID. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1A), POSSIBLE FUNCTION.
      Tissue: Brain.
    2. "Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain."
      Kim I.-J., Lee K.-W., Park B.Y., Lee J.-K., Park J., Choi I.Y., Eom S.-J., Chang T.-S., Kim M.J., Yeom Y.I., Chang S.K., Lee Y.-D., Choi E.-J., Han P.-L.
      J. Neurochem. 72:1335-1343(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS JIP-1B; JIP-1C; JIP-1D AND JIP-1E).
      Strain: BALB/c.
      Tissue: Brain.
    3. "The JIP group of mitogen-activated protein kinase scaffold proteins."
      Yasuda J., Whitmarsh A.J., Cavanagh J., Sharma M., Davis R.J.
      Mol. Cell. Biol. 19:7245-7254(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B), CHARACTERIZATION.
      Tissue: Brain.
    4. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B), VARIANT ARG-10.
      Strain: ILS and ISS.
    5. "Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."
      Taru H., Iijima K., Hase M., Kirino Y., Yagi Y., Suzuki T.
      J. Biol. Chem. 277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B).
      Tissue: Brain.
    6. "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."
      Meyer D., Liu A., Margolis B.
      J. Biol. Chem. 274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGEF28, SUBCELLULAR LOCATION.
    7. "Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain."
      Pellet J.-B., Haefliger J.-A., Staple J.K., Widmann C., Welker E., Hirling H., Bonny C., Nicod P., Catsicas S., Waeber G., Riederer B.M.
      Eur. J. Neurosci. 12:621-632(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    8. "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction."
      Gotthardt M., Trommsdorff M., Nevitt M.F., Shelton J., Richardson J.A., Stockinger W., Nimpf J., Herz J.
      J. Biol. Chem. 275:25616-25624(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRPS.
    9. "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
      Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B.
      J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KLC1.
      Tissue: Brain.
    10. Cited for: FUNCTION.
    11. "Common and divergent roles for members of the mouse DCX superfamily."
      Coquelle F.M., Levy T., Bergmann S., Wolf S.G., Bar-El D., Sapir T., Brody Y., Orr I., Barkai N., Eichele G., Reiner O.
      Cell Cycle 5:976-983(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DCLK2.

    Entry informationi

    Entry nameiJIP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVI9
    Secondary accession number(s): O35145
    , Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: December 5, 2001
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3