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Q9WVI9

- JIP1_MOUSE

UniProt

Q9WVI9 - JIP1_MOUSE

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Protein

C-Jun-amino-terminal kinase-interacting protein 1

Gene
Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response By similarity.2 Publications

GO - Molecular functioni

  1. kinesin binding Source: UniProtKB
  2. MAP-kinase scaffold activity Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. JUN phosphorylation Source: MGI
  2. negative regulation of apoptotic process Source: Ensembl
  3. negative regulation of intrinsic apoptotic signaling pathway Source: MGI
  4. negative regulation of JNK cascade Source: Ensembl
  5. negative regulation of JUN kinase activity Source: Ensembl
  6. positive regulation of signal transduction Source: GOC
  7. regulation of JNK cascade Source: UniProtKB
  8. regulation of transcription, DNA-templated Source: MGI
  9. signal transduction Source: MGI
  10. vesicle-mediated transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 1
Short name:
JIP-1
Short name:
JNK-interacting protein 1
Alternative name(s):
Islet-brain-1
Short name:
IB-1
JNK MAP kinase scaffold protein 1
Mitogen-activated protein kinase 8-interacting protein 1
Gene namesi
Name:Mapk8ip1
Synonyms:Ib1, Jip1, Mapk8ip, Prkm8ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1309464. Mapk8ip1.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Nucleus By similarity. Endoplasmic reticulum membrane By similarity. Mitochondrion membrane By similarity
Note: Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus By similarity.2 Publications

GO - Cellular componenti

  1. axon Source: MGI
  2. axonal growth cone Source: MGI
  3. cell body Source: MGI
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: MGI
  6. dendrite Source: MGI
  7. dendritic growth cone Source: MGI
  8. dentate gyrus mossy fiber Source: MGI
  9. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  10. membrane Source: UniProtKB
  11. mitochondrial membrane Source: UniProtKB-SubCell
  12. neuron projection Source: MGI
  13. nucleus Source: UniProtKB-SubCell
  14. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  15. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707C-Jun-amino-terminal kinase-interacting protein 1PRO_0000220629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391Phosphoserine By similarity
Modified residuei103 – 1031Phosphothreonine; by MAPK8, MAPK9 and MAPK10 By similarity
Modified residuei148 – 1481Phosphoserine By similarity
Modified residuei177 – 1771Phosphoserine By similarity
Modified residuei183 – 1831Phosphoserine By similarity
Modified residuei189 – 1891Phosphoserine By similarity
Modified residuei191 – 1911Phosphoserine By similarity
Modified residuei192 – 1921Phosphoserine By similarity
Modified residuei201 – 2011Phosphothreonine; by MAPK8, MAPK9 and MAPK10 By similarity
Modified residuei210 – 2101Phosphoserine By similarity
Modified residuei307 – 3071Phosphoserine By similarity
Modified residuei324 – 3241Phosphoserine By similarity
Modified residuei326 – 3261Phosphoserine By similarity
Modified residuei336 – 3361Phosphoserine By similarity
Modified residuei351 – 3511Phosphoserine By similarity
Modified residuei362 – 3621Phosphoserine By similarity
Modified residuei365 – 3651Phosphoserine By similarity
Modified residuei403 – 4031Phosphoserine By similarity
Modified residuei405 – 4051Phosphoserine By similarity
Modified residuei407 – 4071Phosphothreonine By similarity
Modified residuei440 – 4401Phosphoserine By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei444 – 4441Phosphothreonine By similarity
Modified residuei465 – 4651Phosphoserine By similarity
Modified residuei467 – 4671Phosphoserine By similarity
Modified residuei468 – 4681Phosphoserine By similarity
Modified residuei469 – 4691Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases By similarity.
Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9WVI9.
PRIDEiQ9WVI9.

PTM databases

PhosphoSiteiQ9WVI9.

Expressioni

Tissue specificityi

Expressed predominantly in the brain and insulin-secreting cells. In the brain, high expression found in the cerebral cortex and hippocampus. Localizes in the synaptic regions of the olfactory bulb, retina, cerebral and cerebellar cortex and hippocampus. Also expressed in a restricted number of axons, including mossy fibers from the hippocampal dentate gyrus, soma, dendrites and axons of cerebellar Purkinje cells. Also expressed in kidney, testis and prostate. Low levels in heart, ovary and small intestine. Isoform JIP-1b is more predominant in the brain than isoform JIP-1a. Isoform Jip1-a is expressed both in the brain and kidney, isoform JIP-1c, isoform JIP-1d and isoform JIP-1e are brain specific.1 Publication

Developmental stagei

Low levels at prenatal stage E15, increased levels during the first postnatal days, with a plateau at postnatal day 15.

Inductioni

Upon neuron differentiation.

Gene expression databases

BgeeiQ9WVI9.
GenevestigatoriQ9WVI9.

Interactioni

Subunit structurei

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9, MAPK10, MAP2K7, MAP3K10, MAP3K11 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2) By similarity. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP By similarity. Interacts, via the PID domain, with ARHGEF28. Interacts with MAP3K7 and VRK2 By similarity. Interacts with DCLK2.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120233EBI-288461,EBI-78814
AppP12023-22EBI-288461,EBI-286828
Lrp1Q91ZX72EBI-74515,EBI-300955
Lrp1bQ9JI183EBI-288461,EBI-8294317
Lrp2A2ARV42EBI-74515,EBI-300875
Map3k7Q620734EBI-288464,EBI-1775345
MAPK8P459832EBI-288461,EBI-286483From a different organism.
VRK2Q86Y07-22EBI-288464,EBI-1207636From a different organism.

Protein-protein interaction databases

BioGridi202375. 4 interactions.
IntActiQ9WVI9. 17 interactions.
MINTiMINT-126863.
STRINGi10090.ENSMUSP00000050773.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UKHX-ray2.35B153-163[»]
1UKIX-ray2.70B153-163[»]
3O17X-ray3.00F/G154-163[»]
3O2MX-ray2.70F/G154-163[»]
3V3VX-ray2.70B153-163[»]
ProteinModelPortaliQ9WVI9.
SMRiQ9WVI9. Positions 486-545.

Miscellaneous databases

EvolutionaryTraceiQ9WVI9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini484 – 54562SH3Add
BLAST
Domaini557 – 696140PIDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 281155JNK-binding domain (JBD)Add
BLAST
Regioni153 – 17220Minimal inhibitory domain (MID)Add
BLAST
Regioni279 – 467189Interaction with MAP3K7 By similarityAdd
BLAST
Regioni467 – 656190Interaction with VRK2 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi349 – 3568D-box 1
Motifi360 – 3689D-box 2

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 477Asp/Glu-rich (acidic)
Compositional biasi107 – 11610Asp/Glu-rich (acidic)
Compositional biasi355 – 3595Poly-Pro

Domaini

The SH3 domain mediates homodimerization By similarity.

Sequence similaritiesi

Belongs to the JIP scaffold family.
Contains 1 PID domain.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG266073.
GeneTreeiENSGT00390000003908.
HOVERGENiHBG018568.
InParanoidiQ9WVI9.
KOiK04434.
OMAiSPCRRSA.
OrthoDBiEOG74J97M.
PhylomeDBiQ9WVI9.
TreeFamiTF325073.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00640. PID. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS01179. PID. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform JIP-1b (identifier: Q9WVI9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAERESGLGG GAASPPAASP FLGLHIASPP NFRLTHDISL EEFEDEDLSE    50
ITDECGISLQ CKDTLSLRPP RAGLLSAGSS GSAGSRLQAE MLQMDLIDAA 100
GDTPGAEDDE EEEDDELAAQ RPGVGPPKAE SNQDPAPRSQ GQGPGTGSGD 150
TYRPKRPTTL NLFPQVPRSQ DTLNNNSLGK KHSWQDRVSR SSSPLKTGEQ 200
TPPHEHICLS DELPPQGSPV PTQDRGTSTD SPCRRSAATQ MAPPSGPPAT 250
APGGRGHSHR DRIHYQADVR LEATEEIYLT PVQRPPDPAE PTSTFMPPTE 300
SRMSVSSDPD PAAYSVTAGR PHPSISEEDE GFDCLSSPER AEPPGGGWRG 350
SLGEPPPPPR ASLSSDTSAL SYDSVKYTLV VDEHAQLELV SLRPCFGDYS 400
DESDSATVYD NCASASSPYE SAIGEEYEEA PQPRPPTCLS EDSTPDEPDV 450
HFSKKFLNVF MSGRSRSSSA ESFGLFSCVI NGEEHEQTHR AIFRFVPRHE 500
DELELEVDDP LLVELQAEDY WYEAYNMRTG ARGVFPAYYA IEVTKEPEHM 550
AALAKNSDWI DQFRVKFLGS VQVPYHKGND VLCAAMQKIA TTRRLTVHFN 600
PPSSCVLEIS VRGVKIGVKA DDALEAKGNK CSHFFQLKNI SFCGYHPKNN 650
KYFGFITKHP ADHRFACHVF VSEDSTKALA ESVGRAFQQF YKQFVEYTCP 700
TEDIYLE 707
Length:707
Mass (Da):77,282
Last modified:December 5, 2001 - v2
Checksum:i274013B12D91049D
GO
Isoform JIP-1a (identifier: Q9WVI9-2) [UniParc]FASTAAdd to Basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     558-604: Missing.

Show »
Length:660
Mass (Da):71,927
Checksum:iA303DB4A3C9A9775
GO
Isoform JIP-1c (identifier: Q9WVI9-3) [UniParc]FASTAAdd to Basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MAERESGLGGGAASPPAASPFLGLHIASPPNFR → MQLVLKMDSSPDNDSWLEDQWEHW

Show »
Length:698
Mass (Da):77,009
Checksum:i7451CE05C930E9F7
GO
Isoform JIP-1d (identifier: Q9WVI9-4) [UniParc]FASTAAdd to Basket

Also known as: 2B

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MAERESGLGGGAASPPAASPFLGLHIASPPNFR → MQLVLKMDSSPDNDSWLEDQWEHW
     69-93: Missing.

Show »
Length:673
Mass (Da):74,585
Checksum:iCCB2C92E28D27E23
GO
Isoform JIP-1e (identifier: Q9WVI9-5) [UniParc]FASTAAdd to Basket

Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:617
Mass (Da):68,005
Checksum:iA22DC803C3DB62DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101G → R in strain: ILS. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform JIP-1e. VSP_002764Add
BLAST
Alternative sequencei1 – 3333MAERE…PPNFR → MQLVLKMDSSPDNDSWLEDQ WEHW in isoform JIP-1c and isoform JIP-1d. VSP_002763Add
BLAST
Alternative sequencei69 – 9325Missing in isoform JIP-1d. VSP_002765Add
BLAST
Alternative sequencei558 – 60447Missing in isoform JIP-1a. VSP_002766Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1452PG → A in AAD38346. 1 Publication
Sequence conflicti144 – 1452PG → A in AAD38347. 1 Publication
Sequence conflicti144 – 1452PG → A in AAD38348. 1 Publication
Sequence conflicti593 – 5931R → RP in AAD38346. 1 Publication
Sequence conflicti593 – 5931R → RP in AAD38347. 1 Publication
Sequence conflicti593 – 5931R → RP in AAD38348. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003115 mRNA. Translation: AAB66317.1.
AF109768 mRNA. Translation: AAD38346.1.
AF109769 mRNA. Translation: AAD38347.1.
AF109770 mRNA. Translation: AAD38348.1.
AF109771 mRNA. Translation: AAD38349.1.
AF054611 mRNA. Translation: AAD22580.1.
AF332075 mRNA. Translation: AAK56103.1.
AF332076 mRNA. Translation: AAK56104.1.
CCDSiCCDS16446.1. [Q9WVI9-1]
CCDS57180.1. [Q9WVI9-3]
PIRiT03038.
RefSeqiNP_035292.2. NM_011162.5. [Q9WVI9-1]
UniGeneiMm.2720.

Genome annotation databases

EnsembliENSMUST00000050312; ENSMUSP00000050773; ENSMUSG00000027223. [Q9WVI9-1]
ENSMUST00000111279; ENSMUSP00000106910; ENSMUSG00000027223. [Q9WVI9-3]
GeneIDi19099.
KEGGimmu:19099.
UCSCiuc008kxw.2. mouse. [Q9WVI9-4]
uc008kxx.2. mouse. [Q9WVI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003115 mRNA. Translation: AAB66317.1 .
AF109768 mRNA. Translation: AAD38346.1 .
AF109769 mRNA. Translation: AAD38347.1 .
AF109770 mRNA. Translation: AAD38348.1 .
AF109771 mRNA. Translation: AAD38349.1 .
AF054611 mRNA. Translation: AAD22580.1 .
AF332075 mRNA. Translation: AAK56103.1 .
AF332076 mRNA. Translation: AAK56104.1 .
CCDSi CCDS16446.1. [Q9WVI9-1 ]
CCDS57180.1. [Q9WVI9-3 ]
PIRi T03038.
RefSeqi NP_035292.2. NM_011162.5. [Q9WVI9-1 ]
UniGenei Mm.2720.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UKH X-ray 2.35 B 153-163 [» ]
1UKI X-ray 2.70 B 153-163 [» ]
3O17 X-ray 3.00 F/G 154-163 [» ]
3O2M X-ray 2.70 F/G 154-163 [» ]
3V3V X-ray 2.70 B 153-163 [» ]
ProteinModelPortali Q9WVI9.
SMRi Q9WVI9. Positions 486-545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202375. 4 interactions.
IntActi Q9WVI9. 17 interactions.
MINTi MINT-126863.
STRINGi 10090.ENSMUSP00000050773.

PTM databases

PhosphoSitei Q9WVI9.

Proteomic databases

PaxDbi Q9WVI9.
PRIDEi Q9WVI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050312 ; ENSMUSP00000050773 ; ENSMUSG00000027223 . [Q9WVI9-1 ]
ENSMUST00000111279 ; ENSMUSP00000106910 ; ENSMUSG00000027223 . [Q9WVI9-3 ]
GeneIDi 19099.
KEGGi mmu:19099.
UCSCi uc008kxw.2. mouse. [Q9WVI9-4 ]
uc008kxx.2. mouse. [Q9WVI9-1 ]

Organism-specific databases

CTDi 9479.
MGIi MGI:1309464. Mapk8ip1.

Phylogenomic databases

eggNOGi NOG266073.
GeneTreei ENSGT00390000003908.
HOVERGENi HBG018568.
InParanoidi Q9WVI9.
KOi K04434.
OMAi SPCRRSA.
OrthoDBi EOG74J97M.
PhylomeDBi Q9WVI9.
TreeFami TF325073.

Miscellaneous databases

EvolutionaryTracei Q9WVI9.
NextBioi 295662.
PROi Q9WVI9.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVI9.
Genevestigatori Q9WVI9.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS01179. PID. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1A), POSSIBLE FUNCTION.
    Tissue: Brain.
  2. "Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain."
    Kim I.-J., Lee K.-W., Park B.Y., Lee J.-K., Park J., Choi I.Y., Eom S.-J., Chang T.-S., Kim M.J., Yeom Y.I., Chang S.K., Lee Y.-D., Choi E.-J., Han P.-L.
    J. Neurochem. 72:1335-1343(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS JIP-1B; JIP-1C; JIP-1D AND JIP-1E).
    Strain: BALB/c.
    Tissue: Brain.
  3. "The JIP group of mitogen-activated protein kinase scaffold proteins."
    Yasuda J., Whitmarsh A.J., Cavanagh J., Sharma M., Davis R.J.
    Mol. Cell. Biol. 19:7245-7254(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B), CHARACTERIZATION.
    Tissue: Brain.
  4. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B), VARIANT ARG-10.
    Strain: ILS and ISS.
  5. "Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."
    Taru H., Iijima K., Hase M., Kirino Y., Yagi Y., Suzuki T.
    J. Biol. Chem. 277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B).
    Tissue: Brain.
  6. "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."
    Meyer D., Liu A., Margolis B.
    J. Biol. Chem. 274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF28, SUBCELLULAR LOCATION.
  7. "Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain."
    Pellet J.-B., Haefliger J.-A., Staple J.K., Widmann C., Welker E., Hirling H., Bonny C., Nicod P., Catsicas S., Waeber G., Riederer B.M.
    Eur. J. Neurosci. 12:621-632(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  8. "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction."
    Gotthardt M., Trommsdorff M., Nevitt M.F., Shelton J., Richardson J.A., Stockinger W., Nimpf J., Herz J.
    J. Biol. Chem. 275:25616-25624(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRPS.
  9. "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
    Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B.
    J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLC1.
    Tissue: Brain.
  10. Cited for: FUNCTION.
  11. "Common and divergent roles for members of the mouse DCX superfamily."
    Coquelle F.M., Levy T., Bergmann S., Wolf S.G., Bar-El D., Sapir T., Brody Y., Orr I., Barkai N., Eichele G., Reiner O.
    Cell Cycle 5:976-983(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DCLK2.

Entry informationi

Entry nameiJIP1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVI9
Secondary accession number(s): O35145
, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi