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Protein

Fibulin-5

Gene

Fbln5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:11805835).By similarity1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. integrin binding Source: UniProtKB
  3. protein C-terminus binding Source: MGI
  4. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. elastic fiber assembly Source: UniProtKB
  3. extracellular matrix organization Source: MGI
  4. protein localization to cell surface Source: BHF-UCL
  5. regulation of cell growth Source: Ensembl
  6. regulation of removal of superoxide radicals Source: BHF-UCL
  7. secretion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_332220. Molecules associated with elastic fibres.
REACT_334317. Elastic fibre formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-5
Short name:
FIBL-5
Alternative name(s):
Developmental arteries and neural crest EGF-like protein
Short name:
Dance
Gene namesi
Name:Fbln5
Synonyms:Dance
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1346091. Fbln5.

Subcellular locationi

Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: co-localizes with ELN in elastic fibers.By similarity

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. extracellular region Source: Reactome
  3. extracellular space Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice survive to adulthood, but have a tortuous aorta with loss of compliance, severe emphisema and loose skin. They exhibit a severely disorganized elastic fiber system throughout the body.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 448425Fibulin-5PRO_0000007578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 68PROSITE-ProRule annotation
Disulfide bondi131 ↔ 144PROSITE-ProRule annotation
Disulfide bondi138 ↔ 153PROSITE-ProRule annotation
Disulfide bondi155 ↔ 166PROSITE-ProRule annotation
Disulfide bondi172 ↔ 181PROSITE-ProRule annotation
Disulfide bondi177 ↔ 190PROSITE-ProRule annotation
Disulfide bondi192 ↔ 205PROSITE-ProRule annotation
Disulfide bondi211 ↔ 221PROSITE-ProRule annotation
Disulfide bondi217 ↔ 230PROSITE-ProRule annotation
Disulfide bondi232 ↔ 245PROSITE-ProRule annotation
Disulfide bondi251 ↔ 262PROSITE-ProRule annotation
Disulfide bondi258 ↔ 271PROSITE-ProRule annotation
Disulfide bondi273 ↔ 286PROSITE-ProRule annotation
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi292 ↔ 305PROSITE-ProRule annotation
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi299 ↔ 314PROSITE-ProRule annotation
Disulfide bondi320 ↔ 332PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WVH9.
PaxDbiQ9WVH9.
PRIDEiQ9WVH9.

Expressioni

Gene expression databases

BgeeiQ9WVH9.
CleanExiMM_FBLN5.
GenevestigatoriQ9WVH9.

Interactioni

Subunit structurei

Homodimer. Monomer, homodimerizes in presence of Ca2+. Interacts with ELN (By similarity). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (PubMed:11805835).By similarity1 Publication

Protein-protein interaction databases

IntActiQ9WVH9. 2 interactions.
MINTiMINT-4094993.

Structurei

3D structure databases

ProteinModelPortaliQ9WVH9.
SMRiQ9WVH9. Positions 42-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 8241EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16741EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini168 – 20639EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini207 – 24640EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 28741EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini288 – 33346EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi54 – 563Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the fibulin family.Curated
Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG309650.
GeneTreeiENSGT00760000118806.
HOGENOMiHOG000234337.
HOVERGENiHBG051560.
InParanoidiQ9WVH9.
KOiK17340.
OMAiPRDIQLD.
OrthoDBiEOG7W9RTF.
PhylomeDBiQ9WVH9.
TreeFamiTF317514.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLKRILTV TILALWLPHP GNAQQQCTNG FDLDRQSGQC LDIDECRTIP
60 70 80 90 100
EACRGDMMCV NQNGGYLCIP RTNPVYRGPY SNPYSTSYSG PYPAAAPPVP
110 120 130 140 150
ASNYPTISRP LVCRFGYQMD EGNQCVDVDE CATDSHQCNP TQICINTEGG
160 170 180 190 200
YTCSCTDGYW LLEGQCLDID ECRYGYCQQL CANVPGSYSC TCNPGFTLND
210 220 230 240 250
DGRSCQDVNE CETENPCVQT CVNTYGSFIC RCDPGYELEE DGIHCSDMDE
260 270 280 290 300
CSFSEFLCQH ECVNQPGSYF CSCPPGYVLL DDNRSCQDIN ECEHRNHTCT
310 320 330 340 350
SLQTCYNLQG GFKCIDPISC EEPYLLIGEN RCMCPAEHTS CRDQPFTILY
360 370 380 390 400
RDMDVVSGRS VPADIFQMQA TTRYPGAYYI FQIKSGNEGR EFYMRQTGPI
410 420 430 440
SATLVMTRPI KGPRDIQLDL EMITVNTVIN FRGSSVIRLR IYVSQYPF
Length:448
Mass (Da):50,193
Last modified:November 1, 1999 - v1
Checksum:iF15CC70CCFBFDC97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112151 mRNA. Translation: AAD41767.1.
AK085170 mRNA. Translation: BAC39381.1.
AK090129 mRNA. Translation: BAC41109.1.
AK159471 mRNA. Translation: BAE35112.1.
AK159960 mRNA. Translation: BAE35515.1.
AK165018 mRNA. Translation: BAE38002.1.
BC006636 mRNA. Translation: AAH06636.1.
CCDSiCCDS36525.1.
RefSeqiNP_035942.1. NM_011812.4.
UniGeneiMm.288381.
Mm.465863.

Genome annotation databases

EnsembliENSMUST00000021603; ENSMUSP00000021603; ENSMUSG00000021186.
GeneIDi23876.
KEGGimmu:23876.
UCSCiuc007otp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112151 mRNA. Translation: AAD41767.1.
AK085170 mRNA. Translation: BAC39381.1.
AK090129 mRNA. Translation: BAC41109.1.
AK159471 mRNA. Translation: BAE35112.1.
AK159960 mRNA. Translation: BAE35515.1.
AK165018 mRNA. Translation: BAE38002.1.
BC006636 mRNA. Translation: AAH06636.1.
CCDSiCCDS36525.1.
RefSeqiNP_035942.1. NM_011812.4.
UniGeneiMm.288381.
Mm.465863.

3D structure databases

ProteinModelPortaliQ9WVH9.
SMRiQ9WVH9. Positions 42-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVH9. 2 interactions.
MINTiMINT-4094993.

Proteomic databases

MaxQBiQ9WVH9.
PaxDbiQ9WVH9.
PRIDEiQ9WVH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021603; ENSMUSP00000021603; ENSMUSG00000021186.
GeneIDi23876.
KEGGimmu:23876.
UCSCiuc007otp.1. mouse.

Organism-specific databases

CTDi10516.
MGIiMGI:1346091. Fbln5.

Phylogenomic databases

eggNOGiNOG309650.
GeneTreeiENSGT00760000118806.
HOGENOMiHOG000234337.
HOVERGENiHBG051560.
InParanoidiQ9WVH9.
KOiK17340.
OMAiPRDIQLD.
OrthoDBiEOG7W9RTF.
PhylomeDBiQ9WVH9.
TreeFamiTF317514.

Enzyme and pathway databases

ReactomeiREACT_332220. Molecules associated with elastic fibres.
REACT_334317. Elastic fibre formation.

Miscellaneous databases

ChiTaRSiFbln5. mouse.
NextBioi303595.
PROiQ9WVH9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVH9.
CleanExiMM_FBLN5.
GenevestigatoriQ9WVH9.

Family and domain databases

InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries."
    Nakamura T., Ruiz-Lozano P., Lindner V., Yabe D., Taniwaki M., Furukawa Y., Kobuke K., Tashiro K., Lu Z., Andon N.L., Schaub R., Matsumori A., Sasayama S., Chien K.R., Honjo T.
    J. Biol. Chem. 274:22476-22483(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH ITGAV/ITGB3; ITGAV/ITGB5 AND ITGA9/ITGB1.

Entry informationi

Entry nameiFBLN5_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH9
Secondary accession number(s): Q541Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.