Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9WVH6

- ANGP4_MOUSE

UniProt

Q9WVH6 - ANGP4_MOUSE

Protein

Angiopoietin-4

Gene

Angpt4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

    GO - Molecular functioni

    1. transmembrane receptor protein tyrosine kinase activator activity Source: Ensembl
    2. vascular endothelial growth factor receptor binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cellular response to hypoxia Source: Ensembl
    3. endoderm development Source: MGI
    4. negative regulation of angiogenesis Source: Ensembl
    5. negative regulation of apoptotic process Source: Ensembl
    6. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    7. positive regulation of angiogenesis Source: Ensembl
    8. positive regulation of blood vessel endothelial cell migration Source: Ensembl
    9. Tie signaling pathway Source: DFLAT

    Keywords - Biological processi

    Angiogenesis

    Enzyme and pathway databases

    ReactomeiREACT_211860. Tie2 Signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-4
    Short name:
    ANG-4
    Alternative name(s):
    Angiopoietin-3
    Short name:
    ANG-3
    Gene namesi
    Name:Angpt4
    Synonyms:Agpt4, Ang3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1336887. Angpt4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 509488Angiopoietin-4PRO_0000009117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi297 ↔ 326PROSITE-ProRule annotation
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi450 ↔ 463PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9WVH6.
    PRIDEiQ9WVH6.

    PTM databases

    PhosphoSiteiQ9WVH6.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ9WVH6.
    BgeeiQ9WVH6.
    CleanExiMM_ANG3.
    MM_ANGPT4.
    GenevestigatoriQ9WVH6.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

    Protein-protein interaction databases

    IntActiQ9WVH6. 2 interactions.
    MINTiMINT-4087749.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVH6.
    SMRiQ9WVH6. Positions 208-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini288 – 508221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili181 – 26989Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG273522.
    GeneTreeiENSGT00720000108441.
    HOGENOMiHOG000037128.
    HOVERGENiHBG001644.
    InParanoidiQ9WVH6.
    KOiK05467.
    OMAiFKERSIF.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ9WVH6.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR028845. Ang-4.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WVH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE    50
    PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE 100
    KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ 150
    TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL 200
    QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL 250
    HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI 300
    KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR 350
    TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY 400
    ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC 450
    AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT 500
    RMMLRPMGA 509
    Length:509
    Mass (Da):57,805
    Last modified:November 1, 1999 - v1
    Checksum:i9B5A74A20A6664F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113707 mRNA. Translation: AAD21586.1.
    CCDSiCCDS16874.1.
    RefSeqiNP_033771.1. NM_009641.1.
    UniGeneiMm.189536.

    Genome annotation databases

    EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
    GeneIDi11602.
    KEGGimmu:11602.
    UCSCiuc008neq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113707 mRNA. Translation: AAD21586.1 .
    CCDSi CCDS16874.1.
    RefSeqi NP_033771.1. NM_009641.1.
    UniGenei Mm.189536.

    3D structure databases

    ProteinModelPortali Q9WVH6.
    SMRi Q9WVH6. Positions 208-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WVH6. 2 interactions.
    MINTi MINT-4087749.

    PTM databases

    PhosphoSitei Q9WVH6.

    Proteomic databases

    PaxDbi Q9WVH6.
    PRIDEi Q9WVH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028955 ; ENSMUSP00000028955 ; ENSMUSG00000027460 .
    GeneIDi 11602.
    KEGGi mmu:11602.
    UCSCi uc008neq.1. mouse.

    Organism-specific databases

    CTDi 51378.
    MGIi MGI:1336887. Angpt4.

    Phylogenomic databases

    eggNOGi NOG273522.
    GeneTreei ENSGT00720000108441.
    HOGENOMi HOG000037128.
    HOVERGENi HBG001644.
    InParanoidi Q9WVH6.
    KOi K05467.
    OMAi FKERSIF.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q9WVH6.
    TreeFami TF336658.

    Enzyme and pathway databases

    Reactomei REACT_211860. Tie2 Signaling.

    Miscellaneous databases

    NextBioi 279124.
    PROi Q9WVH6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WVH6.
    Bgeei Q9WVH6.
    CleanExi MM_ANG3.
    MM_ANGPT4.
    Genevestigatori Q9WVH6.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR028845. Ang-4.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    PANTHERi PTHR19143:SF31. PTHR19143:SF31. 1 hit.
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Myoblast and Uterus.
    2. "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
      FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.

    Entry informationi

    Entry nameiANGP4_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3