Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Angiopoietin-4

Gene

Angpt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiR-MMU-210993. Tie2 Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1336887. Angpt4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000911722 – 509Angiopoietin-4Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi297 ↔ 326PROSITE-ProRule annotation
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi450 ↔ 463PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

PTM databases

iPTMnetiQ9WVH6.
PhosphoSitePlusiQ9WVH6.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000027460.
CleanExiMM_ANG3.
MM_ANGPT4.
ExpressionAtlasiQ9WVH6. baseline and differential.
GenevisibleiQ9WVH6. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: MGI
  • vascular endothelial growth factor receptor binding Source: MGI

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactors.
MINTiMINT-4087749.
STRINGi10090.ENSMUSP00000028955.

Structurei

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 508Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 269Sequence analysisAdd BLAST89

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiKYEASSC.
OrthoDBiEOG091G03M1.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE
60 70 80 90 100
PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE
110 120 130 140 150
KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ
160 170 180 190 200
TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL
210 220 230 240 250
QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL
260 270 280 290 300
HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI
310 320 330 340 350
KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR
360 370 380 390 400
TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY
410 420 430 440 450
ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC
460 470 480 490 500
AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT

RMMLRPMGA
Length:509
Mass (Da):57,805
Last modified:November 1, 1999 - v1
Checksum:i9B5A74A20A6664F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA. Translation: AAD21586.1.
CCDSiCCDS16874.1.
RefSeqiNP_033771.1. NM_009641.2.
UniGeneiMm.189536.

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneIDi11602.
KEGGimmu:11602.
UCSCiuc008neq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA. Translation: AAD21586.1.
CCDSiCCDS16874.1.
RefSeqiNP_033771.1. NM_009641.2.
UniGeneiMm.189536.

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactors.
MINTiMINT-4087749.
STRINGi10090.ENSMUSP00000028955.

PTM databases

iPTMnetiQ9WVH6.
PhosphoSitePlusiQ9WVH6.

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneIDi11602.
KEGGimmu:11602.
UCSCiuc008neq.1. mouse.

Organism-specific databases

CTDi51378.
MGIiMGI:1336887. Angpt4.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiKYEASSC.
OrthoDBiEOG091G03M1.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiR-MMU-210993. Tie2 Signaling.

Miscellaneous databases

PROiQ9WVH6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027460.
CleanExiMM_ANG3.
MM_ANGPT4.
ExpressionAtlasiQ9WVH6. baseline and differential.
GenevisibleiQ9WVH6. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGP4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.