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Q9WVH6

- ANGP4_MOUSE

UniProt

Q9WVH6 - ANGP4_MOUSE

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Protein

Angiopoietin-4

Gene
Angpt4, Agpt4, Ang3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine kinase activator activity Source: Ensembl
  2. vascular endothelial growth factor receptor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cellular response to hypoxia Source: Ensembl
  3. endoderm development Source: MGI
  4. negative regulation of angiogenesis Source: Ensembl
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  7. positive regulation of angiogenesis Source: Ensembl
  8. positive regulation of blood vessel endothelial cell migration Source: Ensembl
  9. Tie signaling pathway Source: DFLAT
Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiREACT_211860. Tie2 Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1336887. Angpt4.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 509488Angiopoietin-4PRO_0000009117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi297 ↔ 326 By similarity
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi450 ↔ 463 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

PTM databases

PhosphoSiteiQ9WVH6.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ9WVH6.
BgeeiQ9WVH6.
CleanExiMM_ANG3.
MM_ANGPT4.
GenevestigatoriQ9WVH6.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactions.
MINTiMINT-4087749.

Structurei

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6. Positions 208-508.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 508221Fibrinogen C-terminalAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 26989 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG273522.
GeneTreeiENSGT00720000108441.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiFKERSIF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVH6-1 [UniParc]FASTAAdd to Basket

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MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE    50
PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE 100
KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ 150
TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL 200
QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL 250
HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI 300
KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR 350
TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY 400
ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC 450
AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT 500
RMMLRPMGA 509
Length:509
Mass (Da):57,805
Last modified:November 1, 1999 - v1
Checksum:i9B5A74A20A6664F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF113707 mRNA. Translation: AAD21586.1.
CCDSiCCDS16874.1.
RefSeqiNP_033771.1. NM_009641.1.
UniGeneiMm.189536.

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneIDi11602.
KEGGimmu:11602.
UCSCiuc008neq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF113707 mRNA. Translation: AAD21586.1 .
CCDSi CCDS16874.1.
RefSeqi NP_033771.1. NM_009641.1.
UniGenei Mm.189536.

3D structure databases

ProteinModelPortali Q9WVH6.
SMRi Q9WVH6. Positions 208-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WVH6. 2 interactions.
MINTi MINT-4087749.

PTM databases

PhosphoSitei Q9WVH6.

Proteomic databases

PaxDbi Q9WVH6.
PRIDEi Q9WVH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028955 ; ENSMUSP00000028955 ; ENSMUSG00000027460 .
GeneIDi 11602.
KEGGi mmu:11602.
UCSCi uc008neq.1. mouse.

Organism-specific databases

CTDi 51378.
MGIi MGI:1336887. Angpt4.

Phylogenomic databases

eggNOGi NOG273522.
GeneTreei ENSGT00720000108441.
HOGENOMi HOG000037128.
HOVERGENi HBG001644.
InParanoidi Q9WVH6.
KOi K05467.
OMAi FKERSIF.
OrthoDBi EOG7X9G60.
PhylomeDBi Q9WVH6.
TreeFami TF336658.

Enzyme and pathway databases

Reactomei REACT_211860. Tie2 Signaling.

Miscellaneous databases

NextBioi 279124.
PROi Q9WVH6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WVH6.
Bgeei Q9WVH6.
CleanExi MM_ANG3.
MM_ANGPT4.
Genevestigatori Q9WVH6.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
PANTHERi PTHR19143:SF31. PTHR19143:SF31. 1 hit.
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Myoblast and Uterus.
  2. "Biological characterization of angiopoietin-3 and angiopoietin-4."
    Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
    FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.

Entry informationi

Entry nameiANGP4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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