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Q9WVH6

- ANGP4_MOUSE

UniProt

Q9WVH6 - ANGP4_MOUSE

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Protein
Angiopoietin-4
Gene
Angpt4, Agpt4, Ang3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine kinase activator activity Source: Ensembl
  2. vascular endothelial growth factor receptor binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. Tie signaling pathway Source: DFLAT
  2. angiogenesis Source: UniProtKB-KW
  3. cellular response to hypoxia Source: Ensembl
  4. endoderm development Source: MGI
  5. negative regulation of angiogenesis Source: Ensembl
  6. negative regulation of apoptotic process Source: Ensembl
  7. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of blood vessel endothelial cell migration Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiREACT_211860. Tie2 Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1336887. Angpt4.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 509488Angiopoietin-4
PRO_0000009117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi297 ↔ 326 By similarity
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi450 ↔ 463 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

PTM databases

PhosphoSiteiQ9WVH6.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ9WVH6.
BgeeiQ9WVH6.
CleanExiMM_ANG3.
MM_ANGPT4.
GenevestigatoriQ9WVH6.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactions.
MINTiMINT-4087749.

Structurei

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6. Positions 208-508.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 508221Fibrinogen C-terminal
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 26989 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG273522.
GeneTreeiENSGT00720000108441.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiFKERSIF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi