Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9WVH6 (ANGP4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiopoietin-4

Short name=ANG-4
Alternative name(s):
Angiopoietin-3
Short name=ANG-3
Gene names
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Ref.2

Subunit structure

Homodimer; disulfide-linked. Interacts with TEK/TIE2. Ref.2

Subcellular location

Secreted Probable.

Tissue specificity

Widely expressed.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 509488Angiopoietin-4
PRO_0000009117

Regions

Domain288 – 508221Fibrinogen C-terminal
Coiled coil181 – 26989 Potential

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Disulfide bond297 ↔ 326 By similarity
Disulfide bond450 ↔ 463 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WVH6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9B5A74A20A6664F6

FASTA50957,805
        10         20         30         40         50         60 
MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE PDICQLAPTA 

        70         80         90        100        110        120 
APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE KILENNTQWL LKLEQSIKVN 

       130        140        150        160        170        180 
LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ TKAQTHKLTA VEAQVLNQTL HMKTQMLENS 

       190        200        210        220        230        240 
LSTNKLERQM LMQSRELQRL QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT 

       250        260        270        280        290        300 
GTLANLKHNL HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI 

       310        320        330        340        350        360 
KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR TWEEYKEGFG 

       370        380        390        400        410        420 
NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY ENFQLGSERQ RYSLSVNDSS 

       430        440        450        460        470        480 
SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC AQMLSGGWWF DACGLSNLNG IYYSVHQHLH 

       490        500 
KINGIRWHYF RGPSYSLHGT RMMLRPMGA 

« Hide

References

[1]"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans."
Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., Yancopoulos G.D.
Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Myoblast and Uterus.
[2]"Biological characterization of angiopoietin-3 and angiopoietin-4."
Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF113707 mRNA. Translation: AAD21586.1.
CCDSCCDS16874.1.
RefSeqNP_033771.1. NM_009641.1.
UniGeneMm.189536.

3D structure databases

ProteinModelPortalQ9WVH6.
SMRQ9WVH6. Positions 208-508.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9WVH6. 2 interactions.
MINTMINT-4087749.

PTM databases

PhosphoSiteQ9WVH6.

Proteomic databases

PaxDbQ9WVH6.
PRIDEQ9WVH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneID11602.
KEGGmmu:11602.
UCSCuc008neq.1. mouse.

Organism-specific databases

CTD51378.
MGIMGI:1336887. Angpt4.

Phylogenomic databases

eggNOGNOG273522.
GeneTreeENSGT00720000108441.
HOGENOMHOG000037128.
HOVERGENHBG001644.
InParanoidQ9WVH6.
KOK05467.
OMAFKERSIF.
OrthoDBEOG7X9G60.
PhylomeDBQ9WVH6.
TreeFamTF336658.

Gene expression databases

ArrayExpressQ9WVH6.
BgeeQ9WVH6.
CleanExMM_ANG3.
MM_ANGPT4.
GenevestigatorQ9WVH6.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279124.
PROQ9WVH6.
SOURCESearch...

Entry information

Entry nameANGP4_MOUSE
AccessionPrimary (citable) accession number: Q9WVH6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot