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Protein

Angiopoietin-4

Gene

Angpt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

  1. receptor tyrosine kinase binding Source: MGI
  2. transmembrane receptor protein tyrosine kinase activator activity Source: MGI
  3. vascular endothelial growth factor receptor binding Source: MGI

GO - Biological processi

  1. activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
  2. angiogenesis Source: UniProtKB-KW
  3. cellular response to hypoxia Source: Ensembl
  4. endoderm development Source: MGI
  5. negative regulation of angiogenesis Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. negative regulation of blood vessel endothelial cell migration Source: MGI
  8. positive regulation of angiogenesis Source: MGI
  9. positive regulation of blood vessel endothelial cell migration Source: MGI
  10. positive regulation of endothelial cell migration Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. Tie signaling pathway Source: DFLAT
Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiREACT_211860. Tie2 Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1336887. Angpt4.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 509488Angiopoietin-4PRO_0000009117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi297 ↔ 326PROSITE-ProRule annotation
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi450 ↔ 463PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

PTM databases

PhosphoSiteiQ9WVH6.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9WVH6.
CleanExiMM_ANG3.
MM_ANGPT4.
ExpressionAtlasiQ9WVH6. baseline and differential.
GenevestigatoriQ9WVH6.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactions.
MINTiMINT-4087749.

Structurei

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6. Positions 208-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 508221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 26989Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG273522.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiKANGIRW.
OrthoDBiEOG7X9G60.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE
60 70 80 90 100
PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE
110 120 130 140 150
KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ
160 170 180 190 200
TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL
210 220 230 240 250
QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL
260 270 280 290 300
HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI
310 320 330 340 350
KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR
360 370 380 390 400
TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY
410 420 430 440 450
ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC
460 470 480 490 500
AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT

RMMLRPMGA
Length:509
Mass (Da):57,805
Last modified:November 1, 1999 - v1
Checksum:i9B5A74A20A6664F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA. Translation: AAD21586.1.
CCDSiCCDS16874.1.
RefSeqiNP_033771.1. NM_009641.1.
UniGeneiMm.189536.

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneIDi11602.
KEGGimmu:11602.
UCSCiuc008neq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA. Translation: AAD21586.1.
CCDSiCCDS16874.1.
RefSeqiNP_033771.1. NM_009641.1.
UniGeneiMm.189536.

3D structure databases

ProteinModelPortaliQ9WVH6.
SMRiQ9WVH6. Positions 208-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVH6. 2 interactions.
MINTiMINT-4087749.

PTM databases

PhosphoSiteiQ9WVH6.

Proteomic databases

PaxDbiQ9WVH6.
PRIDEiQ9WVH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460.
GeneIDi11602.
KEGGimmu:11602.
UCSCiuc008neq.1. mouse.

Organism-specific databases

CTDi51378.
MGIiMGI:1336887. Angpt4.

Phylogenomic databases

eggNOGiNOG273522.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiQ9WVH6.
KOiK05467.
OMAiKANGIRW.
OrthoDBiEOG7X9G60.
PhylomeDBiQ9WVH6.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiREACT_211860. Tie2 Signaling.

Miscellaneous databases

NextBioi279124.
PROiQ9WVH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVH6.
CleanExiMM_ANG3.
MM_ANGPT4.
ExpressionAtlasiQ9WVH6. baseline and differential.
GenevestigatoriQ9WVH6.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Myoblast and Uterus.
  2. "Biological characterization of angiopoietin-3 and angiopoietin-4."
    Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
    FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.

Entry informationi

Entry nameiANGP4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.