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Protein

Protein odd-skipped-related 1

Gene

Osr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: BHF-UCL
  • cell proliferation involved in kidney development Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • chondrocyte differentiation Source: BHF-UCL
  • embryonic digit morphogenesis Source: BHF-UCL
  • embryonic forelimb morphogenesis Source: BHF-UCL
  • embryonic hindlimb morphogenesis Source: BHF-UCL
  • embryonic skeletal joint development Source: BHF-UCL
  • embryonic skeletal joint morphogenesis Source: BHF-UCL
  • embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  • gonad development Source: MGI
  • heart development Source: UniProtKB
  • intermediate mesoderm development Source: MGI
  • mesangial cell development Source: UniProtKB
  • mesonephric duct morphogenesis Source: UniProtKB
  • mesonephros development Source: UniProtKB
  • metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
  • metanephric epithelium development Source: UniProtKB
  • metanephric glomerulus vasculature development Source: UniProtKB
  • metanephric interstitial fibroblast development Source: UniProtKB
  • metanephric mesenchymal cell differentiation Source: UniProtKB
  • metanephric mesenchyme development Source: UniProtKB
  • metanephric mesenchyme morphogenesis Source: UniProtKB
  • metanephric nephron tubule development Source: UniProtKB
  • metanephric smooth muscle tissue development Source: UniProtKB
  • metanephros development Source: MGI
  • middle ear morphogenesis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of epithelial cell differentiation Source: UniProtKB
  • negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • odontogenesis Source: UniProtKB
  • palate development Source: UniProtKB
  • pattern specification involved in metanephros development Source: UniProtKB
  • positive regulation of bone mineralization Source: BHF-UCL
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • posterior mesonephric tubule development Source: UniProtKB
  • pronephros development Source: UniProtKB
  • renal vesicle progenitor cell differentiation Source: UniProtKB
  • specification of anterior mesonephric tubule identity Source: UniProtKB
  • specification of posterior mesonephric tubule identity Source: UniProtKB
  • stem cell differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • ureteric bud development Source: UniProtKB
  • ureter urothelium development Source: UniProtKB
  • urogenital system development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:Osr1
Synonyms:Odd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1344424. Osr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein odd-skipped-related 1PRO_0000047005Add
BLAST

Proteomic databases

PRIDEiQ9WVG7.

PTM databases

PhosphoSiteiQ9WVG7.

Expressioni

Developmental stagei

During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.1 Publication

Inductioni

Transcriptionally regulated by Ikzf1 and Runx2.1 Publication

Gene expression databases

BgeeiQ9WVG7.
CleanExiMM_OSR1.
GenevisibleiQ9WVG7. MM.

Interactioni

Protein-protein interaction databases

BioGridi204828. 1 interaction.
STRINGi10090.ENSMUSP00000055486.

Structurei

3D structure databases

ProteinModelPortaliQ9WVG7.
SMRiQ9WVG7. Positions 166-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ9WVG7.
KOiK09215.
OMAiATQEDHL.
OrthoDBiEOG754HQ2.
PhylomeDBiQ9WVG7.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP
110 120 130 140 150
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Length:266
Mass (Da):29,584
Last modified:November 1, 1999 - v1
Checksum:iCC9948ACFC90F7A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117814 mRNA. Translation: AAD37115.1.
BC023922 mRNA. Translation: AAH23922.1.
CCDSiCCDS25809.1.
RefSeqiNP_035989.1. NM_011859.3.
UniGeneiMm.45055.

Genome annotation databases

EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneIDi23967.
KEGGimmu:23967.
UCSCiuc007nao.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117814 mRNA. Translation: AAD37115.1.
BC023922 mRNA. Translation: AAH23922.1.
CCDSiCCDS25809.1.
RefSeqiNP_035989.1. NM_011859.3.
UniGeneiMm.45055.

3D structure databases

ProteinModelPortaliQ9WVG7.
SMRiQ9WVG7. Positions 166-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204828. 1 interaction.
STRINGi10090.ENSMUSP00000055486.

PTM databases

PhosphoSiteiQ9WVG7.

Proteomic databases

PRIDEiQ9WVG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneIDi23967.
KEGGimmu:23967.
UCSCiuc007nao.2. mouse.

Organism-specific databases

CTDi130497.
MGIiMGI:1344424. Osr1.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119344.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ9WVG7.
KOiK09215.
OMAiATQEDHL.
OrthoDBiEOG754HQ2.
PhylomeDBiQ9WVG7.
TreeFamiTF350876.

Miscellaneous databases

NextBioi303837.
PROiQ9WVG7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WVG7.
CleanExiMM_OSR1.
GenevisibleiQ9WVG7. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped."
    So P.L., Danielian P.S.
    Mech. Dev. 84:157-160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development."
    Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.
    Dev. Biol. 288:582-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  4. "Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors."
    Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.
    Gene 426:81-90(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiOSR1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.