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Q9WVG7

- OSR1_MOUSE

UniProt

Q9WVG7 - OSR1_MOUSE

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Protein
Protein odd-skipped-related 1
Gene
Osr1, Odd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1
Add
BLAST
Zinc fingeri203 – 22523C2H2-type 2
Add
BLAST
Zinc fingeri231 – 25323C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: BHF-UCL
  2. cell proliferation involved in kidney development Source: UniProtKB
  3. cellular response to retinoic acid Source: UniProtKB
  4. chondrocyte differentiation Source: BHF-UCL
  5. embryonic digit morphogenesis Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: BHF-UCL
  7. embryonic hindlimb morphogenesis Source: BHF-UCL
  8. embryonic skeletal joint development Source: BHF-UCL
  9. embryonic skeletal joint morphogenesis Source: BHF-UCL
  10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  11. gonad development Source: MGI
  12. heart development Source: UniProtKB
  13. intermediate mesoderm development Source: MGI
  14. mesangial cell development Source: UniProtKB
  15. mesonephric duct morphogenesis Source: UniProtKB
  16. mesonephros development Source: UniProtKB
  17. metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
  18. metanephric epithelium development Source: UniProtKB
  19. metanephric glomerulus vasculature development Source: UniProtKB
  20. metanephric interstitial cell development Source: UniProtKB
  21. metanephric mesenchymal cell differentiation Source: UniProtKB
  22. metanephric mesenchyme development Source: UniProtKB
  23. metanephric mesenchyme morphogenesis Source: UniProtKB
  24. metanephric nephron tubule development Source: UniProtKB
  25. metanephric smooth muscle tissue development Source: UniProtKB
  26. metanephros development Source: MGI
  27. middle ear morphogenesis Source: UniProtKB
  28. negative regulation of apoptotic process Source: UniProtKB
  29. negative regulation of epithelial cell differentiation Source: UniProtKB
  30. negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  31. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. odontogenesis Source: UniProtKB
  33. palate development Source: UniProtKB
  34. pattern specification involved in metanephros development Source: UniProtKB
  35. positive regulation of bone mineralization Source: BHF-UCL
  36. positive regulation of epithelial cell proliferation Source: UniProtKB
  37. positive regulation of gastrulation Source: UniProtKB
  38. positive regulation of gene expression Source: UniProtKB
  39. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  40. posterior mesonephric tubule development Source: UniProtKB
  41. pronephros development Source: UniProtKB
  42. renal vesicle progenitor cell differentiation Source: UniProtKB
  43. specification of anterior mesonephric tubule identity Source: UniProtKB
  44. specification of posterior mesonephric tubule identity Source: UniProtKB
  45. stem cell differentiation Source: UniProtKB
  46. transcription, DNA-templated Source: UniProtKB-KW
  47. ureter urothelium development Source: UniProtKB
  48. ureteric bud development Source: UniProtKB
  49. urogenital system development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:Osr1
Synonyms:Odd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1344424. Osr1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein odd-skipped-related 1
PRO_0000047005Add
BLAST

Proteomic databases

PRIDEiQ9WVG7.

PTM databases

PhosphoSiteiQ9WVG7.

Expressioni

Developmental stagei

During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.1 Publication

Inductioni

Transcriptionally regulated by Ikzf1 and Runx2.1 Publication

Gene expression databases

BgeeiQ9WVG7.
CleanExiMM_OSR1.
GenevestigatoriQ9WVG7.

Interactioni

Protein-protein interaction databases

BioGridi204828. 1 interaction.
STRINGi10090.ENSMUSP00000055486.

Structurei

3D structure databases

ProteinModelPortaliQ9WVG7.
SMRiQ9WVG7. Positions 166-255.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117413.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ9WVG7.
KOiK09215.
OMAiAKPRFDF.
OrthoDBiEOG754HQ2.
PhylomeDBiQ9WVG7.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WVG7-1 [UniParc]FASTAAdd to Basket

« Hide

MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV    50
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP 100
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL 150
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE 200
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK 250
TLHSQVKELK TSKIKC 266
Length:266
Mass (Da):29,584
Last modified:November 1, 1999 - v1
Checksum:iCC9948ACFC90F7A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117814 mRNA. Translation: AAD37115.1.
BC023922 mRNA. Translation: AAH23922.1.
CCDSiCCDS25809.1.
RefSeqiNP_035989.1. NM_011859.3.
UniGeneiMm.45055.

Genome annotation databases

EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneIDi23967.
KEGGimmu:23967.
UCSCiuc007nao.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117814 mRNA. Translation: AAD37115.1 .
BC023922 mRNA. Translation: AAH23922.1 .
CCDSi CCDS25809.1.
RefSeqi NP_035989.1. NM_011859.3.
UniGenei Mm.45055.

3D structure databases

ProteinModelPortali Q9WVG7.
SMRi Q9WVG7. Positions 166-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204828. 1 interaction.
STRINGi 10090.ENSMUSP00000055486.

PTM databases

PhosphoSitei Q9WVG7.

Proteomic databases

PRIDEi Q9WVG7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057021 ; ENSMUSP00000055486 ; ENSMUSG00000048387 .
GeneIDi 23967.
KEGGi mmu:23967.
UCSCi uc007nao.2. mouse.

Organism-specific databases

CTDi 130497.
MGIi MGI:1344424. Osr1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117413.
HOGENOMi HOG000013107.
HOVERGENi HBG054398.
InParanoidi Q9WVG7.
KOi K09215.
OMAi AKPRFDF.
OrthoDBi EOG754HQ2.
PhylomeDBi Q9WVG7.
TreeFami TF350876.

Miscellaneous databases

NextBioi 303837.
PROi Q9WVG7.
SOURCEi Search...

Gene expression databases

Bgeei Q9WVG7.
CleanExi MM_OSR1.
Genevestigatori Q9WVG7.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped."
    So P.L., Danielian P.S.
    Mech. Dev. 84:157-160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development."
    Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.
    Dev. Biol. 288:582-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  4. "Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors."
    Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.
    Gene 426:81-90(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiOSR1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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