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Q9WVG7

- OSR1_MOUSE

UniProt

Q9WVG7 - OSR1_MOUSE

Protein

Protein odd-skipped-related 1

Gene

Osr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: BHF-UCL
    2. cell proliferation involved in kidney development Source: UniProtKB
    3. cellular response to retinoic acid Source: UniProtKB
    4. chondrocyte differentiation Source: BHF-UCL
    5. embryonic digit morphogenesis Source: BHF-UCL
    6. embryonic forelimb morphogenesis Source: BHF-UCL
    7. embryonic hindlimb morphogenesis Source: BHF-UCL
    8. embryonic skeletal joint development Source: BHF-UCL
    9. embryonic skeletal joint morphogenesis Source: BHF-UCL
    10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
    11. gonad development Source: MGI
    12. heart development Source: UniProtKB
    13. intermediate mesoderm development Source: MGI
    14. mesangial cell development Source: UniProtKB
    15. mesonephric duct morphogenesis Source: UniProtKB
    16. mesonephros development Source: UniProtKB
    17. metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
    18. metanephric epithelium development Source: UniProtKB
    19. metanephric glomerulus vasculature development Source: UniProtKB
    20. metanephric interstitial fibroblast development Source: UniProtKB
    21. metanephric mesenchymal cell differentiation Source: UniProtKB
    22. metanephric mesenchyme development Source: UniProtKB
    23. metanephric mesenchyme morphogenesis Source: UniProtKB
    24. metanephric nephron tubule development Source: UniProtKB
    25. metanephric smooth muscle tissue development Source: UniProtKB
    26. metanephros development Source: MGI
    27. middle ear morphogenesis Source: UniProtKB
    28. negative regulation of apoptotic process Source: UniProtKB
    29. negative regulation of epithelial cell differentiation Source: UniProtKB
    30. negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    31. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    32. odontogenesis Source: UniProtKB
    33. palate development Source: UniProtKB
    34. pattern specification involved in metanephros development Source: UniProtKB
    35. positive regulation of bone mineralization Source: BHF-UCL
    36. positive regulation of epithelial cell proliferation Source: UniProtKB
    37. positive regulation of gastrulation Source: UniProtKB
    38. positive regulation of gene expression Source: UniProtKB
    39. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    40. posterior mesonephric tubule development Source: UniProtKB
    41. pronephros development Source: UniProtKB
    42. renal vesicle progenitor cell differentiation Source: UniProtKB
    43. specification of anterior mesonephric tubule identity Source: UniProtKB
    44. specification of posterior mesonephric tubule identity Source: UniProtKB
    45. stem cell differentiation Source: UniProtKB
    46. transcription, DNA-templated Source: UniProtKB-KW
    47. ureteric bud development Source: UniProtKB
    48. ureter urothelium development Source: UniProtKB
    49. urogenital system development Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein odd-skipped-related 1
    Gene namesi
    Name:Osr1
    Synonyms:Odd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1344424. Osr1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Protein odd-skipped-related 1PRO_0000047005Add
    BLAST

    Proteomic databases

    PRIDEiQ9WVG7.

    PTM databases

    PhosphoSiteiQ9WVG7.

    Expressioni

    Developmental stagei

    During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.1 Publication

    Inductioni

    Transcriptionally regulated by Ikzf1 and Runx2.1 Publication

    Gene expression databases

    BgeeiQ9WVG7.
    CleanExiMM_OSR1.
    GenevestigatoriQ9WVG7.

    Interactioni

    Protein-protein interaction databases

    BioGridi204828. 1 interaction.
    STRINGi10090.ENSMUSP00000055486.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WVG7.
    SMRiQ9WVG7. Positions 166-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117413.
    HOGENOMiHOG000013107.
    HOVERGENiHBG054398.
    InParanoidiQ9WVG7.
    KOiK09215.
    OMAiAKPRFDF.
    OrthoDBiEOG754HQ2.
    PhylomeDBiQ9WVG7.
    TreeFamiTF350876.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WVG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV    50
    HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP 100
    EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL 150
    LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE 200
    RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK 250
    TLHSQVKELK TSKIKC 266
    Length:266
    Mass (Da):29,584
    Last modified:November 1, 1999 - v1
    Checksum:iCC9948ACFC90F7A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117814 mRNA. Translation: AAD37115.1.
    BC023922 mRNA. Translation: AAH23922.1.
    CCDSiCCDS25809.1.
    RefSeqiNP_035989.1. NM_011859.3.
    UniGeneiMm.45055.

    Genome annotation databases

    EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
    GeneIDi23967.
    KEGGimmu:23967.
    UCSCiuc007nao.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117814 mRNA. Translation: AAD37115.1 .
    BC023922 mRNA. Translation: AAH23922.1 .
    CCDSi CCDS25809.1.
    RefSeqi NP_035989.1. NM_011859.3.
    UniGenei Mm.45055.

    3D structure databases

    ProteinModelPortali Q9WVG7.
    SMRi Q9WVG7. Positions 166-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204828. 1 interaction.
    STRINGi 10090.ENSMUSP00000055486.

    PTM databases

    PhosphoSitei Q9WVG7.

    Proteomic databases

    PRIDEi Q9WVG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057021 ; ENSMUSP00000055486 ; ENSMUSG00000048387 .
    GeneIDi 23967.
    KEGGi mmu:23967.
    UCSCi uc007nao.2. mouse.

    Organism-specific databases

    CTDi 130497.
    MGIi MGI:1344424. Osr1.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117413.
    HOGENOMi HOG000013107.
    HOVERGENi HBG054398.
    InParanoidi Q9WVG7.
    KOi K09215.
    OMAi AKPRFDF.
    OrthoDBi EOG754HQ2.
    PhylomeDBi Q9WVG7.
    TreeFami TF350876.

    Miscellaneous databases

    NextBioi 303837.
    PROi Q9WVG7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WVG7.
    CleanExi MM_OSR1.
    Genevestigatori Q9WVG7.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped."
      So P.L., Danielian P.S.
      Mech. Dev. 84:157-160(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development."
      Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.
      Dev. Biol. 288:582-594(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    4. "Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors."
      Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.
      Gene 426:81-90(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiOSR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WVG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3