Q9WVG7 (OSR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein odd-skipped-related 1

Gene names

Name:	Osr1
Synonyms:	Odd1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. Ref.3
Subcellular location	Nucleus Potential.
Developmental stage	During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve. Ref.3
Induction	Transcriptionally regulated by Ikzf1 and Runx2. Ref.4
Disruption phenotype	Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction. Ref.3
Sequence similarities	Belongs to the Odd C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to retinoic acid Inferred from expression pattern PubMed 20171952. Source: UniProtKB chondrocyte differentiation Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL embryonic digit morphogenesis Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL embryonic forelimb morphogenesis Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL embryonic hindlimb morphogenesis Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL embryonic skeletal limb joint morphogenesis Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL gonad development Inferred from mutant phenotype Ref.3. Source: MGI heart development Inferred from mutant phenotype Ref.3PubMed 16790474. Source: UniProtKB intermediate mesoderm development Inferred from mutant phenotype Ref.3. Source: MGI mesangial cell development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB mesonephric duct morphogenesis Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB metanephric cap mesenchymal cell proliferation involved in metanephros development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB metanephric glomerulus vasculature development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB metanephric interstitial cell development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB metanephric mesenchymal cell differentiation Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB metanephric nephron tubule development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB metanephric smooth muscle tissue development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB middle ear morphogenesis Inferred from genetic interaction PubMed 19389375. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB negative regulation of nephron tubule epithelial cell differentiation Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL odontogenesis Inferred from genetic interaction PubMed 19389375. Source: UniProtKB palate development Inferred from genetic interaction PubMed 19389375. Source: UniProtKB pattern specification involved in metanephros development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB positive regulation of bone mineralization Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL positive regulation of epithelial cell proliferation Inferred from genetic interaction PubMed 19389375. Source: UniProtKB positive regulation of gastrulation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL pronephros development Inferred from sequence or structural similarity. Source: UniProtKB renal vesicle progenitor cell differentiation Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB specification of anterior mesonephric tubule identity Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB specification of posterior mesonephric tubule identity Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB stem cell differentiation Inferred from direct assay PubMed 20171952. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW ureter urothelium development Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB ureteric bud development Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB
Cellular_component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Protein odd-skipped-related 1		PRO_0000047005
Regions
	Zinc finger	175 – 197	23	C2H2-type 1
	Zinc finger	203 – 225	23	C2H2-type 2
	Zinc finger	231 – 253	23	C2H2-type 3

Sequences

	Sequence		Length	Mass (Da)
	Q9WVG7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CC9948ACFC90F7A5	FASTA	266	29,584
	10 20 30 40 50 60 MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP 70 80 90 100 110 120 AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA 130 140 150 160 170 180 NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC 190 200 210 220 230 240 GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF 250 260 CQSRTLAVHK TLHSQVKELK TSKIKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped." So P.L., Danielian P.S. Mech. Dev. 84:157-160(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development." Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R. Dev. Biol. 288:582-594(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[4]	"Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors." Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A. Gene 426:81-90(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117814 mRNA. Translation: AAD37115.1. BC023922 mRNA. Translation: AAH23922.1.
IPI	IPI00125951.
RefSeq	NP_035989.1. NM_011859.3.
UniGene	Mm.45055.
3D structure databases
ProteinModelPortal	Q9WVG7.
SMR	Q9WVG7. Positions 166-255.
ModBase	Search...
PTM databases
PhosphoSite	Q9WVG7.
Proteomic databases
PRIDE	Q9WVG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneID	23967.
KEGG	mmu:23967.
UCSC	uc007nao.2. mouse.
Organism-specific databases
CTD	130497.
MGI	MGI:1344424. Osr1.
Phylogenomic databases
eggNOG	COG5048.
GeneTree	ENSGT00390000021402.
HOGENOM	HOG000013107.
HOVERGEN	HBG054398.
InParanoid	Q9WVG7.
KO	K09215.
OMA	AKPRFDF.
OrthoDB	EOG4DFPP5.
Gene expression databases
Bgee	Q9WVG7.
CleanEx	MM_OSR1.
Genevestigator	Q9WVG7.
GermOnline	ENSMUSG00000048387. Mus musculus.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	303837.
SOURCE	Search...

Entry information

Entry name

OSR1_MOUSE

Accession

Primary (citable) accession number: Q9WVG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program