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Q9WVG7 (OSR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein odd-skipped-related 1
Gene names
Name:Osr1
Synonyms:Odd1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. Ref.3

Subcellular location

Nucleus Potential.

Developmental stage

During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve. Ref.3

Induction

Transcriptionally regulated by Ikzf1 and Runx2. Ref.4

Disruption phenotype

Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction. Ref.3

Sequence similarities

Belongs to the Odd C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

cell proliferation involved in kidney development

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

cellular response to retinoic acid

Inferred from expression pattern PubMed 20171952. Source: UniProtKB

chondrocyte differentiation

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic forelimb morphogenesis

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic hindlimb morphogenesis

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic skeletal joint development

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic skeletal joint morphogenesis

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

embryonic skeletal limb joint morphogenesis

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

gonad development

Inferred from mutant phenotype Ref.3. Source: MGI

heart development

Inferred from mutant phenotype Ref.3PubMed 16790474. Source: UniProtKB

intermediate mesoderm development

Inferred from mutant phenotype Ref.3. Source: MGI

mesangial cell development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

mesonephric duct morphogenesis

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

mesonephros development

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

metanephric cap mesenchymal cell proliferation involved in metanephros development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephric epithelium development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephric glomerulus vasculature development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephric interstitial cell development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephric mesenchymal cell differentiation

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

metanephric mesenchyme development

Inferred from direct assay PubMed 20171952. Source: UniProtKB

metanephric mesenchyme morphogenesis

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

metanephric nephron tubule development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephric smooth muscle tissue development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

metanephros development

Inferred from mutant phenotype Ref.3. Source: MGI

middle ear morphogenesis

Inferred from genetic interaction PubMed 19389375. Source: UniProtKB

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

negative regulation of epithelial cell differentiation

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

negative regulation of nephron tubule epithelial cell differentiation

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

odontogenesis

Inferred from genetic interaction PubMed 19389375. Source: UniProtKB

palate development

Inferred from genetic interaction PubMed 19389375. Source: UniProtKB

pattern specification involved in metanephros development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

positive regulation of bone mineralization

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

positive regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 19389375. Source: UniProtKB

positive regulation of gastrulation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 21262216. Source: BHF-UCL

posterior mesonephric tubule development

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

pronephros development

Inferred from sequence or structural similarity. Source: UniProtKB

renal vesicle progenitor cell differentiation

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

specification of anterior mesonephric tubule identity

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

specification of posterior mesonephric tubule identity

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

stem cell differentiation

Inferred from direct assay PubMed 20171952. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

ureter urothelium development

Inferred from mutant phenotype PubMed 18835385. Source: UniProtKB

ureteric bud development

Inferred from mutant phenotype PubMed 16790474. Source: UniProtKB

urogenital system development

Inferred from mutant phenotype Ref.3. Source: UniProtKB

   Cellular_componentnucleolus

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Protein odd-skipped-related 1
PRO_0000047005

Regions

Zinc finger175 – 19723C2H2-type 1
Zinc finger203 – 22523C2H2-type 2
Zinc finger231 – 25323C2H2-type 3

Sequences

Sequence LengthMass (Da)Tools
Q9WVG7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: CC9948ACFC90F7A5

FASTA26629,584
        10         20         30         40         50         60 
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP 

        70         80         90        100        110        120 
AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA 

       130        140        150        160        170        180 
NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC 

       190        200        210        220        230        240 
GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF 

       250        260 
CQSRTLAVHK TLHSQVKELK TSKIKC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped."
So P.L., Danielian P.S.
Mech. Dev. 84:157-160(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development."
Wang Q., Lan Y., Cho E.S., Maltby K.M., Jiang R.
Dev. Biol. 288:582-594(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[4]"Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors."
Yamauchi M., Kawai S., Kato T., Ooshima T., Amano A.
Gene 426:81-90(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117814 mRNA. Translation: AAD37115.1.
BC023922 mRNA. Translation: AAH23922.1.
CCDSCCDS25809.1.
RefSeqNP_035989.1. NM_011859.3.
UniGeneMm.45055.

3D structure databases

ProteinModelPortalQ9WVG7.
SMRQ9WVG7. Positions 166-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204828. 1 interaction.
STRING10090.ENSMUSP00000055486.

PTM databases

PhosphoSiteQ9WVG7.

Proteomic databases

PRIDEQ9WVG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387.
GeneID23967.
KEGGmmu:23967.
UCSCuc007nao.2. mouse.

Organism-specific databases

CTD130497.
MGIMGI:1344424. Osr1.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117413.
HOGENOMHOG000013107.
HOVERGENHBG054398.
InParanoidQ9WVG7.
KOK09215.
OMAAKPRFDF.
OrthoDBEOG754HQ2.
PhylomeDBQ9WVG7.
TreeFamTF350876.

Gene expression databases

BgeeQ9WVG7.
CleanExMM_OSR1.
GenevestigatorQ9WVG7.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio303837.
PROQ9WVG7.
SOURCESearch...

Entry information

Entry nameOSR1_MOUSE
AccessionPrimary (citable) accession number: Q9WVG7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot