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Protein

Endothelial lipase

Gene

Lipg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei193Charge relay systemPROSITE-ProRule annotation1
Active sitei274Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-8964058 HDL remodeling

Protein family/group databases

ESTHERimouse-Lipg Lipoprotein_Lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial lipase (EC:3.1.1.3)
Alternative name(s):
Endothelial cell-derived lipase
Short name:
EDL
Gene namesi
Name:Lipg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1341803 Lipg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2380190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001779821 – 500Endothelial lipaseAdd BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 77PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 272PROSITE-ProRule annotation
Disulfide bondi297 ↔ 316PROSITE-ProRule annotation
Disulfide bondi308 ↔ 311PROSITE-ProRule annotation
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi463 ↔ 483PROSITE-ProRule annotation
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WVG5
PaxDbiQ9WVG5
PRIDEiQ9WVG5

PTM databases

iPTMnetiQ9WVG5
PhosphoSitePlusiQ9WVG5

Expressioni

Tissue specificityi

Expressed in placenta, lung, liver, testis and spleen.

Gene expression databases

BgeeiENSMUSG00000053846
CleanExiMM_LIPG
ExpressionAtlasiQ9WVG5 baseline and differential
GenevisibleiQ9WVG5 MM

Interactioni

Subunit structurei

Head to tail homodimer.By similarity

Protein-protein interaction databases

BioGridi201170, 1 interactor
STRINGi10090.ENSMUSP00000066536

Chemistry databases

BindingDBiQ9WVG5

Structurei

3D structure databases

ProteinModelPortaliQ9WVG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini347 – 482PLATPROSITE-ProRule annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni325 – 337Heparin-bindingBy similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 121Poly-Val4

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJUA Eukaryota
ENOG4111GMM LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiQ9WVG5
KOiK22284
OMAiLKIKLTW
OrthoDBiEOG091G052B
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002330 Lipo_Lipase
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00822 LIPOLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNTVFLLGF WSVYCYFPAG SITTLRPQGS LRDEHHKPTG VPATARPSVA
60 70 80 90 100
FNIRTSKDPE QEGCNLSLGD SKLLENCGFN MTAKTFFIIH GWTMSGMFES
110 120 130 140 150
WLHKLVSALQ MREKDANVVV VDWLPLAHQL YTDAVNNTRV VGQRVAGMLD
160 170 180 190 200
WLQEKEEFSL GNVHLIGYSL GAHVAGYAGN FVKGTVGRIT GLDPAGPMFE
210 220 230 240 250
GVDINRRLSP DDADFVDVLH TYTLSFGLSI GIRMPVGHID IYPNGGDFQP
260 270 280 290 300
GCGFNDVIGS FAYGTISEMV KCEHERAVHL FVDSLVNQDK PSFAFQCTDS
310 320 330 340 350
SRFKRGICLS CRKNRCNNIG YNAKKMRKKR NSKMYLKTRA GMPFKVYHYQ
360 370 380 390 400
LKVHMFSYNN SGDTQPTLYI TLYGSNADSQ NLPLEIVEKI ELNATNTFLV
410 420 430 440 450
YTEEDLGDLL KMRLTWEGVA HSWYNLWNEF RNYLSQPSNP SRELYIRRIR
460 470 480 490 500
VKSGETQRKV TFCTQDPTKS SISPGQELWF HKCQDGWKMK NKTSPFVNLA
Length:500
Mass (Da):56,629
Last modified:July 27, 2011 - v3
Checksum:iD4B8A4A291810759
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Q → E in AAH20991 (PubMed:15489334).Curated1
Sequence conflicti424Y → C in AAD30435 (PubMed:10318835).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118768 mRNA Translation: AAD30435.1
AC125122 Genomic DNA No translation available.
BC020991 mRNA Translation: AAH20991.1
CCDSiCCDS29343.1
RefSeqiNP_034850.3, NM_010720.3
UniGeneiMm.299647

Genome annotation databases

EnsembliENSMUST00000066532; ENSMUSP00000066536; ENSMUSG00000053846
GeneIDi16891
KEGGimmu:16891
UCSCiuc008fpu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPE_MOUSE
AccessioniPrimary (citable) accession number: Q9WVG5
Secondary accession number(s): Q8VDU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health