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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei169Important for interaction with integrinBy similarity1
Sitei177Important for interaction with integrinBy similarity1
Sitei179Important for interaction with integrinBy similarity1
Sitei188Important for interaction with integrinBy similarity1
Sitei202Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152891 – 114By similarityAdd BLAST114
ChainiPRO_0000015290115 – 266Interleukin-1 betaAdd BLAST152

Proteomic databases

PRIDEiQ9WVG1

Expressioni

Gene expression databases

BgeeiENSCPOG00000001975

Interactioni

Subunit structurei

Monomer. Interacts with MEFV. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001784

Structurei

3D structure databases

ProteinModelPortaliQ9WVG1
SMRiQ9WVG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
GeneTreeiENSGT00510000048687
HOGENOMiHOG000246399
HOVERGENiHBG007328
InParanoidiQ9WVG1
OMAiQVVFSMS
OrthoDBiEOG091G0GR9
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPELSSE VTAYHSDENE LFFEVDGPNK MQYCFQDRDL CSLDEGIKLQ
60 70 80 90 100
ISHQHFNKSF RQTVSLIVAV EKLRKKLAPC TWAFQDDDLR PLLPFIFEEE
110 120 130 140 150
PIVCDTWDEE YESDTPVPSR NCTLHDIQHK RLVLSDPCEL KALHLNGDNL
160 170 180 190 200
NRQVVFSMSF VQGERSDNKM PVALGLKGKN LYLSCVMKDG KPVLQLESVD
210 220 230 240 250
GKQYPKKKME KRFVFNKITS KSTVEFESAQ FPNWYISTSQ AEHKPVFLGN
260
NNGQDIIDFK LELVSS
Length:266
Mass (Da):30,531
Last modified:November 1, 1999 - v1
Checksum:i46558BA16B4C529A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119622 mRNA Translation: AAD38502.1
RefSeqiNP_001166439.1, NM_001172968.1
XP_013002735.1, XM_013147281.1

Genome annotation databases

EnsembliENSCPOT00000001999; ENSCPOP00000001784; ENSCPOG00000001975
ENSCPOT00000032308; ENSCPOP00000022138; ENSCPOG00000001975
GeneIDi100135556

Entry informationi

Entry nameiIL1B_CAVPO
AccessioniPrimary (citable) accession number: Q9WVG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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