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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:IL1B
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152891 – 114By similarityAdd BLAST114
ChainiPRO_0000015290115 – 266Interleukin-1 betaAdd BLAST152

Expressioni

Gene expression databases

BgeeiENSCPOG00000001975.

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001784.

Structurei

3D structure databases

ProteinModelPortaliQ9WVG1.
SMRiQ9WVG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
InParanoidiQ9WVG1.
OMAiQVVFSMS.
OrthoDBiEOG091G0GR9.
TreeFamiTF300203.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF42. PTHR10078:SF42. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPELSSE VTAYHSDENE LFFEVDGPNK MQYCFQDRDL CSLDEGIKLQ
60 70 80 90 100
ISHQHFNKSF RQTVSLIVAV EKLRKKLAPC TWAFQDDDLR PLLPFIFEEE
110 120 130 140 150
PIVCDTWDEE YESDTPVPSR NCTLHDIQHK RLVLSDPCEL KALHLNGDNL
160 170 180 190 200
NRQVVFSMSF VQGERSDNKM PVALGLKGKN LYLSCVMKDG KPVLQLESVD
210 220 230 240 250
GKQYPKKKME KRFVFNKITS KSTVEFESAQ FPNWYISTSQ AEHKPVFLGN
260
NNGQDIIDFK LELVSS
Length:266
Mass (Da):30,531
Last modified:November 1, 1999 - v1
Checksum:i46558BA16B4C529A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119622 mRNA. Translation: AAD38502.1.
RefSeqiNP_001166439.1. NM_001172968.1.
XP_013002735.1. XM_013147281.1.

Genome annotation databases

EnsembliENSCPOT00000001999; ENSCPOP00000001784; ENSCPOG00000001975.
GeneIDi100135556.

Similar proteinsi

Entry informationi

Entry nameiIL1B_CAVPO
AccessioniPrimary (citable) accession number: Q9WVG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families